DE69734983D1 - Triarylmethanverbindungen zur behandlung von krebs, aktinischer keratose und kaposisarkom - Google Patents
Triarylmethanverbindungen zur behandlung von krebs, aktinischer keratose und kaposisarkomInfo
- Publication number
- DE69734983D1 DE69734983D1 DE69734983T DE69734983T DE69734983D1 DE 69734983 D1 DE69734983 D1 DE 69734983D1 DE 69734983 T DE69734983 T DE 69734983T DE 69734983 T DE69734983 T DE 69734983T DE 69734983 D1 DE69734983 D1 DE 69734983D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- treatment
- replaced
- caposisarcom
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 206010020649 Hyperkeratosis Diseases 0.000 title 1
- 208000001126 Keratosis Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 230000004663 cell proliferation Effects 0.000 abstract 3
- 210000003743 erythrocyte Anatomy 0.000 abstract 3
- 208000007056 sickle cell anemia Diseases 0.000 abstract 2
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical class C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/02—Halogenated hydrocarbons
- A61K31/025—Halogenated hydrocarbons carbocyclic
- A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A61K31/075—Ethers or acetals
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- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
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- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
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- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- C07C255/33—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
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- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/30—Germanium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/535—Organo-phosphoranes
- C07F9/5352—Phosphoranes containing the structure P=C-
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61875996A | 1996-03-20 | 1996-03-20 | |
US61895296A | 1996-03-20 | 1996-03-20 | |
US61876296A | 1996-03-20 | 1996-03-20 | |
US61876096A | 1996-03-20 | 1996-03-20 | |
US618762 | 1996-03-20 | ||
US618760 | 1996-03-20 | ||
US618952 | 1996-03-20 | ||
PCT/US1997/004551 WO1997034589A1 (en) | 1996-03-20 | 1997-03-19 | Triaryl methane compounds for sickle cell disease |
US618759 | 2000-07-18 |
Publications (2)
Publication Number | Publication Date |
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DE69734983D1 true DE69734983D1 (de) | 2006-02-02 |
DE69734983T2 DE69734983T2 (de) | 2006-09-07 |
Family
ID=27505150
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69734983T Expired - Lifetime DE69734983T2 (de) | 1996-03-20 | 1997-03-19 | Triarylmethanverbindungen zur behandlung von krebs, aktinischer keratose und kaposisarkom |
Country Status (10)
Country | Link |
---|---|
US (2) | US6331564B1 (de) |
EP (1) | EP0918514B9 (de) |
JP (1) | JP4376970B2 (de) |
AT (1) | ATE314060T1 (de) |
AU (1) | AU732881C (de) |
BR (1) | BR9708230A (de) |
CA (1) | CA2250092C (de) |
DE (1) | DE69734983T2 (de) |
NZ (1) | NZ332103A (de) |
WO (1) | WO1997034589A1 (de) |
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US5889038A (en) | 1996-03-20 | 1999-03-30 | Children's Hospital | Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds |
JPH10338658A (ja) * | 1997-04-08 | 1998-12-22 | Hoechst Marion Roussel Kk | レチノイド作用調節剤 |
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AU1598899A (en) * | 1997-11-20 | 1999-06-15 | Children's Medical Center Corporation | Use of substituted diphenyl indanone, indane and indole compounds for the treatment or prevention of sickle cell disease, inflammatory diseases characterized by abnormal cell proliferation, diarrhe and scours |
AU762749B2 (en) * | 1998-07-01 | 2003-07-03 | Trustees Of The University Of Pennsylvania, The | Cavity induced allosteric modification of intermolecular interactions and methods of identifying compounds that effect the same |
ES2230880T3 (es) * | 1998-07-30 | 2005-05-01 | Abbott Laboratories | Agentes selectivos anti-inflmatorios de glucocorticoides. |
US6166013A (en) * | 1998-07-30 | 2000-12-26 | Abbott Laboratories | Glucocortiocoid-selective agents |
AU1596099A (en) * | 1998-11-23 | 2000-06-13 | Eisai Co. Ltd. | Aryl and heteroaryl compounds useful as fibroblast growth factor antagonists |
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WO2000069439A1 (en) * | 1999-05-12 | 2000-11-23 | Neurosearch A/S | Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction |
US6803375B1 (en) * | 2000-01-06 | 2004-10-12 | The Regents Of The University Of California | Non-peptide inhibition of T-lymphocyte activation and therapies related thereto |
