ATE370728T1 - Antagonisten des gardos-kanals - Google Patents

Antagonisten des gardos-kanals

Info

Publication number
ATE370728T1
ATE370728T1 AT00907283T AT00907283T ATE370728T1 AT E370728 T1 ATE370728 T1 AT E370728T1 AT 00907283 T AT00907283 T AT 00907283T AT 00907283 T AT00907283 T AT 00907283T AT E370728 T1 ATE370728 T1 AT E370728T1
Authority
AT
Austria
Prior art keywords
antagonists
gardos channel
gardos
channel
Prior art date
Application number
AT00907283T
Other languages
German (de)
English (en)
Inventor
Grant Mcnaughton-Smith
Gregory Rigdon
Jonathan Stocker
Original Assignee
Icagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icagen Inc filed Critical Icagen Inc
Application granted granted Critical
Publication of ATE370728T1 publication Critical patent/ATE370728T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT00907283T 1999-02-23 2000-02-10 Antagonisten des gardos-kanals ATE370728T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13551199P 1999-02-23 1999-02-23
US09/386,601 US6288122B1 (en) 1999-02-23 1999-08-31 Gardos channel antagonists

Publications (1)

Publication Number Publication Date
ATE370728T1 true ATE370728T1 (de) 2007-09-15

Family

ID=26833406

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00907283T ATE370728T1 (de) 1999-02-23 2000-02-10 Antagonisten des gardos-kanals

Country Status (16)

Country Link
US (1) US6288122B1 (enExample)
EP (1) EP1158971B1 (enExample)
JP (2) JP4038337B2 (enExample)
KR (1) KR100705726B1 (enExample)
CN (1) CN1193748C (enExample)
AP (1) AP1465A (enExample)
AT (1) ATE370728T1 (enExample)
AU (1) AU762039B2 (enExample)
BR (1) BR0008416A (enExample)
CA (1) CA2371857C (enExample)
DE (1) DE60036093T2 (enExample)
ES (1) ES2291191T3 (enExample)
HK (1) HK1045262B (enExample)
IL (2) IL145012A0 (enExample)
OA (1) OA11838A (enExample)
WO (1) WO2000050026A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004010A1 (en) * 2001-07-06 2003-01-16 Poseidon Pharmaceuticals A/S Carbonylamino derivatives useful for obtaining immune regulation
ATE400551T1 (de) 2002-01-04 2008-07-15 Neurosearch As Kaliumkanal-modulatoren
WO2003074038A1 (en) * 2002-02-28 2003-09-12 Icagen, Inc. Methods for treating diseases related to intraocular pressure
WO2005003143A1 (en) * 2003-07-03 2005-01-13 Poseidon Pharmaceuticals A/S Novel potassium channel modulators
WO2005003094A1 (en) * 2003-07-03 2005-01-13 Poseidon Pharmaceuticals A/S Diarylmethyl derivatives as potassium channel modulators
US7709533B2 (en) * 2005-02-01 2010-05-04 Icagen, Inc. Imines as ion channel modulators
CN101437403A (zh) * 2005-12-20 2009-05-20 Icagen公司 使用三芳基甲烷化合物的治疗方法
US20100056637A1 (en) * 2005-12-20 2010-03-04 Icagen, Inc. Treatment methods using triaryl methane compounds
JP2010536827A (ja) 2007-08-24 2010-12-02 ノイロサーチ アクティーゼルスカブ ある種の炎症性障害の治療に有用なカルボニルアミノ誘導体
US20090076157A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched senicapoc
KR101896430B1 (ko) 2008-04-09 2018-09-10 세루스 코포레이션 적혈구 병원체 불활성화를 위한 개선된 퀀칭 방법
US9428568B2 (en) 2008-11-10 2016-08-30 Boehringer Ingelheim International Gmbh Compositions and methods for modulating cell-cell fusion via intermediate-conductance calcium-activated potassium channels
US10179115B2 (en) 2015-02-20 2019-01-15 The Children's Medical Center Corporation Methods for treating malaria using potassium channel inhibitors
EP3106155A1 (en) 2015-06-15 2016-12-21 Universite d'Aix Marseille Treatment and diagnosis of hereditary xerocytosis
US11439607B2 (en) * 2016-10-25 2022-09-13 Paracelsus Neuroscience I, LLC Use of senicapoc for treatment of neuropathic pain
WO2018162426A1 (en) 2017-03-06 2018-09-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Treatment and diagnosis of hereditary xerocytosis
WO2020198939A1 (zh) * 2019-03-29 2020-10-08 深圳仁泰医药科技有限公司 2,2-双(4-氟苯基)-2-苯乙酰胺的晶型a及其制备方法和应用
US12186286B2 (en) * 2019-07-29 2025-01-07 Paracelsus Neuroscience Llc Use of senicapoc for treatment of stroke
EP4181908A4 (en) * 2020-07-14 2024-03-06 Adimabio LLC COMPOSITIONS COMPRISING GARDOS CHANNEL ANTAGONISTS AND THEIR USES
CN116847838A (zh) 2020-12-11 2023-10-03 桑昆专利有限公司 炎症性贫血的治疗和预防

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273992A (en) 1992-11-02 1993-12-28 Beth Israel Hospital Assoc. Inc. Method for reducing sickle erythrocyte dehydration and delaying the occurrence of erythrocyte sickling in-situ
WO1997034589A1 (en) 1996-03-20 1997-09-25 President And Fellows Of Harvard College Triaryl methane compounds for sickle cell disease

Also Published As

Publication number Publication date
IL145012A0 (en) 2002-06-30
CN1344158A (zh) 2002-04-10
HK1045262B (zh) 2005-07-29
JP4038337B2 (ja) 2008-01-23
KR20020002393A (ko) 2002-01-09
CA2371857A1 (en) 2000-08-31
DE60036093T2 (de) 2008-05-15
US6288122B1 (en) 2001-09-11
AU2880700A (en) 2000-09-14
IL145012A (en) 2006-12-10
EP1158971A1 (en) 2001-12-05
CN1193748C (zh) 2005-03-23
EP1158971B1 (en) 2007-08-22
HK1045262A1 (en) 2002-11-22
KR100705726B1 (ko) 2007-04-11
WO2000050026A1 (en) 2000-08-31
CA2371857C (en) 2008-07-29
AP2001002268A0 (en) 2001-09-30
AP1465A (en) 2005-09-22
EP1158971A4 (en) 2003-04-16
OA11838A (en) 2005-08-22
JP2007262075A (ja) 2007-10-11
ES2291191T3 (es) 2008-03-01
JP2002537331A (ja) 2002-11-05
AU762039B2 (en) 2003-06-19
DE60036093D1 (de) 2007-10-04
BR0008416A (pt) 2002-01-29

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