OA11838A - Gardos channel antagonists. - Google Patents
Gardos channel antagonists. Download PDFInfo
- Publication number
- OA11838A OA11838A OA1200100220A OA1200100220A OA11838A OA 11838 A OA11838 A OA 11838A OA 1200100220 A OA1200100220 A OA 1200100220A OA 1200100220 A OA1200100220 A OA 1200100220A OA 11838 A OA11838 A OA 11838A
- Authority
- OA
- OAPI
- Prior art keywords
- substituent
- acetamide
- ring
- compound
- para
- Prior art date
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- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 229940116317 potato starch Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000012439 solid excipient Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 231100000440 toxicity profile Toxicity 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- OHSJPLSEQNCRLW-UHFFFAOYSA-N triphenylmethyl radical Chemical compound C1=CC=CC=C1[C](C=1C=CC=CC=1)C1=CC=CC=C1 OHSJPLSEQNCRLW-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 208000021331 vascular occlusion disease Diseases 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 229960003726 vasopressin Drugs 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 208000003663 ventricular fibrillation Diseases 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13551199P | 1999-02-23 | 1999-02-23 | |
| US09/386,601 US6288122B1 (en) | 1999-02-23 | 1999-08-31 | Gardos channel antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA11838A true OA11838A (en) | 2005-08-22 |
Family
ID=26833406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA1200100220A OA11838A (en) | 1999-02-23 | 2000-02-10 | Gardos channel antagonists. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6288122B1 (enExample) |
| EP (1) | EP1158971B1 (enExample) |
| JP (2) | JP4038337B2 (enExample) |
| KR (1) | KR100705726B1 (enExample) |
| CN (1) | CN1193748C (enExample) |
| AP (1) | AP1465A (enExample) |
| AT (1) | ATE370728T1 (enExample) |
| AU (1) | AU762039B2 (enExample) |
| BR (1) | BR0008416A (enExample) |
| CA (1) | CA2371857C (enExample) |
| DE (1) | DE60036093T2 (enExample) |
| ES (1) | ES2291191T3 (enExample) |
| HK (1) | HK1045262B (enExample) |
| IL (2) | IL145012A0 (enExample) |
| OA (1) | OA11838A (enExample) |
| WO (1) | WO2000050026A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003004010A1 (en) * | 2001-07-06 | 2003-01-16 | Poseidon Pharmaceuticals A/S | Carbonylamino derivatives useful for obtaining immune regulation |
| EP1465863B1 (en) | 2002-01-04 | 2008-07-09 | NeuroSearch A/S | Potassium channel modulators |
| AU2003217810C9 (en) * | 2002-02-28 | 2008-06-12 | Icagen, Inc. | Methods for treating diseases related to intraocular pressure |
| EP1644332A1 (en) * | 2003-07-03 | 2006-04-12 | Poseidon Pharmaceuticals A/S | Diarylmethyl derivatives as potassium channel modulators |
| WO2005003143A1 (en) * | 2003-07-03 | 2005-01-13 | Poseidon Pharmaceuticals A/S | Novel potassium channel modulators |
| WO2006084031A1 (en) * | 2005-02-01 | 2006-08-10 | Icagen, Inc. | Imines as ion channel modulators |
| US20100056637A1 (en) * | 2005-12-20 | 2010-03-04 | Icagen, Inc. | Treatment methods using triaryl methane compounds |
| CA2633805A1 (en) * | 2005-12-20 | 2007-07-05 | Icagen, Inc. | Treatment methods using triaryl methane compounds |
| WO2009027292A1 (en) * | 2007-08-24 | 2009-03-05 | Neurosearch A/S | Carbonylamino derivatives useful for the treatment of certain inflammatory disorders |
| US20090076157A1 (en) * | 2007-09-15 | 2009-03-19 | Protia, Llc | Deuterium-enriched senicapoc |
| KR101896430B1 (ko) * | 2008-04-09 | 2018-09-10 | 세루스 코포레이션 | 적혈구 병원체 불활성화를 위한 개선된 퀀칭 방법 |
| CN102272152B (zh) | 2008-11-10 | 2014-05-28 | 贝林格尔.英格海姆国际有限公司 | 通过中电导钙激活钾通道调控细胞-细胞融合的组合物及方法 |
