BRPI0414215A - tienopirazóis - Google Patents

tienopirazóis

Info

Publication number
BRPI0414215A
BRPI0414215A BRPI0414215-2A BRPI0414215A BRPI0414215A BR PI0414215 A BRPI0414215 A BR PI0414215A BR PI0414215 A BRPI0414215 A BR PI0414215A BR PI0414215 A BRPI0414215 A BR PI0414215A
Authority
BR
Brazil
Prior art keywords
thienopyrazoles
tienopirazois
ith
inhibition
modulated
Prior art date
Application number
BRPI0414215-2A
Other languages
English (en)
Inventor
Gerard John Jurcak
Matthieu Barrague
Timothy Alan Gillespy
Michael Louis Edwards
Kwon Yon Musick
Philip Marvin Weintraub
Yan Du
Ramalinga M Dharanipragada
Ashfap Ahmed Parkar
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of BRPI0414215A publication Critical patent/BRPI0414215A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

"TIENOPIRAZóIS". Tienopirazóis, sua preparação, composições farmacêuticas compreendendo estes compostos, e seus usos farmacêuticos no tratamento de estados patológicos que podem ser modulados pela inibição das cinases protéicas, em particular tirosina cinase induzível por interleucina-2 (ITH).
BRPI0414215-2A 2003-09-08 2004-07-23 tienopirazóis BRPI0414215A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50115903P 2003-09-08 2003-09-08
PCT/US2004/023814 WO2005026175A1 (en) 2003-09-08 2004-07-23 Thienopyrazoles

Publications (1)

Publication Number Publication Date
BRPI0414215A true BRPI0414215A (pt) 2006-11-07

Family

ID=34312256

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414215-2A BRPI0414215A (pt) 2003-09-08 2004-07-23 tienopirazóis

Country Status (30)

