JP3980645B2 - 抗齲蝕口用組成物 - Google Patents
抗齲蝕口用組成物 Download PDFInfo
- Publication number
- JP3980645B2 JP3980645B2 JP53207497A JP53207497A JP3980645B2 JP 3980645 B2 JP3980645 B2 JP 3980645B2 JP 53207497 A JP53207497 A JP 53207497A JP 53207497 A JP53207497 A JP 53207497A JP 3980645 B2 JP3980645 B2 JP 3980645B2
- Authority
- JP
- Japan
- Prior art keywords
- arginine
- calcium
- oral composition
- phytate
- caries
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 125
- 230000000675 anti-caries Effects 0.000 title description 2
- 239000004475 Arginine Substances 0.000 claims abstract description 102
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 102
- 208000002925 dental caries Diseases 0.000 claims abstract description 73
- 239000011575 calcium Substances 0.000 claims abstract description 61
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 60
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 60
- 238000000034 method Methods 0.000 claims abstract description 37
- 150000001450 anions Chemical class 0.000 claims abstract description 36
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims abstract description 33
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims description 63
- 235000002949 phytic acid Nutrition 0.000 claims description 59
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 44
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 22
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 17
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 16
- RYJDNPSQBGFFSF-WCCKRBBISA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;carbonic acid Chemical compound OC(O)=O.OC(=O)[C@@H](N)CCCNC(N)=N RYJDNPSQBGFFSF-WCCKRBBISA-N 0.000 claims description 15
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 15
- 230000000170 anti-cariogenic effect Effects 0.000 claims description 13
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 12
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Diphosphoinositol tetrakisphosphate Chemical compound OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 12
- 229910019142 PO4 Inorganic materials 0.000 claims description 10
- 239000010452 phosphate Substances 0.000 claims description 10
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 9
- -1 inositol phosphates derivative salt Chemical class 0.000 claims description 7
- 239000005022 packaging material Substances 0.000 claims description 7
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- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical class [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 4
- KOELRIARTUZUKB-WJXVXWFNSA-L [Ca++].OC(O)=O.[O-]C([O-])=O.N[C@@H](CCCNC(N)=N)C(O)=O Chemical compound [Ca++].OC(O)=O.[O-]C([O-])=O.N[C@@H](CCCNC(N)=N)C(O)=O KOELRIARTUZUKB-WJXVXWFNSA-L 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims description 2
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 claims description 2
- 229910000020 calcium bicarbonate Inorganic materials 0.000 claims description 2
- 235000015218 chewing gum Nutrition 0.000 claims description 2
- 229940112822 chewing gum Drugs 0.000 claims description 2
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims description 2
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims 1
- 229960000367 inositol Drugs 0.000 claims 1
- 235000021317 phosphate Nutrition 0.000 claims 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 abstract description 11
- 239000004075 cariostatic agent Substances 0.000 abstract description 10
- 230000000248 cariostatic effect Effects 0.000 abstract 2
- 210000003298 dental enamel Anatomy 0.000 description 40
- 239000002253 acid Substances 0.000 description 27
- 238000011534 incubation Methods 0.000 description 26
- 239000008103 glucose Substances 0.000 description 25
- 241000894006 Bacteria Species 0.000 description 24
- 239000002244 precipitate Substances 0.000 description 24
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 22
- 210000003296 saliva Anatomy 0.000 description 20
- 238000004458 analytical method Methods 0.000 description 16
- 150000001875 compounds Chemical class 0.000 description 16
- 230000007928 solubilization Effects 0.000 description 15
- 238000005063 solubilization Methods 0.000 description 15
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 14
- 229910052698 phosphorus Inorganic materials 0.000 description 14
