ATE133545T1 - Verfahren für laserinduzierte fluoreszenz von gewebe - Google Patents

Verfahren für laserinduzierte fluoreszenz von gewebe

Info

Publication number
ATE133545T1
ATE133545T1 AT90900642T AT90900642T ATE133545T1 AT E133545 T1 ATE133545 T1 AT E133545T1 AT 90900642 T AT90900642 T AT 90900642T AT 90900642 T AT90900642 T AT 90900642T AT E133545 T1 ATE133545 T1 AT E133545T1
Authority
AT
Austria
Prior art keywords
tissue
laser
induced fluorescence
fluorescence
chemical composition
Prior art date
Application number
AT90900642T
Other languages
English (en)
Inventor
Carter Kittrell
Robert M Cothren
Michael S Feld
Joseph J Baraga
Kyungwon An
Rebecca Richards-Kortum
Richard P Rava
Young D Park
Anand Mehta
Paola Taroni
Lucene Tong
Ramachandra Rao Dasari
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of ATE133545T1 publication Critical patent/ATE133545T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A61B18/24—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
    • A61B18/245—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter for removing obstructions in blood vessels or calculi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0238—Optical sensor arrangements for performing transmission measurements on body tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Vascular Medicine (AREA)
  • Electromagnetism (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Laser Surgery Devices (AREA)
AT90900642T 1988-12-21 1989-11-17 Verfahren für laserinduzierte fluoreszenz von gewebe ATE133545T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28877288A 1988-12-21 1988-12-21

Publications (1)

Publication Number Publication Date
ATE133545T1 true ATE133545T1 (de) 1996-02-15

Family

ID=23108573

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90900642T ATE133545T1 (de) 1988-12-21 1989-11-17 Verfahren für laserinduzierte fluoreszenz von gewebe

Country Status (5)

Country Link
US (2) US5419323A (de)
EP (1) EP0449883B1 (de)
AT (1) ATE133545T1 (de)
DE (1) DE68925586T2 (de)
WO (1) WO1990006718A1 (de)

