WO2002088741A1 - Detection of candida - Google Patents

Detection of candida Download PDF

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Publication number
WO2002088741A1
WO2002088741A1 PCT/AU2002/000507 AU0200507W WO02088741A1 WO 2002088741 A1 WO2002088741 A1 WO 2002088741A1 AU 0200507 W AU0200507 W AU 0200507W WO 02088741 A1 WO02088741 A1 WO 02088741A1
Authority
WO
WIPO (PCT)
Prior art keywords
candida
antigen
antibody
biological sample
cytoplasmic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AU2002/000507
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English (en)
French (fr)
Inventor
John Warmington
Dennis Ballantyne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rockeby Biomed Ltd
Original Assignee
Rockeby Biomed Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rockeby Biomed Ltd filed Critical Rockeby Biomed Ltd
Priority to DE60228557T priority Critical patent/DE60228557D1/de
Priority to EP02717869A priority patent/EP1381864B1/en
Priority to CA002445430A priority patent/CA2445430A1/en
Priority to JP2002585990A priority patent/JP3969722B2/ja
Priority to AU2002248996A priority patent/AU2002248996B2/en
Publication of WO2002088741A1 publication Critical patent/WO2002088741A1/en
Priority to US10/682,807 priority patent/US20040166546A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56961—Plant cells or fungi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/571—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses for venereal disease, e.g. syphilis, gonorrhoea
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/37—Assays involving biological materials from specific organisms or of a specific nature from fungi
    • G01N2333/39—Assays involving biological materials from specific organisms or of a specific nature from fungi from yeasts
    • G01N2333/40—Assays involving biological materials from specific organisms or of a specific nature from fungi from yeasts from Candida

Definitions

  • PCR polymerase chain reaction
  • the diagnostic assay further utilises other Candida antigens in combination with the cytoplasmic antigen.
  • the cell wall antigen including mannose
  • purified immunodominant antigen enolase
  • the invention provides a kit when used for detecting the presence or absence of a Candida antibody in a biological sample, comprising: a) . a biological sample collection device; b) . a cytoplasmic Candida antigen; and c) . means for detecting reaction between the antibody and antigen in the sample.
  • Figure 10 shows an error bar graph of the Applicant antigen test data for invasive candidiasis and healthy controls.
  • Sensitivity may also be improved by preliminary treatment of biological samples with lysing agents such as isotonic solution, sound, or lysozyme to release Candida antibody into the extracellular environment.
  • lysing agents such as isotonic solution, sound, or lysozyme to release Candida antibody into the extracellular environment.
  • U.S. Pat. No. 4,166,765 discloses suitable lysing procedures for biological samples containing bacteria. Any lysing agent may be employed which does not interfere with subsequent enzyme activity.
  • Candida antigen The following three types of Candida antigen were prepared:
  • the soluble Candida cell extracts were collected and dispensed into 50ml centrifuge tubes. The extracts were centrifuged for 12h at 8,517 x g and 4°C to precipitate insoluble cell walls. The supernatants containing the soluble cytoplasmic antigen fraction were recovered and passed through a 0.45 ⁇ m filter membrane.
  • the Applicant antigen test was used to test sera from patients with invasive candidiasis, superficial candidiasis (oral or vaginal thrush) and healthy male controls.
  • healthy individuals can have a measurable antibody titre to Candida antigens.
  • a cut-off calibrator serum was supplied. The absorbance of the serum being tested was divided by the cut-off calibrator serum absorbance and multiplied by 10 to give an arbitrary unit value. Using a value of 20 units or above as an indicator of a positive test gave the greatest discrimination between the patient group with invasive candidiasis and the healthy controls (positive predictive value of 83%, negative predictive value 100%) .

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
PCT/AU2002/000507 2001-04-25 2002-04-23 Detection of candida Ceased WO2002088741A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE60228557T DE60228557D1 (de) 2001-04-25 2002-04-23 Candida-nachweis
EP02717869A EP1381864B1 (en) 2001-04-25 2002-04-23 Detection of candida
CA002445430A CA2445430A1 (en) 2001-04-25 2002-04-23 Detection of candida
JP2002585990A JP3969722B2 (ja) 2001-04-25 2002-04-23 カンジダの検出
AU2002248996A AU2002248996B2 (en) 2001-04-25 2002-04-23 Detection of candida
US10/682,807 US20040166546A1 (en) 2001-04-25 2003-10-10 Cytoplasmic antigens for detection of candida

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/841,188 US6916626B1 (en) 2001-04-25 2001-04-25 Detection of Candida
US09/841,188 2001-04-25

Publications (1)

Publication Number Publication Date
WO2002088741A1 true WO2002088741A1 (en) 2002-11-07

Family

ID=25284255

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU2002/000507 Ceased WO2002088741A1 (en) 2001-04-25 2002-04-23 Detection of candida

Country Status (9)

Country Link
US (5) US6916626B1 (https=)
EP (1) EP1381864B1 (https=)
JP (1) JP3969722B2 (https=)
CN (1) CN1505759A (https=)
AT (1) ATE406578T1 (https=)
AU (1) AU2002248996B2 (https=)
CA (1) CA2445430A1 (https=)
DE (1) DE60228557D1 (https=)
WO (1) WO2002088741A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007036352A3 (de) * 2005-09-28 2007-06-07 Fraunhofer Ges Forschung Candida-diagnose-chip
CN109085353A (zh) * 2018-06-13 2018-12-25 比杭生物科技（杭州）有限公司 一种白色念珠菌胶体金检测卡及其应用

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007036352A3 (de) * 2005-09-28 2007-06-07 Fraunhofer Ges Forschung Candida-diagnose-chip
CN109085353A (zh) * 2018-06-13 2018-12-25 比杭生物科技（杭州）有限公司 一种白色念珠菌胶体金检测卡及其应用

Also Published As

Publication number Publication date
DE60228557D1 (de) 2008-10-09
CN1505759A (zh) 2004-06-16
EP1381864A4 (en) 2004-06-16
JP3969722B2 (ja) 2007-09-05
EP1381864A1 (en) 2004-01-21
US6916626B1 (en) 2005-07-12
AU2002248996B2 (en) 2004-09-30
CA2445430A1 (en) 2002-11-07
JP2004529350A (ja) 2004-09-24
US20080187988A1 (en) 2008-08-07
EP1381864B1 (en) 2008-08-27
ATE406578T1 (de) 2008-09-15
US20040166546A1 (en) 2004-08-26
US20060105406A1 (en) 2006-05-18
US20090030054A1 (en) 2009-01-29

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