GB0111872D0 (en) | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
EP1465863B1 (de) | 2002-01-04 | 2008-07-09 | NeuroSearch A/S | Kaliumkanal-modulatoren |
US7968605B2 (en) * | 2002-02-04 | 2011-06-28 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
US20080026984A1 (en) * | 2002-02-04 | 2008-01-31 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
AU2003208525B9 (en) * | 2002-02-04 | 2009-08-27 | Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda | Amend the invention title to read Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof |
US7122580B2 (en) * | 2002-08-09 | 2006-10-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds and methods to modulate coagulation |
EP1562590A4 (de) * | 2002-10-30 | 2006-04-05 | Univ California | Verbindungen, verfahren und vorrichtungen zur hemmung von neoproliferativen veränderungen in den blutgefässwänden |
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US20070027205A1 (en) * | 2003-07-03 | 2007-02-01 | Joachim Demnitz | Diarylmethyl derivatives as potassium channel modulators |
US7208601B2 (en) * | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
WO2005014534A1 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
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US8158828B2 (en) * | 2005-11-28 | 2012-04-17 | Gtx, Inc. | Nuclear receptor binding agents |
US8637706B2 (en) | 2005-11-28 | 2014-01-28 | Gtx, Inc. | Nuclear receptor binding agents |
US8546451B2 (en) * | 2005-11-28 | 2013-10-01 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
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CN102702013B (zh) * | 2005-11-28 | 2016-02-10 | Gtx公司 | 核受体结合剂 |
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US20100056637A1 (en) * | 2005-12-20 | 2010-03-04 | Icagen, Inc. | Treatment methods using triaryl methane compounds |
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GB0601394D0 (en) | 2006-01-24 | 2006-03-01 | Hemocorm Ltd | Therapeutic delivery of carbon monoxide |
US20070185045A1 (en) * | 2006-02-06 | 2007-08-09 | Ratcliffe Peter J | Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers |
WO2007104696A1 (en) * | 2006-03-15 | 2007-09-20 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Antimalarial agents having polyaromatic structure |
WO2007140335A2 (en) * | 2006-05-25 | 2007-12-06 | The Regents Of The University Of Michigan | Screening methods and transgenic animals for treatment of beta-globin related diseases and conditions |
EP2100603A4 (de) * | 2006-11-29 | 2011-06-22 | Germanov Evgeny Pavlovich | Verwendung von malachitgrün in form eines arzneimittels zur behandlung von malignen neoplasien |
MX2009013354A (es) | 2007-06-04 | 2010-07-06 | Univ Ben Gurion | Compuestos de triarilo y composiciones que los contienen. |
ATE494891T1 (de) | 2007-08-24 | 2011-01-15 | Neurosearch As | Carbonylamino-derivate zur behandlung von entzündlicher darmerkrankung |
CA2711221C (en) * | 2007-12-31 | 2017-02-28 | Emory University | Triarylmethane analogs and their use in treating cancers |
US8835506B2 (en) | 2008-06-05 | 2014-09-16 | Stc.Unm | Methods and related compositions for the treatment of cancer |
WO2010042596A2 (en) * | 2008-10-08 | 2010-04-15 | The Uab Research Foundation | Photo-activated protecting groups |
US9624161B2 (en) | 2009-02-23 | 2017-04-18 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
US9427418B2 (en) | 2009-02-23 | 2016-08-30 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
WO2010124004A2 (en) | 2009-04-22 | 2010-10-28 | Emory University | Nanocarrier therapy for treating invasive tumors |
JP5978291B2 (ja) | 2011-04-19 | 2016-08-24 | アルファーマ インコーポレイテッドAlfama,Inc. | 一酸化炭素放出分子およびその使用 |
ES2628634T3 (es) | 2011-07-21 | 2017-08-03 | Alfama, Inc. | Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas |
JP2015500344A (ja) * | 2011-12-14 | 2015-01-05 | インディケイター システムズ インターナショナル インコーポレイテッド | 三置換メチルアルコールおよびそれらの重合可能な誘導体 |
US9567291B2 (en) | 2013-04-25 | 2017-02-14 | Emory University | N-(4-(bis(4-(dimethylamino)phenyl)methylene)-8-(dimethylamino) |
AU2014347668A1 (en) | 2013-11-05 | 2016-05-19 | Ben-Gurion University Of The Negev Research And Development Authority | Compounds for the treatment of diabetes and disease complications arising from same |
FR3024778B1 (fr) * | 2014-08-05 | 2021-01-22 | Screencell | Procede pour le depistage de la drepanocytose et kit pour sa mise en oeuvre |
US10179115B2 (en) | 2015-02-20 | 2019-01-15 | The Children's Medical Center Corporation | Methods for treating malaria using potassium channel inhibitors |
WO2022124900A1 (en) | 2020-12-11 | 2022-06-16 | Sanquin Innovatie B.V. | Treatment and prevention of anaemia of inflammation |
