JP3943600B2 - インビボでの組織の診断およびインビボでの組織への介入手順の実施 - Google Patents
インビボでの組織の診断およびインビボでの組織への介入手順の実施 Download PDFInfo
- Publication number
- JP3943600B2 JP3943600B2 JP50533198A JP50533198A JP3943600B2 JP 3943600 B2 JP3943600 B2 JP 3943600B2 JP 50533198 A JP50533198 A JP 50533198A JP 50533198 A JP50533198 A JP 50533198A JP 3943600 B2 JP3943600 B2 JP 3943600B2
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- Prior art keywords
- tissue
- catheter
- optical fiber
- catheter shaft
- distal end
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
- A61B8/4461—Features of the scanning mechanism, e.g. for moving the transducer within the housing of the probe
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/06—Biopsy forceps, e.g. with cup-shaped jaws
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00491—Surgical glue applicators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/28—Surgical forceps
- A61B17/29—Forceps for use in minimally invasive surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/32—Surgical cutting instruments
- A61B17/320016—Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/32—Surgical cutting instruments
- A61B17/3201—Scissors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/32—Surgical cutting instruments
- A61B17/3205—Excision instruments
- A61B17/32056—Surgical snare instruments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/32—Surgical cutting instruments
- A61B17/3209—Incision instruments
- A61B17/3211—Surgical scalpels, knives; Accessories therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00057—Light
- A61B2017/00061—Light spectrum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00106—Sensing or detecting at the treatment site ultrasonic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22072—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with an instrument channel, e.g. for replacing one instrument by the other
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22072—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with an instrument channel, e.g. for replacing one instrument by the other
- A61B2017/22074—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with an instrument channel, e.g. for replacing one instrument by the other the instrument being only slidable in a channel, e.g. advancing optical fibre through a channel
- A61B2017/22077—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with an instrument channel, e.g. for replacing one instrument by the other the instrument being only slidable in a channel, e.g. advancing optical fibre through a channel with a part piercing the tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22082—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/30—Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
- A61B2090/306—Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure using optical fibres
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/361—Image-producing devices, e.g. surgical cameras
- A61B2090/3614—Image-producing devices, e.g. surgical cameras using optical fibre
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
- A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3937—Visible markers
- A61B2090/395—Visible markers with marking agent for marking skin or other tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2217/00—General characteristics of surgical instruments
- A61B2217/002—Auxiliary appliance
- A61B2217/005—Auxiliary appliance with suction drainage system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Optics & Photonics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Endoscopes (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/679,425 | 1996-07-08 | ||
| US08/679,425 US6296608B1 (en) | 1996-07-08 | 1996-07-08 | Diagnosing and performing interventional procedures on tissue in vivo |
