JP3969722B2 - カンジダの検出 - Google Patents
カンジダの検出 Download PDFInfo
- Publication number
- JP3969722B2 JP3969722B2 JP2002585990A JP2002585990A JP3969722B2 JP 3969722 B2 JP3969722 B2 JP 3969722B2 JP 2002585990 A JP2002585990 A JP 2002585990A JP 2002585990 A JP2002585990 A JP 2002585990A JP 3969722 B2 JP3969722 B2 JP 3969722B2
- Authority
- JP
- Japan
- Prior art keywords
- candida
- antigen
- antibody
- kda
- antigens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241000222120 Candida <Saccharomycetales> Species 0.000 title claims abstract description 134
- 238000001514 detection method Methods 0.000 title claims description 16
- 238000000034 method Methods 0.000 claims abstract description 73
- 201000003984 candidiasis Diseases 0.000 claims abstract description 49
- 206010007134 Candida infections Diseases 0.000 claims abstract description 42
- 101710178376 Heat shock 70 kDa protein Proteins 0.000 claims abstract description 28
- 239000012472 biological sample Substances 0.000 claims abstract description 22
- 239000000427 antigen Substances 0.000 claims description 164
- 108091007433 antigens Proteins 0.000 claims description 163
- 102000036639 antigens Human genes 0.000 claims description 163
- 210000002966 serum Anatomy 0.000 claims description 42
- 239000000523 sample Substances 0.000 claims description 34
- 238000003556 assay Methods 0.000 claims description 27
- 210000002421 cell wall Anatomy 0.000 claims description 27
- 238000002965 ELISA Methods 0.000 claims description 23
- 102000012288 Phosphopyruvate Hydratase Human genes 0.000 claims description 20
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 claims description 20
- 238000002360 preparation method Methods 0.000 claims description 18
- 239000008280 blood Substances 0.000 claims description 17
- 102000004190 Enzymes Human genes 0.000 claims description 16
- 108090000790 Enzymes Proteins 0.000 claims description 16
- 210000004369 blood Anatomy 0.000 claims description 16
- 238000006243 chemical reaction Methods 0.000 claims description 16
- 241000222122 Candida albicans Species 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 12
- 230000027455 binding Effects 0.000 claims description 11
- 239000000872 buffer Substances 0.000 claims description 11
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 9
- 238000003127 radioimmunoassay Methods 0.000 claims description 6
- 238000011161 development Methods 0.000 claims description 5
- 238000002372 labelling Methods 0.000 claims description 5
- 210000000056 organ Anatomy 0.000 claims description 5
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 210000000601 blood cell Anatomy 0.000 claims description 4
- 210000002381 plasma Anatomy 0.000 claims description 4
- 210000001185 bone marrow Anatomy 0.000 claims description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 3
- 239000003446 ligand Substances 0.000 claims description 3
- 210000002751 lymph Anatomy 0.000 claims description 3
- 239000008267 milk Substances 0.000 claims description 3
- 210000004080 milk Anatomy 0.000 claims description 3
- 235000013336 milk Nutrition 0.000 claims description 3
- 230000000241 respiratory effect Effects 0.000 claims description 3
- 210000003296 saliva Anatomy 0.000 claims description 3
- 210000001138 tear Anatomy 0.000 claims description 3
- 238000005070 sampling Methods 0.000 claims description 2
- 239000007790 solid phase Substances 0.000 claims 2
- 230000000274 adsorptive effect Effects 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 57
- 238000009640 blood culture Methods 0.000 description 33
- 206010042938 Systemic candida Diseases 0.000 description 27
- 108090000623 proteins and genes Proteins 0.000 description 22
- 102000004169 proteins and genes Human genes 0.000 description 22
- 208000015181 infectious disease Diseases 0.000 description 21
- 239000000243 solution Substances 0.000 description 21
- 229940088598 enzyme Drugs 0.000 description 18
- 238000010998 test method Methods 0.000 description 15
- 239000003153 chemical reaction reagent Substances 0.000 description 14
- 230000035945 sensitivity Effects 0.000 description 14