Country Link
US (2) US7518000B2 (pt)
JP (1) JP4879739B2 (pt)
KR (1) KR20060069490A (pt)
CN (1) CN100398545C (pt)
AT (1) ATE468341T1 (pt)
AU (1) AU2004272507B2 (pt)
BR (1) BRPI0414215A (pt)
CA (1) CA2538032C (pt)
CR (1) CR8255A (pt)
DE (1) DE602004027288D1 (pt)
DK (1) DK1682553T3 (pt)
EC (1) ECSP066411A (pt)
ES (1) ES2345257T3 (pt)
HK (1) HK1095587A1 (pt)
HR (1) HRP20100398T1 (pt)
IL (1) IL173916A (pt)
MA (1) MA28038A1 (pt)
ME (1) MEP20908A (pt)
MX (1) MXPA06001827A (pt)
MY (1) MY144339A (pt)
NO (1) NO20061626L (pt)
NZ (1) NZ545421A (pt)
OA (1) OA13252A (pt)
PT (1) PT1682553E (pt)
RS (2) RS20060162A (pt)
RU (1) RU2358978C2 (pt)
TN (1) TNSN06058A1 (pt)
TW (1) TWI352705B (pt)
WO (1) WO2005026175A1 (pt)
ZA (1) ZA200601947B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006101454A1 (en) * 2005-03-21 2006-09-28 S*Bio Pte Ltd Benzothiophene derivatives: preparation and pharmaceutical applications
WO2007076228A2 (en) * 2005-12-20 2007-07-05 Boehringer Ingelheim International Gmbh 2-(ih-thieno [3,2-c] pyrazol-3yl)-ih-indole derivatives and related compounds as tec kinase inhibitors for the treatment of inflammations and immunological disorders
EP2151434A1 (en) 2008-08-05 2010-02-10 Institut Pasteur Alkoxypyrazoles and the process for their preparation
EP2151433A1 (en) 2008-08-05 2010-02-10 Institut Pasteur Alkoxypyrazoles and the process for their preparation
US8299070B2 (en) * 2009-11-25 2012-10-30 Japan Tobacco Inc. Indole compounds and pharmaceutical use thereof
US20130158066A1 (en) * 2011-12-20 2013-06-20 Hoffmann-La Roche Inc. 4-azaindole inhibitors of crac
WO2013153539A1 (en) 2012-04-13 2013-10-17 Glenmark Pharmaceuticals S.A. Tricyclic compounds as tec kinase inhibitors
CN103467481B (zh) * 2012-06-07 2016-08-31 上海汇伦生命科技有限公司 二氢吡啶类化合物、其组合物、制备方法和用途
TW201414734A (zh) 2012-07-10 2014-04-16 Takeda Pharmaceutical 氮雜吲哚衍生物
WO2014041518A1 (en) * 2012-09-14 2014-03-20 Glenmark Pharmaceuticals S.A. Thienopyrrole derivatives as itk inhibitors
CN103720694A (zh) * 2012-10-11 2014-04-16 韩冰 一类治疗脑性瘫痪的化合物及其用途
CN103772391A (zh) * 2012-10-23 2014-05-07 杨子娇 一类治疗房角狭窄的化合物及其用途
KR101571590B1 (ko) * 2012-11-21 2015-11-25 주식회사 두산 유기 화합물 및 이를 이용하는 유기 전계 발광 소자
US9795604B2 (en) 2013-10-25 2017-10-24 Pharmacyclics Llc Methods of treating and preventing graft versus host disease
WO2015106012A1 (en) 2014-01-09 2015-07-16 Takeda Pharmaceutical Company Limited Azaindole derivatives
WO2016010108A1 (ja) * 2014-07-18 2016-01-21 塩野義製薬株式会社 含窒素複素環誘導体およびそれらを含有する医薬組成物
BR112018003836A2 (pt) 2015-08-31 2018-12-04 Pharmacyclics Llc combinações de inibidor de btk para tratar mieloma múltiplo
WO2018085731A2 (en) 2016-11-03 2018-05-11 Juno Therapeutics, Inc. Combination therapy of a t cell therapy and a btk inhibitor
CA3098497A1 (en) 2018-05-03 2019-11-07 Juno Therapeutics, Inc. Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor
WO2023139248A1 (en) * 2022-01-21 2023-07-27 Ecole Polytechnique Federale De Lausanne (Epfl) Inhibitors of acyl protein thioesterases against microbial infections
WO2023220655A1 (en) 2022-05-11 2023-11-16 Celgene Corporation Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6462036B1 (en) * 1998-11-06 2002-10-08 Basf Aktiengesellschaft Tricyclic pyrazole derivatives
US6297238B1 (en) * 1999-04-06 2001-10-02 Basf Aktiengesellschaft Therapeutic agents
KR100718830B1 (ko) * 1999-06-23 2007-05-17 사노피-아벤티스 도이칠란트 게엠베하 치환된 벤즈이미다졸 및 이의 제조방법
YU54202A (sh) * 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
WO2003024969A1 (en) * 2001-09-14 2003-03-27 Merck & Co., Inc. Tyrosine kinase inhibitors
AU2002334217B2 (en) * 2001-10-26 2008-07-03 Aventis Pharmaceuticals Inc. Benzimidazoles and analogues and their use as protein kinases inhibitors
FR2831536A1 (fr) * 2001-10-26 2003-05-02 Aventis Pharma Sa Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr

Also Published As

Publication number Publication date
WO2005026175A1 (en) 2005-03-24
RS20060162A (en) 2008-06-05
TWI352705B (en) 2011-11-21
US7518000B2 (en) 2009-04-14
JP2007505038A (ja) 2007-03-08
RU2358978C2 (ru) 2009-06-20
CR8255A (es) 2006-07-14
HRP20100398T1 (hr) 2010-09-30
US7928231B2 (en) 2011-04-19
ECSP066411A (es) 2006-09-18
IL173916A (en) 2011-07-31
IL173916A0 (en) 2006-07-05
NZ545421A (en) 2010-03-26
US20100056514A1 (en) 2010-03-04
HK1095587A1 (en) 2007-05-11
KR20060069490A (ko) 2006-06-21
MEP20908A (en) 2010-06-10
AU2004272507A1 (en) 2005-03-24
TW200519118A (en) 2005-06-16
US20070254937A1 (en) 2007-11-01
MXPA06001827A (es) 2006-05-31
MY144339A (en) 2011-08-29
CA2538032A1 (en) 2005-03-24
ATE468341T1 (de) 2010-06-15
CN100398545C (zh) 2008-07-02
ZA200601947B (en) 2007-05-30
PT1682553E (pt) 2010-07-29
DK1682553T3 (da) 2010-08-23
RS51846B (en) 2012-02-29
JP4879739B2 (ja) 2012-02-22
RU2006111470A (ru) 2007-10-27
NO20061626L (no) 2006-04-10
OA13252A (en) 2007-01-31
AU2004272507B2 (en) 2011-05-12
TNSN06058A1 (en) 2007-10-03
ES2345257T3 (es) 2010-09-20
CN1849322A (zh) 2006-10-18
DE602004027288D1 (en) 2010-07-01
CA2538032C (en) 2011-01-11
MA28038A1 (fr) 2006-07-03