| WO2016134353A1 (en) * | 2015-02-20 | 2016-08-25 | Children's Medical Center Corporation | Methods for treating malaria using potassium channel inhibitors |
| EP3106155A1 (en) * | 2015-06-15 | 2016-12-21 | Universite d'Aix Marseille | Treatment and diagnosis of hereditary xerocytosis |
| CN110177548A (zh) * | 2016-10-25 | 2019-08-27 | 罗兰·斯塔尔 | Senicapoc用于治疗神经性疼痛的用途 |
| WO2018162426A1 (en) | 2017-03-06 | 2018-09-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Treatment and diagnosis of hereditary xerocytosis |
| CN112020353A (zh) | 2019-03-29 | 2020-12-01 | 深圳仁泰医药科技有限公司 | 2,2-双(4-氟苯基)-2-苯乙酰胺的晶型a及其制备方法和应用 |
| US12186286B2 (en) * | 2019-07-29 | 2025-01-07 | Paracelsus Neuroscience Llc | Use of senicapoc for treatment of stroke |
| CN115943138A (zh) * | 2020-07-14 | 2023-04-07 | 阿迪玛生物有限责任公司 | 包含gardos通道拮抗剂的组合物及其用途 |
| US20240024335A1 (en) * | 2020-12-11 | 2024-01-25 | Sanquin IP B.V. | Treatment and prevention of anaemia of inflammation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5273992A (en) | 1992-11-02 | 1993-12-28 | Beth Israel Hospital Assoc. Inc. | Method for reducing sickle erythrocyte dehydration and delaying the occurrence of erythrocyte sickling in-situ |
| ATE314060T1 (de) | 1996-03-20 | 2006-01-15 | Harvard College | Triarylmethanverbindungen zur behandlung von krebs, aktinischer keratose und kaposisarkom |
-
1999
- 1999-08-31 US US09/386,601 patent/US6288122B1/en not_active Expired - Lifetime
-
2000
- 2000-02-10 JP JP2000600638A patent/JP4038337B2/ja not_active Expired - Fee Related
- 2000-02-10 OA OA1200100220A patent/OA11838A/en unknown
- 2000-02-10 IL IL14501200A patent/IL145012A0/xx active IP Right Grant
- 2000-02-10 AU AU28807/00A patent/AU762039B2/en not_active Ceased
- 2000-02-10 AP APAP/P/2001/002268A patent/AP1465A/en active
- 2000-02-10 EP EP00907283A patent/EP1158971B1/en not_active Expired - Lifetime
- 2000-02-10 HK HK02106773.8A patent/HK1045262B/zh not_active IP Right Cessation
- 2000-02-10 CN CNB008054525A patent/CN1193748C/zh not_active Expired - Fee Related
- 2000-02-10 BR BR0008416-6A patent/BR0008416A/pt not_active IP Right Cessation
- 2000-02-10 WO PCT/US2000/003663 patent/WO2000050026A1/en not_active Ceased
- 2000-02-10 KR KR1020017010707A patent/KR100705726B1/ko not_active Expired - Fee Related
- 2000-02-10 ES ES00907283T patent/ES2291191T3/es not_active Expired - Lifetime
- 2000-02-10 DE DE60036093T patent/DE60036093T2/de not_active Expired - Lifetime
- 2000-02-10 AT AT00907283T patent/ATE370728T1/de active
- 2000-02-10 CA CA002371857A patent/CA2371857C/en not_active Expired - Fee Related
-
2001
- 2001-08-21 IL IL145012A patent/IL145012A/en not_active IP Right Cessation
-
2007
- 2007-05-02 JP JP2007121967A patent/JP2007262075A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2880700A (en) | 2000-09-14 |
| HK1045262B (zh) | 2005-07-29 |
| AP1465A (en) | 2005-09-22 |
| AU762039B2 (en) | 2003-06-19 |
| JP4038337B2 (ja) | 2008-01-23 |
| CA2371857A1 (en) | 2000-08-31 |
| KR20020002393A (ko) | 2002-01-09 |
| JP2007262075A (ja) | 2007-10-11 |
| CA2371857C (en) | 2008-07-29 |
| IL145012A0 (en) | 2002-06-30 |
| KR100705726B1 (ko) | 2007-04-11 |
| ATE370728T1 (de) | 2007-09-15 |
| EP1158971A1 (en) | 2001-12-05 |
| WO2000050026A1 (en) | 2000-08-31 |
| CN1344158A (zh) | 2002-04-10 |
| BR0008416A (pt) | 2002-01-29 |
| AP2001002268A0 (en) | 2001-09-30 |
| DE60036093D1 (de) | 2007-10-04 |
| ES2291191T3 (es) | 2008-03-01 |
| DE60036093T2 (de) | 2008-05-15 |
| US6288122B1 (en) | 2001-09-11 |
| EP1158971B1 (en) | 2007-08-22 |
| HK1045262A1 (en) | 2002-11-22 |
| IL145012A (en) | 2006-12-10 |
| JP2002537331A (ja) | 2002-11-05 |
| CN1193748C (zh) | 2005-03-23 |
| EP1158971A4 (en) | 2003-04-16 |
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