- 238000002835 absorbance Methods 0.000 description 12
- 210000004027 cell Anatomy 0.000 description 12
- 208000036732 invasive candidiasis Diseases 0.000 description 12
- 238000003018 immunoassay Methods 0.000 description 11
- 239000011248 coating agent Substances 0.000 description 10
- 238000000576 coating method Methods 0.000 description 10
- 238000002405 diagnostic procedure Methods 0.000 description 9
- 238000000502 dialysis Methods 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 230000001086 cytosolic effect Effects 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 239000002609 medium Substances 0.000 description 8
- 239000012528 membrane Substances 0.000 description 8
- 238000009589 serological test Methods 0.000 description 8
- 238000005119 centrifugation Methods 0.000 description 7
- 238000004587 chromatography analysis Methods 0.000 description 7
- 239000000284 extract Substances 0.000 description 7
- 230000008901 benefit Effects 0.000 description 6
- 210000000805 cytoplasm Anatomy 0.000 description 6
- 238000003745 diagnosis Methods 0.000 description 6
- QFVHZQCOUORWEI-UHFFFAOYSA-N 4-[(4-anilino-5-sulfonaphthalen-1-yl)diazenyl]-5-hydroxynaphthalene-2,7-disulfonic acid Chemical compound C=12C(O)=CC(S(O)(=O)=O)=CC2=CC(S(O)(=O)=O)=CC=1N=NC(C1=CC=CC(=C11)S(O)(=O)=O)=CC=C1NC1=CC=CC=C1 QFVHZQCOUORWEI-UHFFFAOYSA-N 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 5
- 201000007096 Vulvovaginal Candidiasis Diseases 0.000 description 5
- 239000012491 analyte Substances 0.000 description 5
- 239000012148 binding buffer Substances 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 239000013642 negative control Substances 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- 230000009885 systemic effect Effects 0.000 description 5
- GXIURPTVHJPJLF-UWTATZPHSA-N 2-phosphoglycerate Natural products OC[C@H](C(O)=O)OP(O)(O)=O GXIURPTVHJPJLF-UWTATZPHSA-N 0.000 description 4
- GXIURPTVHJPJLF-UHFFFAOYSA-N 2-phosphoglyceric acid Chemical compound OCC(C(O)=O)OP(O)(O)=O GXIURPTVHJPJLF-UHFFFAOYSA-N 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- 102100024023 Histone PARylation factor 1 Human genes 0.000 description 4
- 229920000057 Mannan Polymers 0.000 description 4
- 229920001213 Polysorbate 20 Polymers 0.000 description 4
- 229920002684 Sepharose Polymers 0.000 description 4
- 230000005875 antibody response Effects 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 230000000903 blocking effect Effects 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 230000007935 neutral effect Effects 0.000 description 4
- 230000009871 nonspecific binding Effects 0.000 description 4
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 230000002285 radioactive effect Effects 0.000 description 4
- 230000009257 reactivity Effects 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 208000007027 Oral Candidiasis Diseases 0.000 description 3
- 239000007983 Tris buffer Substances 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 238000001574 biopsy Methods 0.000 description 3
- 208000017773 candidemia Diseases 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000001332 colony forming effect Effects 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 210000005260 human cell Anatomy 0.000 description 3
- 238000003317 immunochromatography Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000010369 molecular cloning Methods 0.000 description 3
- DTBNBXWJWCWCIK-UHFFFAOYSA-K phosphonatoenolpyruvate Chemical compound [O-]C(=O)C(=C)OP([O-])([O-])=O DTBNBXWJWCWCIK-UHFFFAOYSA-K 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 238000003752 polymerase chain reaction Methods 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 239000000376 reactant Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 3
- -1 sonic waves Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 230000001052 transient effect Effects 0.000 description 3
- UFBJCMHMOXMLKC-UHFFFAOYSA-N 2,4-dinitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O UFBJCMHMOXMLKC-UHFFFAOYSA-N 0.000 description 2
