JP2945261B2 - １５−デオキシスペルグアリン類似体、それらの製造方法および治療法での使用 - Google Patents

１５−デオキシスペルグアリン類似体、それらの製造方法および治療法での使用

Info

Publication number
JP2945261B2
JP2945261B2 JP5342673A JP34267393A JP2945261B2 JP 2945261 B2 JP2945261 B2 JP 2945261B2 JP 5342673 A JP5342673 A JP 5342673A JP 34267393 A JP34267393 A JP 34267393A JP 2945261 B2 JP2945261 B2 JP 2945261B2
Authority
JP
Japan
Prior art keywords
group
preparation
amino
mol
carbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP5342673A
Other languages
English (en)
Japanese (ja)
Other versions
JPH06293728A (ja
Inventor
ルノー パトリス
ルブルトン リュック
デュタルトル パトリック
デルパ フィリップ
サムレ ソト
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FURUNIE IND E SANTE
Original Assignee
FURUNIE IND E SANTE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FURUNIE IND E SANTE filed Critical FURUNIE IND E SANTE
Publication of JPH06293728A publication Critical patent/JPH06293728A/ja
Application granted granted Critical
Publication of JP2945261B2 publication Critical patent/JP2945261B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Soil Conditioners And Soil-Stabilizing Materials (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
JP5342673A 1992-12-02 1993-12-02 １５−デオキシスペルグアリン類似体、それらの製造方法および治療法での使用 Expired - Fee Related JP2945261B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9214517A FR2698628B1 (fr) 1992-12-02 1992-12-02 Analogues de 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.
FR9214517 1992-12-02

Publications (2)

Publication Number Publication Date
JPH06293728A JPH06293728A (ja) 1994-10-21
JP2945261B2 true JP2945261B2 (ja) 1999-09-06

Family

ID=9436147

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5342673A Expired - Fee Related JP2945261B2 (ja) 1992-12-02 1993-12-02 １５−デオキシスペルグアリン類似体、それらの製造方法および治療法での使用

Country Status (23)

Country Link
US (1) US5476870A (enExample)
EP (1) EP0600762B1 (enExample)
JP (1) JP2945261B2 (enExample)
KR (1) KR100187328B1 (enExample)
CN (1) CN1045431C (enExample)
AT (1) ATE140215T1 (enExample)
AU (1) AU664124B2 (enExample)
CA (1) CA2110437C (enExample)
CZ (1) CZ284958B6 (enExample)
DE (1) DE69303583T2 (enExample)
DK (1) DK0600762T3 (enExample)
ES (1) ES2092263T3 (enExample)
FI (1) FI112211B (enExample)
FR (1) FR2698628B1 (enExample)
GR (1) GR3021269T3 (enExample)
HU (1) HU218908B (enExample)
NO (1) NO180483C (enExample)
NZ (1) NZ250330A (enExample)
RU (1) RU2114823C1 (enExample)
SK (1) SK280286B6 (enExample)
TW (1) TW311132B (enExample)
UA (1) UA39920C2 (enExample)
ZA (1) ZA938821B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09511765A (ja) * 1995-02-10 1997-11-25 フルニエ・アンデュストリ・エ・サンテ １５−デオキシスペルグアリン類似体、その治療用途及びその調製方法
FR2734263B1 (fr) * 1995-05-17 1997-06-20 Fournier Ind & Sante Analogues de la 15-deoxyspergualine, leur procede de preparation et leur utilisation en therapeutique
ES2139465T3 (es) * 1996-12-20 2000-02-01 Sueddeutsche Kalkstickstoff Piruvatos de creatina y procedimiento para su preparacion.
DE19728436A1 (de) * 1997-07-03 1999-01-07 Niels Franke Niedrigdosierte 15-Desoxyspergualin-Präparate
HK1043801A1 (zh) * 1998-08-28 2002-09-27 格莱风科学公司 精确长度的聚酰胺链、其制备方法和其与蛋白质的缀合物
DE19923961A1 (de) * 1999-05-25 2000-11-30 Euro Nippon Kayaku Gmbh Verwendung von 15-Deoxyspergualin zur Behandlung von hyperreaktiven entzündlichen Erkrankungen und Autoimmunerkrankungen
CA2565633C (en) * 2004-05-05 2016-04-26 Atugen Ag Lipids, lipid complexes and use thereof
WO2006069782A2 (en) 2004-12-27 2006-07-06 Silence Therapeutics Ag. Lipid complexes coated with peg and their use
WO2010074591A1 (ru) 2008-12-24 2010-07-01 Закрытое Акционерное Общество "Beptekc" Амиды креатина, способ их получения, средство, обладающее нейропротекторным действием
RU2428414C2 (ru) 2009-11-03 2011-09-10 Закрытое Акционерное Общество "Вертекс" Способ получения амидов креатина
JP5878172B2 (ja) * 2010-07-29 2016-03-08 ラボラトワール フルニエ エスアーエス 炎症性眼疾患の治療／予防用化合物
FR2963238B1 (fr) * 2010-07-29 2012-12-28 Fournier Lab Sa Derives de 15-desoxyspergualine pour le traitement et/ou la prevention des maladies inflammatoires oculaires
KR101695730B1 (ko) 2015-03-10 2017-01-12 하경훈 마늘꼭지 절단기의 절단장치
FR3050455B1 (fr) * 2016-04-26 2019-06-14 Temisis Derives amides des acides polycafeoylquiniques, procede de preparation et utilisations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
DE3770680D1 (de) * 1986-04-04 1991-07-18 Microbial Chem Res Found Spergualinaehnliche verbindungen und ihr herstellungsverfahren.
US5061787A (en) * 1988-06-24 1991-10-29 Nippon Kayaku Kabushiki Kaisha Novel spergualin-related compounds and compositions

Also Published As

Publication number Publication date
CN1045431C (zh) 1999-10-06
HU218908B (hu) 2000-12-28
FR2698628B1 (fr) 1995-02-17
EP0600762B1 (fr) 1996-07-10
NO180483C (no) 1997-04-30
SK280286B6 (sk) 1999-11-08
TW311132B (enExample) 1997-07-21
RU2114823C1 (ru) 1998-07-10
FI935318A0 (fi) 1993-11-29
DE69303583T2 (de) 1996-11-21
CA2110437A1 (en) 1994-06-03
NO180483B (no) 1997-01-20
JPH06293728A (ja) 1994-10-21
CZ262293A3 (en) 1994-06-15
NO934338L (no) 1994-06-03
CN1095709A (zh) 1994-11-30
NZ250330A (en) 1995-06-27
DE69303583D1 (de) 1996-08-14
US5476870A (en) 1995-12-19
NO934338D0 (no) 1993-11-30
HK1000467A1 (en) 1998-03-27
FR2698628A1 (fr) 1994-06-03
HUT65782A (en) 1994-07-28
FI935318L (fi) 1994-06-03
ATE140215T1 (de) 1996-07-15
CA2110437C (en) 1999-04-13
EP0600762A1 (fr) 1994-06-08
AU5188393A (en) 1994-06-16
HU9303406D0 (en) 1994-03-28
CZ284958B6 (cs) 1999-04-14
SK135793A3 (en) 1994-06-08
ZA938821B (en) 1994-06-30
KR940014435A (ko) 1994-07-18
GR3021269T3 (en) 1997-01-31
DK0600762T3 (da) 1996-11-11
KR100187328B1 (ko) 1999-05-15
UA39920C2 (uk) 2001-07-16
FI112211B (fi) 2003-11-14
AU664124B2 (en) 1995-11-02
ES2092263T3 (es) 1996-11-16

Similar Documents

Publication Publication Date Title
JP2945261B2 (ja) １５−デオキシスペルグアリン類似体、それらの製造方法および治療法での使用
CA1318457C (en) Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them
JP2874839B2 (ja) １５−デオキシスペルグアリンアナローグ、その製造方法および治療用としての用途
US5733928A (en) 15-deoxyspergualin analogs, their method of preparation and their use in therapeutics
US5110798A (en) Purine derivatives having pharmacological action
US5883132A (en) 15-deoxyspergualin analogs, their use in therapeutics and their method of preparation
US5137917A (en) Spergualin-related compound and use thereof
WO2000064865A1 (en) Monomers and oligourea peptidomimetics and process for the prepa ration thereof

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees