JP3307641B2 - ベラパミルのラセミ分割法 - Google Patents

ベラパミルのラセミ分割法

Info

Publication number
JP3307641B2
JP3307641B2 JP51371693A JP51371693A JP3307641B2 JP 3307641 B2 JP3307641 B2 JP 3307641B2 JP 51371693 A JP51371693 A JP 51371693A JP 51371693 A JP51371693 A JP 51371693A JP 3307641 B2 JP3307641 B2 JP 3307641B2
Authority
JP
Japan
Prior art keywords
acid
verapamil
ratio
optically active
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP51371693A
Other languages
English (en)
Japanese (ja)
Other versions
JPH07503475A (ja
Inventor
オスカー エールマン，
ヘルベルト ナーゲル，
Original Assignee
クノル アクチエンゲゼルシヤフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by クノル アクチエンゲゼルシヤフト filed Critical クノル アクチエンゲゼルシヤフト
Publication of JPH07503475A publication Critical patent/JPH07503475A/ja
Application granted granted Critical
Publication of JP3307641B2 publication Critical patent/JP3307641B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Electrotherapy Devices (AREA)
  • Steroid Compounds (AREA)
JP51371693A 1992-02-07 1993-01-28 ベラパミルのラセミ分割法 Expired - Lifetime JP3307641B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4203547.3 1992-02-07
DE4203547A DE4203547A1 (de) 1992-02-07 1992-02-07 Verfahren zur racemattrennung von verapamil
PCT/EP1993/000196 WO1993016035A1 (fr) 1992-02-07 1993-01-28 Procede de separation des racemates du verapamil

Publications (2)

Publication Number Publication Date
JPH07503475A JPH07503475A (ja) 1995-04-13
JP3307641B2 true JP3307641B2 (ja) 2002-07-24

Family

ID=6451183

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51371693A Expired - Lifetime JP3307641B2 (ja) 1992-02-07 1993-01-28 ベラパミルのラセミ分割法

Country Status (10)

Country Link
US (1) US5457224A (fr)
EP (1) EP0625137B1 (fr)
JP (1) JP3307641B2 (fr)
AT (1) ATE151413T1 (fr)
CA (1) CA2122254C (fr)
DE (2) DE4203547A1 (fr)
DK (1) DK0625137T3 (fr)
ES (1) ES2099421T3 (fr)
MX (1) MX9300473A (fr)
WO (1) WO1993016035A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9319918D0 (en) * 1993-09-27 1993-11-10 Chiros Ltd Chiral compounds and their preparation
US5910601A (en) * 1994-09-26 1999-06-08 Darwin Discovery Limited Chiral nitriles, their preparation and their use for the manufacture of verapamil and analogues
DE19502967A1 (de) * 1995-01-31 1996-08-01 Basf Ag Verfahren zur Racemattrennung von 2-Aryl-2-omega-alkylaminoalkannitrilen
AU3205497A (en) * 1996-05-23 1997-12-09 G.D. Searle & Co. Pharmaceutical compositions containing non-racemic verapamil and process for optimizing the pharmaceutical activity of r- and s-verapamil
GB9616549D0 (en) * 1996-08-06 1996-09-25 Chiroscience Ltd Therapeutic product and its use
KR100341256B1 (ko) * 1999-09-11 2002-06-21 박호군 리파제를 이용한 베라파밀 중간체의 분할 및 (ｒ)- 및 (ｓ)-베라파밀의 제조 방법
KR20080027969A (ko) * 2004-05-18 2008-03-28 에프. 호프만-라 로슈 아게 신규 ｃｉｓ-이미다졸린
US7893278B2 (en) * 2004-06-17 2011-02-22 Hoffman-La Roche Inc. CIS-imidazolines
BRPI0621028A2 (pt) 2006-01-17 2011-11-29 Glenmark Pharmaceuticals Ltd processo para a preparação de um derivado de 5h-pirrolo[3,4-b]pirazina oticamente ativo
ES2537759T3 (es) * 2006-06-19 2015-06-11 Merck Patent Gmbh Compuestos enriquecidos enantioméricamente y proceso
ITMI20071160A1 (it) * 2007-06-07 2008-12-08 Cosma S P A Procedimento di risoluzione del verapamil
CA2964177A1 (fr) * 2014-10-29 2016-05-06 Center Laboratories, Inc. Formes cristallines de chlorhydrate de verapamil

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1154810B (de) * 1961-04-01 1963-09-26 Knoll Ag Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
DE2059923C3 (de) * 1970-12-05 1979-01-25 Knoll Ag, 6700 Ludwigshafen l-a-Isopropyl-o-[(N-methyl-N-homoveratryl)v-aminopropyl] -3,4-dimethoxyphenylacetonitril, Verfahren zu dessen Herstellung und dieses enthaltende Arzneimittel
DE2946545A1 (de) * 1979-11-17 1981-05-27 Basf Ag, 6700 Ludwigshafen Verfahren zur gewinnung der enantiomeren formen von 4-cyan-1-(n-methyl-n-(2'-((3'',4'',-dimethoxyphenyl))-aethyl)-amino)-5-methyl-4-(3',4',5'-trimethoxyphenyl)-hexan und dessen salzen
DE3723684A1 (de) * 1987-07-17 1989-01-26 Basf Ag Verfahren zur herstellung der enantiomeren von verapamil

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ｊ．Ｌｉｑ．Ｃｈｒｏｍａｔｏｇｒ．，Ｖｏｌ．１１，Ｎｏ．９−１０（１９８８），ｐ．２１４７−２１６３

Also Published As

Publication number Publication date
WO1993016035A1 (fr) 1993-08-19
CA2122254C (fr) 2004-05-18
DK0625137T3 (da) 1997-05-05
CA2122254A1 (fr) 1993-08-19
EP0625137A1 (fr) 1994-11-23
MX9300473A (es) 1993-09-01
JPH07503475A (ja) 1995-04-13
DE4203547A1 (de) 1993-08-12
ES2099421T3 (es) 1997-05-16
ATE151413T1 (de) 1997-04-15
EP0625137B1 (fr) 1997-04-09
DE59306121D1 (de) 1997-05-15
US5457224A (en) 1995-10-10

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