- 239000011574 phosphorus Substances 0.000 description 14
- 239000000843 powder Substances 0.000 description 13
- 230000008569 process Effects 0.000 description 13
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 230000015572 biosynthetic process Effects 0.000 description 11
- 238000006298 dechlorination reaction Methods 0.000 description 11
- 239000012153 distilled water Substances 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 150000001720 carbohydrates Chemical class 0.000 description 10
- 238000005115 demineralization Methods 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 10
- 230000002401 inhibitory effect Effects 0.000 description 10
- 229940068041 phytic acid Drugs 0.000 description 10
- 239000000467 phytic acid Substances 0.000 description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 9
- 235000014633 carbohydrates Nutrition 0.000 description 9
- 230000002328 demineralizing effect Effects 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 239000004091 cariogenic agent Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 239000006228 supernatant Substances 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000002585 base Substances 0.000 description 6
- DIKBFYAXUHHXCS-UHFFFAOYSA-N bromoform Chemical compound BrC(Br)Br DIKBFYAXUHHXCS-UHFFFAOYSA-N 0.000 description 6
- 210000004268 dentin Anatomy 0.000 description 6
- 238000001727 in vivo Methods 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- 239000000606 toothpaste Substances 0.000 description 6
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
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- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 229940083982 sodium phytate Drugs 0.000 description 5
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- 229940034610 toothpaste Drugs 0.000 description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 4
- 150000007513 acids Chemical class 0.000 description 4
- 239000001506 calcium phosphate Substances 0.000 description 4
- 229910000389 calcium phosphate Inorganic materials 0.000 description 4
- 235000011010 calcium phosphates Nutrition 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 4
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- 239000002324 mouth wash Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000004278 EU approved seasoning Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
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- 238000005119 centrifugation Methods 0.000 description 3
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- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 2
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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| PCT/US1997/005273 WO1997032565A1 (en) | 1996-03-05 | 1997-03-04 | Anti-caries oral compositions |
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| US6436370B1 (en) * | 1999-06-23 | 2002-08-20 | The Research Foundation Of State University Of New York | Dental anti-hypersensitivity composition and method |
| AU2002227247A1 (en) * | 2000-12-08 | 2002-06-18 | Brown, Dale G. | Biofilm therapy process and elements |
| US20060216248A1 (en) * | 2003-04-30 | 2006-09-28 | Asahi Breweries, Ltd. | Material for inhibiting enamel decalcification |
| US20040258629A1 (en) * | 2003-06-23 | 2004-12-23 | Boyd Thomas J. | Antiplaque confectionery dental composition |
| US8287843B2 (en) | 2003-06-23 | 2012-10-16 | Colgate-Palmolive Company | Antiplaque oral care compositions |
| AU2004251727B2 (en) | 2003-06-23 | 2010-06-17 | Colgate-Palmolive Company | Stable dentifrice compositions |
| US7198653B2 (en) * | 2003-07-31 | 2007-04-03 | Delavau Llc | Calcium carbonate granulation |
| CA2632009A1 (en) * | 2005-12-16 | 2007-06-21 | David Kannar | Surface active calcium phosphates |
| US20070212449A1 (en) * | 2006-03-02 | 2007-09-13 | Shamsuddin Abulkalam M | Reduction of the titratable acidity and the prevention of tooth and other bone degeneration |
| JP2009536663A (ja) | 2006-05-09 | 2009-10-15 | コルゲート・パーモリブ・カンパニー | 口腔ケア措置 |
| US20080274065A1 (en) * | 2006-05-09 | 2008-11-06 | Richard Scott Robinson | Oral Care Regimen |
| US9138414B1 (en) | 2006-09-15 | 2015-09-22 | Delavau Llc | Calcium supplement having enhanced absorption |
| EP2091505A2 (en) * | 2006-10-31 | 2009-08-26 | Oroscience, Inc | Process to form nano-sized materials, the compositions and uses thereof |
