JP3307641B2 - ベラパミルのラセミ分割法 - Google Patents
ベラパミルのラセミ分割法Info
- Publication number
- JP3307641B2 JP3307641B2 JP51371693A JP51371693A JP3307641B2 JP 3307641 B2 JP3307641 B2 JP 3307641B2 JP 51371693 A JP51371693 A JP 51371693A JP 51371693 A JP51371693 A JP 51371693A JP 3307641 B2 JP3307641 B2 JP 3307641B2
- Authority
- JP
- Japan
- Prior art keywords
- acid
- verapamil
- ratio
- optically active
- pct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 title claims abstract description 18
- 229960001722 verapamil Drugs 0.000 title claims abstract description 18
- 239000002253 acid Substances 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 11
- 150000003839 salts Chemical class 0.000 claims abstract description 11
- 239000000203 mixture Substances 0.000 claims abstract description 10
- KMGUEILFFWDGFV-UHFFFAOYSA-N 2-benzoyl-2-benzoyloxy-3-hydroxybutanedioic acid Chemical compound C=1C=CC=CC=1C(=O)C(C(C(O)=O)O)(C(O)=O)OC(=O)C1=CC=CC=C1 KMGUEILFFWDGFV-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000012458 free base Substances 0.000 claims abstract description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 3
- 238000002425 crystallisation Methods 0.000 claims abstract description 3
- 230000008025 crystallization Effects 0.000 claims abstract description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 7
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 claims description 2
- OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 claims description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 12
- 239000002585 base Substances 0.000 abstract description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract description 6
- 150000007513 acids Chemical class 0.000 abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 238000001953 recrystallisation Methods 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000013078 crystal Substances 0.000 description 6
- 238000002844 melting Methods 0.000 description 5
- 230000008018 melting Effects 0.000 description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 4
- DOQPXTMNIUCOSY-UHFFFAOYSA-N [4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]-[2-(3,4-dimethoxyphenyl)ethyl]-methylazanium;chloride Chemical compound [H+].[Cl-].C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 DOQPXTMNIUCOSY-UHFFFAOYSA-N 0.000 description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 description 4
- 229960001367 tartaric acid Drugs 0.000 description 4
- 235000002906 tartaric acid Nutrition 0.000 description 4
- 239000011975 tartaric acid Substances 0.000 description 4
- 229960000881 verapamil hydrochloride Drugs 0.000 description 4
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- SGTNSNPWRIOYBX-MHZLTWQESA-N (S)-verapamil Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCC[C@](C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-MHZLTWQESA-N 0.000 description 2
- ASNHGEVAWNWCRQ-UHFFFAOYSA-N 4-(hydroxymethyl)oxolane-2,3,4-triol Chemical compound OCC1(O)COC(O)C1O ASNHGEVAWNWCRQ-UHFFFAOYSA-N 0.000 description 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- SGTNSNPWRIOYBX-HHHXNRCGSA-N dexverapamil Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCC[C@@](C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-HHHXNRCGSA-N 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000012452 mother liquor Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- OCQAXYHNMWVLRH-QZTJIDSGSA-N (2r,3r)-2,3-dibenzoyl-2,3-dihydroxybutanedioic acid Chemical class O=C([C@@](O)(C(=O)O)[C@](O)(C(O)=O)C(=O)C=1C=CC=CC=1)C1=CC=CC=C1 OCQAXYHNMWVLRH-QZTJIDSGSA-N 0.000 description 1
- YONLFQNRGZXBBF-ZIAGYGMSSA-N (2r,3r)-2,3-dibenzoyloxybutanedioic acid Chemical compound O([C@@H](C(=O)O)[C@@H](OC(=O)C=1C=CC=CC=1)C(O)=O)C(=O)C1=CC=CC=C1 YONLFQNRGZXBBF-ZIAGYGMSSA-N 0.000 description 1
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-M 3-carboxy-2,3-dihydroxypropanoate Chemical compound OC(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-M 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- BJDFYLUYYXGVFW-UHFFFAOYSA-N bis(2-methylphenyl) 2,3-dihydroxybutanedioate Chemical compound CC1=CC=CC=C1OC(=O)C(O)C(O)C(=O)OC1=CC=CC=C1C BJDFYLUYYXGVFW-UHFFFAOYSA-N 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229960001270 d- tartaric acid Drugs 0.000 description 1
- DOQPXTMNIUCOSY-HZPIKELBSA-N dexverapamil hydrochloride Chemical compound Cl.C1=C(OC)C(OC)=CC=C1CCN(C)CCC[C@@](C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 DOQPXTMNIUCOSY-HZPIKELBSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Electrotherapy Devices (AREA)