| PCT/US1997/011864 WO1998001074A1 (en) | 1996-07-08 | 1997-07-07 | Diagnosing and performing interventional procedures on tissue in vivo |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2000516112A JP2000516112A (ja) | 2000-12-05 |
| JP2000516112A5 JP2000516112A5 (OSRAM) | 2005-03-10 |
| JP3943600B2 true JP3943600B2 (ja) | 2007-07-11 |
Family
ID=24726865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50533198A Expired - Fee Related JP3943600B2 (ja) | 1996-07-08 | 1997-07-07 | インビボでの組織の診断およびインビボでの組織への介入手順の実施 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US6296608B1 (OSRAM) |
| EP (1) | EP0925034B1 (OSRAM) |
| JP (1) | JP3943600B2 (OSRAM) |
| CA (1) | CA2260147A1 (OSRAM) |
| DE (1) | DE69728277T2 (OSRAM) |
| WO (1) | WO1998001074A1 (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013506498A (ja) * | 2009-09-30 | 2013-02-28 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 医療処置中の撮像のためのシステムおよび方法 |
Families Citing this family (268)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6564087B1 (en) * | 1991-04-29 | 2003-05-13 | Massachusetts Institute Of Technology | Fiber optic needle probes for optical coherence tomography imaging |
| US6296608B1 (en) * | 1996-07-08 | 2001-10-02 | Boston Scientific Corporation | Diagnosing and performing interventional procedures on tissue in vivo |
| US5924976A (en) * | 1997-08-21 | 1999-07-20 | Stelzer; Paul | Minimally invasive surgery device |
| US6537211B1 (en) * | 1998-01-26 | 2003-03-25 | Massachusetts Institute Of Technology | Flourescence imaging endoscope |
| US6976957B1 (en) * | 1998-06-22 | 2005-12-20 | Origin Medsystems, Inc. | Cannula-based surgical instrument and method |
| US6228076B1 (en) * | 1999-01-09 | 2001-05-08 | Intraluminal Therapeutics, Inc. | System and method for controlling tissue ablation |
| US6697666B1 (en) * | 1999-06-22 | 2004-02-24 | Board Of Regents, The University Of Texas System | Apparatus for the characterization of tissue of epithelial lined viscus |
| US6537205B1 (en) * | 1999-10-14 | 2003-03-25 | Scimed Life Systems, Inc. | Endoscopic instrument system having reduced backlash control wire action |
| US6454702B1 (en) * | 1999-10-14 | 2002-09-24 | Scimed Life Systems, Inc. | Endoscope and endoscopic instrument system having reduced backlash when moving the endoscopic instrument within a working channel of the endoscope |
| AU8028400A (en) * | 1999-10-22 | 2001-05-08 | Scimed Life Systems, Inc. | Guided injection device |
| US6685666B1 (en) * | 1999-11-12 | 2004-02-03 | Mark G. Fontenot | Catheters for breast surgery |
| US6458076B1 (en) | 2000-02-01 | 2002-10-01 | 5 Star Medical | Multi-lumen medical device |
| NZ522128A (en) | 2000-03-31 | 2003-08-29 | Rita Medical Systems Inc | Tissue biopsy and treatment apparatus and method |
| AU2002230842A1 (en) | 2000-10-30 | 2002-05-15 | The General Hospital Corporation | Optical methods and systems for tissue analysis |
| US9295391B1 (en) | 2000-11-10 | 2016-03-29 | The General Hospital Corporation | Spectrally encoded miniature endoscopic imaging probe |
| US6673023B2 (en) | 2001-03-23 | 2004-01-06 | Stryker Puerto Rico Limited | Micro-invasive breast biopsy device |
| US6432064B1 (en) * | 2001-04-09 | 2002-08-13 | Ethicon Endo-Surgery, Inc. | Biopsy instrument with tissue marking element |
| EP1402244B1 (en) | 2001-04-30 | 2020-03-11 | The General Hospital Corporation | Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating |
| US20060201351A1 (en) * | 2001-07-02 | 2006-09-14 | Gi View Ltd. | Self-propelled imaging system |
| US20080154090A1 (en) * | 2005-01-04 | 2008-06-26 | Dune Medical Devices Ltd. | Endoscopic System for In-Vivo Procedures |
| US8721565B2 (en) | 2005-08-04 | 2014-05-13 | Dune Medical Devices Ltd. | Device for forming an effective sensor-to-tissue contact |
| US20080287750A1 (en) * | 2002-01-04 | 2008-11-20 | Dune Medical Devices Ltd. | Ergonomic probes |
| US8116845B2 (en) | 2005-08-04 | 2012-02-14 | Dune Medical Devices Ltd. | Tissue-characterization probe with effective sensor-to-tissue contact |