| US20080267891A1 (en) * | 2007-04-30 | 2008-10-30 | Colgate-Palmolive Company | Oral Care Composition To Reduce Or Eliminate Dental Sensitivity |
| US20090053267A1 (en) * | 2007-08-20 | 2009-02-26 | Depierro Karen | Dentifrice composition containing silicone oil beads |
| EP2070422A1 (en) | 2007-12-05 | 2009-06-17 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Confectionery products promoting dental health |
| CA2707085C (en) * | 2008-02-08 | 2013-11-26 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| BRPI0906466A2 (pt) * | 2008-02-08 | 2015-07-14 | Colgate Palmolive Co | Composição para cuidado oral, e, métodos para preparar uma composição oral, e para aplicar uma quantidade eficaz da composição oral |
| TW200946083A (en) | 2008-02-08 | 2009-11-16 | Colgate Palmolive Co | Dental floss |
| RU2519329C2 (ru) * | 2008-02-08 | 2014-06-10 | Колгейт-Палмолив Компани | Композиции и устройства |
| MX2010007739A (es) * | 2008-02-08 | 2010-08-10 | Colgate Palmolive Co | Composiciones y dispositivos. |
| AU2013200182B2 (en) * | 2008-02-08 | 2015-05-21 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| WO2009099450A1 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Oral care regimen |
| MX360815B (es) * | 2008-02-08 | 2018-11-15 | Colgate Palmolive Co | Producto para el cuidado oral y métodos de uso y fabricación del mismo. |
| CA2706516C (en) * | 2008-02-08 | 2014-12-16 | Colgate-Palmolive Company | Cleaning compositions and methods |
| TWI458468B (zh) | 2008-02-08 | 2014-11-01 | Colgate Palmolive Co | 牙齒擦拭件 |
| CN101938970A (zh) * | 2008-02-08 | 2011-01-05 | 高露洁-棕榄公司 | 牙齿密封剂 |
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| AU2009212328B2 (en) * | 2008-02-08 | 2011-12-08 | Colgate-Palmolive Company | Effervescent compositions |
| CN101951877A (zh) * | 2008-02-08 | 2011-01-19 | 高露洁-棕榄公司 | 用于治疗口腔干燥的组合物和方法 |
| AU2012211481B2 (en) * | 2008-02-08 | 2013-08-22 | Colgate-Palmolive Company | Arginine salts and their uses for the treatment of illnesses in the oral cavity |
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| US20090202452A1 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Oral care regimen |
| AR070585A1 (es) * | 2008-02-08 | 2010-04-21 | Colgate Palmolive Co | Cepillo de dientes para cuidado oral |
| TWI389876B (zh) * | 2008-02-08 | 2013-03-21 | Colgate Palmolive Co | 鹽的製造方法 |
| AU2015215853B2 (en) * | 2008-02-08 | 2016-11-03 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| RU2469701C2 (ru) * | 2008-02-08 | 2012-12-20 | Колгейт-Палмолив Компани | Продукт для ухода за полостью рта и способы его применения |
| CN101938916A (zh) * | 2008-02-08 | 2011-01-05 | 高露洁-棕榄公司 | 包含精氨酸的饮料 |
| RU2482835C2 (ru) * | 2008-02-08 | 2013-05-27 | Колгейт-Палмолив Компани | Продукт для ухода за ротовой полостью и способы его применения и изготовления |
| CA2706486C (en) * | 2008-02-08 | 2013-12-24 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| MX2010004571A (es) * | 2008-02-08 | 2010-05-17 | Colgate Palmolive Co | Composiciones y metodos que comprenden peptidos y proteasas de aminoacidos basicos. |
| RU2476200C2 (ru) | 2008-02-08 | 2013-02-27 | Колгейт-Палмолив Компани | Двухкомпонентный продукт для ухода за ротовой полостью |
| US20090005320A1 (en) * | 2008-09-02 | 2009-01-01 | Bruce Kneller | Compositions comprising amino acid bicarbonate and methods of use thereof |
| RU2497496C2 (ru) * | 2008-11-25 | 2013-11-10 | Дзе Проктер Энд Гэмбл Компани | Антибактериальные композиции для ухода за полостью рта, содержащие аморфный кварц |
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| US8741268B2 (en) * | 2009-09-10 | 2014-06-03 | Preventive Technologies, Inc. | Dental prophylactic paste |
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| US20220313595A1 (en) | 2021-03-25 | 2022-10-06 | The Procter & Gamble Company | Oral Care Compositions Comprising Hops |
| US20220304919A1 (en) | 2021-03-25 | 2022-09-29 | The Procter & Gamble Company | Edible Oral Compositions Comprising Hops |
| JP2024509602A (ja) | 2021-03-25 | 2024-03-04 | ザ プロクター アンド ギャンブル カンパニー | ホップ及び甘味料を含む口腔ケア組成物 |
| CN115572309B (zh) * | 2022-09-20 | 2024-05-03 | 浙江工业大学 | 一种高效阻燃、抗熔滴的环境友好型阻燃剂 |
| WO2025006664A2 (en) | 2023-06-28 | 2025-01-02 | The Procter & Gamble Company | Oral care compositions comprising hops beta acids and tin |
| WO2025006671A2 (en) | 2023-06-28 | 2025-01-02 | The Procter & Gamble Company | Oral care compositions comprising hops beta acids |
| WO2025000250A1 (en) | 2023-06-28 | 2025-01-02 | The Procter & Gamble Company | Oral care compositions comprising hops beta acids |
| US20250120890A1 (en) | 2023-09-14 | 2025-04-17 | The Procter & Gamble Company | Oral Care Compositions Comprising Hops Beta Acids And Tin |
| US20250120896A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| US20250120892A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| WO2025080746A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| WO2025080745A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| WO2025080743A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| WO2025076709A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3932608A (en) * | 1971-08-30 | 1976-01-13 | General Mills, Inc. | Food composition |
| US3943241A (en) * | 1971-08-30 | 1976-03-09 | General Mills, Inc. | Cariostatic composition |
| US4064138A (en) * | 1975-11-12 | 1977-12-20 | General Mills, Inc. | Amino acid derivatives |
| USRE31181E (en) * | 1976-06-18 | 1983-03-15 | Means and method for improving natural defenses against caries | |
| ZA773318B (en) * | 1976-06-18 | 1978-04-26 | I Kleinberg | Means and method for improving natural defenses against caries |
| GB1573727A (en) * | 1978-05-19 | 1980-08-28 | Colgate Palmolive Co | Dentifrices |
| US4225579A (en) * | 1979-02-27 | 1980-09-30 | Israel Kleinberg | Means and method for improving defenses against caries |
| JPS5835965B2 (ja) * | 1979-07-31 | 1983-08-05 | ライオン株式会社 | 口腔用組成物 |
| US4367218A (en) * | 1979-09-06 | 1983-01-04 | Jacobson Jerry I | Anti-caries oral rinse |
| US4528181A (en) * | 1984-02-01 | 1985-07-09 | Colgate-Palmolive Company | Dentifrice containing dual sources of fluoride |
| JPS61233612A (ja) * | 1985-04-10 | 1986-10-17 | Kao Corp | チユ−インガム |
| US5370865A (en) * | 1992-05-15 | 1994-12-06 | Kao Corporation | Composition for use in oral cavity |
| CN1094309A (zh) * | 1993-04-27 | 1994-11-02 | 李颖 | 一种矿质吸收因子肽钙及其制剂的制备方法 |
-
1996
- 1996-03-05 US US08/611,206 patent/US5762911A/en not_active Expired - Lifetime
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1997
- 1997-03-04 WO PCT/US1997/005273 patent/WO1997032565A1/en not_active Ceased
- 1997-03-04 CN CNB2005100727356A patent/CN1305530C/zh not_active Expired - Lifetime
- 1997-03-04 BR BRPI9711797-8A patent/BR9711797B1/pt not_active IP Right Cessation
- 1997-03-04 NZ NZ332172A patent/NZ332172A/xx not_active IP Right Cessation
- 1997-03-04 DK DK97917135T patent/DK0928184T3/da active
- 1997-03-04 CA CA002252071A patent/CA2252071C/en not_active Expired - Lifetime
- 1997-03-04 AT AT97917135T patent/ATE432685T1/de active
- 1997-03-04 PT PT97917135T patent/PT928184E/pt unknown
- 1997-03-04 DE DE69739440T patent/DE69739440D1/de not_active Expired - Lifetime
- 1997-03-04 CN CNB971969965A patent/CN1206978C/zh not_active Expired - Lifetime
- 1997-03-04 EP EP97917135A patent/EP0928184B1/en not_active Expired - Lifetime
- 1997-03-04 ES ES97917135T patent/ES2328301T3/es not_active Expired - Lifetime
- 1997-03-04 AU AU25563/97A patent/AU719465B2/en not_active Expired
- 1997-03-04 JP JP53207497A patent/JP3980645B2/ja not_active Expired - Lifetime
-
1998
- 1998-02-19 US US09/026,132 patent/US6217851B1/en not_active Expired - Lifetime
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2006
- 2006-06-26 JP JP2006175656A patent/JP2006265268A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001504083A (ja) | 2001-03-27 |
| EP0928184A4 (en) | 1999-10-20 |
| PT928184E (pt) | 2009-09-09 |
| BR9711797A (pt) | 2000-01-18 |
| BR9711797B1 (pt) | 2010-12-14 |
| NZ332172A (en) | 2000-11-24 |
| CN1206978C (zh) | 2005-06-22 |
| US6217851B1 (en) | 2001-04-17 |
| DK0928184T3 (da) | 2009-09-28 |
| ES2328301T3 (es) | 2009-11-11 |
| AU719465B2 (en) | 2000-05-11 |
| CA2252071C (en) | 2004-12-21 |
| WO1997032565A1 (en) | 1997-09-12 |
| JP2006265268A (ja) | 2006-10-05 |
| AU2556397A (en) | 1997-09-22 |
| EP0928184B1 (en) | 2009-06-03 |
| CN1701815A (zh) | 2005-11-30 |
| EP0928184A1 (en) | 1999-07-14 |
| CA2252071A1 (en) | 1997-09-12 |
| ATE432685T1 (de) | 2009-06-15 |
| DE69739440D1 (de) | 2009-07-16 |
| CN1227483A (zh) | 1999-09-01 |
| US5762911A (en) | 1998-06-09 |
| CN1305530C (zh) | 2007-03-21 |
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