JP2944048B2 - 二環式テトラヒドロピラゾロピリジン - Google Patents
二環式テトラヒドロピラゾロピリジンInfo
- Publication number
- JP2944048B2 JP2944048B2 JP7503938A JP50393895A JP2944048B2 JP 2944048 B2 JP2944048 B2 JP 2944048B2 JP 7503938 A JP7503938 A JP 7503938A JP 50393895 A JP50393895 A JP 50393895A JP 2944048 B2 JP2944048 B2 JP 2944048B2
- Authority
- JP
- Japan
- Prior art keywords
- ethyl
- oxo
- pyridine
- tetrahydro
- pyrazolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US088,292 | 1987-08-24 | ||
| US8829293A | 1993-07-06 | 1993-07-06 | |
| US08/088,292 | 1993-07-06 | ||
| PCT/IB1994/000156 WO1995001980A1 (en) | 1993-07-06 | 1994-06-16 | Bicyclic tetrahydro pyrazolopyridines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH08507084A JPH08507084A (ja) | 1996-07-30 |
| JP2944048B2 true JP2944048B2 (ja) | 1999-08-30 |
Family
ID=22210524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7503938A Expired - Lifetime JP2944048B2 (ja) | 1993-07-06 | 1994-06-16 | 二環式テトラヒドロピラゾロピリジン |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0707585A1 (pt) |
| JP (1) | JP2944048B2 (pt) |
| KR (1) | KR100228949B1 (pt) |
| CN (1) | CN1048015C (pt) |
| AU (1) | AU695301B2 (pt) |
| BR (1) | BR9406946A (pt) |
| CA (1) | CA2166721C (pt) |
| CZ (1) | CZ3696A3 (pt) |
| EG (1) | EG20513A (pt) |
| FI (1) | FI943208A (pt) |
| HU (1) | HUT74170A (pt) |
| IL (1) | IL110175A (pt) |
| MX (1) | MX9405132A (pt) |
| NO (1) | NO305029B1 (pt) |
| NZ (1) | NZ266525A (pt) |
| PL (1) | PL312426A1 (pt) |
| RU (1) | RU2131876C1 (pt) |
| TW (1) | TW316904B (pt) |
| WO (1) | WO1995001980A1 (pt) |
| ZA (1) | ZA944844B (pt) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996012720A1 (en) * | 1994-10-20 | 1996-05-02 | Pfizer Inc. | Bicyclic tetrahydro pyrazolopyridines and their use as medicaments |
| JP3107827B2 (ja) * | 1995-06-06 | 2000-11-13 | ファイザー・インコーポレーテッド | トリサイクリック５，６−ジヒドロ−９Ｈ−ピラゾロ［３，４−ｃ］−１，２，４−トリアゾロ［４，３−ａ］ピリジン類 |
| AP932A (en) * | 1996-08-26 | 2001-02-02 | Pfizer | Tricyclic 5,6-dihydro-9H-pyrazolo (3,4c)-1,2,4,-triazolo (4,3-a) pyridines. |
| YU11299A (sh) * | 1996-09-04 | 2001-07-10 | Pfizer Inc. | Derivati indazola |
| KR100628407B1 (ko) | 1998-12-23 | 2006-09-26 | 브리스톨-마이어스 스퀴브 파마 컴파니 | Ｘａ 인자 억제제로서의 질소 함유 헤테로비시클릭 화합물 |
| US6858616B2 (en) | 1998-12-23 | 2005-02-22 | Bristol-Myers Squibb Pharma Company | Nitrogen containing heterobicycles as factor Xa inhibitors |
| US6326495B2 (en) | 1999-04-30 | 2001-12-04 | Pfizer Inc. | Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein |
| CA2715683A1 (en) | 1999-08-21 | 2001-03-01 | Nycomed Gmbh | Synergistic combination |
| TWI243055B (en) * | 2000-04-13 | 2005-11-11 | Nippon Zoki Pharmaceutical Co | Pharmaceutical composition for use in treatment of dermatitis |
| MXPA03001169A (es) * | 2000-08-10 | 2003-06-30 | Pharmacia Italia Spa | Biciclo-pirazoles activos como inhibidores de quinasa, proceso para su preparacion y composiciones farmaceuticas que comprenden los mismos. |
| US6960595B2 (en) * | 2001-03-23 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | 5-6 to 5-7 Heterobicycles as factor Xa inhibitors |
| CA2444571A1 (en) | 2001-04-18 | 2002-10-31 | Bristol-Myers Squibb Company | 1, 4, 5, 6-tetrahydropyrazolo-¬3, 4-c|-pyridin-7-ones as factor xa inhi bitors |
| CA2441772A1 (en) | 2001-04-18 | 2002-10-31 | Bristol-Myers Squibb Company | 1,4,5,6-tetrahydropyrazolo-¬3,4-c|-pyridin-7-ones as factor xa inhibitors |
| US7902179B2 (en) | 2001-04-26 | 2011-03-08 | Ajinomoto Co., Inc. | Heterocyclic compounds |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| CL2004000398A1 (es) | 2003-02-27 | 2005-03-18 | Uriach Y Compania S A J | Compuestos derivados de pirazolopiridinas, sus sales; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar enfermedades mediadas por quinasas p38, en especial por citocinas, tnf-alfa, il-1, il-6 y/o il-8, tales como enfermedad |
| US7135469B2 (en) * | 2003-03-18 | 2006-11-14 | Bristol Myers Squibb, Co. | Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors |
| AU2004226353A1 (en) | 2003-04-01 | 2004-10-14 | Laboratoires Serono Sa | Inhibitors of phosphodiesterases in infertility |
| US7145012B2 (en) | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| DE102005031580A1 (de) * | 2005-07-06 | 2007-01-11 | Aicuris Gmbh & Co. Kg | Substituierte Sulfolanylpyrazole und ihre Verwendung |
| PE20081889A1 (es) * | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| ES2393885T7 (es) | 2007-06-04 | 2014-01-30 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| JP6251038B2 (ja) | 2011-03-01 | 2017-12-20 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼｃアゴニストの調製方法 |
| AU2014218599C1 (en) | 2013-02-25 | 2018-09-06 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists for use in colonic cleansing |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| US10011637B2 (en) | 2013-06-05 | 2018-07-03 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
| JP6694385B2 (ja) | 2013-08-09 | 2020-05-13 | アーデリクス，インコーポレーテッド | リン酸塩輸送阻害のための化合物及び方法 |
| CN110357888A (zh) * | 2018-04-09 | 2019-10-22 | 南京药捷安康生物科技有限公司 | 杂环磷酸二酯酶抑制剂及其用途 |
| JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス， インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3365459A (en) * | 1964-09-08 | 1968-01-23 | Ciba Geigy Corp | Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives |
| US3340269A (en) * | 1964-09-08 | 1967-09-05 | Ciba Geigy Corp | 1-substituted 4-acyl-2, 3-dioxo-piperidine |
| FR1463883A (fr) * | 1964-09-08 | 1966-07-22 | Ciba Geigy | Procédé de préparation de triaza-composés bicycliques |
| US5356897A (en) * | 1991-09-09 | 1994-10-18 | Fujisawa Pharmaceutical Co., Ltd. | 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines |
-
1994
- 1994-06-16 CN CN94193233A patent/CN1048015C/zh not_active Expired - Fee Related
- 1994-06-16 PL PL94312426A patent/PL312426A1/xx unknown
- 1994-06-16 JP JP7503938A patent/JP2944048B2/ja not_active Expired - Lifetime
- 1994-06-16 BR BR9406946A patent/BR9406946A/pt not_active Application Discontinuation
- 1994-06-16 CA CA002166721A patent/CA2166721C/en not_active Expired - Fee Related
- 1994-06-16 KR KR1019960700019A patent/KR100228949B1/ko not_active IP Right Cessation
- 1994-06-16 EP EP94916370A patent/EP0707585A1/en not_active Withdrawn
- 1994-06-16 AU AU68057/94A patent/AU695301B2/en not_active Ceased
- 1994-06-16 NZ NZ266525A patent/NZ266525A/en unknown
- 1994-06-16 CZ CZ9636A patent/CZ3696A3/cs unknown
- 1994-06-16 HU HU9503934A patent/HUT74170A/hu unknown
- 1994-06-16 WO PCT/IB1994/000156 patent/WO1995001980A1/en not_active Application Discontinuation
- 1994-06-16 RU RU96103653A patent/RU2131876C1/ru active
- 1994-06-17 TW TW083105518A patent/TW316904B/zh active
- 1994-06-30 IL IL11017594A patent/IL110175A/xx active IP Right Grant
- 1994-07-05 EG EG40294A patent/EG20513A/xx active
- 1994-07-05 ZA ZA944844A patent/ZA944844B/xx unknown
- 1994-07-05 FI FI943208A patent/FI943208A/fi unknown
- 1994-07-05 MX MX9405132A patent/MX9405132A/es unknown
-
1996
- 1996-01-05 NO NO960056A patent/NO305029B1/no unknown
Non-Patent Citations (1)
| Title |
|---|
| Ｃｈｅｎ，Ｐｈａｒｍ，Ｂｕｌｌ，２４（８），１８７０〜８（１９７６） |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2166721A1 (en) | 1995-01-19 |
| AU6805794A (en) | 1995-02-06 |
| EP0707585A1 (en) | 1996-04-24 |
| JPH08507084A (ja) | 1996-07-30 |
| NO305029B1 (no) | 1999-03-22 |
| IL110175A0 (en) | 1994-10-07 |
| FI943208A0 (fi) | 1994-07-05 |
| CN1048015C (zh) | 2000-01-05 |
| CN1129940A (zh) | 1996-08-28 |
| KR100228949B1 (ko) | 1999-11-01 |
| PL312426A1 (en) | 1996-04-29 |
| CA2166721C (en) | 1999-07-27 |
| WO1995001980A1 (en) | 1995-01-19 |
| NZ266525A (en) | 1997-10-24 |
| CZ3696A3 (en) | 1997-06-11 |
| NO960056D0 (no) | 1996-01-05 |
| RU2131876C1 (ru) | 1999-06-20 |
| KR960703852A (ko) | 1996-08-31 |
| HU9503934D0 (en) | 1996-03-28 |
| TW316904B (pt) | 1997-10-01 |
| MX9405132A (es) | 1995-01-31 |
| NO960056L (no) | 1996-01-05 |
| FI943208A (fi) | 1995-01-07 |
| BR9406946A (pt) | 1996-08-06 |
| EG20513A (en) | 1999-06-30 |
| IL110175A (en) | 2000-01-31 |
| AU695301B2 (en) | 1998-08-13 |
| ZA944844B (en) | 1996-01-05 |
| HUT74170A (en) | 1996-11-28 |
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