PT970074E - Metodo e composicoes para a sintese de nucleosidos de dioxolano com configuracao beta - Google Patents
Metodo e composicoes para a sintese de nucleosidos de dioxolano com configuracao betaInfo
- Publication number
- PT970074E PT970074E PT96941539T PT96941539T PT970074E PT 970074 E PT970074 E PT 970074E PT 96941539 T PT96941539 T PT 96941539T PT 96941539 T PT96941539 T PT 96941539T PT 970074 E PT970074 E PT 970074E
- Authority
- PT
- Portugal
- Prior art keywords
- synthesis
- compositions
- beta configuration
- dioxolane nucleoside
- dioxolane
- Prior art date
Links
- YNWUIBSEOAWSHW-HIQWKFPQSA-N 5-[(e)-2-bromoethenyl]-1-[(2s,4s)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidine-2,4-dione Chemical compound O1[C@@H](CO)OC[C@H]1N1C(=O)NC(=O)C(\C=C\Br)=C1 YNWUIBSEOAWSHW-HIQWKFPQSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9525606.1A GB9525606D0 (en) | 1995-12-14 | 1995-12-14 | Method and compositions for the synthesis of dioxolane nucleosides with - configuration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT970074E true PT970074E (pt) | 2002-09-30 |
Family
ID=10785435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96941539T PT970074E (pt) | 1995-12-14 | 1996-12-13 | Metodo e composicoes para a sintese de nucleosidos de dioxolano com configuracao beta |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US5922867A (OSRAM) |
| EP (1) | EP0970074B1 (OSRAM) |
| JP (1) | JP3229990B2 (OSRAM) |
| KR (1) | KR100406159B1 (OSRAM) |
| CN (1) | CN1080263C (OSRAM) |
| AP (1) | AP879A (OSRAM) |
| AT (1) | ATE214699T1 (OSRAM) |
| AU (1) | AU706328B2 (OSRAM) |
| BR (1) | BR9612351A (OSRAM) |
| CA (1) | CA2237730C (OSRAM) |
| DE (1) | DE69620042T2 (OSRAM) |
| DK (1) | DK0970074T3 (OSRAM) |
| EA (1) | EA000844B1 (OSRAM) |
| ES (1) | ES2172697T3 (OSRAM) |
| GB (1) | GB9525606D0 (OSRAM) |
| HU (1) | HU224076B1 (OSRAM) |
| IL (3) | IL124663A (OSRAM) |
| IN (1) | IN187349B (OSRAM) |
| MX (1) | MX9804701A (OSRAM) |
| NO (1) | NO309901B1 (OSRAM) |
| NZ (1) | NZ323855A (OSRAM) |
| OA (1) | OA11094A (OSRAM) |
| PL (1) | PL188447B1 (OSRAM) |
| PT (1) | PT970074E (OSRAM) |
| TW (1) | TW341574B (OSRAM) |
| WO (1) | WO1997021706A1 (OSRAM) |
| ZA (1) | ZA9610544B (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001518899A (ja) | 1997-04-07 | 2001-10-16 | トライアングル ファーマシューティカルズ，インコーポレイティド | 他の抗ウイルス剤との組合せにおけるｍｋｃ−４４２の使用 |
| ES2232169T3 (es) | 1998-08-12 | 2005-05-16 | Gilead Sciences, Inc. | Procedimiento de fabricacion de nucleosidos de 1,3-oxatiolano. |
| US6979561B1 (en) * | 1998-10-09 | 2005-12-27 | Gilead Sciences, Inc. | Non-homogeneous systems for the resolution of enantiomeric mixtures |
| NZ513094A (en) | 1998-12-23 | 2004-05-28 | Shire Biochem Inc | Antiviral nucleoside analogues |
| WO2000047759A1 (en) * | 1999-02-11 | 2000-08-17 | Shire Biochem Inc. | Stereoselective synthesis of nucleoside analogues |
| ES2218216T3 (es) | 1999-09-24 | 2004-11-16 | Shire Biochem Inc. | Analogos de nucleosidos de dioxolano para el tratamiento o la prevencion de infecciones viricas. |
| WO2001032153A2 (en) * | 1999-11-04 | 2001-05-10 | Shire Biochem Inc. | Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues |
| DE60134196D1 (de) * | 2000-02-10 | 2008-07-10 | Mitsui Chemicals Inc | Verfahren zur selektiven herstellung eines 1-phosphoryliertem zuckerderivativ-anomers und verfahren zur herstellung von nukleosiden |
| ES2284613T3 (es) | 2000-02-11 | 2007-11-16 | Shire Biochem Inc. | Sintesis estereoselectiva de analogos de nucleosido. |
| WO2002051852A1 (fr) * | 2000-12-27 | 2002-07-04 | Mitsui Chemicals, Inc. | Procede de production d'un derive de saccharide non naturel |
| DE60224592T2 (de) * | 2001-03-01 | 2009-01-29 | Abbott Laboratories, Abbott Park | Polymorphe und andere kristalline Formen von cis-FTC |
| WO2003020222A2 (en) * | 2001-09-04 | 2003-03-13 | Merck & Co., Inc. | PYRROLO[2,3-d]PYRIMIDINES FOR INHIBITING RNA-DEPENDENT RNA VIRAL POLYMERASE |
| AU2002336864B2 (en) * | 2001-11-02 | 2006-08-17 | Shire Biochem Inc. | Pharmaceutical compositions for the treatment of leukemia comprising dioxolane nucleosides analogs |
| BR0214944A (pt) * | 2001-12-14 | 2005-06-07 | Pharmasset Ltd | Nucleosìdeos de n4-acilcitosina para o tratamento de infecções virais |
| EP1467990B1 (en) * | 2002-01-25 | 2012-03-07 | Shire BioChem Inc. | Process for producing dioxolane nucleoside analogue precursors |
| ATE496054T1 (de) | 2002-08-06 | 2011-02-15 | Pharmasset Inc | Verfahren zur herstellung von 1,3-dioxolan- nucleosiden |
| EP2261292B1 (en) | 2002-10-15 | 2014-07-23 | ExxonMobil Chemical Patents Inc. | Polyolefin adhesive compositions |
| DE10335061B4 (de) * | 2003-07-31 | 2005-11-17 | Wacker-Chemie Gmbh | Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten |
| CN101044122A (zh) | 2004-02-03 | 2007-09-26 | 埃莫里大学 | 制备1,3－二氧戊环核苷的方法 |
| US7749531B2 (en) * | 2005-06-08 | 2010-07-06 | Indicator Systems International | Apparatus and method for detecting bacterial growth beneath a wound dressing |
| BRPI0813036A2 (pt) * | 2007-07-30 | 2017-10-24 | Rfs Pharma Llc | processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina. |
| CN101862676B (zh) * | 2009-04-17 | 2012-01-25 | 中国石油化工股份有限公司 | 大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用 |
| CN103288806A (zh) * | 2013-07-02 | 2013-09-11 | 山东大学 | 一种曲沙他滨的合成方法 |
| WO2018022263A1 (en) | 2016-07-29 | 2018-02-01 | Exxonmobil Chemical Patents Inc. | Polymerization processes using high molecular weight polyhydric quenching agents |
| JP7337539B2 (ja) * | 2018-06-21 | 2023-09-04 | メディヴィル・アクチエボラーグ | 白血病療法のための塩基修飾シチジンヌクレオチド |
| WO2019245444A1 (en) | 2018-06-21 | 2019-12-26 | Medivir Ab | Base-modified cytidine nucleotides for leukemia therapy |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5276151A (en) * | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
| CZ123493A3 (en) * | 1992-06-22 | 1994-02-16 | Lilly Co Eli | Stereoselective anionic glycosylation process |
-
1995
- 1995-12-14 GB GBGB9525606.1A patent/GB9525606D0/en active Pending
-
1996
- 1996-12-13 KR KR10-1998-0704473A patent/KR100406159B1/ko not_active Expired - Fee Related
- 1996-12-13 JP JP52157397A patent/JP3229990B2/ja not_active Expired - Lifetime
- 1996-12-13 PL PL96327443A patent/PL188447B1/pl not_active IP Right Cessation
- 1996-12-13 IL IL12466396A patent/IL124663A/en not_active IP Right Cessation
- 1996-12-13 EP EP96941539A patent/EP0970074B1/en not_active Expired - Lifetime
- 1996-12-13 NZ NZ323855A patent/NZ323855A/xx unknown
- 1996-12-13 WO PCT/CA1996/000845 patent/WO1997021706A1/en not_active Ceased
- 1996-12-13 PT PT96941539T patent/PT970074E/pt unknown
- 1996-12-13 US US08/849,722 patent/US5922867A/en not_active Expired - Lifetime
- 1996-12-13 AT AT96941539T patent/ATE214699T1/de not_active IP Right Cessation
- 1996-12-13 EA EA199800555A patent/EA000844B1/ru not_active IP Right Cessation
- 1996-12-13 CA CA002237730A patent/CA2237730C/en not_active Expired - Lifetime
- 1996-12-13 TW TW085115392A patent/TW341574B/zh active
- 1996-12-13 HU HU9901050A patent/HU224076B1/hu active IP Right Grant
- 1996-12-13 AU AU10893/97A patent/AU706328B2/en not_active Expired
- 1996-12-13 IL IL14415596A patent/IL144155A/xx not_active IP Right Cessation
- 1996-12-13 AP APAP/P/1998/001252A patent/AP879A/en active
- 1996-12-13 DE DE69620042T patent/DE69620042T2/de not_active Expired - Lifetime
- 1996-12-13 CN CN96199879A patent/CN1080263C/zh not_active Expired - Lifetime
- 1996-12-13 ZA ZA9610544A patent/ZA9610544B/xx unknown
- 1996-12-13 BR BR9612351A patent/BR9612351A/pt not_active Application Discontinuation
- 1996-12-13 DK DK96941539T patent/DK0970074T3/da active
- 1996-12-13 IN IN2810DE1996 patent/IN187349B/en unknown
- 1996-12-13 ES ES96941539T patent/ES2172697T3/es not_active Expired - Lifetime
-
1998
- 1998-06-09 OA OA9800077A patent/OA11094A/en unknown
- 1998-06-11 MX MX9804701A patent/MX9804701A/es unknown
- 1998-06-12 NO NO982716A patent/NO309901B1/no unknown
-
1999
- 1999-02-17 US US09/251,431 patent/US6069250A/en not_active Expired - Lifetime
-
2001
- 2001-07-05 IL IL14415501A patent/IL144155A0/xx unknown
- 2001-11-16 US US09/987,845 patent/US20020058670A1/en not_active Abandoned
-
2002
- 2002-10-02 US US10/262,107 patent/US20030060476A1/en not_active Abandoned
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