JP2818097B2 - アゾール化合物、その製造方法及びその用途 - Google Patents

アゾール化合物、その製造方法及びその用途

Info

Publication number
JP2818097B2
JP2818097B2 JP5101216A JP10121693A JP2818097B2 JP 2818097 B2 JP2818097 B2 JP 2818097B2 JP 5101216 A JP5101216 A JP 5101216A JP 10121693 A JP10121693 A JP 10121693A JP 2818097 B2 JP2818097 B2 JP 2818097B2
Authority
JP
Japan
Prior art keywords
difluorophenyl
group
salt
phenyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP5101216A
Other languages
English (en)
Japanese (ja)
Other versions
JPH06293740A (ja
Inventor
克己 伊藤
研二 小此木
典一 田村
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Priority to JP5101216A priority Critical patent/JP2818097B2/ja
Priority to MYPI93001631A priority patent/MY109672A/en
Priority to MX9305295A priority patent/MX9305295A/es
Publication of JPH06293740A publication Critical patent/JPH06293740A/ja
Application granted granted Critical
Publication of JP2818097B2 publication Critical patent/JP2818097B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polymerization Catalysts (AREA)
  • Coloring (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Lubricants (AREA)
  • Adhesives Or Adhesive Processes (AREA)
JP5101216A 1992-04-28 1993-04-27 アゾール化合物、その製造方法及びその用途 Expired - Fee Related JP2818097B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP5101216A JP2818097B2 (ja) 1992-04-28 1993-04-27 アゾール化合物、その製造方法及びその用途
MYPI93001631A MY109672A (en) 1993-02-10 1993-08-17 Azole compounds, their production and use
MX9305295A MX9305295A (es) 1993-02-10 1993-08-31 Compuestos azol y proceso para su preparacion.

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP11040092 1992-04-28
JP5-22623 1993-02-10
JP2262393 1993-02-10
JP4-110400 1993-02-10
JP5101216A JP2818097B2 (ja) 1992-04-28 1993-04-27 アゾール化合物、その製造方法及びその用途

Publications (2)

Publication Number Publication Date
JPH06293740A JPH06293740A (ja) 1994-10-21
JP2818097B2 true JP2818097B2 (ja) 1998-10-30

Family

ID=26359882

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5101216A Expired - Fee Related JP2818097B2 (ja) 1992-04-28 1993-04-27 アゾール化合物、その製造方法及びその用途

Country Status (18)

Country Link
US (2) US5371101A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0567982B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP2818097B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR100257619B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1040433C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE167857T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU655544B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2094962A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE69319380T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK0567982T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2118160T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI931901A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (2) HUT64327A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO303284B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ247488A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH31082A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SG (1) SG48939A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW218017B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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TW297813B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1993-09-24 1997-02-11 Takeda Pharm Industry Co Ltd
CA2134417A1 (en) * 1993-12-22 1995-06-23 Katsumi Itoh Optically active azole derivatives, their production and use
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
US5814324A (en) * 1994-02-25 1998-09-29 Takeda Chemical Industries, Ltd. Injectable composition and a method of producing the same
US5677464A (en) * 1994-05-31 1997-10-14 Takeda Chemical Industries, Ltd. Production of optically active triazole compounds and their intermediates
US5637592A (en) * 1994-07-12 1997-06-10 Janssen Pharmaceutica N.V. Acyl derivatives of azolones
US5639754A (en) * 1994-07-12 1997-06-17 Janssen Pharmaceutica N.V. Urea and thiourea derivatives of azolones
WO1996025410A1 (en) * 1995-02-17 1996-08-22 Takeda Chemical Industries, Ltd. Azole compounds, their production and use
TW318841B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1995-02-17 1997-11-01 Takeda Pharm Industry Co Ltd
US5700825A (en) * 1995-03-31 1997-12-23 Florida State University Radiosensitizing diamines and their pharmaceutical preparations
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
DE19520597A1 (de) * 1995-06-06 1996-12-12 Bayer Ag Mercapto-bis-triazole
JP4049207B2 (ja) * 1995-08-02 2008-02-20 ホタ．ウリアチ イ コンパニア ソシエダッド アノニマ 抗真菌活性を有する新規ピリミドン誘導体
ES2120885B1 (es) * 1996-03-15 1999-06-16 Uriach & Cia Sa J Nuevas tienopirimidonas con actividad antifungica.
ES2107376B1 (es) * 1995-08-02 1998-07-01 Uriach & Cia Sa J Nuevos derivados de pirimidona con actividad antifungica.
KR970705560A (ko) * 1995-08-02 1997-10-09 호아껭 우리아치 토렐로 항진균 활성을 갖는 신규한 카르복사미드(new carboxamides with antifungal activity)
GB9602080D0 (en) 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
US6001835A (en) * 1996-04-03 1999-12-14 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JP2000507585A (ja) * 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド ファルネシルタンパク質トランスフェラーゼの阻害剤
WO1998039305A1 (en) * 1997-03-05 1998-09-11 Takeda Chemical Industries, Ltd. Crystalline form of a bis 1,2,4-triazole compound
KR20010005792A (ko) * 1997-03-31 2001-01-15 다케다 야쿠힌 고교 가부시키가이샤 아졸 화합물, 이의 제조 방법 및 용도
EP0884311A3 (en) * 1997-06-06 1999-01-27 Takeda Chemical Industries, Ltd. Triazole Derivatives and their production
US6133485A (en) * 1998-04-15 2000-10-17 Synphar Laboratories, Inc. Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols
AU5760999A (en) * 1998-09-29 2000-04-17 Takeda Chemical Industries Ltd. Antimycotic drug composition
IN191188B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2000-03-07 2003-10-04 Ranbaxy Lab Ltd
ES2159488B1 (es) 2000-03-07 2002-04-16 Uriach & Cia Sa J Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica.
JP2004501867A (ja) * 2000-03-07 2004-01-22 ランバクシー　ラボラトリーズ　リミテッド 真菌感染症に対する治療薬としてのアゾール化合物
CN1489465A (zh) 2000-12-26 2004-04-14 ʵ 作为抗真菌剂的吡咯化合物
JP2004524348A (ja) * 2001-03-23 2004-08-12 リチュテル・ゲデオン・ヴェジェーセティ・ジャール・エルテー フルコナゾールおよびその結晶変形の製造方法
IN191819B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 2001-07-19 2004-01-03 Ranbaxy Lab Ltd
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WO2003105841A1 (ja) 2002-06-18 2003-12-24 ポーラ化成工業株式会社 抗真菌医薬組成物
WO2004018485A1 (en) * 2002-08-26 2004-03-04 Ranbaxy Laboratories Limited Azole derivatives as antifungal agents
KR100572996B1 (ko) * 2003-08-12 2006-04-25 한국화학연구원 불소화 비닐 에테르 측쇄기를 갖는 아졸계 살균제 화합물및 그의 제조방법
HRP20130095T1 (hr) 2004-11-18 2013-03-31 Synta Pharmaceuticals Corp. Spojevi triazola koji moduliraju aktivnost hsp90
CN1304376C (zh) * 2005-03-04 2007-03-14 清华大学 一种卤化烷基咪唑型离子液体的制备方法
WO2007021966A1 (en) * 2005-08-12 2007-02-22 Synta Pharmaceuticals Corp. Pyrazole compounds that modulate hsp90 activity
US7662813B2 (en) * 2005-08-18 2010-02-16 Synta Pharmaceuticals Corp. Triazole compounds that modulate HSP90 activity
WO2007139960A2 (en) * 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Compounds that modulate hsp90 activity and methods for identifying same
CA2653332A1 (en) * 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
JP5441690B2 (ja) * 2006-05-25 2014-03-12 シンタ ファーマシューティカルズ コーポレーション Ｈｓｐ９０活性を調節するトリアゾール化合物
ES2484042T3 (es) * 2006-05-25 2014-08-08 Synta Pharmaceuticals Corporation Compuestos de triazol que modulan la actividad de HSP90
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KR101118410B1 (ko) * 2006-10-19 2012-04-23 에프. 호프만-라 로슈 아게 당뇨병을 위한 11베타-에이치에스디1 억제제로서의 이미다졸론 및 이미다졸리딘온 유도체
US9205086B2 (en) 2010-04-19 2015-12-08 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a Hsp90 inhibitory compounds and a EGFR inhibitor
CN102824342B (zh) * 2011-06-17 2016-03-30 全哲山 一类用作抗癫痫药的化合物及其可药用盐
US20140286902A1 (en) 2011-11-02 2014-09-25 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with platinum-containing agents
US9439899B2 (en) 2011-11-02 2016-09-13 Synta Pharmaceuticals Corp. Cancer therapy using a combination of HSP90 inhibitors with topoisomerase I inhibitors
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GB8306351D0 (en) * 1983-03-08 1983-04-13 Ici Plc Azole fungicides
DK159205C (da) * 1983-03-16 1991-03-04 Pfizer Bis(triazol)alkanol-forbindelser, anvendelse af disse, farmaceutiske praeparater og landbrugsfungicider indeholdende disse og fremgangsmaade til behandling af planter eller froe, som har en svampeinfektion
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NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
DK105189A (da) * 1988-03-04 1989-09-05 Sankyo Co Triazolderivater og fremgangsmaade til fremstilling deraf samt fungicide midler indeholdende derivaterne
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Also Published As

Publication number Publication date
NO931533L (no) 1993-10-29
AU3822193A (en) 1993-11-04
ES2118160T3 (es) 1998-09-16
FI931901A0 (fi) 1993-04-27
HUT64327A (en) 1993-12-28
DK0567982T3 (da) 1999-04-12
JPH06293740A (ja) 1994-10-21
EP0567982B1 (en) 1998-07-01
AU655544B2 (en) 1994-12-22
NO303284B1 (no) 1998-06-22
HU9301226D0 (en) 1993-07-28
NZ247488A (en) 1995-02-24
FI931901L (fi) 1993-10-29
ATE167857T1 (de) 1998-07-15
CN1040433C (zh) 1998-10-28
US5371101A (en) 1994-12-06
KR940005616A (ko) 1994-03-21
DE69319380D1 (de) 1998-08-06
SG48939A1 (en) 1998-05-18
PH31082A (en) 1998-02-05
EP0567982A1 (en) 1993-11-03
NO931533D0 (no) 1993-04-27
US5466820A (en) 1995-11-14
DE69319380T2 (de) 1998-10-29
CA2094962A1 (en) 1993-10-29
KR100257619B1 (en) 2000-07-01
CN1079467A (zh) 1993-12-15
HU211474A9 (en) 1995-11-28
TW218017B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-12-21
FI931901A7 (fi) 1993-10-29

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