Similar Documents

Publication Publication Date Title
BRPI0414215A (pt) tienopirazóis
PT1347971E (pt) Inibidores tiazolilicos de tirosina-cinases da familia tec
BR0206985A (pt) Anticorpos modificados e métodos de uso
SE0102315D0 (sv) Compounds
BR0107643A (pt) Composições e processos para a terapia e diagnóstico de c ncer de próstata
SE0100901D0 (sv) New composition
DK2009025T3 (da) Fremgangsmåde til hæmning af osteoklast-aktivitet
TR200200716T2 (tr) Ketiyapin granülleri
ATE260650T1 (de) Orale darreichungsformen zur verabreichung einer fixen kombination von tramadol und diclofenac
EE200300504A (et) 3,7-diasabitsüklo[3.3.1]preparaadid, nende valmistamise meetod ja nimetatud preparaatide kasutaminesüdame arütmiate profülaktikas või ravis
SE0102147D0 (sv) New methods
ITMI20031396A1 (it) Composizione per uso farmaceutico o dietetico o cosmetico dotata di attivita' antiossidante.
DK1139980T3 (da) Kosmetisk eller medicinsk praparat til topisk anvendelse
ATE264309T1 (de) Substituierte caprolactam-derivate, diese enthaltende pharmazeutische zubereitungen sowie ihre verwendung zur behandlung von tumoren
DK1331940T3 (da) Anvendelse af det lange pentraxin PTX3 til behandling af sygdomme forårsaget af ændret aktivering af vækstfaktoren FGF-2
EA200200853A1 (ru) Применение 2-метилтиазолидин-3,3-дикарбоновой кислоты (2-мтдк) и/или ее физиологически совместимых солей для лечения и/или предупреждения рака
SE0001916D0 (sv) Novel formulation
DK1268522T3 (da) LH-RH-antagonister samt fremstilling deraf og anvendelse deraf som lægemidler
HK1065305A1 (en) Substituted 4-aminocyclohexanol derivatives
EE200300495A (et) 3,7-diasabitsüklo[3.3.1]preparaadid, nende valmistamise meetod ja nimetatud preparaatide kasutaminesüdame arütmiate profülaktikas või ravis
EE200300506A (et) 3,7-diasabitsüklo[3.3.1]preparaadid, nende valmistamise meetod ja nimetatud preparaatide kasutaminesüdame arütmiate profülaktikas või ravis
DE60003074D1 (de) Fusidinsäure-derivate
ATE392213T1 (de) Verwendung von gamma-gt inhibitoren zur behandlung von chronischen degenerativerkrankungen
BR0303384A (pt) Citalopram e seus usos no tratamento de pressão sanguìnea elevada
BR0016168A (pt) Combinações terapêuticas de (s)-2-(benzilaminometil)-2,3,8,9tetrahidro-7h-1,4-dioxi no[2,3 -e]indol-8-ona e neurolépticos para o tratamento ou prevenção de distúrbios psicóticos

Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: AVENTIS PHARMACEUTICALS, INC. (US)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070165509/RJ DE 23/11/2007.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. C07D 495/04; A61P 11/06

Ipc: C07D 495/04 (2011.01), A61P 11/06 (2011.01)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014.