JP2005504507A5 - - Google Patents

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Publication number
JP2005504507A5
JP2005504507A5 JP2002570676A JP2002570676A JP2005504507A5 JP 2005504507 A5 JP2005504507 A5 JP 2005504507A5 JP 2002570676 A JP2002570676 A JP 2002570676A JP 2002570676 A JP2002570676 A JP 2002570676A JP 2005504507 A5 JP2005504507 A5 JP 2005504507A5
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JP
Japan
Prior art keywords
human
cells
gene
ungulate
cell
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JP2002570676A
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English (en)
Japanese (ja)
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JP3797974B2 (ja
JP2005504507A (ja
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Priority claimed from PCT/US2001/043128 external-priority patent/WO2002070648A2/en
Publication of JP2005504507A publication Critical patent/JP2005504507A/ja
Publication of JP2005504507A5 publication Critical patent/JP2005504507A5/ja
Application granted granted Critical
Publication of JP3797974B2 publication Critical patent/JP3797974B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2002570676A 2000-11-17 2001-11-16 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現 Expired - Fee Related JP3797974B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71418500A 2000-11-17 2000-11-17
US25645800P 2000-12-20 2000-12-20
US31162501P 2001-08-09 2001-08-09
PCT/US2001/043128 WO2002070648A2 (en) 2000-11-17 2001-11-16 Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005136675A Division JP2005224250A (ja) 2000-11-17 2005-05-09 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現

Publications (3)

Publication Number Publication Date
JP2005504507A JP2005504507A (ja) 2005-02-17
JP2005504507A5 true JP2005504507A5 (cg-RX-API-DMAC7.html) 2005-09-02
JP3797974B2 JP3797974B2 (ja) 2006-07-19

Family

ID=27400960

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002570676A Expired - Fee Related JP3797974B2 (ja) 2000-11-17 2001-11-16 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現
JP2005136675A Pending JP2005224250A (ja) 2000-11-17 2005-05-09 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2005136675A Pending JP2005224250A (ja) 2000-11-17 2005-05-09 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現

Country Status (11)

Country Link
EP (2) EP2042594B1 (cg-RX-API-DMAC7.html)
JP (2) JP3797974B2 (cg-RX-API-DMAC7.html)
KR (2) KR100882029B1 (cg-RX-API-DMAC7.html)
CN (1) CN1486365B (cg-RX-API-DMAC7.html)
AT (2) ATE432343T1 (cg-RX-API-DMAC7.html)
AU (2) AU2001297523B2 (cg-RX-API-DMAC7.html)
CA (1) CA2428053C (cg-RX-API-DMAC7.html)
DE (2) DE60144305D1 (cg-RX-API-DMAC7.html)
MX (1) MXPA03004313A (cg-RX-API-DMAC7.html)
NZ (1) NZ525664A (cg-RX-API-DMAC7.html)
WO (1) WO2002070648A2 (cg-RX-API-DMAC7.html)

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MXPA05004870A (es) 2002-11-08 2005-11-04 Hematech Llc Ungulados transgenicos que tienen actividad reducida de la proteina prion y sus usos.
AU2004266246A1 (en) * 2003-08-14 2005-03-03 Dyax Corp. Endotheliase-2 ligands
CA2540667A1 (en) * 2003-09-30 2005-04-14 Sterrenbeld Biotechnologie North America, Inc. A process for producing exogenous protein in the milk of trangenic mammals and a process for purifying proteins therefrom
NZ550106A (en) * 2004-04-22 2009-06-26 Kyowa Hakko Kirin Co Ltd Transgenic animals and uses thereof
KR20070072608A (ko) * 2004-10-22 2007-07-04 레비비코르 인코포레이션 유전자 변형된 면역계를 가지는 유제류
US20080026457A1 (en) 2004-10-22 2008-01-31 Kevin Wells Ungulates with genetically modified immune systems
WO2006117910A1 (ja) 2005-04-28 2006-11-09 Mochida Pharmaceutical Co., Ltd. 抗血小板膜糖蛋白質ⅵモノクローナル抗体
ES2548377T3 (es) 2008-10-27 2015-10-16 Revivicor, Inc. Ungulados inmunodeprimidos
RU2011129459A (ru) * 2008-12-18 2013-01-27 Эрасмус Юниверсити Медикал Сентр Роттердам Трансгенные животные (не человек), экспрессирующие гуманизированные антитела, и их применение
US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
EP2517556B2 (en) 2009-07-08 2023-03-22 Kymab Limited Site-Specific Recombination Method, Rodents & Rodent Cells capable of Expressing Chimaeric Antibodies or Chains
NZ600002A (en) 2009-11-17 2014-08-29 Sanford Applied Biosciences L L C Human artificial chromosome vector
CA2846319A1 (en) 2011-09-19 2013-03-28 Kymab Limited Antibodies, variable domains & chains tailored for human use
KR101720394B1 (ko) 2011-09-21 2017-03-27 후지레비오 가부시키가이샤 친화성 복합체에 대한 항체
EP2761008A1 (en) 2011-09-26 2014-08-06 Kymab Limited Chimaeric surrogate light chains (slc) comprising human vpreb
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
MX355625B (es) 2011-12-22 2018-04-25 Hoffmann La Roche Organizacion de vector de expresion, metodos novedosos de generacion de celulas de produccion y su uso para la produccion recombinante de polipeptidos.
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
NZ703973A (en) 2012-08-03 2018-04-27 Sab Llc Complex chromosome engineering for production of human antibodies in transgenic animals
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US9783618B2 (en) 2013-05-01 2017-10-10 Kymab Limited Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
ES2993142T3 (en) 2013-10-01 2024-12-23 Kymab Ltd Animal models and therapeutic molecules
CN116059378A (zh) 2014-12-10 2023-05-05 明尼苏达大学董事会 用于治疗疾病的遗传修饰的细胞、组织和器官
AU2017285224B2 (en) * 2016-06-14 2023-05-18 Regents Of The University Of Minnesota Genetically modified cells, tissues, and organs for treating disease
US12063913B2 (en) 2016-10-31 2024-08-20 National University Corporation Tottori University Human antibody-producing non-human animal and method for preparing human antibodies using same
KR20220140800A (ko) * 2020-02-12 2022-10-18 에스에이비, 엘엘씨 항-흉선세포 글로불린

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