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DE1088972B (de) * | 1958-12-11 | 1960-09-15 | Hoechst Ag | Verfahren zur Herstellung von ª†, ª†, ª†-Triphenylpropylaminen |
DE1165575B (de) * | 1960-06-14 | 1964-03-19 | Hoechst Ag | Verfahren zur Herstellung von 3, 3, 3-Tris-(4'-halogenphenyl)-propionsaeuren |
DE1445722A1 (de) * | 1962-12-21 | 1968-12-05 | Hoechst Ag | Verfahren zur Herstellung von Carbonsaeurepiperaziden |
DE1620412C3 (de) * | 1966-10-14 | 1975-12-18 | Shell Internationale Research Maatschappij B.V., Den Haag (Niederlande) | Verfahren zur Herstellung von Tritylaminen |
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US4806685A (en) * | 1985-08-05 | 1989-02-21 | Gyogyszerkutato Inteezet/Pharmaceutical Research Institute | 1,1,2-triphenylpropane and -propene derivatives |
EP0323740A3 (de) * | 1987-12-24 | 1990-12-12 | California Biotechnology, Inc. | Lineare Analoge von atrialen natriuretischen Peptiden |
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US5273992A (en) * | 1992-11-02 | 1993-12-28 | Beth Israel Hospital Assoc. Inc. | Method for reducing sickle erythrocyte dehydration and delaying the occurrence of erythrocyte sickling in-situ |
US5512591A (en) | 1993-02-18 | 1996-04-30 | President And Fellows Of Harvard College | Treatments for diseases characterized by neovascularization |
US5650425A (en) | 1994-04-04 | 1997-07-22 | Pharmos Corporation | Permanently ionic derivatives of steroid hormones and their antagonists |
WO1996001107A1 (en) | 1994-07-06 | 1996-01-18 | Bo Arne Hofmann | Use of pharmaceutical agents for restoring, alleviation, or treatment of immunodeficiency, including the alleviation or treatment of the immune dysfunction related to infection with human immunodeficiency viruses (hiv) or related viruses |
WO1996008242A2 (en) * | 1994-09-16 | 1996-03-21 | Children's Medical Center Corporation | Clotrimazole metabolites in the treatment of sickle cell disease |
US6028103A (en) * | 1994-09-16 | 2000-02-22 | Children's Medical Center Corporation | Triaryl methane compounds and analogues thereof useful for the treatment or prevention of sickle cell disease or diseases characterized by abnormal cell proliferation |
US5889038A (en) | 1996-03-20 | 1999-03-30 | Children's Hospital | Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds |
BR9708230A (pt) | 1996-03-20 | 2000-01-04 | Harvard College | Compostos de triaril metano, composição farmacêutica, e métodos de inibição do transporte de potássio ativado por cálcio de uma célula, para reduzir a desidrataçào de eritrócito falciforme e/ou retaradar a ocorrência de afoiçamento ou deformação de eritrócitos, e tratamento ou prevenção de doença, de inibição da proliferação celular em mamìferos, e de tratamento ou prevenção de uma desordem. |
EP1052990A2 (de) | 1997-11-14 | 2000-11-22 | Neurosearch A/S | Chemische verbindungen mit ionenkanalblockierender aktivität zur behandlung von dysfunktionen des immunsystems |
-
1997
- 1997-03-19 BR BR9708230-9A patent/BR9708230A/pt not_active Application Discontinuation
- 1997-03-19 AU AU25388/97A patent/AU732881C/en not_active Ceased
- 1997-03-19 CA CA002250092A patent/CA2250092C/en not_active Expired - Lifetime
- 1997-03-19 EP EP97916889A patent/EP0918514B9/de not_active Expired - Lifetime
- 1997-03-19 NZ NZ332103A patent/NZ332103A/xx not_active IP Right Cessation
- 1997-03-19 JP JP53372197A patent/JP4376970B2/ja not_active Expired - Lifetime
- 1997-03-19 DE DE69734983T patent/DE69734983T2/de not_active Expired - Lifetime
- 1997-03-19 AT AT97916889T patent/ATE314060T1/de not_active IP Right Cessation
- 1997-03-19 WO PCT/US1997/004551 patent/WO1997034589A1/en active IP Right Grant
-
1998
- 1998-09-23 US US09/159,335 patent/US6331564B1/en not_active Expired - Lifetime
-
2001
- 2001-08-28 US US09/942,258 patent/US20020119953A1/en not_active Abandoned
Also Published As
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---|---|
ATE314060T1 (de) | 2006-01-15 |
DE69734983T2 (de) | 2006-09-07 |
CA2250092A1 (en) | 1997-09-25 |
BR9708230A (pt) | 2000-01-04 |
AU732881B2 (en) | 2001-05-03 |
JP4376970B2 (ja) | 2009-12-02 |
US20020119953A1 (en) | 2002-08-29 |
EP0918514A1 (de) | 1999-06-02 |
EP0918514A4 (de) | 2001-05-09 |
CA2250092C (en) | 2001-10-02 |
US6331564B1 (en) | 2001-12-18 |
JP2001521485A (ja) | 2001-11-06 |
EP0918514B9 (de) | 2006-07-05 |
WO1997034589A1 (en) | 1997-09-25 |
EP0918514B1 (de) | 2005-12-28 |
NZ332103A (en) | 2000-08-25 |
AU732881C (en) | 2002-11-07 |
AU2538897A (en) | 1997-10-10 |
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