JP4035589B2 - 修飾バックボーンを有するアンチセンスプローブと核酸の液中ハイブリッド形成 - Google Patents

修飾バックボーンを有するアンチセンスプローブと核酸の液中ハイブリッド形成 Download PDF

Info

Publication number
JP4035589B2
JP4035589B2 JP2000551045A JP2000551045A JP4035589B2 JP 4035589 B2 JP4035589 B2 JP 4035589B2 JP 2000551045 A JP2000551045 A JP 2000551045A JP 2000551045 A JP2000551045 A JP 2000551045A JP 4035589 B2 JP4035589 B2 JP 4035589B2
Authority
JP
Japan
Prior art keywords
probe
nucleobase
backbone
antisense probe
target sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2000551045A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002516667A5 (enExample
JP2002516667A (ja
Inventor
ニー,エイリーン・ジャオ−フェン
ウー,ユアン・ミン
Original Assignee
インジェネウス・インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by インジェネウス・インコーポレーテッド filed Critical インジェネウス・インコーポレーテッド
Publication of JP2002516667A publication Critical patent/JP2002516667A/ja
Publication of JP2002516667A5 publication Critical patent/JP2002516667A5/ja
Application granted granted Critical
Publication of JP4035589B2 publication Critical patent/JP4035589B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2000551045A 1998-05-22 1999-05-20 修飾バックボーンを有するアンチセンスプローブと核酸の液中ハイブリッド形成 Expired - Fee Related JP4035589B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/083,410 US6046004A (en) 1997-02-27 1998-05-22 Solution hybridization of nucleic acids with antisense probes having modified backbones
US09/083,410 1998-05-22
PCT/IB1999/000909 WO1999061665A2 (en) 1998-05-22 1999-05-20 Solution hybridization of nucleic acids with antisense probes having modified backbones

Publications (3)

Publication Number Publication Date
JP2002516667A JP2002516667A (ja) 2002-06-11
JP2002516667A5 JP2002516667A5 (enExample) 2005-11-17
JP4035589B2 true JP4035589B2 (ja) 2008-01-23

Family

ID=22178135

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000551045A Expired - Fee Related JP4035589B2 (ja) 1998-05-22 1999-05-20 修飾バックボーンを有するアンチセンスプローブと核酸の液中ハイブリッド形成

Country Status (5)