Families Citing this family (353)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06505183A (ja) * 1991-02-26 1994-06-16 マサチユセツツ・インスチチユート・オブ・テクノロジー 組織を診断するための分子分光計のシステムおよび方法
US6111645A (en) 1991-04-29 2000-08-29 Massachusetts Institute Of Technology Grating based phase control optical delay line
US6564087B1 (en) 1991-04-29 2003-05-13 Massachusetts Institute Of Technology Fiber optic needle probes for optical coherence tomography imaging
US6485413B1 (en) 1991-04-29 2002-11-26 The General Hospital Corporation Methods and apparatus for forward-directed optical scanning instruments
DE4325529C2 (de) * 1993-07-29 1996-11-28 Pulsion Verwaltungs Gmbh & Co Vorrichtung zum Bestimmen der Konzentration von Stoffen im Blut
US6304771B1 (en) * 1993-10-29 2001-10-16 The Trustees Of The University Of Pennsylvania Systems and methods for imaging fluorophores
US5991653A (en) * 1995-03-14 1999-11-23 Board Of Regents, The University Of Texas System Near-infrared raman spectroscopy for in vitro and in vivo detection of cervical precancers
US6258576B1 (en) 1996-06-19 2001-07-10 Board Of Regents, The University Of Texas System Diagnostic method and apparatus for cervical squamous intraepithelial lesions in vitro and in vivo using fluorescence spectroscopy
US5697373A (en) * 1995-03-14 1997-12-16 Board Of Regents, The University Of Texas System Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies
US5735276A (en) * 1995-03-21 1998-04-07 Lemelson; Jerome Method and apparatus for scanning and evaluating matter
US5612540A (en) * 1995-03-31 1997-03-18 Board Of Regents, The University Of Texas Systems Optical method for the detection of cervical neoplasias using fluorescence spectroscopy
FR2737845B1 (fr) * 1995-08-16 1998-01-02 Centre Nat Rech Scient Dispositif d'imagerie endoscopique pour la detection precoce de lesions superficielles cancereuses ou precancereuses
US6571119B2 (en) 1996-03-06 2003-05-27 Fuji Photo Film Co., Ltd. Fluorescence detecting apparatus
JP3796635B2 (ja) * 1996-03-06 2006-07-12 富士写真フイルム株式会社 蛍光検出装置
US5773835A (en) * 1996-06-07 1998-06-30 Rare Earth Medical, Inc. Fiber optic spectroscopy
US5842995A (en) * 1996-06-28 1998-12-01 Board Of Regents, The Univerisity Of Texas System Spectroscopic probe for in vivo measurement of raman signals
US6296608B1 (en) * 1996-07-08 2001-10-02 Boston Scientific Corporation Diagnosing and performing interventional procedures on tissue in vivo
US6119031A (en) 1996-11-21 2000-09-12 Boston Scientific Corporation Miniature spectrometer
US6847490B1 (en) * 1997-01-13 2005-01-25 Medispectra, Inc. Optical probe accessory device for use in vivo diagnostic procedures
US6826422B1 (en) 1997-01-13 2004-11-30 Medispectra, Inc. Spectral volume microprobe arrays
US6317624B1 (en) 1997-05-05 2001-11-13 The General Hospital Corporation Apparatus and method for demarcating tumors
US6124597A (en) * 1997-07-07 2000-09-26 Cedars-Sinai Medical Center Method and devices for laser induced fluorescence attenuation spectroscopy
US6096065A (en) 1997-09-29 2000-08-01 Boston Scientific Corporation Sheath for tissue spectroscopy
US5984861A (en) 1997-09-29 1999-11-16 Boston Scientific Corporation Endofluorescence imaging module for an endoscope
US6185443B1 (en) 1997-09-29 2001-02-06 Boston Scientific Corporation Visible display for an interventional device
US6324418B1 (en) 1997-09-29 2001-11-27 Boston Scientific Corporation Portable tissue spectroscopy apparatus and method
US6238348B1 (en) 1997-07-22 2001-05-29 Scimed Life Systems, Inc. Miniature spectrometer system and method
US6393315B1 (en) * 1997-09-12 2002-05-21 Communaute Europeenne Detecting and mapping of inflamed zones in a living tissue
US5980468A (en) * 1997-09-22 1999-11-09 Zimmon Scientific Corporation Apparatus and method for serial collection storage and processing of biopsy specimens
WO2000015101A1 (en) * 1998-09-11 2000-03-23 Spectrx, Inc. Multi-modal optical tissue diagnostic system
US6055451A (en) 1997-12-12 2000-04-25 Spectrx, Inc. Apparatus and method for determining tissue characteristics
US20030135122A1 (en) * 1997-12-12 2003-07-17 Spectrx, Inc. Multi-modal optical tissue diagnostic system
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
US6174291B1 (en) 1998-03-09 2001-01-16 Spectrascience, Inc. Optical biopsy system and methods for tissue diagnosis
US6066102A (en) * 1998-03-09 2000-05-23 Spectrascience, Inc. Optical biopsy forceps system and method of diagnosing tissue
US6462770B1 (en) 1998-04-20 2002-10-08 Xillix Technologies Corp. Imaging system with automatic gain control for reflectance and fluorescence endoscopy
CA2332833A1 (en) 1998-05-19 1999-11-25 Spectrx, Inc. Apparatus and method for determining tissue characteristics
US6064897A (en) * 1998-06-01 2000-05-16 Abbott Laboratories Sensor utilizing Raman spectroscopy for non-invasive monitoring of analytes in biological fluid and method of use
US6405070B1 (en) * 1998-06-16 2002-06-11 Bhaskar Banerjee Detection of cancer using cellular autofluorescence
GB9813179D0 (en) * 1998-06-19 1998-08-19 Aortech Europ Ltd Spectrophotometry
US6377842B1 (en) 1998-09-22 2002-04-23 Aurora Optics, Inc. Method for quantitative measurement of fluorescent and phosphorescent drugs within tissue utilizing a fiber optic probe
US6678541B1 (en) 1998-10-28 2004-01-13 The Governmemt Of The United States Of America Optical fiber probe and methods for measuring optical properties
CA2356195A1 (en) 1998-12-23 2000-06-29 Medispectra, Inc. Optical methods and systems for cervical screening
EP1161178A2 (de) 1998-12-23 2001-12-12 Medispectra Inc. Systeme und verfahren zur optischen untersuchung von proben
US6272376B1 (en) 1999-01-22 2001-08-07 Cedars-Sinai Medical Center Time-resolved, laser-induced fluorescence for the characterization of organic material
US6584342B1 (en) * 1999-02-12 2003-06-24 Alexei I. Trushin Method for diagnosing proliferation regions and device for realizing the same
JP2000262460A (ja) * 1999-03-18 2000-09-26 Inst Of Physical & Chemical Res 生体試料の特定部位検出方法、生体試料の生理学的測定方法、生体試料の特定部位検出装置、光ファイバ保持装置
US20040147843A1 (en) * 1999-11-05 2004-07-29 Shabbir Bambot System and method for determining tissue characteristics
US6697666B1 (en) 1999-06-22 2004-02-24 Board Of Regents, The University Of Texas System Apparatus for the characterization of tissue of epithelial lined viscus
US6219566B1 (en) 1999-07-13 2001-04-17 Photonics Research Ontario Method of measuring concentration of luminescent materials in turbid media
US6445939B1 (en) 1999-08-09 2002-09-03 Lightlab Imaging, Llc Ultra-small optical probes, imaging optics, and methods for using same
US6902935B2 (en) * 1999-12-15 2005-06-07 Medispectra, Inc. Methods of monitoring effects of chemical agents on a sample
US7187810B2 (en) 1999-12-15 2007-03-06 Medispectra, Inc. Methods and systems for correcting image misalignment
US7260248B2 (en) 1999-12-15 2007-08-21 Medispectra, Inc. Image processing using measures of similarity
US6603552B1 (en) * 1999-12-22 2003-08-05 Xillix Technologies Corp. Portable system for detecting skin abnormalities based on characteristic autofluorescence
AU779659B2 (en) 2000-02-08 2005-02-03 Cornell Research Foundation Inc. Multiphoton excitation through optical fibers for fluorescence spectroscopy
US6749623B1 (en) * 2000-03-31 2004-06-15 Richard A Hsi Method and apparatus for catheter phototherapy with dose sensing
DE60122894T2 (de) 2000-07-14 2007-03-15 Xillix Technologies Corp., Richmond Kompaktes fluorezenz endoskopisches video system
US20020155455A1 (en) * 2000-08-11 2002-10-24 Invitrogen Corporation Highly homogeneous molecular markers for electrophoresis
US20040014082A1 (en) * 2000-08-11 2004-01-22 Invitrogen Corporation Highly homogeneous molecular markers for electrophoresis
AU2001293592A1 (en) * 2000-10-06 2002-04-15 Peter R. Herman Multi-spectral fluorescence imaging and spectroscopy device
ATE454845T1 (de) 2000-10-30 2010-01-15 Gen Hospital Corp Optische systeme zur gewebeanalyse
JP2004518488A (ja) 2000-11-02 2004-06-24 コーネル リサーチ ファンデーション インコーポレーテッド インビボ多光子診断的な神経変性疾患の検出および撮像
US9295391B1 (en) 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
EP1207387A1 (de) * 2000-11-20 2002-05-22 Institut Curie Multiphotonabbildungsvorrichtung
US6839661B2 (en) * 2000-12-15 2005-01-04 Medispectra, Inc. System for normalizing spectra
US6697652B2 (en) 2001-01-19 2004-02-24 Massachusetts Institute Of Technology Fluorescence, reflectance and light scattering spectroscopy for measuring tissue
US20040038320A1 (en) * 2001-03-09 2004-02-26 Bhaskar Banerjee Methods of detecting cancer using cellular autofluorescence
US20070276199A1 (en) * 2002-04-04 2007-11-29 Ediger Marwood N Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence
US7139598B2 (en) * 2002-04-04 2006-11-21 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence
EP2333521B1 (de) * 2001-04-30 2019-12-04 The General Hospital Corporation Verfahren und vorrichtung zur verbesserung der bildklarheit und empfindlichkeit bei der optischen kohärenz-tomographie unter verwendung von dynamischer rückkopplung zur kontrolle der fokussierungseigenschaften und der kohärenzsteuerung
AT503309B1 (de) 2001-05-01 2011-08-15 Gen Hospital Corp Vorrichtung zur bestimmung von atherosklerotischem belag durch messung von optischen gewebeeigenschaften
CN1635910A (zh) * 2001-05-02 2005-07-06 普渡研究基金会 巨噬细胞介导的疾病的治疗和诊断
WO2003003975A2 (en) * 2001-06-04 2003-01-16 The General Hospital Corporation Detection and therapy of vulnerable plaque with photodynamic compounds
US6694159B2 (en) * 2001-07-16 2004-02-17 Art, Advanced Research Technologies Inc. Choice of wavelengths for multiwavelength optical imaging
DE10239028B4 (de) * 2001-08-21 2004-07-29 Becker & Hickl Gmbh Verfahren zur Identifizierung von natürlich vorkommenden oder synthetisch hergestellten Melaninsorten
US6980299B1 (en) * 2001-10-16 2005-12-27 General Hospital Corporation Systems and methods for imaging a sample
US6723308B2 (en) * 2001-11-02 2004-04-20 Kenra, Llc Hair clarifying treatment
US20030109787A1 (en) * 2001-12-12 2003-06-12 Michael Black Multiple laser diagnostics
US20040082940A1 (en) * 2002-10-22 2004-04-29 Michael Black Dermatological apparatus and method
EP2290318B1 (de) * 2002-01-11 2015-08-26 The General Hospital Corporation OCT Einrichtung mit axialem Linienfokus für verbesserte Auflösung und Tiefenschärfe
US20060241496A1 (en) * 2002-01-15 2006-10-26 Xillix Technologies Corp. Filter for use with imaging endoscopes
US6899675B2 (en) * 2002-01-15 2005-05-31 Xillix Technologies Corp. Fluorescence endoscopy video systems with no moving parts in the camera
EP1472517A1 (de) * 2002-01-18 2004-11-03 Newton Laboratories, Inc. Spektroskopisches diagnoseverfahren und system
US7355716B2 (en) * 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US8043602B2 (en) 2002-02-07 2011-10-25 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
US8043603B2 (en) * 2002-02-07 2011-10-25 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
WO2003075765A1 (en) 2002-03-05 2003-09-18 Board Of Regents, The University Of Texas System Biospecific contrast agents
AU2003260583A1 (en) * 2002-04-03 2003-10-20 The Regents Of The University Of California System and method for quantitative or qualitative measurement of exogenous substances in tissue and other materials using laser-induced fluorescence spectroscopy
US8140147B2 (en) * 2002-04-04 2012-03-20 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using a flexible probe to determine tissue fluorescence of various sites
US8131332B2 (en) * 2002-04-04 2012-03-06 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence of various sites
US7469160B2 (en) 2003-04-18 2008-12-23 Banks Perry S Methods and apparatus for evaluating image focus
US20040209237A1 (en) * 2003-04-18 2004-10-21 Medispectra, Inc. Methods and apparatus for characterization of tissue samples
US20040208385A1 (en) * 2003-04-18 2004-10-21 Medispectra, Inc. Methods and apparatus for visually enhancing images
US7136518B2 (en) 2003-04-18 2006-11-14 Medispectra, Inc. Methods and apparatus for displaying diagnostic data
US7282723B2 (en) * 2002-07-09 2007-10-16 Medispectra, Inc. Methods and apparatus for processing spectral data for use in tissue characterization
US6933154B2 (en) * 2002-07-09 2005-08-23 Medispectra, Inc. Optimal windows for obtaining optical data for characterization of tissue samples
US7459696B2 (en) 2003-04-18 2008-12-02 Schomacker Kevin T Methods and apparatus for calibrating spectral data
US6818903B2 (en) 2002-07-09 2004-11-16 Medispectra, Inc. Method and apparatus for identifying spectral artifacts
US7309867B2 (en) 2003-04-18 2007-12-18 Medispectra, Inc. Methods and apparatus for characterization of tissue samples
US6768918B2 (en) * 2002-07-10 2004-07-27 Medispectra, Inc. Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof
US7103401B2 (en) 2002-07-10 2006-09-05 Medispectra, Inc. Colonic polyp discrimination by tissue fluorescence and fiberoptic probe
US20040064053A1 (en) * 2002-09-30 2004-04-01 Chang Sung K. Diagnostic fluorescence and reflectance
US7761139B2 (en) * 2003-01-24 2010-07-20 The General Hospital Corporation System and method for identifying tissue using low-coherence interferometry
US8054468B2 (en) 2003-01-24 2011-11-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US20070265606A1 (en) * 2003-02-14 2007-11-15 Reliant Technologies, Inc. Method and Apparatus for Fractional Light-based Treatment of Obstructive Sleep Apnea
AU2004225188B2 (en) * 2003-03-31 2010-04-15 The General Hospital Corporation Speckle reduction in optical coherence tomography by path length encoded angular compounding
ATE412897T1 (de) 2003-05-30 2008-11-15 Purdue Research Foundation Diagnoseverfahren für atherosklerose
JP2007526620A (ja) 2003-06-06 2007-09-13 ザ・ジェネラル・ホスピタル・コーポレイション 波長同調発信源装置及びその方法
EP1653876A1 (de) * 2003-07-11 2006-05-10 Reliant Technologies, Inc. Verfahren und vorrichtung zur fraktionellen phototherapie von haut
CA2535843A1 (en) * 2003-08-19 2005-06-23 Cornell Research Foundation, Inc. Optical fiber delivery and collection system for biological applications such as multiphoton microscopy, spectroscopy, and endoscopy
DE202004021953U1 (de) 2003-09-12 2013-06-19 Vessix Vascular, Inc. Auswählbare exzentrische Remodellierung und/oder Ablation von atherosklerotischem Material
US7733497B2 (en) 2003-10-27 2010-06-08 The General Hospital Corporation Method and apparatus for performing optical imaging using frequency-domain interferometry
WO2005054780A1 (en) * 2003-11-28 2005-06-16 The General Hospital Corporation Method and apparatus for three-dimensional spectrally encoded imaging
KR101239250B1 (ko) 2004-05-29 2013-03-05 더 제너럴 하스피탈 코포레이션 광간섭 단층촬영 화상 진단에서 반사층을 이용한 색 분산보상을 위한 프로세스, 시스템 및 소프트웨어 배열
US7413572B2 (en) * 2004-06-14 2008-08-19 Reliant Technologies, Inc. Adaptive control of optical pulses for laser medicine
US20060035302A1 (en) * 2004-06-21 2006-02-16 Applera Corporation Kinase substrates with multiple phosphorylation sites
EP1771755B1 (de) * 2004-07-02 2016-09-21 The General Hospital Corporation Endoskopische darstellungssonde mit doppelt kaschierter faser
EP1782020B1 (de) 2004-08-06 2012-10-03 The General Hospital Corporation Prozess, system und softwareanordnung zur bestimmung mindestens einer position in einer probe unter verwendung von optischer kohärenztomographie
US8208995B2 (en) 2004-08-24 2012-06-26 The General Hospital Corporation Method and apparatus for imaging of vessel segments
ATE538714T1 (de) 2004-08-24 2012-01-15 Gen Hospital Corp Verfahren, system und software-anordnung zur bestimmung des elastizitätsmoduls
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
KR101269455B1 (ko) * 2004-09-10 2013-05-30 더 제너럴 하스피탈 코포레이션 광 간섭 영상화를 위한 시스템 및 방법
US9277955B2 (en) 2010-04-09 2016-03-08 Vessix Vascular, Inc. Power generating and control apparatus for the treatment of tissue
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
US20060094940A1 (en) * 2004-09-21 2006-05-04 Art, Advanced Research Technologies, Inc. Method for selecting wavelengths for optical data acquisition
JP4997112B2 (ja) 2004-09-29 2012-08-08 ザ ジェネラル ホスピタル コーポレイション 少なくとも１つの電磁放射を伝送させるための装置およびその製造方法
JP5175101B2 (ja) * 2004-10-29 2013-04-03 ザ ジェネラル ホスピタル コーポレイション 偏光感応性光コヒーレンストモグラフィを用いて偏光非解消の偏光パラメータを測定するジョーンズ行列に基づく解析を行うシステム及び方法
EP1807722B1 (de) * 2004-11-02 2022-08-10 The General Hospital Corporation Faseroptische drehvorrichtung, optisches system zur abbildung einer probe
US10413188B2 (en) 2004-11-17 2019-09-17 Lawrence Livermore National Security, Llc Assessment of tissue or lesion depth using temporally resolved light scattering spectroscopy
US20060229515A1 (en) * 2004-11-17 2006-10-12 The Regents Of The University Of California Fiber optic evaluation of tissue modification
EP2278267A3 (de) 2004-11-24 2011-06-29 The General Hospital Corporation Interferometer mit gemeinsamem Pfad für endoskopische optische Kohärenztomographie
WO2006058346A1 (en) 2004-11-29 2006-06-01 The General Hospital Corporation Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample
EP1827238A4 (de) * 2004-12-06 2009-04-22 Cambridge Res & Instrmnt Inc Systeme und verfahren zur optischen bilddarstellung und messung in vivo
US7854705B2 (en) * 2004-12-16 2010-12-21 Olga Pawluczyk Ex vivo verification of biopsy tissue samples
CN101128152A (zh) * 2004-12-23 2008-02-20 普渡研究基金会 发射正电子段层成像方法
US8346346B1 (en) 2005-01-24 2013-01-01 The Board Of Trustees Of The Leland Stanford Junior University Optical analysis system and approach therefor