- AGGUKALRPKAKSM-UHFFFAOYSA-N 2,5-dichloro-1,3-dinitrobenzene Chemical compound [O-][N+](=O)C1=CC(Cl)=CC([N+]([O-])=O)=C1Cl AGGUKALRPKAKSM-UHFFFAOYSA-N 0.000 description 2
- XZKIHKMTEMTJQX-UHFFFAOYSA-N 4-Nitrophenyl Phosphate Chemical compound OP(O)(=O)OC1=CC=C([N+]([O-])=O)C=C1 XZKIHKMTEMTJQX-UHFFFAOYSA-N 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 241000222173 Candida parapsilosis Species 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 2
- HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 101001047783 Homo sapiens Histone PARylation factor 1 Proteins 0.000 description 2
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- 239000000020 Nitrocellulose Substances 0.000 description 2
- 229920002494 Zein Polymers 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 238000011888 autopsy Methods 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- OWMVSZAMULFTJU-UHFFFAOYSA-N bis-tris Chemical compound OCCN(CCO)C(CO)(CO)CO OWMVSZAMULFTJU-UHFFFAOYSA-N 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000002274 desiccant Substances 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000013399 early diagnosis Methods 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 238000001952 enzyme assay Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 238000010832 independent-sample T-test Methods 0.000 description 2
- 108010005335 mannoproteins Proteins 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920001220 nitrocellulos Polymers 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 229930029653 phosphoenolpyruvate Natural products 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 229940093612 zein Drugs 0.000 description 2
- 239000005019 zein Substances 0.000 description 2
- WQZGKKKJIJFFOK-SVZMEOIVSA-N (+)-Galactose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-SVZMEOIVSA-N 0.000 description 1
- LOTKRQAVGJMPNV-UHFFFAOYSA-N 1-fluoro-2,4-dinitrobenzene Chemical compound [O-][N+](=O)C1=CC=C(F)C([N+]([O-])=O)=C1 LOTKRQAVGJMPNV-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 description 1
- DANYDKIZJCAJNC-UHFFFAOYSA-N 4-[[4-(dibutylamino)phenyl]diazenyl]benzenesulfonic acid Chemical compound C1=CC(N(CCCC)CCCC)=CC=C1N=NC1=CC=C(S(O)(=O)=O)C=C1 DANYDKIZJCAJNC-UHFFFAOYSA-N 0.000 description 1
- CMUHFUGDYMFHEI-QMMMGPOBSA-N 4-amino-L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N)C=C1 CMUHFUGDYMFHEI-QMMMGPOBSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 238000011537 Coomassie blue staining Methods 0.000 description 1
- 238000012286 ELISA Assay Methods 0.000 description 1
- 206010053172 Fatal outcomes Diseases 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- 239000004366 Glucose oxidase Substances 0.000 description 1
- 108010068370 Glutens Proteins 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 101710120037 Toxin CcdB Proteins 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 108010055615 Zein Proteins 0.000 description 1
- 238000011481 absorbance measurement Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 238000001261 affinity purification Methods 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 238000005571 anion exchange chromatography Methods 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000009830 antibody antigen interaction Effects 0.000 description 1
- 230000009831 antigen interaction Effects 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 229940055022 candida parapsilosis Drugs 0.000 description 1
- 238000005277 cation exchange chromatography Methods 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 1
- 239000012916 chromogenic reagent Substances 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 229960005188 collagen Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000012468 concentrated sample Substances 0.000 description 1
- 239000003636 conditioned culture medium Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 239000011536 extraction buffer Substances 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 1
- 229960004884 fluconazole Drugs 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 108010074605 gamma-Globulins Proteins 0.000 description 1