Country Link
US (1) US6046004A (enExample)
EP (1) EP1078101A2 (enExample)
JP (1) JP4035589B2 (enExample)
AU (1) AU3724499A (enExample)
WO (1) WO1999061665A2 (enExample)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6656692B2 (en) 1999-12-21 2003-12-02 Ingeneus Corporation Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes
US6403313B1 (en) * 1999-12-21 2002-06-11 Ingeneus Corporation Fluorescent intensity assay for duplex and triplex nucleic acid hybridization solution utilizing fluorescent intercalators
US6420115B1 (en) * 1999-12-21 2002-07-16 Ingeneus Corporation Cation mediated triplex hybridization assay
US6858390B2 (en) 1998-12-31 2005-02-22 Ingeneus Corporation Aptamers containing sequences of nucleic acid or nucleic acid analogues bound homologously, or in novel complexes
US6924108B2 (en) 1999-12-21 2005-08-02 Ingeneus Corporation Nucleic acid binding enhancement by conjugation with nucleotides, nucleosides, bases and/or their analogues
US20030181412A1 (en) * 1999-12-21 2003-09-25 Ingeneus Corporation Method for modifying transcription and/or translation in an organism for therapeutic, prophylactic and/or analytic uses
US7052844B2 (en) * 1999-12-21 2006-05-30 Ingeneus, Inc. Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism
US6911536B1 (en) 1999-12-21 2005-06-28 Ingeneus Corporation Triplex and quadruplex catalytic hybridization
US6927027B2 (en) 1999-12-21 2005-08-09 Ingeneus Corporation Nucleic acid multiplex formation
US7309569B2 (en) 1999-12-21 2007-12-18 Ingeneus, Inc. Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes
US20030170659A1 (en) * 2000-01-24 2003-09-11 Ingeneus Corporation Electrical treatment of binding media to encourage, discourage and/or study biopolymer binding
US7220541B2 (en) 2000-01-24 2007-05-22 Ingeneus, Inc. Homogeneous assay of biopolymer binding by means of multiple measurements under varied conditions
US6613524B1 (en) 2000-01-24 2003-09-02 Ingeneus Corporation Amperometric affinity assay and electrically stimulated complexes of nucleic acids
US6982147B2 (en) * 2000-01-24 2006-01-03 Ingeneus Corporation Apparatus for assaying biopolymer binding by means of multiple measurements under varied conditions
US7060436B2 (en) * 2000-06-17 2006-06-13 Third Wave Technologies, Inc. Nucleic acid accessible hybridization sites
US8568766B2 (en) 2000-08-24 2013-10-29 Gattadahalli M. Anantharamaiah Peptides and peptide mimetics to treat pathologies associated with eye disease
US7264925B2 (en) * 2000-08-30 2007-09-04 Avi Biopharma, Inc. Method for analysis of oligonucleotide analogs
JP5305553B2 (ja) 2000-10-12 2013-10-02 ユニバーシティー オブ ロチェスター 癌細胞の増殖を阻害する組成物
DE10155031A1 (de) * 2001-11-09 2003-05-28 Friz Biochem Gmbh Fluoreszenz-Quenchen zur Detektion von Ligat-Ligand Assoziationsereignissen in elektrischen Feldern
EP2311852A1 (en) 2002-02-06 2011-04-20 Stasys Technologies, Inc. Anti-infarction molecules
AU2003253580A1 (en) * 2002-02-26 2003-11-17 University Of Minnesota Variants of nedd4l associated with hypertension and viral budding
CA2495478A1 (en) 2002-08-05 2004-02-12 University Of Rochester Protein transducing domain/deaminase chimeric proteins, related compounds, and uses thereof
US20040180345A1 (en) * 2003-03-14 2004-09-16 Ingeneus Corporation Pre-incubation method to improve signal/noise ratio of nucleic acid assays
CA2544476A1 (en) * 2003-12-12 2005-06-23 Infectio Recherche Inc. System for charge-based detection of nucleic acids
US8029815B2 (en) * 2004-04-28 2011-10-04 Elford Howard L Methods for treating or preventing restenosis and other vascular proliferative disorders
NZ554538A (en) * 2004-09-24 2009-12-24 Ingeneus Inc Genomic assay
EA015584B1 (ru) 2005-03-23 2011-10-31 Генмаб А/С Антитело к cd38 человека и его применение
US7476733B2 (en) * 2005-03-25 2009-01-13 The United States Of America As Represented By The Department Of Health And Human Services Development of a real-time PCR assay for detection of pneumococcal DNA and diagnosis of pneumococccal disease
EP2189522A1 (en) 2005-10-14 2010-05-26 MUSC Foundation For Research Development Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy
US8080534B2 (en) 2005-10-14 2011-12-20 Phigenix, Inc Targeting PAX2 for the treatment of breast cancer
EP2066812A4 (en) 2006-09-21 2010-04-28 Univ Rochester COMPOSITIONS AND METHODS RELATED TO PROTEIN SHIFT THERAPY FOR MYOTONE DYSTROPHY
EP2104516B1 (en) 2006-11-01 2015-01-07 University of Rochester Methods and compositions related to the structure and function of apobec3g
WO2008073441A2 (en) 2006-12-11 2008-06-19 University Of Utah Research Foundation Compositions and methods for treating pathologic angiogenesis and vascular permeability
EP2030615A3 (en) * 2007-08-13 2009-12-02 ELFORD, Howard L. Ribonucleotide reductase inhibitors for use in the treatment or prevention of neuroinflammatory or autoimmune diseases
JP2010537638A (ja) 2007-08-28 2010-12-09 ユーエービー リサーチ ファウンデーション 合成アポリポ蛋白質e模倣ポリペプチドおよび使用方法
AU2008296478B9 (en) 2007-08-28 2015-03-19 The Uab Research Foundation Synthetic apolipoprotein E mimicking polypeptides and methods of use
US8501912B2 (en) * 2007-12-03 2013-08-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Filipil compositions and methods for treating cancer
EP2853897A1 (en) 2008-05-08 2015-04-01 University Of Utah Research Foundation Sensory receptors for chronic fatigue and pain and uses thereof
US8816095B2 (en) * 2008-08-15 2014-08-26 Georgetown University Na channels, disease, and related assays and compositions
US20120070443A1 (en) 2008-12-02 2012-03-22 University Of Utah Research Foundation Pde1 as a target therapeutic in heart disease
US20110060000A1 (en) 2009-09-10 2011-03-10 Maurizio Grimaldi Acridine analogs in the treatment of gliomas
US20110207789A1 (en) 2010-02-19 2011-08-25 Ye Fang Methods related to casein kinase ii (ck2) inhibitors and the use of purinosome-disrupting ck2 inhibitors for anti-cancer therapy agents
EP2580243B1 (en) 2010-06-09 2019-10-16 Genmab A/S Antibodies against human cd38
WO2014093688A1 (en) 2012-12-12 2014-06-19 1Massachusetts Institute Of Technology Compositions and methods for functional nucleic acid delivery
CN105960410B (zh) 2013-11-21 2020-12-04 硒瑞恩生物科技有限公司 硒衍生的核酸复合物的结构测定方法
ES2689568T3 (es) * 2014-02-21 2018-11-14 Ventana Medical Systems, Inc. Sondas de oligonucleótidos monocatenarias para la enumeración de copias de cromosomas o genes
CA2954475C (en) 2014-07-31 2023-05-16 Uab Research Foundation Apoe mimetic peptides and higher potency to clear plasma cholesterol
US20170015699A1 (en) * 2015-07-15 2017-01-19 Orizhan Bioscience Limited Partially Neutral Single-Stranded Oligonucleotide
KR20240027874A (ko) 2016-07-28 2024-03-04 리제너론 파마슈티칼스 인코포레이티드 Gpr156 변이체 및 이들의 용도
EP3496736A4 (en) 2016-08-03 2020-05-13 H. Lee Moffitt Cancer Center And Research Institute, Inc. Tlr9 targeted therapeutics
KR102712656B1 (ko) 2017-01-23 2024-10-04 리제너론 파마슈티칼스 인코포레이티드 Hsd17b13 변종 및 이것의 용도
CN110997906B (zh) 2017-06-05 2024-05-07 雷杰纳荣制药公司 B4galt1变体及其用途
AU2018328120B2 (en) 2017-09-06 2024-11-14 Regeneron Pharmaceuticals, Inc. Single Immunoglobulin Interleukin-1 Receptor Related (SIGIRR) variants and uses thereof
CA3074682A1 (en) 2017-09-07 2019-03-14 Regeneron Pharmaceuticals, Inc. Solute carrier family 14 member 1 (slc14a1) variants and uses thereof
WO2019051355A1 (en) 2017-09-08 2019-03-14 Ohio State Innovation Foundation NEW MICROARN INHIBITOR THERAPY FOR SYSTEMIC LUPUS ERYTHEMATOSUS
AU2018348195B2 (en) 2017-10-11 2025-05-15 Regeneron Pharmaceuticals, Inc. Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the PNPLA3 I148M variation
SG11202002822XA (en) 2017-10-16 2020-04-29 Regeneron Pharma Cornulin (crnn) variants and uses thereof
CN112930404A (zh) * 2018-09-05 2021-06-08 瑞德库尔有限责任公司 用于治疗剂分析的方法和系统
WO2020076976A1 (en) 2018-10-10 2020-04-16 Readcoor, Inc. Three-dimensional spatial molecular indexing
US11957687B2 (en) 2019-07-02 2024-04-16 Regeneron Pharmaceuticals, Inc. Modulators of HSD17B13 and methods of use thereof
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants
WO2024173343A1 (en) 2023-02-14 2024-08-22 Regeneron Pharmaceuticals, Inc. Compounds targeting hydroxysteroid 17-beta dehydrogenase (hsd17b) and uses thereof

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4220450A (en) * 1978-04-05 1980-09-02 Syva Company Chemically induced fluorescence immunoassay
US4469863A (en) * 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US5166330A (en) * 1983-09-06 1992-11-24 Hoechst Aktiengesellschaft Process for the preparation of nucleoside alkyl-aralkyl- and aryl-phosphonites and -phosphonates
FR2558172B1 (fr) * 1984-01-16 1986-06-13 Inst Nat Sante Rech Med Sonde contenant un acide nucleique modifie et reconnaissance par des anticorps specifiques et utilisation de cette sonde et de ces anticorps specifiques pour detecter et caracteriser une sequence d'adn homologue
US5405938A (en) * 1989-12-20 1995-04-11 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
DE3687030T2 (de) * 1985-03-15 1993-03-11 Eugene Stirchak Stereoregulare polynukleotiden bindende polymere.
US5217866A (en) * 1985-03-15 1993-06-08 Anti-Gene Development Group Polynucleotide assay reagent and method
US5166315A (en) * 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5521063A (en) * 1985-03-15 1996-05-28 Antivirals Inc. Polynucleotide reagent containing chiral subunits and methods of use
US5470974A (en) * 1985-03-15 1995-11-28 Neu-Gene Development Group Uncharged polynucleotide-binding polymers
US5217592A (en) * 1985-09-26 1993-06-08 Jones Kenneth W Electrophoresis and vacuum molecular transfer apparatus
US5501949A (en) * 1985-12-10 1996-03-26 Murex Diagnostics Corporation Particle bound binding component immunoassay
EP0232967B1 (en) * 1986-01-10 1993-04-28 Amoco Corporation Competitive homogeneous assay
US5310650A (en) * 1986-09-29 1994-05-10 Abbott Laboratoires Method and device for improved reaction kinetics in nucleic acid hybridizations
US4787963A (en) * 1987-05-04 1988-11-29 Syntro Corporation Method and means for annealing complementary nucleic acid molecules at an accelerated rate
US5100775A (en) * 1988-03-16 1992-03-31 Smyczek Peter J Method for conducting nucleic acid hybridization in chamber with precise fluid delivery
CA1337639C (en) * 1989-08-01 1995-11-28 Joseph Eugene Celebuski Dna probe assay using neutrally charged probe strands
US5623065A (en) * 1990-08-13 1997-04-22 Isis Pharmaceuticals, Inc. Gapped 2' modified oligonucleotides
US5459255A (en) * 1990-01-11 1995-10-17 Isis Pharmaceuticals, Inc. N-2 substituted purines
US5677437A (en) * 1990-07-27 1997-10-14 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
US5541307A (en) * 1990-07-27 1996-07-30 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs and solid phase synthesis thereof
US5610289A (en) * 1990-07-27 1997-03-11 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogues
US5223618A (en) * 1990-08-13 1993-06-29 Isis Pharmaceuticals, Inc. 4'-desmethyl nucleoside analog compounds
US5602240A (en) * 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
US5618704A (en) * 1990-07-27 1997-04-08 Isis Pharmacueticals, Inc. Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
WO1992018650A1 (en) * 1991-04-11 1992-10-29 Baxter Diagnostics Inc. Detection of dna/rna by fluorescence polarization
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5332659A (en) * 1992-04-09 1994-07-26 The United States Of America As Represented By The Secretary Of The Navy Light emission-or absorbance-based binding assays for polynucleic acids
DE4216949C2 (de) * 1992-05-22 1997-07-24 Christoph Prof Dr Dr Cremer Nichtenzymatisches Verfahren zur In-situ-Hybridisierung bei spezifischen Proben
US5674698A (en) * 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5503980A (en) * 1992-11-06 1996-04-02 Trustees Of Boston University Positional sequencing by hybridization
JP3789471B2 (ja) * 1993-07-19 2006-06-21 ジェン−プローブ・インコーポレイテッド オリゴヌクレオチドスクリーニングアッセイ
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5723288A (en) * 1994-05-06 1998-03-03 The University Of North Carolina At Chapel Hill Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans, and kits useful therefor
US5747247A (en) * 1994-07-25 1998-05-05 The Regents Of The University Of California Spectroscopic helicase assay
JPH11512617A (ja) * 1995-10-06 1999-11-02 パーセプテイブ・バイオシステムズ・インコーポレイテツド ペプチド核酸プローブを用いるハイブリダイゼーション分析のための方法、装置及びキット
US5846729A (en) * 1997-02-27 1998-12-08 Lorne Park Research, Inc. Assaying nucleotides in solution using a fluorescent intensity quenching effect
PT975800E (pt) * 1997-02-27 2003-10-31 Ingeneus Corp Doseamento de nucleotidos em solucao usando sondas anp