US7307774B1 (en) 2005-01-24 2007-12-11 The Board Of Trustees Of The Leland Standford Junior University Micro-optical analysis system and approach therefor
US8788021B1 (en) 2005-01-24 2014-07-22 The Board Of Trustees Of The Leland Stanford Junior Univerity Live being optical analysis system and approach
US7524671B2 (en) * 2005-01-27 2009-04-28 Prescient Medical, Inc. Handheld raman blood analyzer
US7688440B2 (en) 2005-01-27 2010-03-30 Prescient Medical, Inc. Raman spectroscopic test strip systems
US7651851B2 (en) * 2005-01-27 2010-01-26 Prescient Medical, Inc. Handheld Raman body fluid analyzer
WO2006099537A2 (en) 2005-03-15 2006-09-21 Applera Corporation The use of antibody-surrogate antigen systems for detection of analytes
CN102125430A (zh) 2005-03-28 2011-07-20 明诺医学有限公司 选择性地治疗目标组织的内腔电组织表征和调谐射频能量
DE602006010993D1 (de) 2005-04-28 2010-01-21 Gen Hospital Corp Bewertung von bildmerkmalen einer anatomischen struktur in optischen kohärenztomographiebildern
EP1887926B1 (de) * 2005-05-31 2014-07-30 The General Hospital Corporation System und verfahren die spektrale interferometrietechniken zur codierungsüberlagerung zur bildgebung benutzen
US9060689B2 (en) 2005-06-01 2015-06-23 The General Hospital Corporation Apparatus, method and system for performing phase-resolved optical frequency domain imaging
WO2007002323A2 (en) * 2005-06-23 2007-01-04 Epoc, Inc. System and method for monitoring of end organ oxygenation by measurement of in vivo cellular energy status
US7499161B2 (en) * 2005-07-05 2009-03-03 The Board Of Regents Of The University Of Texas System Depth-resolved spectroscopy method and apparatus
EP1904183B1 (de) 2005-07-05 2014-10-15 Purdue Research Foundation Pharmazeutische Zusammensetzung zur Behandlung von Arthrose
EP2207008A1 (de) 2005-08-09 2010-07-14 The General Hospital Corporation Gerät und Verfahren zur Durchführung von polarisationsbasierter Quadraturdemulation bei optischer Kohärenztomographie
US20070049996A1 (en) * 2005-08-29 2007-03-01 Reliant Technologies, Inc. Monitoring Method and Apparatus for Fractional Photo-Therapy Treatment
EP1931263A2 (de) * 2005-08-29 2008-06-18 Reliant Technologies, Inc. Verfahren und gerät zur überwachung und kontrolle von thermisch induzierter gewebebehandlung
US20070122344A1 (en) 2005-09-02 2007-05-31 University Of Rochester Medical Center Office Of Technology Transfer Intraoperative determination of nerve location
US8795633B2 (en) 2005-09-23 2014-08-05 Purdue Research Foundation Multiphoton in vivo flow cytometry method and device
US7843572B2 (en) 2005-09-29 2010-11-30 The General Hospital Corporation Method and apparatus for optical imaging via spectral encoding
US20070173736A1 (en) * 2005-10-07 2007-07-26 Femspec Llc Apparatus and methods for endometrial biopsies
WO2007047690A1 (en) * 2005-10-14 2007-04-26 The General Hospital Corporation Spectral- and frequency- encoded fluorescence imaging
WO2007081811A2 (en) 2006-01-04 2007-07-19 The Trustees Of The University Of Pennsylvania Oxygen sensor for internal monitoring of tissue oxygen in vivo
JP5680826B2 (ja) 2006-01-10 2015-03-04 ザ ジェネラル ホスピタル コーポレイション １以上のスペクトルを符号化する内視鏡技術によるデータ生成システム
WO2007084995A2 (en) 2006-01-19 2007-07-26 The General Hospital Corporation Methods and systems for optical imaging of epithelial luminal organs by beam scanning thereof
WO2007084945A1 (en) * 2006-01-19 2007-07-26 The General Hospital Corporation Systems and methods for performing rapid fluorescense lifetime, excitation and emission spectral measurements
WO2007084903A2 (en) 2006-01-19 2007-07-26 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and method for producing one or more optical arrangements
US20070171430A1 (en) * 2006-01-20 2007-07-26 The General Hospital Corporation Systems and methods for providing mirror tunnel micropscopy
JP5524487B2 (ja) 2006-02-01 2014-06-18 ザ ジェネラル ホスピタル コーポレイション コンフォーマルレーザ治療手順を用いてサンプルの少なくとも一部分に電磁放射を放射する方法及びシステム。
WO2007149601A2 (en) * 2006-02-01 2007-12-27 The General Hospital Corporation Apparatus for controlling at least one of at least two sections of at least one fiber
US7538859B2 (en) * 2006-02-01 2009-05-26 The General Hospital Corporation Methods and systems for monitoring and obtaining information of at least one portion of a sample using conformal laser therapy procedures, and providing electromagnetic radiation thereto
US20090303317A1 (en) 2006-02-07 2009-12-10 Novadaq Technologies Inc. Near infrared imaging
US9777053B2 (en) 2006-02-08 2017-10-03 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy
US7982879B2 (en) 2006-02-24 2011-07-19 The General Hospital Corporation Methods and systems for performing angle-resolved fourier-domain optical coherence tomography
US20070208400A1 (en) * 2006-03-01 2007-09-06 The General Hospital Corporation System and method for providing cell specific laser therapy of atherosclerotic plaques by targeting light absorbers in macrophages
US20070212335A1 (en) * 2006-03-07 2007-09-13 Hantash Basil M Treatment of alopecia by micropore delivery of stem cells
WO2007109540A2 (en) * 2006-03-17 2007-09-27 The General Hospital Corporation Arrangement, method and computer-accessible medium for identifying characteristics of at least a portion of a blood vessel contained within a tissue using spectral domain low coherence interferometry
US7742173B2 (en) * 2006-04-05 2010-06-22 The General Hospital Corporation Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
WO2007133961A2 (en) 2006-05-10 2007-11-22 The General Hospital Corporation Processes, arrangements and systems for providing frequency domain imaging of a sample
WO2007133964A2 (en) * 2006-05-12 2007-11-22 The General Hospital Corporation Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images
EP2051603B1 (de) 2006-07-28 2019-09-11 Novadaq Technologies ULC System und verfahren zur ablage und entfernung eines optischen elements auf bzw. von einem endoskopobjektiv
WO2008024948A2 (en) 2006-08-25 2008-02-28 The General Hospital Corporation Apparatus and methods for enhancing optical coherence tomography imaging using volumetric filtering techniques
US20080058782A1 (en) * 2006-08-29 2008-03-06 Reliant Technologies, Inc. Method and apparatus for monitoring and controlling density of fractional tissue treatments
WO2008028298A1 (en) * 2006-09-06 2008-03-13 University Health Network Fluorescence quantification and image acquisition in highly turbid media
US20080161744A1 (en) 2006-09-07 2008-07-03 University Of Rochester Medical Center Pre-And Intra-Operative Localization of Penile Sentinel Nodes
JP5559539B2 (ja) 2006-10-18 2014-07-23 べシックス・バスキュラー・インコーポレイテッド 身体組織に望ましい温度作用を誘発するシステム
EP2455036B1 (de) 2006-10-18 2015-07-15 Vessix Vascular, Inc. Abgestimmte HF-Energie und elektrische Gewebecharakterisierung zur selektiven Behandlung von Zielgeweben
AU2007310986B2 (en) 2006-10-18 2013-07-04 Boston Scientific Scimed, Inc. Inducing desirable temperature effects on body tissue
US8838213B2 (en) 2006-10-19 2014-09-16 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s)
US8155730B2 (en) * 2006-10-24 2012-04-10 The Research Foundation Of State University Of New York Composition, method, system, and kit for optical electrophysiology
CA2668197A1 (en) 2006-11-03 2008-05-15 Philip S. Low Ex vivo flow cytometry method and device
US7654716B1 (en) 2006-11-10 2010-02-02 Doheny Eye Institute Enhanced visualization illumination system
US8417959B2 (en) 2006-12-18 2013-04-09 Southwest Research Institute Biometric device based on luminescence
US8498695B2 (en) 2006-12-22 2013-07-30 Novadaq Technologies Inc. Imaging system with a single color image sensor for simultaneous fluorescence and color video endoscopy
EP2104968A1 (de) 2007-01-19 2009-09-30 The General Hospital Corporation Drehscheiben-reflexion zur schnellen erfassung der wellenlänge von dispergiertem licht
EP2102583A2 (de) 2007-01-19 2009-09-23 The General Hospital Corporation Vorrichtung und verfahren zur steuerung der entfernungsmessungstiefe bei der bildgebung im optischen frequenzbereich
US20080206804A1 (en) * 2007-01-19 2008-08-28 The General Hospital Corporation Arrangements and methods for multidimensional multiplexed luminescence imaging and diagnosis
US20080177140A1 (en) * 2007-01-23 2008-07-24 Xillix Technologies Corp. Cameras for fluorescence and reflectance imaging
US8586595B2 (en) 2007-02-07 2013-11-19 Purdue Research Foundation Positron emission tomography imaging method
JP2010520589A (ja) * 2007-02-28 2010-06-10 ドヘニー アイ インスティテュート 可搬手持ち照明装置
WO2008116010A1 (en) * 2007-03-19 2008-09-25 The General Hospital Corporation System and method for providing noninvasive diagnosis of compartment syndrome exemplary laser speckle imaging procedure
