CN112020353A - 2,2-双(4-氟苯基)-2-苯乙酰胺的晶型a及其制备方法和应用 - Google Patents

2,2-双(4-氟苯基)-2-苯乙酰胺的晶型a及其制备方法和应用 Download PDF

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Publication number
CN112020353A
CN112020353A CN201980003580.0A CN201980003580A CN112020353A CN 112020353 A CN112020353 A CN 112020353A CN 201980003580 A CN201980003580 A CN 201980003580A CN 112020353 A CN112020353 A CN 112020353A
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CN
China
Prior art keywords
organic solvent
crystal form
solvent
fluorophenyl
bis
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Pending
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CN201980003580.0A
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English (en)
Inventor
任国宾
弋东旭
季伟杰
黄嘉骏
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Shenzhen Rentai Pharmaceutical Technology Co Ltd
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Shenzhen Rentai Pharmaceutical Technology Co Ltd
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Application filed by Shenzhen Rentai Pharmaceutical Technology Co Ltd filed Critical Shenzhen Rentai Pharmaceutical Technology Co Ltd
Publication of CN112020353A publication Critical patent/CN112020353A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

本发明提供了2,2‑双(4‑氟苯基)‑2‑苯乙酰胺的晶型A，该晶型具有良好的光照稳定性、高温稳定性和高湿稳定性。

Description

PCT国内申请，说明书已公开。

Claims (25)

  1. PCT国内申请，权利要求书已公开。
CN201980003580.0A 2019-03-29 2019-03-29 2,2-双(4-氟苯基)-2-苯乙酰胺的晶型a及其制备方法和应用 Pending CN112020353A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2019/080419 WO2020198939A1 (zh) 2019-03-29 2019-03-29 2,2-双(4-氟苯基)-2-苯乙酰胺的晶型a及其制备方法和应用

Publications (1)

Publication Number Publication Date
CN112020353A true CN112020353A (zh) 2020-12-01

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CN201980003580.0A Pending CN112020353A (zh) 2019-03-29 2019-03-29 2,2-双(4-氟苯基)-2-苯乙酰胺的晶型a及其制备方法和应用

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US (1) US20220033347A1 (zh)
CN (1) CN112020353A (zh)
WO (1) WO2020198939A1 (zh)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1344158A (zh) * 1999-02-23 2002-04-10 安克进药物公司 Gardos通道拮抗剂
CN101437403A (zh) * 2005-12-20 2009-05-20 Icagen公司 使用三芳基甲烷化合物的治疗方法
US20100056637A1 (en) * 2005-12-20 2010-03-04 Icagen, Inc. Treatment methods using triaryl methane compounds
US20180042872A1 (en) * 2015-02-20 2018-02-15 The Children's Medical Center Corporation Methods for treating malaria using potassium channel inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017070536A1 (en) * 2015-10-23 2017-04-27 Angion Biomedica Corp. Methods and agents for treating diseases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1344158A (zh) * 1999-02-23 2002-04-10 安克进药物公司 Gardos通道拮抗剂
CN101437403A (zh) * 2005-12-20 2009-05-20 Icagen公司 使用三芳基甲烷化合物的治疗方法
US20100056637A1 (en) * 2005-12-20 2010-03-04 Icagen, Inc. Treatment methods using triaryl methane compounds
US20180042872A1 (en) * 2015-02-20 2018-02-15 The Children's Medical Center Corporation Methods for treating malaria using potassium channel inhibitors

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US20220033347A1 (en) 2022-02-03
WO2020198939A1 (zh) 2020-10-08

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