| US7355716B2 (en) | 2002-01-24 | 2008-04-08 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
| US20040010204A1 (en) * | 2002-03-28 | 2004-01-15 | Pearl Technology Holdings, Llc | Electronic/fiberoptic tissue differentiation instrumentation |
| US20030225432A1 (en) * | 2002-05-31 | 2003-12-04 | Baptiste Reginald C. | Soft tissue retraction device for an endoscopic instrument |
| JP2004024331A (ja) * | 2002-06-21 | 2004-01-29 | Vayu:Kk | カテーテル |
| AU2003258250A1 (en) * | 2002-08-16 | 2004-03-03 | Beth Israel Deaconess Medical Center | Apparatus for multifocal deposition and analysis and methods for its use |
| US8123698B2 (en) * | 2002-10-07 | 2012-02-28 | Suros Surgical Systems, Inc. | System and method for minimally invasive disease therapy |
| WO2004088361A2 (en) | 2003-03-31 | 2004-10-14 | The General Hospital Corporation | Speckle reduction in optical coherence tomography by path length encoded angular compounding |
| US7643153B2 (en) | 2003-01-24 | 2010-01-05 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
| JP4477382B2 (ja) * | 2003-03-04 | 2010-06-09 | オリンパス株式会社 | 内視鏡的腹腔内処置システム |
| US8187288B2 (en) | 2003-03-10 | 2012-05-29 | Boston Scientific Scimed, Inc. | Re-shapeable medical device |
| US20040199052A1 (en) | 2003-04-01 | 2004-10-07 | Scimed Life Systems, Inc. | Endoscopic imaging system |
| WO2005000096A2 (en) | 2003-06-05 | 2005-01-06 | Hydrocision, Inc. | Disposable endoscope and method of making a disposable endoscope |
| DE602004016998D1 (de) | 2003-06-06 | 2008-11-20 | Gen Hospital Corp | Wellenlängenabstimmbare lichtquelle |
| US8403828B2 (en) * | 2003-07-21 | 2013-03-26 | Vanderbilt University | Ophthalmic orbital surgery apparatus and method and image-guide navigation system |
| US10610406B2 (en) * | 2004-07-21 | 2020-04-07 | Vanderbilt University | Drug delivery device and applications of same |
| US7833176B2 (en) * | 2003-08-13 | 2010-11-16 | G. I. View Ltd. | Pressure-propelled system for body lumen |
| US20050038319A1 (en) * | 2003-08-13 | 2005-02-17 | Benad Goldwasser | Gastrointestinal tool over guidewire |
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| US20050036059A1 (en) * | 2003-08-13 | 2005-02-17 | Benad Goldwasser | Ingestible imaging system |
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| CN103082996A (zh) | 2003-10-27 | 2013-05-08 | 通用医疗公司 | 用于使用频域干涉测量法进行光学成像的方法和设备 |
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| KR101332222B1 (ko) | 2004-08-06 | 2013-11-22 | 더 제너럴 하스피탈 코포레이션 | 광간섭 단층촬영법을 이용해서 샘플 내에서 적어도 하나의 위치를 결정하는 방법, 시스템 및 그 방법을 구현하기 위한 소프트웨어가 저장되어 컴퓨터로 판독 가능한 매체 |
| JP5324095B2 (ja) | 2004-08-24 | 2013-10-23 | ザ ジェネラル ホスピタル コーポレイション | 血管セグメントを画像化する方法および装置 |
| WO2006024014A2 (en) | 2004-08-24 | 2006-03-02 | The General Hospital Corporation | Process, system and software arrangement for measuring a mechanical strain and elastic properties of a sample |
| EP2329759B1 (en) | 2004-09-29 | 2014-03-12 | The General Hospital Corporation | System and method for optical coherence imaging |
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| US8797392B2 (en) | 2005-01-05 | 2014-08-05 | Avantis Medical Sytems, Inc. | Endoscope assembly with a polarizing filter |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2013506498A (ja) * | 2009-09-30 | 2013-02-28 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 医療処置中の撮像のためのシステムおよび方法 |
Also Published As
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|---|---|
| US20010047135A1 (en) | 2001-11-29 |
| JP2000516112A (ja) | 2000-12-05 |
| EP0925034A1 (en) | 1999-06-30 |
| CA2260147A1 (en) | 1998-01-15 |
| WO1998001074A1 (en) | 1998-01-15 |
| US8135454B2 (en) | 2012-03-13 |
| US6296608B1 (en) | 2001-10-02 |
| US20060036182A1 (en) | 2006-02-16 |
| EP0925034B1 (en) | 2004-03-24 |
| DE69728277T2 (de) | 2004-08-12 |
| DE69728277D1 (de) | 2004-04-29 |
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