- 238000012215 gene cloning Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940116332 glucose oxidase Drugs 0.000 description 1
- 235000019420 glucose oxidase Nutrition 0.000 description 1
- 230000002414 glycolytic effect Effects 0.000 description 1
- 108091005608 glycosylated proteins Proteins 0.000 description 1
- 102000035122 glycosylated proteins Human genes 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 230000003067 hemagglutinative effect Effects 0.000 description 1
- 201000005787 hematologic cancer Diseases 0.000 description 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
- 238000000703 high-speed centrifugation Methods 0.000 description 1
- 230000005745 host immune response Effects 0.000 description 1
- 210000001822 immobilized cell Anatomy 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000001155 isoelectric focusing Methods 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 description 1
- 235000011285 magnesium acetate Nutrition 0.000 description 1
- 239000011654 magnesium acetate Substances 0.000 description 1
- 229940069446 magnesium acetate Drugs 0.000 description 1
- 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- STZCRXQWRGQSJD-GEEYTBSJSA-M methyl orange Chemical compound [Na+].C1=CC(N(C)C)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 STZCRXQWRGQSJD-GEEYTBSJSA-M 0.000 description 1
- 229940012189 methyl orange Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 108010057904 polyisoleucine Proteins 0.000 description 1
- 108010039177 polyphenylalanine Proteins 0.000 description 1
- 108010011723 polytryptophan Proteins 0.000 description 1
- 108010033949 polytyrosine Proteins 0.000 description 1
- 238000011176 pooling Methods 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000000751 protein extraction Methods 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000012508 resin bead Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000006152 selective media Substances 0.000 description 1
- 238000004092 self-diagnosis Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960001479 tosylchloramide sodium Drugs 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 238000007693 zone electrophoresis Methods 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56961—Plant cells or fungi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/571—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses for venereal disease, e.g. syphilis, gonorrhoea
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/37—Assays involving biological materials from specific organisms or of a specific nature from fungi
- G01N2333/39—Assays involving biological materials from specific organisms or of a specific nature from fungi from yeasts
- G01N2333/40—Assays involving biological materials from specific organisms or of a specific nature from fungi from yeasts from Candida
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Virology (AREA)
- Botany (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/841,188 US6916626B1 (en) | 2001-04-25 | 2001-04-25 | Detection of Candida |
| PCT/AU2002/000507 WO2002088741A1 (en) | 2001-04-25 | 2002-04-23 | Detection of candida |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004529350A JP2004529350A (ja) | 2004-09-24 |
| JP2004529350A5 JP2004529350A5 (https=) | 2005-09-15 |
| JP3969722B2 true JP3969722B2 (ja) | 2007-09-05 |
Family
ID=25284255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002585990A Expired - Fee Related JP3969722B2 (ja) | 2001-04-25 | 2002-04-23 | カンジダの検出 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US6916626B1 (https=) |
| EP (1) | EP1381864B1 (https=) |
| JP (1) | JP3969722B2 (https=) |
| CN (1) | CN1505759A (https=) |
| AT (1) | ATE406578T1 (https=) |
| AU (1) | AU2002248996B2 (https=) |
| CA (1) | CA2445430A1 (https=) |
| DE (1) | DE60228557D1 (https=) |
| WO (1) | WO2002088741A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103962399A (zh) * | 2014-04-08 | 2014-08-06 | 中天钢铁集团有限公司 | P/f线散卷冷却站 |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6916626B1 (en) * | 2001-04-25 | 2005-07-12 | Rockeby Biomed Ltd. | Detection of Candida |
