JP3602826B2 - ペリンドプリルtert−ブチルアミン塩のα結晶形 - Google Patents

ペリンドプリルtert−ブチルアミン塩のα結晶形 Download PDF

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Publication number
JP3602826B2
JP3602826B2 JP2001584232A JP2001584232A JP3602826B2 JP 3602826 B2 JP3602826 B2 JP 3602826B2 JP 2001584232 A JP2001584232 A JP 2001584232A JP 2001584232 A JP2001584232 A JP 2001584232A JP 3602826 B2 JP3602826 B2 JP 3602826B2
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JP
Japan
Prior art keywords
formula
compound
temperature
crystal form
butylamine salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2001584232A
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English (en)
Japanese (ja)
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JP2003533507A (ja
Inventor
ファイファ,ブルーノ
ジノ,イブ−ミシェル
コクレル,ジェラール
ベーレ,ステファン
Original Assignee
レ ラボラトワール セルヴィエ
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Application filed by レ ラボラトワール セルヴィエ filed Critical レ ラボラトワール セルヴィエ
Publication of JP2003533507A publication Critical patent/JP2003533507A/ja
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Publication of JP3602826B2 publication Critical patent/JP3602826B2/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2001584232A 2000-07-06 2001-07-06 ペリンドプリルtert−ブチルアミン塩のα結晶形 Expired - Fee Related JP3602826B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0008793A FR2811320B1 (fr) 2000-07-06 2000-07-06 Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR00/08793 2000-07-06
PCT/FR2001/002167 WO2001087835A1 (fr) 2000-07-06 2001-07-06 FORME CRISTALLINE α DU SEL DE TERT-BUTYLAMINE DU PERINDOPRIL

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2004206158A Division JP5016185B2 (ja) 2000-07-06 2004-07-13 ペリンドプリルtert−ブチルアミン塩のα結晶形

Publications (2)

Publication Number Publication Date
JP2003533507A JP2003533507A (ja) 2003-11-11
JP3602826B2 true JP3602826B2 (ja) 2004-12-15

Family

ID=8852172

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2001584232A Expired - Fee Related JP3602826B2 (ja) 2000-07-06 2001-07-06 ペリンドプリルtert−ブチルアミン塩のα結晶形
JP2004206158A Expired - Fee Related JP5016185B2 (ja) 2000-07-06 2004-07-13 ペリンドプリルtert−ブチルアミン塩のα結晶形

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2004206158A Expired - Fee Related JP5016185B2 (ja) 2000-07-06 2004-07-13 ペリンドプリルtert−ブチルアミン塩のα結晶形

Country Status (35)

Country Link
US (2) US20030186896A1 (pl)
EP (1) EP1296947B1 (pl)
JP (2) JP3602826B2 (pl)
KR (1) KR100513570B1 (pl)
CN (1) CN1328259C (pl)
AP (1) AP1537A (pl)
AR (1) AR034124A1 (pl)
AT (1) ATE258918T1 (pl)
AU (2) AU7641801A (pl)
BG (1) BG64868B1 (pl)
BR (1) BR0112367A (pl)
CA (1) CA2415438C (pl)
CZ (1) CZ297672B6 (pl)
DE (1) DE60101968T2 (pl)
DK (1) DK1296947T3 (pl)
EA (1) EA005008B1 (pl)
EE (1) EE05268B1 (pl)
ES (1) ES2214434T3 (pl)
FR (1) FR2811320B1 (pl)
GE (1) GEP20043361B (pl)
HK (1) HK1055425A1 (pl)
HR (1) HRP20030077B1 (pl)
ME (1) ME00443B (pl)
MX (1) MXPA02012949A (pl)
NO (1) NO323447B1 (pl)
NZ (1) NZ523173A (pl)
OA (1) OA12304A (pl)
PL (1) PL206359B1 (pl)
PT (1) PT1296947E (pl)
RS (1) RS50915B (pl)
SK (1) SK285714B6 (pl)
TR (1) TR200400238T4 (pl)
UA (1) UA57188C2 (pl)
WO (1) WO2001087835A1 (pl)
ZA (1) ZA200210092B (pl)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2811319B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811318B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2838648B1 (fr) * 2002-04-18 2004-05-21 Servier Lab Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent
GB2395195A (en) 2002-11-18 2004-05-19 Cipla Ltd Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
PT1636185E (pt) * 2003-06-24 2012-04-16 Servier Lab Novas formas cristalinas de perindopril erbumina
JP4677611B2 (ja) 2003-10-21 2011-04-27 レ ラボラトワール セルヴィエ 結晶ペリンドプリルエルブミンの新規な調製方法
SI21703A (en) 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia
WO2005094793A1 (en) * 2004-03-29 2005-10-13 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for preparing a solid pharmaceutical composition
US20050250706A1 (en) * 2004-05-07 2005-11-10 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
WO2005108365A1 (en) * 2004-05-07 2005-11-17 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
SI21800A (sl) 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
SI21881A (sl) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine
SG125975A1 (en) * 2005-03-11 2006-10-30 Servier Lab New alpha crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
SG125976A1 (en) * 2005-03-11 2006-10-30 Servier Lab New gama crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
JP2006290825A (ja) * 2005-04-13 2006-10-26 Shiono Chemical Co Ltd アルファ型ペリンドプリルエルブミンの製造法
WO2007017894A2 (en) * 2005-05-05 2007-02-15 Arch Pharmalabs Limited PREPARATION OF NOVEL CRYSTALLINE η(ETA) FORM OF PERINDOPRIL ERBUMINE
US20070032661A1 (en) * 2005-08-03 2007-02-08 Glenmark Pharmaceuticals Limited Process for the preparation of intermediates of perindopril
JP2009505970A (ja) * 2005-08-12 2009-02-12 サンド・アクチエンゲゼルシヤフト ペリンドプリルエルブミンの新規結晶形
CN101228179B (zh) * 2005-08-12 2011-02-02 力奇制药公司 制备培哚普利特丁胺的方法
EP1815857A1 (en) 2006-02-02 2007-08-08 LEK Pharmaceuticals D.D. A pharmaceutical composition comprising perindopril
WO2007092758A2 (en) * 2006-02-03 2007-08-16 Dr. Reddy's Laboratories Ltd. Crystalline forms of perindopril erbumine
FR2897866B1 (fr) * 2006-02-28 2008-04-18 Servier Lab Forme cristalline alpha du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2897865B1 (fr) * 2006-02-28 2008-04-18 Servier Lab Forme cristalline beta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
EA007988B1 (ru) * 2006-04-20 2007-02-27 ИСМАГИЛОВ, Искандар Халиуллович ξ-ЗЕТА ФОРМА ПЕРИНДОПРИЛ ЭРБУМИНА
EP1964836A3 (en) * 2006-11-06 2008-11-19 IPCA Laboratories Limited A process for the preparation of perindopril erbumine in alpha crystalline form
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
WO2008114270A1 (en) * 2007-03-22 2008-09-25 Aarti Healthcare Limited Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
WO2008120241A2 (en) * 2007-03-29 2008-10-09 Ipca Laboratories Limited Novel alcohol solvates of perindopril erbumine
AU2013201812B2 (en) * 2007-06-27 2015-04-02 Les Laboratoires Servier Salts of perindopril
SI22543A (sl) * 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
SI23149A (sl) 2009-09-21 2011-03-31 Silverstone Pharma Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
PT105315B (pt) * 2010-09-29 2013-01-16 Inst Superior Tecnico Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas
CN103822996A (zh) * 2014-03-20 2014-05-28 东英(江苏)药业有限公司 一种培哚普利叔丁胺盐含量的测定方法
CN105395497B (zh) * 2015-12-04 2019-06-18 杭州新诺华医药有限公司 一种稳定的α晶型培哚普利叔丁胺片及制备方法
EP3842035A1 (en) 2019-12-23 2021-06-30 KRKA, d.d., Novo mesto Composition for the preparation of perindopril arginine granules, a method for their preparation and pharmaceutical composition comprising the granules

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2620703B1 (fr) * 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
FR2620744A1 (fr) * 1987-09-17 1989-03-24 Degremont Procede de traitement par l'ozone de materiaux ligno-cellulosiques, notamment de pates a papier et reacteur pour la mise en oeuvre de ce procede
FR2771010B1 (fr) * 1997-11-19 2003-08-15 Adir Utilisation d'une combinaison d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un diuretique pour le traitement des desordres microcirculatoires
FR2811318B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811319B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent

Also Published As

Publication number Publication date
CA2415438A1 (fr) 2001-11-22
NO20030024D0 (no) 2003-01-03
RS50915B (sr) 2010-08-31
AP1537A (en) 2006-01-10
US20030186896A1 (en) 2003-10-02
UA57188C2 (uk) 2003-06-16
CN1440387A (zh) 2003-09-03
JP2005047902A (ja) 2005-02-24
EA200300107A1 (ru) 2003-06-26
SK285714B6 (sk) 2007-06-07
BR0112367A (pt) 2003-05-13
ES2214434T3 (es) 2004-09-16
BG107532A (en) 2003-12-31
NO20030024L (no) 2003-01-03
CZ297672B6 (cs) 2007-02-28
EP1296947A1 (fr) 2003-04-02
WO2001087835A1 (fr) 2001-11-22
JP5016185B2 (ja) 2012-09-05
AU7641801A (en) 2001-11-26
GEP20043361B (en) 2004-06-10
EA005008B1 (ru) 2004-10-28
SK1492003A3 (en) 2003-06-03
EE05268B1 (et) 2010-02-15
KR20030024773A (ko) 2003-03-26
CA2415438C (fr) 2009-01-20
AR034124A1 (es) 2004-02-04
KR100513570B1 (ko) 2005-09-09
AP2002002691A0 (en) 2002-12-31
EE200300001A (et) 2004-08-16
BG64868B1 (bg) 2006-07-31
AU2001276418B2 (en) 2005-07-28
CZ2003357A3 (cs) 2003-05-14
ZA200210092B (en) 2003-12-12
NO323447B1 (no) 2007-05-07
DE60101968D1 (de) 2004-03-11
YU100402A (sh) 2003-08-29
HRP20030077A2 (en) 2003-04-30
JP2003533507A (ja) 2003-11-11
PL348492A1 (en) 2002-01-14
DE60101968T2 (de) 2004-12-23
MXPA02012949A (es) 2003-05-15
ATE258918T1 (de) 2004-02-15
FR2811320A1 (fr) 2002-01-11
CN1328259C (zh) 2007-07-25
DK1296947T3 (da) 2004-06-01
FR2811320B1 (fr) 2002-08-23
PL206359B1 (pl) 2010-07-30
ME00443B (me) 2011-10-10
NZ523173A (en) 2004-04-30
HK1055425A1 (en) 2004-01-09
EP1296947B1 (fr) 2004-02-04
TR200400238T4 (tr) 2004-03-22
PT1296947E (pt) 2004-05-31
OA12304A (en) 2003-12-29
HRP20030077B1 (en) 2011-07-31
US20050059609A1 (en) 2005-03-17

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