JP3605825B2 - インドール誘導体，その製造方法およびその医薬用途 - Google Patents

インドール誘導体，その製造方法およびその医薬用途 Download PDF

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Publication number
JP3605825B2
JP3605825B2 JP50889694A JP50889694A JP3605825B2 JP 3605825 B2 JP3605825 B2 JP 3605825B2 JP 50889694 A JP50889694 A JP 50889694A JP 50889694 A JP50889694 A JP 50889694A JP 3605825 B2 JP3605825 B2 JP 3605825B2
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Japan
Prior art keywords
epoxy
didehydro
dihydroxy
indolomorphinan
cyclopropylmethyl
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Expired - Fee Related
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JP50889694A
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English (en)
Japanese (ja)
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JPWO1994007896A1 (ja
Inventor
長瀬　　博
明 水砂
孝治 河合
泉 中谷
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Toray Industries Inc
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Toray Industries Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
JP50889694A 1992-09-29 1993-09-29 インドール誘導体，その製造方法およびその医薬用途 Expired - Fee Related JP3605825B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP4-259841 1992-09-29
JP25984192 1992-09-29
PCT/JP1993/001388 WO1994007896A1 (fr) 1992-09-29 1993-09-29 Derive indole, procede pour sa fabrication, et son usage medicinal

Publications (2)

Publication Number Publication Date
JPWO1994007896A1 JPWO1994007896A1 (ja) 1994-10-06
JP3605825B2 true JP3605825B2 (ja) 2004-12-22

Family

ID=17339733

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50889694A Expired - Fee Related JP3605825B2 (ja) 1992-09-29 1993-09-29 インドール誘導体，その製造方法およびその医薬用途

Country Status (14)

Country Link
US (2) US6087369A (https=)
EP (1) EP0614898B1 (https=)
JP (1) JP3605825B2 (https=)
KR (1) KR100301093B1 (https=)
CN (1) CN1043766C (https=)
AT (1) ATE239732T1 (https=)
AU (1) AU672033B2 (https=)
CA (1) CA2124455C (https=)
DE (1) DE69332945T2 (https=)
ES (1) ES2199220T3 (https=)
FI (1) FI942499A7 (https=)
NO (1) NO941977L (https=)
TW (1) TW271440B (https=)
WO (1) WO1994007896A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1043766C (zh) 1992-09-29 1999-06-23 东丽株式会社 吲哚衍生物及其制法和它们在制备药物中的应用
US5464841A (en) * 1993-11-08 1995-11-07 Univ Minnesota Use of delta opioid receptor antagonists to treat immunoregulatory disorders
SE9401727D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds I
SE9401728D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds II
US5578725A (en) * 1995-01-30 1996-11-26 Regents Of The University Of Minnesota Delta opioid receptor antagonists
US5849731A (en) * 1995-09-26 1998-12-15 Toray Industries, Inc. Indole derivatives and medical application thereof
US5994327A (en) * 1995-11-17 1999-11-30 Astra Ab Process for the preparation of morphinans
ATE229958T1 (de) * 1996-01-10 2003-01-15 Glaxosmithkline Spa Heterocyclische kondensierte morphin-derivate
ES2217533T3 (es) * 1997-01-16 2004-11-01 Toray Industries, Inc. Derivados de indolomorfinano y medicamentos/preventivos para transtornos cerebrales.
DE69839508D1 (de) 1997-03-31 2008-07-03 Toray Industries Chinolinmorphinan-derivate und ihre medizinische anwendung
US5986141A (en) * 1998-09-29 1999-11-16 Eastman Chemical Company Process for the production of cyclopropanemethylamine
CN1204139C (zh) * 1999-08-24 2005-06-01 东丽株式会社 神经性疼痛治疗剂
US8205237B2 (en) 2000-09-14 2012-06-19 Cox Ingemar J Identifying works, using a sub-linear time search, such as an approximate nearest neighbor search, for initiating a work-based action, such as an action on the internet
US7232829B2 (en) 2001-04-06 2007-06-19 Regents Of The University Of Minnesota Therapeutic compounds and methods
ATE422887T1 (de) 2001-05-04 2009-03-15 Amgen Inc Kondensierte heterozyklische verbindungen
US6809104B2 (en) 2001-05-04 2004-10-26 Tularik Inc. Fused heterocyclic compounds
JP2005530685A (ja) * 2002-01-25 2005-10-13 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 選択的鎮痛剤
US7253179B2 (en) 2002-11-06 2007-08-07 Amgen Inc. Fused heterocyclic compounds
EP1595541A1 (en) * 2004-05-12 2005-11-16 Alcasynn Pharmaceuticals Gmbh Use of opioid receptor antagonist compounds for the prevention and/or treatment of diseases associated with the target calcineurin
WO2015082932A1 (en) 2013-12-05 2015-06-11 The University Of Bath Novel opioid compounds and their uses

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3631829A1 (de) * 1986-09-19 1988-07-28 Hoechst Ag Klonierung und verwendung des transaminase gens-tyrb
US4816586A (en) * 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
JP2906654B2 (ja) * 1989-11-28 1999-06-21 東レ株式会社 免疫抑制剤及びその製造方法
JPH04342529A (ja) * 1991-05-21 1992-11-30 Toray Ind Inc 抗アレルギー剤
US5354863A (en) * 1992-01-21 1994-10-11 G. D. Searle & Co. Opioid agonist compounds
US5225417A (en) * 1992-01-21 1993-07-06 G. D. Searle & Co. Opioid agonist compounds
US5352680A (en) * 1992-07-15 1994-10-04 Regents Of The University Of Minnesota Delta opioid receptor antagonists to block opioid agonist tolerance and dependence
CN1043766C (zh) * 1992-09-29 1999-06-23 东丽株式会社 吲哚衍生物及其制法和它们在制备药物中的应用
US5457208A (en) * 1993-06-21 1995-10-10 Regents Of The University Of Minnesota Kappa opioid receptor antagonists
US5849731A (en) * 1995-09-26 1998-12-15 Toray Industries, Inc. Indole derivatives and medical application thereof

Also Published As

Publication number Publication date
NO941977L (no) 1994-07-29
FI942499A0 (fi) 1994-05-27
CA2124455C (en) 2004-09-14
US6087369A (en) 2000-07-11
AU672033B2 (en) 1996-09-19
WO1994007896A1 (fr) 1994-04-14
TW271440B (https=) 1996-03-01
EP0614898B1 (en) 2003-05-07
US6291470B1 (en) 2001-09-18
CA2124455A1 (en) 1994-04-14
CN1092425A (zh) 1994-09-21
FI942499L (fi) 1994-07-27
ES2199220T3 (es) 2004-02-16
KR100301093B1 (ko) 2001-10-22
NO941977D0 (no) 1994-05-27
DE69332945T2 (de) 2004-05-19
AU4834193A (en) 1994-04-26
FI942499A7 (fi) 1994-07-27
CN1043766C (zh) 1999-06-23
DE69332945D1 (de) 2003-06-12
EP0614898A1 (en) 1994-09-14
EP0614898A4 (en) 1994-10-12
ATE239732T1 (de) 2003-05-15

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