JP5558839B2 (ja) 2007-03-23 2014-07-23 ザ ジェネラル ホスピタル コーポレイション 角度走査及び分散手順を用いて波長掃引レーザを利用するための方法、構成及び装置
US10534129B2 (en) 2007-03-30 2020-01-14 The General Hospital Corporation System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
GB0707199D0 (en) * 2007-04-13 2007-05-23 Univ St Andrews Nash Matthews
US8045177B2 (en) 2007-04-17 2011-10-25 The General Hospital Corporation Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy
US8496653B2 (en) 2007-04-23 2013-07-30 Boston Scientific Scimed, Inc. Thrombus removal
WO2008137637A2 (en) * 2007-05-04 2008-11-13 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with a sample using brillouin microscopy
CA2688308A1 (en) * 2007-05-25 2008-12-04 Purdue Research Foundation Method of imaging localized infections
WO2009018456A2 (en) 2007-07-31 2009-02-05 The General Hospital Corporation Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging
WO2009029843A1 (en) 2007-08-31 2009-03-05 The General Hospital Corporation System and method for self-interference fluoresence microscopy, and computer-accessible medium associated therewith
US7933021B2 (en) * 2007-10-30 2011-04-26 The General Hospital Corporation System and method for cladding mode detection
US8406860B2 (en) 2008-01-25 2013-03-26 Novadaq Technologies Inc. Method for evaluating blush in myocardial tissue
US9332942B2 (en) * 2008-01-28 2016-05-10 The General Hospital Corporation Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging
US11123047B2 (en) 2008-01-28 2021-09-21 The General Hospital Corporation Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood
DE102008011013B4 (de) * 2008-02-25 2014-11-13 Mevitec Gmbh Verfahren und Einrichtung zur komplexen Stoffwechselanalyse
US9173554B2 (en) 2008-03-18 2015-11-03 Novadaq Technologies, Inc. Imaging system for combined full-color reflectance and near-infrared imaging
US10219742B2 (en) 2008-04-14 2019-03-05 Novadaq Technologies ULC Locating and analyzing perforator flaps for plastic and reconstructive surgery
EP2285421B1 (de) 2008-05-02 2018-04-11 Novadaq Technologies ULC Verfahren zur herstellung und verwendung substanzbeladener erythrozyten zur beobachtung und behandlung von mikrovaskulärer hämodynamik
US8593619B2 (en) 2008-05-07 2013-11-26 The General Hospital Corporation System, method and computer-accessible medium for tracking vessel motion during three-dimensional coronary artery microscopy
EP3501384B1 (de) 2008-05-20 2024-07-17 University Health Network Verfahren zur bildgebung und überwachung auf fluoreszenzbasis
EP2288948A4 (de) 2008-06-20 2011-12-28 Gen Hospital Corp Anordnung aus kondensierten glasfaserkopplern und verfahren zu ihrer verwendung
WO2010009136A2 (en) 2008-07-14 2010-01-21 The General Hospital Corporation Apparatus and methods for color endoscopy
US20100249607A1 (en) * 2008-09-26 2010-09-30 Massachusetts Institute Of Technology Quantitative spectroscopic imaging
KR20110104504A (ko) 2008-11-17 2011-09-22 미노우 메디컬, 인코포레이티드 조직 토폴로지의 지식 여하에 따른 에너지의 선택적 축적
US8937724B2 (en) 2008-12-10 2015-01-20 The General Hospital Corporation Systems and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling
DE102009005953A1 (de) * 2009-01-19 2010-07-22 Universität Tübingen Verfahren und System zur Charakterisierung einer Probe mittels bildgebender Fluoreszenzmikroskopie
JP2012515930A (ja) 2009-01-26 2012-07-12 ザ ジェネラル ホスピタル コーポレーション 広視野の超解像顕微鏡を提供するためのシステム、方法及びコンピューターがアクセス可能な媒体
US9178330B2 (en) * 2009-02-04 2015-11-03 The General Hospital Corporation Apparatus and method for utilization of a high-speed optical wavelength tuning source
US9351642B2 (en) 2009-03-12 2016-05-31 The General Hospital Corporation Non-contact optical system, computer-accessible medium and method for measurement at least one mechanical property of tissue using coherent speckle technique(s)
US10492671B2 (en) 2009-05-08 2019-12-03 Novadaq Technologies ULC Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest
US8551096B2 (en) 2009-05-13 2013-10-08 Boston Scientific Scimed, Inc. Directional delivery of energy and bioactives
WO2010130254A1 (de) 2009-05-15 2010-11-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren und vorrichtung zur erkennung von tumorbehaftetem lebendem zellgewebe
EP2251675A1 (de) 2009-05-15 2010-11-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Erkennung von Tumorbehaftetem Zellgewebe
US11490826B2 (en) 2009-07-14 2022-11-08 The General Hospital Corporation Apparatus, systems and methods for measuring flow and pressure within a vessel
FR2948007B1 (fr) 2009-07-20 2012-06-08 Chab Lama Al Sonde a aiguille fibree tranchante pour le diagnostic optique en profondeur de tumeurs.
KR20130004326A (ko) 2010-03-05 2013-01-09 더 제너럴 하스피탈 코포레이션 특정 해상도에서 적어도 하나의 해부학적 구조의 미세 영상을 제공하는 시스템, 방법 및 컴퓨터 접근 가능 매체
US9192790B2 (en) 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
EP2568937B1 (de) 2010-05-13 2018-04-11 Doheny Eye Institute Selbstständiges system mit beleuchteter infusionskanüle
US9795301B2 (en) 2010-05-25 2017-10-24 The General Hospital Corporation Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images
US9557154B2 (en) 2010-05-25 2017-01-31 The General Hospital Corporation Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions
US10285568B2 (en) 2010-06-03 2019-05-14 The General Hospital Corporation Apparatus and method for devices for imaging structures in or at one or more luminal organs
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
DE102010024732A1 (de) 2010-06-23 2011-12-29 Siemens Aktiengesellschaft Verfahren und Vorrichtung zur Erkennung von tumorbehaftetem Gewebe im Gastrointestinaltrakt mit Hilfe einer Endokapsel
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US8974451B2 (en) 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
US9220558B2 (en) 2010-10-27 2015-12-29 Boston Scientific Scimed, Inc. RF renal denervation catheter with multiple independent electrodes
US9510758B2 (en) 2010-10-27 2016-12-06 The General Hospital Corporation Apparatus, systems and methods for measuring blood pressure within at least one vessel
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
US9060761B2 (en) 2010-11-18 2015-06-23 Boston Scientific Scime, Inc. Catheter-focused magnetic field induced renal nerve ablation
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
WO2012100095A1 (en) 2011-01-19 2012-07-26 Boston Scientific Scimed, Inc. Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury
CN107582016B (zh) 2011-03-08 2020-04-28 诺瓦达克技术公司 全光谱led照明器
JP6240064B2 (ja) 2011-04-29 2017-11-29 ザ ジェネラル ホスピタル コーポレイション 散乱媒質の深さ分解した物理的及び／又は光学的特性を決定する方法
JP2014523536A (ja) 2011-07-19 2014-09-11 ザ ジェネラル ホスピタル コーポレイション 光コヒーレンストモグラフィーにおいて偏波モード分散補償を提供するためのシステム、方法、装置およびコンピュータアクセス可能な媒体
AU2012283908B2 (en) 2011-07-20 2017-02-16 Boston Scientific Scimed, Inc. Percutaneous devices and methods to visualize, target and ablate nerves
EP2734264B1 (de) 2011-07-22 2018-11-21 Boston Scientific Scimed, Inc. System zur nervenmodulation mit einem in eine spiralförmige führung positionierbaren element zur nervenmodulation
US10241028B2 (en) 2011-08-25 2019-03-26 The General Hospital Corporation Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures
WO2013044182A1 (en) 2011-09-22 2013-03-28 The George Washington University Systems and methods for visualizing ablated tissue
EP2757933B1 (de) * 2011-09-22 2019-02-06 The George Washington University Systeme zur visualisierung von ablatiertem gewebe
EP2765942B1 (de) 2011-10-10 2016-02-24 Boston Scientific Scimed, Inc. Medizinische vorrichtungen mit ablationselektroden
EP2765940B1 (de) 2011-10-11 2015-08-26 Boston Scientific Scimed, Inc. Wandferne elektrodenvorrichtung zur nervenmodulation
US9420955B2 (en) 2011-10-11 2016-08-23 Boston Scientific Scimed, Inc. Intravascular temperature monitoring system and method
US9364284B2 (en) 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
EP2768568B1 (de) 2011-10-18 2020-05-06 Boston Scientific Scimed, Inc. Ballonkatheter mit integrierter vernetzung
JP2015502562A (ja) 2011-10-18 2015-01-22 ザ ジェネラル ホスピタル コーポレイション 再循環光学遅延を生成および／または提供するための装置および方法
WO2013058962A1 (en) 2011-10-18 2013-04-25 Boston Scientific Scimed, Inc. Deflectable medical devices
US8951251B2 (en) 2011-11-08 2015-02-10 Boston Scientific Scimed, Inc. Ostial renal nerve ablation
US9119600B2 (en) 2011-11-15 2015-09-01 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
US9265969B2 (en) 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
CN104244856B (zh) 2011-12-23 2017-03-29 维西克斯血管公司 重建身体通道的组织或身体通路附近的组织的方法及设备
WO2013101452A1 (en) 2011-12-28 2013-07-04 Boston Scientific Scimed, Inc. Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
DE102012002086A1 (de) 2012-02-06 2013-08-08 Carl Zeiss Meditec Ag Verfahren zum Untersuchen von biologischem Gewebe und Vorrichtungen zum Untersuchen und Behandeln des Gewebes
US9629528B2 (en) 2012-03-30 2017-04-25 The General Hospital Corporation Imaging system, method and distal attachment for multidirectional field of view endoscopy
WO2013169927A1 (en) 2012-05-08 2013-11-14 Boston Scientific Scimed, Inc. Renal nerve modulation devices
US11490797B2 (en) 2012-05-21 2022-11-08 The General Hospital Corporation Apparatus, device and method for capsule microscopy
WO2013190391A2 (en) 2012-06-21 2013-12-27 Novadaq Technologies Inc. Quantification and analysis of angiography and perfusion
JP6227652B2 (ja) 2012-08-22 2017-11-08 ザ ジェネラル ホスピタル コーポレイション ソフトリソグラフィを用いてミニチュア内視鏡を製作するためのシステム、方法、およびコンピュータ・アクセス可能媒体
CN104540465A (zh) 2012-08-24 2015-04-22 波士顿科学西美德公司 带有含单独微孔隙区域的球囊的血管内导管
US9173696B2 (en) 2012-09-17 2015-11-03 Boston Scientific Scimed, Inc. Self-positioning electrode system and method for renal nerve modulation
WO2014047411A1 (en) 2012-09-21 2014-03-27 Boston Scientific Scimed, Inc. System for nerve modulation and innocuous thermal gradient nerve block
WO2014047454A2 (en) 2012-09-21 2014-03-27 Boston Scientific Scimed, Inc. Self-cooling ultrasound ablation catheter
CN104869930B (zh) 2012-10-10 2020-12-25 波士顿科学国际有限公司 肾神经调制装置和方法
WO2014120791A1 (en) 2013-01-29 2014-08-07 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
US11179028B2 (en) 2013-02-01 2021-11-23 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
US9956033B2 (en) 2013-03-11 2018-05-01 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9693821B2 (en) 2013-03-11 2017-07-04 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9808311B2 (en) 2013-03-13 2017-11-07 Boston Scientific Scimed, Inc. Deflectable medical devices
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
WO2014168734A1 (en) * 2013-03-15 2014-10-16 Cedars-Sinai Medical Center Time-resolved laser-induced fluorescence spectroscopy systems and uses thereof
EP2967734B1 (de) 2013-03-15 2019-05-15 Boston Scientific Scimed, Inc. Verfahren und vorrichtungen zur gewebeneumodellierung in oder neben einem körperdurchgang
CN105228546B (zh) 2013-03-15 2017-11-14 波士顿科学国际有限公司 利用阻抗补偿的用于治疗高血压的医疗器械和方法
EP2967491B1 (de) 2013-03-15 2022-05-11 The General Hospital Corporation Ein transösophageales endoskopisches system zur bestimmung einer gemischten venösen sauerstoffsättigung einer lungenarterie
US9784681B2 (en) 2013-05-13 2017-10-10 The General Hospital Corporation System and method for efficient detection of the phase and amplitude of a periodic modulation associated with self-interfering fluorescence
EP3003177B1 (de) * 2013-05-31 2021-03-10 Covidien LP Chirurgische vorrichtung mit einer endeffektorbaugruppe zur gewebeüberwachung bei chirurgischen eingriffen
US9943365B2 (en) 2013-06-21 2018-04-17 Boston Scientific Scimed, Inc. Renal denervation balloon catheter with ride along electrode support
JP2016524949A (ja) 2013-06-21 2016-08-22 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 回転可能シャフトを有する腎神経アブレーション用医療装置
US9707036B2 (en) 2013-06-25 2017-07-18 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation using localized indifferent electrodes
EP3016605B1 (de) 2013-07-01 2019-06-05 Boston Scientific Scimed, Inc. Medizinische vorrichtungen zur nierennervenablation
EP3019106A1 (de) 2013-07-11 2016-05-18 Boston Scientific Scimed, Inc. Medizinische vorrichtung mit dehnbaren elektrodenanordnungen
WO2015006480A1 (en) 2013-07-11 2015-01-15 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation
US9925001B2 (en) 2013-07-19 2018-03-27 Boston Scientific Scimed, Inc. Spiral bipolar electrode renal denervation balloon
EP3021735A4 (de) 2013-07-19 2017-04-19 The General Hospital Corporation Bestimmung der augenbewegung mittels netzhautabbildung mit rückkopplung
WO2015009932A1 (en) 2013-07-19 2015-01-22 The General Hospital Corporation Imaging apparatus and method which utilizes multidirectional field of view endoscopy
EP3024406B1 (de) 2013-07-22 2019-06-19 Boston Scientific Scimed, Inc. Medizinische geräte zur renalen nervenablation
CN105392435B (zh) 2013-07-22 2018-11-09 波士顿科学国际有限公司 具有扭绞球囊的肾神经消融导管
EP3025173B1 (de) 2013-07-26 2021-07-07 The General Hospital Corporation Vorrichtung mit optische dispersion nutzender laseranordnung zur anwendung in der fourier-raum optischen kohärenztomographie
WO2015027096A1 (en) 2013-08-22 2015-02-26 Boston Scientific Scimed, Inc. Flexible circuit having improved adhesion to a renal nerve modulation balloon
CN105555218B (zh) 2013-09-04 2019-01-15 波士顿科学国际有限公司 具有冲洗和冷却能力的射频(rf)球囊导管
CN105530885B (zh) 2013-09-13 2020-09-22 波士顿科学国际有限公司 具有气相沉积覆盖层的消融球囊
US11246654B2 (en) 2013-10-14 2022-02-15 Boston Scientific Scimed, Inc. Flexible renal nerve ablation devices and related methods of use and manufacture
US9687166B2 (en) 2013-10-14 2017-06-27 Boston Scientific Scimed, Inc. High resolution cardiac mapping electrode array catheter
AU2014334574B2 (en) 2013-10-15 2017-07-06 Boston Scientific Scimed, Inc. Medical device balloon
US9770606B2 (en) 2013-10-15 2017-09-26 Boston Scientific Scimed, Inc. Ultrasound ablation catheter with cooling infusion and centering basket
JP6259099B2 (ja) 2013-10-18 2018-01-10 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 可撓性を備える導電性ワイヤを備えるバルーン・カテーテル、並びに関連する使用および製造方法
CN105658163B (zh) 2013-10-25 2020-08-18 波士顿科学国际有限公司 去神经柔性电路中的嵌入式热电偶
WO2015073871A2 (en) 2013-11-14 2015-05-21 The George Washington University Systems and methods for determining lesion depth using fluorescence imaging
US20150141847A1 (en) 2013-11-20 2015-05-21 The George Washington University Systems and methods for hyperspectral analysis of cardiac tissue
CN105899157B (zh) 2014-01-06 2019-08-09 波士顿科学国际有限公司 抗撕裂柔性电路组件
WO2015105870A1 (en) 2014-01-08 2015-07-16 The General Hospital Corporation Method and apparatus for microscopic imaging
WO2015116986A2 (en) 2014-01-31 2015-08-06 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
CN106572881B (zh) 2014-02-04 2019-07-26 波士顿科学国际有限公司 热传感器在双极电极上的替代放置
US11000679B2 (en) 2014-02-04 2021-05-11 Boston Scientific Scimed, Inc. Balloon protection and rewrapping devices and related methods of use
WO2015153982A1 (en) 2014-04-04 2015-10-08 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
PL3171765T3 (pl) 2014-07-24 2022-01-03 University Health Network Zbieranie i analiza danych do celów diagnostycznych
JP2017525435A (ja) 2014-07-25 2017-09-07 ザ ジェネラル ホスピタル コーポレイション インビボ・イメージングおよび診断のための機器、デバイスならびに方法
EP3201607B1 (de) 2014-09-29 2020-12-30 Novadaq Technologies ULC Bildgebung eines zielfluorophors in einem biologischen material in anwesenheit von autofluoreszenz
CA2963450A1 (en) 2014-10-09 2016-04-14 Novadaq Technologies Inc. Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography
EP3215001A4 (de) 2014-11-03 2018-04-04 Luxcath, LLC Systeme und verfahren zur beurteilung der kontaktqualität
CN113143440B (zh) 2014-11-03 2024-07-30 乔治华盛顿大学 用于损伤评估的系统和方法
US10779904B2 (en) 2015-07-19 2020-09-22 460Medical, Inc. Systems and methods for lesion formation and assessment
JP6743137B2 (ja) 2015-11-13 2020-08-19 ノバダック テクノロジーズ ユーエルシー ターゲットの照明およびイメージングのためのシステムおよび方法
EP3408654B1 (de) 2016-01-26 2022-08-03 Stryker European Operations Limited Flurorezenzbildgebungssystem und methode zur fluoreszenzbildgebung
US10293122B2 (en) 2016-03-17 2019-05-21 Novadaq Technologies ULC Endoluminal introducer with contamination avoidance
EP3436805A4 (de) 2016-04-01 2019-12-11 Black Light Surgical, Inc. Systeme, vorrichtungen und verfahren zur zeitaufgelösten fluoreszenzspektroskopie
USD916294S1 (en) 2016-04-28 2021-04-13 Stryker European Operations Limited Illumination and imaging device
DE102016210357A1 (de) * 2016-06-10 2017-12-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren und Vorrichtung zur Erfassung einer Belegung einer Oberfläche mittels induzierter Fluoreszenz
EP3469420A4 (de) 2016-06-14 2020-02-12 Novadaq Technologies ULC Verfahren und systeme zur adaptiven bildgebung zur verstärkung eines schwachen lichtsignals bei einer medizinischen visualisierung
JP6931705B2 (ja) 2017-02-10 2021-09-08 ノバダック テクノロジーズ ユーエルシー オープンフィールドハンドヘルド蛍光イメージングシステムおよび方法
US10952616B2 (en) 2018-03-30 2021-03-23 Canon U.S.A., Inc. Fluorescence imaging apparatus
US11262309B2 (en) * 2018-07-11 2022-03-01 Advanced Cytometry Instrumentation Systems, Llc Methods for lipid measurement in cells
US10743749B2 (en) 2018-09-14 2020-08-18 Canon U.S.A., Inc. System and method for detecting optical probe connection
WO2021142368A1 (en) 2020-01-08 2021-07-15 460Medical, Inc. Systems and methods for optical interrogation of ablation lesions
WO2021243061A1 (en) 2020-05-27 2021-12-02 The George Washington University Lesion visualization using dual wavelength approach
US12518875B2 (en) * 2020-06-19 2026-01-06 The General Hospital Corporation Near-infrared autofluorescence imaging systems and methods

