NO309901B1 - FremgangsmÕte for syntese av dioksalan-nukleotider med <beta>- konfigurasjon - Google Patents

FremgangsmÕte for syntese av dioksalan-nukleotider med <beta>- konfigurasjon Download PDF

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Publication number
NO309901B1
NO309901B1 NO982716A NO982716A NO309901B1 NO 309901 B1 NO309901 B1 NO 309901B1 NO 982716 A NO982716 A NO 982716A NO 982716 A NO982716 A NO 982716A NO 309901 B1 NO309901 B1 NO 309901B1
Authority
NO
Norway
Prior art keywords
group
formula
alkyl
iodine
hydrogen
Prior art date
Application number
NO982716A
Other languages
English (en)
Norwegian (no)
Other versions
NO982716L (no
NO982716D0 (no
Inventor
Tarek Mansour
Alex Cimpoia
Krzystof Bednarski
Original Assignee
Iaf Biochem Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Publication of NO982716L publication Critical patent/NO982716L/no
Publication of NO982716D0 publication Critical patent/NO982716D0/no
Publication of NO309901B1 publication Critical patent/NO309901B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO982716A 1995-12-14 1998-06-12 FremgangsmÕte for syntese av dioksalan-nukleotider med <beta>- konfigurasjon NO309901B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9525606.1A GB9525606D0 (en) 1995-12-14 1995-12-14 Method and compositions for the synthesis of dioxolane nucleosides with › - configuration
PCT/CA1996/000845 WO1997021706A1 (en) 1995-12-14 1996-12-13 METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION

Publications (3)

Publication Number Publication Date
NO982716L NO982716L (no) 1998-06-12
NO982716D0 NO982716D0 (no) 1998-06-12
NO309901B1 true NO309901B1 (no) 2001-04-17

Family

ID=10785435

Family Applications (1)

Application Number Title Priority Date Filing Date
NO982716A NO309901B1 (no) 1995-12-14 1998-06-12 FremgangsmÕte for syntese av dioksalan-nukleotider med <beta>- konfigurasjon

Country Status (27)

Country Link
US (4) US5922867A (OSRAM)
EP (1) EP0970074B1 (OSRAM)
JP (1) JP3229990B2 (OSRAM)
KR (1) KR100406159B1 (OSRAM)
CN (1) CN1080263C (OSRAM)
AP (1) AP879A (OSRAM)
AT (1) ATE214699T1 (OSRAM)
AU (1) AU706328B2 (OSRAM)
BR (1) BR9612351A (OSRAM)
CA (1) CA2237730C (OSRAM)
DE (1) DE69620042T2 (OSRAM)
DK (1) DK0970074T3 (OSRAM)
EA (1) EA000844B1 (OSRAM)
ES (1) ES2172697T3 (OSRAM)
GB (1) GB9525606D0 (OSRAM)
HU (1) HU224076B1 (OSRAM)
IL (3) IL124663A (OSRAM)
IN (1) IN187349B (OSRAM)
MX (1) MX9804701A (OSRAM)
NO (1) NO309901B1 (OSRAM)
NZ (1) NZ323855A (OSRAM)
OA (1) OA11094A (OSRAM)
PL (1) PL188447B1 (OSRAM)
PT (1) PT970074E (OSRAM)
TW (1) TW341574B (OSRAM)
WO (1) WO1997021706A1 (OSRAM)
ZA (1) ZA9610544B (OSRAM)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998044913A2 (en) 1997-04-07 1998-10-15 Triangle Pharmaceuticals, Inc. Compositions containing mkc-442 in combination with other antiviral agents
RU2244712C2 (ru) 1998-08-12 2005-01-20 Гайлид Сайенсиз, Инк. Способ получения 1,3-оксатиоланового нуклеозида, способ получения производного 1,3-оксатиоланил-5-она
US6979561B1 (en) * 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
DE69912842T2 (de) 1998-12-23 2004-05-13 Shire Biochem Inc., Laval Antivirale nukleosidanaloga
JP2002538780A (ja) * 1999-02-11 2002-11-19 シェア バイオケム インコーポレーテッド ヌクレオシド類似体の立体選択的合成
ATE269081T1 (de) * 1999-09-24 2004-07-15 Shire Biochem Inc Dioxolan nukleosidanalogen zur behandlung und vorbeugung von viralen infektionen
EP1225899A2 (en) * 1999-11-04 2002-07-31 Virochem Pharma Inc. Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues
CA2366513A1 (en) * 2000-02-10 2001-08-16 Mitsui Chemicals, Inc. Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing a nucleoside
EP1265890B1 (en) * 2000-02-11 2007-04-18 Shire BioChem Inc. Stereoselective synthesis of nucleoside analogues
WO2002051852A1 (fr) * 2000-12-27 2002-07-04 Mitsui Chemicals, Inc. Procede de production d'un derive de saccharide non naturel
DK1574512T3 (da) * 2001-03-01 2008-03-03 Abbott Lab Polymorfe og andre krystallinske former af cis-FTC
AU2002329970A1 (en) * 2001-09-04 2003-03-18 Isis Pharmaceuticals, Inc. Pyrrolo(2,3-d)pyrimidines for inhibiting rna-dependent rna viral polymerase
US6645972B2 (en) * 2001-11-02 2003-11-11 Shire Biochem Inc. Methods of treating leukemia
EP1569652A4 (en) * 2001-12-14 2008-07-02 Pharmasset Inc NUCLEOSIDES N SP 4 / SP-ACYLCYTOSINES FOR THE TREATMENT OF VIRAL INFECTIONS
WO2003062229A1 (en) 2002-01-25 2003-07-31 Shire Biochem Inc. Process for producing dioxolane nucleoside analogues
ATE496054T1 (de) 2002-08-06 2011-02-15 Pharmasset Inc Verfahren zur herstellung von 1,3-dioxolan- nucleosiden
WO2004046214A2 (en) 2002-10-15 2004-06-03 Exxonmobil Chemical Patents Inc. Multiple catalyst system for olefin polymerization and polymers produced therefrom
DE10335061B4 (de) * 2003-07-31 2005-11-17 Wacker-Chemie Gmbh Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
WO2005074654A2 (en) 2004-02-03 2005-08-18 Emory University Methods to manufacture 1,3-dioxolane nucleosides
US7749531B2 (en) * 2005-06-08 2010-07-06 Indicator Systems International Apparatus and method for detecting bacterial growth beneath a wound dressing
BRPI0813036A2 (pt) * 2007-07-30 2017-10-24 Rfs Pharma Llc processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina.
CN101862676B (zh) * 2009-04-17 2012-01-25 中国石油化工股份有限公司 大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用
CN103288806A (zh) * 2013-07-02 2013-09-11 山东大学 一种曲沙他滨的合成方法
WO2018022263A1 (en) 2016-07-29 2018-02-01 Exxonmobil Chemical Patents Inc. Polymerization processes using high molecular weight polyhydric quenching agents
WO2019245444A1 (en) 2018-06-21 2019-12-26 Medivir Ab Base-modified cytidine nucleotides for leukemia therapy
JP7337539B2 (ja) * 2018-06-21 2023-09-04 メディヴィル・アクチエボラーグ 白血病療法のための塩基修飾シチジンヌクレオチド

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
IL106078A0 (en) * 1992-06-22 1993-10-20 Lilly Co Eli Stereoselective anion glycosylation process

Also Published As

Publication number Publication date
IL144155A0 (en) 2002-05-23
CN1208414A (zh) 1999-02-17
NO982716L (no) 1998-06-12
EA199800555A1 (ru) 1999-02-25
WO1997021706A1 (en) 1997-06-19
PL327443A1 (en) 1998-12-07
IL124663A (en) 2001-10-31
IN187349B (OSRAM) 2002-03-30
NO982716D0 (no) 1998-06-12
IL144155A (en) 2003-07-06
AP879A (en) 2000-10-02
DE69620042D1 (de) 2002-04-25
DK0970074T3 (da) 2002-07-15
ZA9610544B (en) 1997-07-29
AU1089397A (en) 1997-07-03
DE69620042T2 (de) 2002-10-17
US5922867A (en) 1999-07-13
JP3229990B2 (ja) 2001-11-19
HUP9901050A3 (en) 2001-05-28
US20030060476A1 (en) 2003-03-27
US20020058670A1 (en) 2002-05-16
PL188447B1 (pl) 2005-02-28
GB9525606D0 (en) 1996-02-14
EP0970074A1 (en) 2000-01-12
KR100406159B1 (ko) 2004-11-16
KR19990072141A (ko) 1999-09-27
CA2237730C (en) 2001-12-04
BR9612351A (pt) 1999-07-13
MX9804701A (es) 1998-10-31
PT970074E (pt) 2002-09-30
EP0970074B1 (en) 2002-03-20
AP9801252A0 (en) 1998-06-30
TW341574B (en) 1998-10-01
ATE214699T1 (de) 2002-04-15
HU224076B1 (hu) 2005-05-30
CA2237730A1 (en) 1997-06-19
OA11094A (en) 2003-03-13
HK1017886A1 (en) 1999-12-03
NZ323855A (en) 1999-11-29
JP2000501714A (ja) 2000-02-15
CN1080263C (zh) 2002-03-06
ES2172697T3 (es) 2002-10-01
US6069250A (en) 2000-05-30
HUP9901050A2 (hu) 2001-04-28
IL124663A0 (en) 1998-12-06
AU706328B2 (en) 1999-06-17
EA000844B1 (ru) 2000-06-26

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