Also Published As

Publication number Publication date
US6046004A (en) 2000-04-04
EP1078101A2 (en) 2001-02-28
AU3724499A (en) 1999-12-13
WO1999061665A2 (en) 1999-12-02
WO1999061665A3 (en) 2000-01-27
JP2002516667A (ja) 2002-06-11

Similar Documents

Publication Publication Date Title
JP4035589B2 (ja) 修飾バックボーンを有するアンチセンスプローブと核酸の液中ハイブリッド形成
US5846729A (en) Assaying nucleotides in solution using a fluorescent intensity quenching effect
US6060242A (en) PNA diagnostic methods
EP1078100B1 (en) Quantitative method for detecting nucleotide concentration
ES2352417T3 (es) Método para la detección de una alteración en un ácido nucléico.
EP0975800B1 (en) Assaying nucleotides in solution using pna probes
KR20160003814A (ko) 순차적 하이브리드화 바코딩에 의한 분자의 멀티플렉스 표지화
JPH09107996A (ja) 検出可能にラベルされた二元的形態、オリゴヌクレオチドプローブ、アッセイおよびキット
JP2004500867A (ja) アレイ利用型核酸ハイブリダイゼーションのための新規な組成物および方法
KR20110025993A (ko) 단일-분자 전체 게놈 분석용 장치 및 방법
JP3495752B2 (ja) 生標的個体の検出方法およびプローブ
US20090130650A1 (en) Methods for the production of highly sensitive and specific cell surface probes
JP5663491B2 (ja) 標的核酸の検出方法
JPH08510910A (ja) ヒトゲノムの延長ヌクレオチド反復配列の直接検出
WO1998010097A2 (en) Method and apparatus for single molecule two color fluorescent detection and molecular weight and concentration determination
KR20190020133A (ko) 염색체에 대한 인-시츄 혼성화를 위한 dna 탐침
JP4541731B2 (ja) 核酸検出方法
WO2005028647A1 (ja) 核酸プローブ、核酸チップ、標的核酸検出方法、薬剤スクリーニング方法、標的核酸検出装置及び遺伝子診断方法
CN118265800A (zh) 用于多路fish的比率计量符号与顺序编码
JPH11178600A (ja) 標的核酸検出プローブ
JPH0484751A (ja) 遺伝子の検出方法
JP2013135679A (ja) 分子的認識によって作用する新規な検出プローブ
JP2004089092A (ja) ヒトチトクロムp4502c19遺伝子の点突然変異の検出用核酸及びそれを用いたヒトチトクロムp4502c19遺伝子の点突然変異の検出方法
JP2008199904A (ja) ラットにおけるストレス関連の蛋白質をコードするmRNAの測定方法、そのためのプローブ及びキット
JP2002101900A (ja) ヒトにおけるアセチル抱合に関与する酵素の測定方法、そのためのプローブ及びキット

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040412

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20040412

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20040916

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070510

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070810

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20070904

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20071002

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20071003

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20071003

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20071002

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20101109

Year of fee payment: 3

LAPS Cancellation because of no payment of annual fees