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4236526A (en) * 1978-01-31 1980-12-02 Richard Patricia A Method of screening for sickle cell disease by detection of porphyrins and porphyrin metabolites in human dentition
SU929050A1 (ru) * 1978-04-12 1982-05-23 Больница N1 Четвертого Главного Управления При Министерстве Здравоохранения Рсфср Эндоскоп
US4162405A (en) * 1978-05-23 1979-07-24 Britton Chance Flying spot fluoro-meter for oxidized flavoprotein and reduced pyridine nucleotide
US4178917A (en) * 1979-01-03 1979-12-18 Shapiro Howard M Method and system for non-invasive detection of zinc protoporphyrin in erythrocytes
USRE31815E (en) * 1979-08-20 1985-01-29 Philips Medical Systems, Inc. Method and apparatus for detecting the presence of caries in teeth using visible luminescence
FR2521727A2 (fr) * 1981-03-25 1983-08-19 Cilas Dispositif pour mesurer l'etat d'oxydo-reduction d'un organe vivant in situ
JPS5940830A (ja) * 1982-08-31 1984-03-06 浜松ホトニクス株式会社 レ−ザ光パルスを用いた癌の診断装置
US4541438A (en) * 1983-06-02 1985-09-17 The Johns Hopkins University Localization of cancerous tissue by monitoring infrared fluorescence emitted by intravenously injected porphyrin tumor-specific markers excited by long wavelength light
US4737628A (en) * 1984-02-07 1988-04-12 International Technical Associates Method and system for controlled and selective removal of material
US4641650A (en) * 1985-03-11 1987-02-10 Mcm Laboratories, Inc. Probe-and-fire lasers
US4718417A (en) * 1985-03-22 1988-01-12 Massachusetts Institute Of Technology Visible fluorescence spectral diagnostic for laser angiosurgery
US5106387A (en) * 1985-03-22 1992-04-21 Massachusetts Institute Of Technology Method for spectroscopic diagnosis of tissue
CN85100424B (zh) * 1985-04-01 1986-10-29 上海医疗器械研究所 恶性肿瘤固有荧光诊断仪
US5042494A (en) * 1985-11-13 1991-08-27 Alfano Robert R Method and apparatus for detecting cancerous tissue using luminescence excitation spectra
GB2203831B (en) * 1986-07-07 1991-02-06 Academy Of Applied Sciences Apparatus and method for the diagnosis of malignant tumours
DE3623862A1 (de) * 1986-07-11 1988-01-21 Schering Ag Verwendung von dicarbonsaeuren mit 7 - 13 kohlenstoffatomen oder physiologisch vertraeglichen salzen davon zur topischen behandlung von rosazea
US4835871A (en) * 1986-10-31 1989-06-06 Brown & Sharpe Manufacturing Co. Counterweight for coordinate measuring machine
DE3718202C1 (de) * 1987-05-29 1988-11-17 Wolfgang Prof Dr Lohmann Anordnung zur Messung eines Zustandswertes fuer organische Gewebeflaechen
ATE187315T1 (de) * 1987-09-24 1999-12-15 Massachusetts Inst Technology Kathetersystem zur abbildung
WO1989005295A1 (en) * 1987-12-02 1989-06-15 Pfizer Inc. Acyl derivatives of hydroxypyrimidines
US4981138A (en) * 1988-06-30 1991-01-01 Yale University Endoscopic fiberoptic fluorescence spectrometer
US5111821A (en) * 1988-11-08 1992-05-12 Health Research, Inc. Fluorometric method for detecting abnormal tissue using dual long-wavelength excitation
CA2003535A1 (en) * 1988-11-22 1990-05-22 Michael D. House Method and apparatus for detecting and removing plaque from arteries by laser pulses
US5046501A (en) * 1989-01-18 1991-09-10 Wayne State University Atherosclerotic identification

Also Published As

Publication number Publication date
DE68925586D1 (de) 1996-03-14
EP0449883B1 (de) 1996-01-31
EP0449883A1 (de) 1991-10-09
US5562100A (en) 1996-10-08
US5419323A (en) 1995-05-30
DE68925586T2 (de) 1996-10-24
WO1990006718A1 (en) 1990-06-28

Similar Documents

Publication Publication Date Title
ATE133545T1 (de) Verfahren für laserinduzierte fluoreszenz von gewebe
DE69631738D1 (de) Medizinische implantierbare Vorrichtung für elektrochemische Messungen von Bluteigenschaften
ATE187315T1 (de) Kathetersystem zur abbildung
SE7701901L (sv) Instrument for bestemmande av halten av emnesomsettningsprodukter i blod
NO904001D0 (no) Fremgangsmaate og anordning for amperometrisk diagnoseanalyse.
DE69017324D1 (de) Lebendes Gewebeäquivalent.
ATE243846T1 (de) Glukose fluoreszenzmonitor und verfahren
ATE167792T1 (de) Faseroptisches sondensystem zur spektralen diagnose von gewebe
NO870396L (no) Undersoekelses-instrument og fremgangsmaate for optisk undersoekelse av biologisk materiale.
ES2126156T3 (es) Recogida de fluido intersticial y medicion de los constituyentes.
ATE151615T1 (de) Diagnosebildgerät
DE69637163D1 (de) Diagnose von zervix-praekanzerosen mittels raman- und fluoreszenz-spektroskopie
DE69837425D1 (de) Verfahren und Vorrichtung zur nichtinvasiven photoakustischen Messung von Blutglukose
DE3875511D1 (de) Verfahren und vorrichtung zur desinfektion von instrumenten.
DE69333010D1 (de) Nicht-invasives verfahren und instrument zur messung des blutzuckerspiegels
PT931264E (pt) Metodo de diagnostico da aterosclerose
DE69712352D1 (de) Diagnostisches verfahren für atherosklerosis
FI874129L (fi) Analyysiväline biologiselle nesteelle
SE9202428D0 (sv) Inlaegg, inlaeggsbaerare och foerfarande foer tandrestaurering samt tandrestaureringsset foer genomfoerande av foerfarandet
DE69115479D1 (de) Vorrichtung zur fluidbehandlung mit hohlfasern sowie vorrichtung zur blutoxidation
NO179344C (no) Fremgangsmåte for undersökelse av en blodpröve og måling av polarisert fluorescensutstråling
ATE117090T1 (de) Verfahren zur diagnose von tumoren.
Rogatkin et al. Noninvasive fluorescence diagnostics in radiotherapy of mucosal oral tumors
IT1219142B (it) Strumento per applicare sostanze fluide specialmente medicamentose
FR2646510B1 (fr) Sonde permettant la mesure de l'activite photosynthetique d'organismes vivants comprenant une electrode a oxygene et une fibre optique integree

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties