JP3229990B2 - β―立体配置をもつジオキソランヌクレオシドの合成のための方法および成分 - Google Patents

β―立体配置をもつジオキソランヌクレオシドの合成のための方法および成分

Info

Publication number
JP3229990B2
JP3229990B2 JP52157397A JP52157397A JP3229990B2 JP 3229990 B2 JP3229990 B2 JP 3229990B2 JP 52157397 A JP52157397 A JP 52157397A JP 52157397 A JP52157397 A JP 52157397A JP 3229990 B2 JP3229990 B2 JP 3229990B2
Authority
JP
Japan
Prior art keywords
group
carbon atoms
atom
formula
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP52157397A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000501714A (ja
Inventor
マンサワ，タレク
シムポイア，アレックス
ベドナルスキ，クルジスズトフ
Original Assignee
バイオケム ファーマ インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by バイオケム ファーマ インコーポレイテッド filed Critical バイオケム ファーマ インコーポレイテッド
Publication of JP2000501714A publication Critical patent/JP2000501714A/ja
Application granted granted Critical
Publication of JP3229990B2 publication Critical patent/JP3229990B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP52157397A 1995-12-14 1996-12-13 β―立体配置をもつジオキソランヌクレオシドの合成のための方法および成分 Expired - Lifetime JP3229990B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9525606.1 1995-12-14
GBGB9525606.1A GB9525606D0 (en) 1995-12-14 1995-12-14 Method and compositions for the synthesis of dioxolane nucleosides with › - configuration
PCT/CA1996/000845 WO1997021706A1 (en) 1995-12-14 1996-12-13 METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION

Publications (2)

Publication Number Publication Date
JP2000501714A JP2000501714A (ja) 2000-02-15
JP3229990B2 true JP3229990B2 (ja) 2001-11-19

Family

ID=10785435

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52157397A Expired - Lifetime JP3229990B2 (ja) 1995-12-14 1996-12-13 β―立体配置をもつジオキソランヌクレオシドの合成のための方法および成分

Country Status (27)

Country Link
US (4) US5922867A (OSRAM)
EP (1) EP0970074B1 (OSRAM)
JP (1) JP3229990B2 (OSRAM)
KR (1) KR100406159B1 (OSRAM)
CN (1) CN1080263C (OSRAM)
AP (1) AP879A (OSRAM)
AT (1) ATE214699T1 (OSRAM)
AU (1) AU706328B2 (OSRAM)
BR (1) BR9612351A (OSRAM)
CA (1) CA2237730C (OSRAM)
DE (1) DE69620042T2 (OSRAM)
DK (1) DK0970074T3 (OSRAM)
EA (1) EA000844B1 (OSRAM)
ES (1) ES2172697T3 (OSRAM)
GB (1) GB9525606D0 (OSRAM)
HU (1) HU224076B1 (OSRAM)
IL (3) IL124663A (OSRAM)
IN (1) IN187349B (OSRAM)
MX (1) MX9804701A (OSRAM)
NO (1) NO309901B1 (OSRAM)
NZ (1) NZ323855A (OSRAM)
OA (1) OA11094A (OSRAM)
PL (1) PL188447B1 (OSRAM)
PT (1) PT970074E (OSRAM)
TW (1) TW341574B (OSRAM)
WO (1) WO1997021706A1 (OSRAM)
ZA (1) ZA9610544B (OSRAM)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6898498A (en) 1997-04-07 1998-10-30 Triangle Pharmaceuticals, Inc. Use of mkc-442 in combination with other antiviral agents
ES2232169T3 (es) 1998-08-12 2005-05-16 Gilead Sciences, Inc. Procedimiento de fabricacion de nucleosidos de 1,3-oxatiolano.
US6979561B1 (en) 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
JP2002533470A (ja) * 1998-12-23 2002-10-08 シャイアー・バイオケム・インコーポレイテッド 抗ウイルス性ヌクレオシド類似体
JP2002538780A (ja) * 1999-02-11 2002-11-19 シェア バイオケム インコーポレーテッド ヌクレオシド類似体の立体選択的合成
ES2218216T3 (es) * 1999-09-24 2004-11-16 Shire Biochem Inc. Analogos de nucleosidos de dioxolano para el tratamiento o la prevencion de infecciones viricas.
EP1225899A2 (en) * 1999-11-04 2002-07-31 Virochem Pharma Inc. Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues
EP1178051B1 (en) * 2000-02-10 2008-05-28 Mitsui Chemicals, Inc. Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside
WO2001058894A1 (en) * 2000-02-11 2001-08-16 Shire Biochem Inc. Stereoselective synthesis of nucleoside analogues
WO2002051852A1 (fr) * 2000-12-27 2002-07-04 Mitsui Chemicals, Inc. Procede de production d'un derive de saccharide non naturel
CN1503796B (zh) 2001-03-01 2012-07-04 三角药品公司 顺-ftc的多晶型物及其它晶型
WO2003020222A2 (en) * 2001-09-04 2003-03-13 Merck & Co., Inc. PYRROLO[2,3-d]PYRIMIDINES FOR INHIBITING RNA-DEPENDENT RNA VIRAL POLYMERASE
EP1441733A1 (en) * 2001-11-02 2004-08-04 Shire Biochem Inc. Pharmaceutical compositions for the treatment of leukemia comprising dioxolane nucleosides analogs
WO2003063771A2 (en) * 2001-12-14 2003-08-07 Pharmasset Ltd. N4-acylcytosine nucleosides for treatment of viral iinfections
US20050085638A1 (en) * 2002-01-25 2005-04-21 Shire Biochem Inc Process for producing dioxolane nucleoside analogues
ES2360096T3 (es) 2002-08-06 2011-05-31 Pharmasset, Inc. Procedimientos de preparación de nucleosidos de 1,3-dioxolano.
WO2005108442A1 (en) 2002-10-15 2005-11-17 Exxonmobil Chemical Patents Inc. Polyolefin adhesive compositions and articles made therefrom
DE10335061B4 (de) 2003-07-31 2005-11-17 Wacker-Chemie Gmbh Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
BRPI0507363A (pt) * 2004-02-03 2007-07-03 Univ Emory métodos para manufatura de 1,3-dioxolano nucleosìdeos
US7749531B2 (en) * 2005-06-08 2010-07-06 Indicator Systems International Apparatus and method for detecting bacterial growth beneath a wound dressing
BRPI0813036A2 (pt) * 2007-07-30 2017-10-24 Rfs Pharma Llc processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina.
CN101862676B (zh) * 2009-04-17 2012-01-25 中国石油化工股份有限公司 大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用
CN103288806A (zh) * 2013-07-02 2013-09-11 山东大学 一种曲沙他滨的合成方法
WO2018022263A1 (en) 2016-07-29 2018-02-01 Exxonmobil Chemical Patents Inc. Polymerization processes using high molecular weight polyhydric quenching agents
WO2019245444A1 (en) 2018-06-21 2019-12-26 Medivir Ab Base-modified cytidine nucleotides for leukemia therapy
JP7337539B2 (ja) 2018-06-21 2023-09-04 メディヴィル・アクチエボラーグ 白血病療法のための塩基修飾シチジンヌクレオチド

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
HUT64359A (en) * 1992-06-22 1993-12-28 Lilly Co Eli A stereoselective glycosyling procedure

Also Published As

Publication number Publication date
GB9525606D0 (en) 1996-02-14
EA199800555A1 (ru) 1999-02-25
NZ323855A (en) 1999-11-29
US6069250A (en) 2000-05-30
US20030060476A1 (en) 2003-03-27
AP879A (en) 2000-10-02
CA2237730A1 (en) 1997-06-19
PL327443A1 (en) 1998-12-07
CN1080263C (zh) 2002-03-06
DK0970074T3 (da) 2002-07-15
PT970074E (pt) 2002-09-30
WO1997021706A1 (en) 1997-06-19
IN187349B (OSRAM) 2002-03-30
HUP9901050A2 (hu) 2001-04-28
BR9612351A (pt) 1999-07-13
NO982716D0 (no) 1998-06-12
DE69620042D1 (de) 2002-04-25
AU1089397A (en) 1997-07-03
EP0970074B1 (en) 2002-03-20
IL144155A (en) 2003-07-06
US20020058670A1 (en) 2002-05-16
AP9801252A0 (en) 1998-06-30
EA000844B1 (ru) 2000-06-26
HU224076B1 (hu) 2005-05-30
ATE214699T1 (de) 2002-04-15
ES2172697T3 (es) 2002-10-01
PL188447B1 (pl) 2005-02-28
IL144155A0 (en) 2002-05-23
CN1208414A (zh) 1999-02-17
NO982716L (no) 1998-06-12
HK1017886A1 (en) 1999-12-03
JP2000501714A (ja) 2000-02-15
HUP9901050A3 (en) 2001-05-28
DE69620042T2 (de) 2002-10-17
TW341574B (en) 1998-10-01
NO309901B1 (no) 2001-04-17
ZA9610544B (en) 1997-07-29
US5922867A (en) 1999-07-13
KR19990072141A (ko) 1999-09-27
MX9804701A (es) 1998-10-31
CA2237730C (en) 2001-12-04
KR100406159B1 (ko) 2004-11-16
OA11094A (en) 2003-03-13
IL124663A (en) 2001-10-31
IL124663A0 (en) 1998-12-06
EP0970074A1 (en) 2000-01-12
AU706328B2 (en) 1999-06-17

Similar Documents

Publication Publication Date Title
JP3229990B2 (ja) β―立体配置をもつジオキソランヌクレオシドの合成のための方法および成分
KR0160144B1 (ko) 뉴클레오시드의 부분 입체 이성체를 선택적으로 합성하는 방법
EP2277878B1 (en) Process for production of ethynylthymidine compound using 5-methyluridine as starting raw material
JP2004123758A (ja) Ｎ４−アシル−５′−デオキシ−５−フルオロシチジン誘導体の新規製造法
CZ309696A3 (en) Diastereoselective process for preparing nucleoside analogs
EP0688783B1 (en) Method for preparing 2'-deoxy-2',2'-difluornucleosides
FI112078B (fi) Nukleosidianalogien stereoselektiivinen synteesi kaksirenkaista välituotetta käyttämällä
JP2009526782A (ja) ゲムシタビンおよび関連中間体の製造方法
WO1993018051A1 (fr) Procede de production de derive de nucleosides
KR100319127B1 (ko) 에이제트티및그의유도체의제조방법
JPWO1997043295A1 (ja) Ｄ−ペントフラノース誘導体及びその製造法
HK1017886B (en) METHOD AND INTERMEDIATE FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDE WITH β-CONFIGURATION
JPH04368382A (ja) ２′，３′−ジデオキシ−β−ヌクレオシドの製造方法
WO2003010179A1 (en) Process for the preparation of 2'-3'-dideoxy-2',3'-didehydro-nucleosides
JP2000154197A (ja) Ｄ―ペントフラノ―ス誘導体及びその製造法
JPH08253483A (ja) 二環性複素環化合物
WO1994010186A1 (en) One vessel stereoselective glycosylation of purines and pyrimidines
WO2003040139A1 (en) Diastereoselective process for the preparation of the antiviral agent4-amino-1-(2r-hydroxymethyl-[1,3]oxathiolan-5s-yl)-1h-pyrimidin-2-one
IL102144A (en) Process for the preparation of '2 - deoxy -' 2, '2 - difluoro nucleosides
JPWO1993018051A1 (ja) ヌクレオシド誘導体の製造方法

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20080914

Year of fee payment: 7

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20090914

Year of fee payment: 8

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20100914

Year of fee payment: 9

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110914

Year of fee payment: 10

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110914

Year of fee payment: 10

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120914

Year of fee payment: 11

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120914

Year of fee payment: 11

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130914

Year of fee payment: 12

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term