- Steroid Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4203547A DE4203547A1 (de) | 1992-02-07 | 1992-02-07 | Verfahren zur racemattrennung von verapamil |
| DE4203547.3 | 1992-02-07 | ||
| PCT/EP1993/000196 WO1993016035A1 (fr) | 1992-02-07 | 1993-01-28 | Procede de separation des racemates du verapamil |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH07503475A JPH07503475A (ja) | 1995-04-13 |
| JP3307641B2 true JP3307641B2 (ja) | 2002-07-24 |
Family
ID=6451183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51371693A Expired - Lifetime JP3307641B2 (ja) | 1992-02-07 | 1993-01-28 | ベラパミルのラセミ分割法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5457224A (fr) |
| EP (1) | EP0625137B1 (fr) |
| JP (1) | JP3307641B2 (fr) |
| AT (1) | ATE151413T1 (fr) |
| CA (1) | CA2122254C (fr) |
| DE (2) | DE4203547A1 (fr) |
| DK (1) | DK0625137T3 (fr) |
| ES (1) | ES2099421T3 (fr) |
| MX (1) | MX9300473A (fr) |
| WO (1) | WO1993016035A1 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9319918D0 (en) * | 1993-09-27 | 1993-11-10 | Chiros Ltd | Chiral compounds and their preparation |
| US5910601A (en) * | 1994-09-26 | 1999-06-08 | Darwin Discovery Limited | Chiral nitriles, their preparation and their use for the manufacture of verapamil and analogues |
| DE19502967A1 (de) * | 1995-01-31 | 1996-08-01 | Basf Ag | Verfahren zur Racemattrennung von 2-Aryl-2-omega-alkylaminoalkannitrilen |
| WO1997044025A1 (fr) * | 1996-05-23 | 1997-11-27 | G.D. Searle & Co. | Compositions pharmaceutiques contenant du verapamil non racemique et procede pour optimiser l'activite pharmaceutique du r- et s-verapamil |
| GB9616549D0 (en) * | 1996-08-06 | 1996-09-25 | Chiroscience Ltd | Therapeutic product and its use |
| KR100341256B1 (ko) * | 1999-09-11 | 2002-06-21 | 박호군 | 리파제를 이용한 베라파밀 중간체의 분할 및 (ｒ)- 및 (ｓ)-베라파밀의 제조 방법 |
| KR20080027969A (ko) * | 2004-05-18 | 2008-03-28 | 에프. 호프만-라 로슈 아게 | 신규 ｃｉｓ-이미다졸린 |
| US7893278B2 (en) | 2004-06-17 | 2011-02-22 | Hoffman-La Roche Inc. | CIS-imidazolines |
| US7863273B2 (en) | 2006-01-17 | 2011-01-04 | Glenmark Generics Ltd. | Process for the preparation of an optically active 5H-pyrrolo [3,4-B] pyrazine derivative |
| EP2032581B1 (fr) * | 2006-06-19 | 2015-03-11 | Merck Patent GmbH | Composés enrichis en énantiomères et procédé |
| ITMI20071160A1 (it) * | 2007-06-07 | 2008-12-08 | Cosma S P A | Procedimento di risoluzione del verapamil |
| CN107108477A (zh) * | 2014-10-29 | 2017-08-29 | 晟德大药厂股份有限公司 | 盐酸维拉帕米结晶型 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1154810B (de) * | 1961-04-01 | 1963-09-26 | Knoll Ag | Verfahren zur Herstellung basisch substituierter Phenylacetonitrile |
| DE2059923C3 (de) * | 1970-12-05 | 1979-01-25 | Knoll Ag, 6700 Ludwigshafen | l-a-Isopropyl-o-[(N-methyl-N-homoveratryl)v-aminopropyl] -3,4-dimethoxyphenylacetonitril, Verfahren zu dessen Herstellung und dieses enthaltende Arzneimittel |
| DE2946545A1 (de) * | 1979-11-17 | 1981-05-27 | Basf Ag, 6700 Ludwigshafen | Verfahren zur gewinnung der enantiomeren formen von 4-cyan-1-(n-methyl-n-(2'-((3'',4'',-dimethoxyphenyl))-aethyl)-amino)-5-methyl-4-(3',4',5'-trimethoxyphenyl)-hexan und dessen salzen |
| DE3723684A1 (de) * | 1987-07-17 | 1989-01-26 | Basf Ag | Verfahren zur herstellung der enantiomeren von verapamil |
-
1992
- 1992-02-07 DE DE4203547A patent/DE4203547A1/de not_active Withdrawn
-
1993
- 1993-01-09 US US08/244,681 patent/US5457224A/en not_active Expired - Lifetime
- 1993-01-28 MX MX9300473A patent/MX9300473A/es unknown
- 1993-01-28 WO PCT/EP1993/000196 patent/WO1993016035A1/fr active IP Right Grant
- 1993-01-28 DK DK93903886.5T patent/DK0625137T3/da active
- 1993-01-28 JP JP51371693A patent/JP3307641B2/ja not_active Expired - Lifetime
- 1993-01-28 EP EP93903886A patent/EP0625137B1/fr not_active Expired - Lifetime
- 1993-01-28 CA CA002122254A patent/CA2122254C/fr not_active Expired - Lifetime
- 1993-01-28 AT AT93903886T patent/ATE151413T1/de active
- 1993-01-28 DE DE59306121T patent/DE59306121D1/de not_active Expired - Lifetime
- 1993-01-28 ES ES93903886T patent/ES2099421T3/es not_active Expired - Lifetime
Non-Patent Citations (1)
| Title |
|---|
| Ｊ．Ｌｉｑ．Ｃｈｒｏｍａｔｏｇｒ．，Ｖｏｌ．１１，Ｎｏ．９−１０（１９８８），ｐ．２１４７−２１６３ |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0625137A1 (fr) | 1994-11-23 |
| JPH07503475A (ja) | 1995-04-13 |
| US5457224A (en) | 1995-10-10 |
| DE59306121D1 (de) | 1997-05-15 |
| DE4203547A1 (de) | 1993-08-12 |
| WO1993016035A1 (fr) | 1993-08-19 |
| ES2099421T3 (es) | 1997-05-16 |
| CA2122254C (fr) | 2004-05-18 |
| DK0625137T3 (da) | 1997-05-05 |
| CA2122254A1 (fr) | 1993-08-19 |
| MX9300473A (es) | 1993-09-01 |
| ATE151413T1 (de) | 1997-04-15 |
| EP0625137B1 (fr) | 1997-04-09 |
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