JP3797974B2 - クローン化トランスジェニック有蹄動物における異種（ヒト）免疫グロブリンの発現 - Google Patents

クローン化トランスジェニック有蹄動物における異種（ヒト）免疫グロブリンの発現 Download PDF

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Publication number
JP3797974B2
JP3797974B2 JP2002570676A JP2002570676A JP3797974B2 JP 3797974 B2 JP3797974 B2 JP 3797974B2 JP 2002570676 A JP2002570676 A JP 2002570676A JP 2002570676 A JP2002570676 A JP 2002570676A JP 3797974 B2 JP3797974 B2 JP 3797974B2
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nucleic acid
ungulate
cell
human
antibody
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Expired - Fee Related
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JP2002570676A
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Japanese (ja)
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JP2005504507A5 (cg-RX-API-DMAC7.html
JP2005504507A (ja
Inventor
ロブル，ジェイムス，エム．
ゴールズビー，リチャード，エー．
フェルグソン，ステイシー，イー．
義巳 黒岩
一磨 富塚
功 石田
オズボーン，バーバラ，エー．
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Kirin Brewery Co Ltd
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Kirin Brewery Co Ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0273—Cloned vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/101—Bovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2002570676A 2000-11-17 2001-11-16 クローン化トランスジェニック有蹄動物における異種（ヒト）免疫グロブリンの発現 Expired - Fee Related JP3797974B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71418500A 2000-11-17 2000-11-17
US25645800P 2000-12-20 2000-12-20
US31162501P 2001-08-09 2001-08-09
PCT/US2001/043128 WO2002070648A2 (en) 2000-11-17 2001-11-16 Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005136675A Division JP2005224250A (ja) 2000-11-17 2005-05-09 クローン化トランスジェニック有蹄動物における異種（ヒト）免疫グロブリンの発現

Publications (3)

Publication Number Publication Date
JP2005504507A JP2005504507A (ja) 2005-02-17
JP2005504507A5 JP2005504507A5 (cg-RX-API-DMAC7.html) 2005-09-02
JP3797974B2 true JP3797974B2 (ja) 2006-07-19

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JP2002570676A Expired - Fee Related JP3797974B2 (ja) 2000-11-17 2001-11-16 クローン化トランスジェニック有蹄動物における異種（ヒト）免疫グロブリンの発現
JP2005136675A Pending JP2005224250A (ja) 2000-11-17 2005-05-09 クローン化トランスジェニック有蹄動物における異種（ヒト）免疫グロブリンの発現

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JP2005136675A Pending JP2005224250A (ja) 2000-11-17 2005-05-09 クローン化トランスジェニック有蹄動物における異種（ヒト）免疫グロブリンの発現

Country Status (11)

Country Link
EP (2) EP2042594B1 (cg-RX-API-DMAC7.html)
JP (2) JP3797974B2 (cg-RX-API-DMAC7.html)
KR (2) KR100882029B1 (cg-RX-API-DMAC7.html)
CN (1) CN1486365B (cg-RX-API-DMAC7.html)
AT (2) ATE432343T1 (cg-RX-API-DMAC7.html)
AU (2) AU2001297523B2 (cg-RX-API-DMAC7.html)
CA (1) CA2428053C (cg-RX-API-DMAC7.html)
DE (2) DE60144305D1 (cg-RX-API-DMAC7.html)
MX (1) MXPA03004313A (cg-RX-API-DMAC7.html)
NZ (1) NZ525664A (cg-RX-API-DMAC7.html)
WO (1) WO2002070648A2 (cg-RX-API-DMAC7.html)

Cited By (1)

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WO2018079857A1 (ja) 2016-10-31 2018-05-03 国立大学法人鳥取大学 ヒト抗体産生非ヒト動物及びそれを用いたヒト抗体作製法

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WO2018079857A1 (ja) 2016-10-31 2018-05-03 国立大学法人鳥取大学 ヒト抗体産生非ヒト動物及びそれを用いたヒト抗体作製法

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Publication number Publication date
KR20080005616A (ko) 2008-01-14
AU2007201700A1 (en) 2007-05-10
EP1343880A2 (en) 2003-09-17
WO2002070648A3 (en) 2003-02-13
MXPA03004313A (es) 2007-02-27
WO2002070648A2 (en) 2002-09-12
CA2428053C (en) 2012-08-21
EP2042594A1 (en) 2009-04-01
ATE503012T1 (de) 2011-04-15
CA2428053A1 (en) 2002-09-12
EP1343880B1 (en) 2009-05-27
JP2005224250A (ja) 2005-08-25
KR100882029B1 (ko) 2009-02-09
DE60144305D1 (de) 2011-05-05
EP1343880A4 (en) 2005-03-16
DE60138832D1 (de) 2009-07-09
ATE432343T1 (de) 2009-06-15
CN1486365B (zh) 2010-05-12
NZ525664A (en) 2008-08-29
AU2001297523B2 (en) 2007-01-18
JP2005504507A (ja) 2005-02-17
KR20030059260A (ko) 2003-07-07
CN1486365A (zh) 2004-03-31
KR100882030B1 (ko) 2009-02-09
EP2042594B1 (en) 2011-03-23

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