| US20050266499A1 (en) * | 2001-04-25 | 2005-12-01 | Rockeby Biomed Corporation, Ltd. | Method and apparatus for testing for presence or absence of select biological substances |
| ITMI20030643A1 (it) | 2003-04-01 | 2004-10-02 | Copan Innovation Ltd | Tampone per il prelievo di campioni biologici |
| US7935479B2 (en) | 2004-07-19 | 2011-05-03 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
| US7846676B2 (en) * | 2004-07-19 | 2010-12-07 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
| ES2355265T3 (es) * | 2005-04-30 | 2011-03-24 | Institute Of Radiation Medicine, Academy Of Military Medical Sciences; People's Liberation Army Of | Un kit para detección inmunologica de nuroglobulina ligada a enzima y uso del mismo. |
| WO2006133434A2 (en) * | 2005-06-08 | 2006-12-14 | Board Of Regents, The University Of Texas System | Membranolytic polypeptides and methods of use |
| US8945361B2 (en) * | 2005-09-20 | 2015-02-03 | ProteinSimple | Electrophoresis standards, methods and kits |
| DE102005047384A1 (de) * | 2005-09-28 | 2007-04-05 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Candida-Diagnostik-Chip |
| WO2008122241A1 (en) * | 2007-04-04 | 2008-10-16 | Diagcor Bioscience Incorporation Limited | Rapid protein analyses and the device thereof |
| US10107782B2 (en) | 2008-01-25 | 2018-10-23 | ProteinSimple | Method to perform limited two dimensional separation of proteins and other biologicals |
| EP2096438A1 (en) * | 2008-02-28 | 2009-09-02 | Martin Thurnher | Methods for prognosing the status of patients |
| AU2009218461A1 (en) * | 2008-02-28 | 2009-09-03 | Martin Thurnher | Methods for prognosing the status of tumor patients |
| IT1401447B1 (it) * | 2010-06-09 | 2013-07-26 | Copan Italia Spa | Metodo per il trasferimento quantitativo di analiti |
| IT1403618B1 (it) | 2011-01-05 | 2013-10-31 | Copan Italia Spa | Procedimento per realizzare un dispositivo per il prelievo ed il trasferimento di campioni per biologia molecolare |
| US8735367B2 (en) | 2011-06-27 | 2014-05-27 | University Of Utah Research Foundation | Small molecule-dependent split aptamer ligation |
| US9804079B2 (en) | 2012-04-19 | 2017-10-31 | ProteinSimple | Dual wavelength isoelectric focusing for determining drug load in antibody drug conjugates |
| US8945838B2 (en) | 2012-06-20 | 2015-02-03 | University Of Utah Research Foundation | Aptamer-based lateral flow assay and associated methods |
| US9766206B2 (en) | 2013-09-27 | 2017-09-19 | ProteinSimple | Apparatus, systems, and methods for capillary electrophoresis |
| US10457716B2 (en) * | 2014-08-06 | 2019-10-29 | University Of Notre Dame Du Lac | Protein folding and methods of using same |
| JP6574713B2 (ja) * | 2016-01-20 | 2019-09-11 | 国立大学法人信州大学 | 免疫力検査方法および免疫力検査キット |
| US11051532B2 (en) | 2017-09-22 | 2021-07-06 | Impossible Foods Inc. | Methods for purifying protein |
| WO2019152657A1 (en) * | 2018-02-03 | 2019-08-08 | Simple Healthkit, Inc. | Reliable, comprehensive, and rapid sexual health assessment |
| CN109085353A (zh) * | 2018-06-13 | 2018-12-25 | 比杭生物科技(杭州)有限公司 | 一种白色念珠菌胶体金检测卡及其应用 |
| EP3670646A1 (en) * | 2018-12-21 | 2020-06-24 | Ohly GmbH | Functional yeast protein concentrate |
| JP7383249B2 (ja) * | 2019-11-20 | 2023-11-20 | オリンパス株式会社 | β-1,3-1,6-グルカンの測定方法 |
| US12011016B2 (en) | 2020-09-14 | 2024-06-18 | Impossible Foods Inc. | Protein methods and compositions |
| CN113670907B (zh) * | 2021-08-13 | 2023-06-09 | 广东海洋大学 | 一种cgc杂化纳米复合物及其制备方法和应用 |
| CN113791216A (zh) * | 2021-08-31 | 2021-12-14 | 石家庄和亚生物技术有限公司 | 一种检测人血清光滑念珠菌烯醇化酶IgG抗体的ELISA检测方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4366241A (en) * | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4670382A (en) * | 1983-12-02 | 1987-06-02 | Temple University--of the Commonwealth System of Higher Education | Monoclonal antibody to Candida albicans cytoplasmic antigens and methods of preparing same |
| US4806465A (en) * | 1984-01-16 | 1989-02-21 | Temple University Of The Commonwealth System Of Higher Education | Cytoplasmic antigens of candida albicans and methods of using the same |
| US4632901A (en) * | 1984-05-11 | 1986-12-30 | Hybritech Incorporated | Method and apparatus for immunoassays |
| DE3445816C1 (de) * | 1984-12-15 | 1986-06-12 | Behringwerke Ag, 3550 Marburg | Flaechenfoermiges diagnostisches Mittel |
| US5879881A (en) * | 1985-04-04 | 1999-03-09 | Hybritech, Incorporated | Solid phase system for use in ligand-receptor assays |
| US4920046A (en) * | 1987-02-20 | 1990-04-24 | Becton, Dickinson And Company | Process, test device, and test kit for a rapid assay having a visible readout |
| US4946945A (en) * | 1987-06-23 | 1990-08-07 | Allergy Immuno Technologies, Inc. | Immunotherapy agents for treatment of IgE mediated allergies |
| US5116612A (en) * | 1987-06-23 | 1992-05-26 | Allergy Immuno Technologies, Inc. | Immunotherapy agents for treatment of IgE mediated allergies |
| US5521153A (en) * | 1987-10-02 | 1996-05-28 | Ciba-Geigy Corporation | Synergistic antifungal protein and compositions containing same |
| US5075078A (en) * | 1989-10-05 | 1991-12-24 | Abbott Laboratories | Self-performing immunochromatographic device |
| JP2868900B2 (ja) * | 1991-01-11 | 1999-03-10 | クイデル コーポレイション | ワンステップ側方流非吸収性アッセイ |
| JP3203268B2 (ja) * | 1991-07-12 | 2001-08-27 | デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | カンジダ感染の検出方法 |
| US5786221A (en) * | 1991-11-26 | 1998-07-28 | Biomerica, Inc. | Diagnostic test for measuring islet cell autoantibodies and reagents relating thereto |
| GB2270076A (en) * | 1992-08-18 | 1994-03-02 | Univ Manchester | Human HSP 90 Epitopes |
| US5545525A (en) | 1994-03-07 | 1996-08-13 | Universite De Montreal | Detection of candida albicans |
| US20030008410A1 (en) * | 1995-03-13 | 2003-01-09 | Hechinger Mark K. | Immunoassay apparatus, kit and methods |
| US5741662A (en) * | 1995-12-18 | 1998-04-21 | Quidel Corporation | Direct stain specific binding assays for microorganisms |
| US5798273A (en) * | 1996-09-25 | 1998-08-25 | Becton Dickinson And Company | Direct read lateral flow assay for small analytes |
| US5710005A (en) * | 1996-10-29 | 1998-01-20 | Biocode, Inc. | Analyte detection with a gradient lateral flow device |
| US6979576B1 (en) * | 1997-07-25 | 2005-12-27 | Shu-Ching Cheng | Methods of use of one step immunochromatographic device for Streptococcus A antigen |
| US6194221B1 (en) * | 1996-11-19 | 2001-02-27 | Wyntek Diagnostics, Inc. | Hybrid one-step immunochromatographic device and method of use |
| US5707816A (en) * | 1997-02-06 | 1998-01-13 | Immunosciences Lab, Inc. | Immunological cross reactivity between Candida and human tissue or food antigens |
| US6057165A (en) * | 1997-02-07 | 2000-05-02 | Becton, Dickinson And Company | Quality control procedure for membrane flow-through diagnostic assay devices |
| JPH11103862A (ja) * | 1997-10-01 | 1999-04-20 | Takara Shuzo Co Ltd | 抗原タンパク質及び該タンパク質をコードする核酸 |
| US6057127A (en) * | 1998-01-29 | 2000-05-02 | Heska Corporation | Equine Fc epsilon receptor alpha chain nucleic acid molecules and uses thereof |
| US6824997B1 (en) * | 1998-09-18 | 2004-11-30 | Binax, Inc. | Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies |
| US6497880B1 (en) * | 1998-12-08 | 2002-12-24 | Stressgen Biotechnologies Corporation | Heat shock genes and proteins from Neisseria meningitidis, Candida glabrata and Aspergillus fumigatus |
| US6875855B1 (en) * | 1999-02-26 | 2005-04-05 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nucleic acid and amino acid sequences of hemoglobin-response genes in candida albicans and the use of reagents derived from these sequences in the diagnosis of disseminated candida albicans infection |
| JP2003527584A (ja) * | 2000-03-09 | 2003-09-16 | ヘスカ コーポレイション | 動物の免疫状態を決定するための組換え抗原の使用 |
| US20040241876A1 (en) * | 2000-12-22 | 2004-12-02 | France Fannes | Flow through assay device, diagnostic kit comprising said assay device and use of said assay device in the detection of an analyte present in a sample |
| US6916626B1 (en) * | 2001-04-25 | 2005-07-12 | Rockeby Biomed Ltd. | Detection of Candida |
| US20050266499A1 (en) * | 2001-04-25 | 2005-12-01 | Rockeby Biomed Corporation, Ltd. | Method and apparatus for testing for presence or absence of select biological substances |
| US6867004B2 (en) * | 2001-12-21 | 2005-03-15 | Focus Technologies, Inc. | Methods of using oxidized fungal antigens in antibody testing |
-
2001
- 2001-04-25 US US09/841,188 patent/US6916626B1/en not_active Expired - Fee Related
-
2002
- 2002-04-23 AU AU2002248996A patent/AU2002248996B2/en not_active Ceased
- 2002-04-23 CA CA002445430A patent/CA2445430A1/en not_active Abandoned
- 2002-04-23 DE DE60228557T patent/DE60228557D1/de not_active Expired - Fee Related
- 2002-04-23 WO PCT/AU2002/000507 patent/WO2002088741A1/en not_active Ceased
- 2002-04-23 CN CNA028088093A patent/CN1505759A/zh active Pending
- 2002-04-23 JP JP2002585990A patent/JP3969722B2/ja not_active Expired - Fee Related
- 2002-04-23 AT AT02717869T patent/ATE406578T1/de not_active IP Right Cessation
- 2002-04-23 EP EP02717869A patent/EP1381864B1/en not_active Expired - Lifetime
-
2003
- 2003-10-10 US US10/682,807 patent/US20040166546A1/en not_active Abandoned
-
2005
- 2005-12-27 US US11/316,739 patent/US20060105406A1/en not_active Abandoned
-
2007
- 2007-10-30 US US11/928,632 patent/US20080187988A1/en not_active Abandoned
-
2008
- 2008-09-30 US US12/242,663 patent/US20090030054A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103962399A (zh) * | 2014-04-08 | 2014-08-06 | 中天钢铁集团有限公司 | P/f线散卷冷却站 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60228557D1 (de) | 2008-10-09 |
| CN1505759A (zh) | 2004-06-16 |
| EP1381864A4 (en) | 2004-06-16 |
| EP1381864A1 (en) | 2004-01-21 |
| US6916626B1 (en) | 2005-07-12 |
| AU2002248996B2 (en) | 2004-09-30 |
| CA2445430A1 (en) | 2002-11-07 |
| JP2004529350A (ja) | 2004-09-24 |
| US20080187988A1 (en) | 2008-08-07 |
| EP1381864B1 (en) | 2008-08-27 |
| ATE406578T1 (de) | 2008-09-15 |
| US20040166546A1 (en) | 2004-08-26 |
| US20060105406A1 (en) | 2006-05-18 |
| WO2002088741A1 (en) | 2002-11-07 |
| US20090030054A1 (en) | 2009-01-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3969722B2 (ja) | カンジダの検出 | |
| AU2002248996A1 (en) | Detection of candida | |
| JP2901296B2 (ja) | カンピロバクター・ピロリの高分子型細胞関連蛋白の調製法とカンピロバクター・ピロリ感染の血清学的検出のための用法 | |
| EP0702794B1 (en) | Method and analytical device for simultaneous immunoassay | |
| AU621310B2 (en) | Immunometric assay kit and method applicable to whole cells | |
| CN106153893B (zh) | 唾液抗线粒体抗体m2型的酶联免疫检测试剂盒 | |
| US6461825B1 (en) | Immunometric assay kit and method applicable to whole cells | |
| EP0236605B1 (en) | Method for the assay of immunoglobulin a protease | |
| EP1278065A1 (en) | Method of detecting streptococcus sobrinus and antibody therefor | |
| CN105652006A (zh) | 梅毒螺旋体总抗体Dot-ELISA检测方法 | |
| KR102739746B1 (ko) | 바르토넬라 헨셀라이 유래 세포외 소포체를 이용한 바르토넬라 감염증 진단 방법 | |
| KR100254414B1 (ko) | 항-결핵균 항체 및 나균 항원에 대한 항혈청을 포함하는 결핵균 항원 검출용 진단키트 | |
| CN117491650B (zh) | 一种外周血Hb-Aβ复合物定量检测试剂盒、检测方法及应用 | |
| CN105738625A (zh) | 梅毒螺旋体IgG抗体Dot-ELISA检测方法 | |
| CN117405887A (zh) | 腺苷酸环化酶作为标志物在制备诊断和/或鉴别腹泻的病原体的产品中的应用 | |
| EP0850418A1 (en) | Method for the diagnosis of coeliac disease | |
| RU2196335C1 (ru) | Способ определения гетерогенных антигенов, сходных для микроорганизмов и органов человека и животного | |
| JPS62232568A (ja) | 免疫グロブリンaプロテア−ゼの測定および淋病を迅速に診断する方法、並びにそれに使用する試薬、および検出キツト | |
| CN105548578A (zh) | 梅毒螺旋体IgM抗体Dot-ELISA检测方法 | |
| JPH04258766A (ja) | 多数検体処理可能な簡易免疫診断方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20040831 |
|
| A871 | Explanation of circumstances concerning accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A871 Effective date: 20040831 |
|
| A975 | Report on accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A971005 Effective date: 20041108 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20041117 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20041201 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20050523 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20060405 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060623 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20070508 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20070604 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| LAPS | Cancellation because of no payment of annual fees |