DK0625137T3 - Fremgangsmåde til racematadskillelse af verapamil - Google Patents

Fremgangsmåde til racematadskillelse af verapamil

Info

Publication number
DK0625137T3
DK0625137T3 DK93903886.5T DK93903886T DK0625137T3 DK 0625137 T3 DK0625137 T3 DK 0625137T3 DK 93903886 T DK93903886 T DK 93903886T DK 0625137 T3 DK0625137 T3 DK 0625137T3
Authority
DK
Denmark
Prior art keywords
pct
ratio
verapamil
sec
date
Prior art date
Application number
DK93903886.5T
Other languages
Danish (da)
English (en)
Inventor
Oskar Ehrmann
Herbert Nagel
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag filed Critical Knoll Ag
Application granted granted Critical
Publication of DK0625137T3 publication Critical patent/DK0625137T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Electrotherapy Devices (AREA)
  • Steroid Compounds (AREA)
DK93903886.5T 1992-02-07 1993-01-28 Fremgangsmåde til racematadskillelse af verapamil DK0625137T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4203547A DE4203547A1 (de) 1992-02-07 1992-02-07 Verfahren zur racemattrennung von verapamil

Publications (1)

Publication Number Publication Date
DK0625137T3 true DK0625137T3 (da) 1997-05-05

Family

ID=6451183

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93903886.5T DK0625137T3 (da) 1992-02-07 1993-01-28 Fremgangsmåde til racematadskillelse af verapamil

Country Status (10)

Country Link
US (1) US5457224A (fr)
EP (1) EP0625137B1 (fr)
JP (1) JP3307641B2 (fr)
AT (1) ATE151413T1 (fr)
CA (1) CA2122254C (fr)
DE (2) DE4203547A1 (fr)
DK (1) DK0625137T3 (fr)
ES (1) ES2099421T3 (fr)
MX (1) MX9300473A (fr)
WO (1) WO1993016035A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9319918D0 (en) * 1993-09-27 1993-11-10 Chiros Ltd Chiral compounds and their preparation
US5910601A (en) * 1994-09-26 1999-06-08 Darwin Discovery Limited Chiral nitriles, their preparation and their use for the manufacture of verapamil and analogues
DE19502967A1 (de) * 1995-01-31 1996-08-01 Basf Ag Verfahren zur Racemattrennung von 2-Aryl-2-omega-alkylaminoalkannitrilen
AU3205497A (en) * 1996-05-23 1997-12-09 G.D. Searle & Co. Pharmaceutical compositions containing non-racemic verapamil and process for optimizing the pharmaceutical activity of r- and s-verapamil
GB9616549D0 (en) * 1996-08-06 1996-09-25 Chiroscience Ltd Therapeutic product and its use
KR100341256B1 (ko) * 1999-09-11 2002-06-21 박호군 리파제를 이용한 베라파밀 중간체의 분할 및 (ｒ)- 및 (ｓ)-베라파밀의 제조 방법
KR20080027969A (ko) * 2004-05-18 2008-03-28 에프. 호프만-라 로슈 아게 신규 ｃｉｓ-이미다졸린
US7893278B2 (en) * 2004-06-17 2011-02-22 Hoffman-La Roche Inc. CIS-imidazolines
BRPI0621028A2 (pt) 2006-01-17 2011-11-29 Glenmark Pharmaceuticals Ltd processo para a preparação de um derivado de 5h-pirrolo[3,4-b]pirazina oticamente ativo
ES2537759T3 (es) * 2006-06-19 2015-06-11 Merck Patent Gmbh Compuestos enriquecidos enantioméricamente y proceso
ITMI20071160A1 (it) * 2007-06-07 2008-12-08 Cosma S P A Procedimento di risoluzione del verapamil
CA2964177A1 (fr) * 2014-10-29 2016-05-06 Center Laboratories, Inc. Formes cristallines de chlorhydrate de verapamil

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1154810B (de) * 1961-04-01 1963-09-26 Knoll Ag Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
DE2059923C3 (de) * 1970-12-05 1979-01-25 Knoll Ag, 6700 Ludwigshafen l-a-Isopropyl-o-[(N-methyl-N-homoveratryl)v-aminopropyl] -3,4-dimethoxyphenylacetonitril, Verfahren zu dessen Herstellung und dieses enthaltende Arzneimittel
DE2946545A1 (de) * 1979-11-17 1981-05-27 Basf Ag, 6700 Ludwigshafen Verfahren zur gewinnung der enantiomeren formen von 4-cyan-1-(n-methyl-n-(2'-((3'',4'',-dimethoxyphenyl))-aethyl)-amino)-5-methyl-4-(3',4',5'-trimethoxyphenyl)-hexan und dessen salzen
DE3723684A1 (de) * 1987-07-17 1989-01-26 Basf Ag Verfahren zur herstellung der enantiomeren von verapamil

Also Published As

Publication number Publication date
WO1993016035A1 (fr) 1993-08-19
CA2122254C (fr) 2004-05-18
CA2122254A1 (fr) 1993-08-19
EP0625137A1 (fr) 1994-11-23
MX9300473A (es) 1993-09-01
JPH07503475A (ja) 1995-04-13
DE4203547A1 (de) 1993-08-12
ES2099421T3 (es) 1997-05-16
ATE151413T1 (de) 1997-04-15
EP0625137B1 (fr) 1997-04-09
JP3307641B2 (ja) 2002-07-24
DE59306121D1 (de) 1997-05-15
US5457224A (en) 1995-10-10

Similar Documents

Publication Publication Date Title
DK0625137T3 (da) Fremgangsmåde til racematadskillelse af verapamil
ATE49195T1 (de) Herstellung von fibraten.
ATE143941T1 (de) Salpetersäureester von 2-(2,6- dihalophenylamino)phenylessigsäurederivaten und verfahren zu ihrer herstellung
DE69023280D1 (de) Kristalline 4-Amino-1-hydroxybutyliden-1,1-bisphosphon-säure, Verfahren zu ihrer Herstellung, Zusammensetzungen und deren Verwendung.
ES8601100A1 (es) Un procedimiento para producir 3-(3, 4-dihidroxifenil) serina
ATE61344T1 (de) Verfahren zur herstellung von o-substituierten hydroxylaminen.
ES2052714T3 (es) Un proceso para la preparacion de un compuesto denominado "cornexistina".
ES2039272T3 (es) Sales opticamente activas a base de un tiazolidin-4-carboxilato sustituido y 3-cloro-2-hidroxipropiltrimetilamonio, su preparacion y empleo.
DK0787124T3 (da) Fremgangsmåde til fremstilling af substituerede 3-aminobenzonitriler
ES522436A0 (es) Procedimiento analogo para preparar acido (r,s)-5-amino-hepta-5,6-dienoico,acido (s)-4-amino-hepta-5,6-dienoico o sus sales farmaceuticamente aceptables.
ATE41154T1 (de) Verfahren zur herstellung alkanphosphoniger saeuren.
ATE144519T1 (de) Phosphinesterhaltige n-acyl-2-aminosäureamide, verfahren zu ihrer herstellung und n-acyl-2- aminosäurenitrile als vorprodukte
ATE173922T1 (de) 2-arylpropionsäure-zubereitungen und verfahren zu ihrer herstellung
DK1046627T3 (da) Fremgangsmåde til separation af enantiomerer og enantiometrisk ren reaktant
DK0543845T3 (da) Fremgangsmåde til fremstilling af aminomethanphosphonsyre og aminomethyl-phosphinsyrer
AR241137A2 (es) "procedimiento para preparar beta-metilen-2 o 3-tiofenetanamina".
ATE110055T1 (de) Verfahren zur herstellung von substituierten ethenen.
GR3002020T3 (en) Carboxylic acid synthesis process
ES2044832T3 (es) Procedimiento para preparar derivados de glicina quirales.
ES2042409B1 (es) Procedimiento para la preparacion de d-aminoacidos o derivados de d-aminoacidos.
DK537789A (da) Fremgangsmaade til fremstilling af 3-chlor-2,4,5-triflourbenzoesyre
DK0661263T3 (da) Fremgangsmåde til fremstilling af 2,4,5-tribrompyrrol-3-carbonitril
ATE157655T1 (de) Verfahren zur herstellung von gegebenfalls 2- substituierten 5-chlorimidazolen
DK0635021T3 (da) Fremgangsmåde til fremstilling af derivater af bis(aminomethyl)phosphinsyre
DE58902254D1 (de) Verfahren zur herstellung von n,n'-bis(3-aminophenyl)harnstoffen.