CN1040433C - 唑类化合物及其生产方法和应用 - Google Patents

唑类化合物及其生产方法和应用 Download PDF

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Publication number
CN1040433C
CN1040433C CN93105239A CN93105239A CN1040433C CN 1040433 C CN1040433 C CN 1040433C CN 93105239 A CN93105239 A CN 93105239A CN 93105239 A CN93105239 A CN 93105239A CN 1040433 C CN1040433 C CN 1040433C
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CN
China
Prior art keywords
compound
phenyl
salt
difluorophenyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN93105239A
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English (en)
Chinese (zh)
Other versions
CN1079467A (zh
Inventor
伊藤克己
小此木研二
田村典一
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of CN1079467A publication Critical patent/CN1079467A/zh
Application granted granted Critical
Publication of CN1040433C publication Critical patent/CN1040433C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polymerization Catalysts (AREA)
  • Coloring (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Lubricants (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN93105239A 1992-04-28 1993-04-28 唑类化合物及其生产方法和应用 Expired - Fee Related CN1040433C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP110400/92 1992-04-28
JP11040092 1992-04-28
JP2262393 1993-02-10
JP22623/93 1993-02-10

Publications (2)

Publication Number Publication Date
CN1079467A CN1079467A (zh) 1993-12-15
CN1040433C true CN1040433C (zh) 1998-10-28

Family

ID=26359882

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93105239A Expired - Fee Related CN1040433C (zh) 1992-04-28 1993-04-28 唑类化合物及其生产方法和应用

Country Status (18)

Country Link
US (2) US5371101A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0567982B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP2818097B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR100257619B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1040433C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE167857T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU655544B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2094962A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE69319380T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK0567982T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2118160T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI931901L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (2) HUT64327A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO303284B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ247488A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH31082A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SG (1) SG48939A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW218017B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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TW297813B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1993-09-24 1997-02-11 Takeda Pharm Industry Co Ltd
CA2134417A1 (en) * 1993-12-22 1995-06-23 Katsumi Itoh Optically active azole derivatives, their production and use
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
CA2182698A1 (en) * 1994-02-25 1995-08-31 Jun Sato Injectable emulsions containing antifungal triazole derivatives
US5677464A (en) * 1994-05-31 1997-10-14 Takeda Chemical Industries, Ltd. Production of optically active triazole compounds and their intermediates
US5637592A (en) * 1994-07-12 1997-06-10 Janssen Pharmaceutica N.V. Acyl derivatives of azolones
US5639754A (en) * 1994-07-12 1997-06-17 Janssen Pharmaceutica N.V. Urea and thiourea derivatives of azolones
WO1996025410A1 (en) * 1995-02-17 1996-08-22 Takeda Chemical Industries, Ltd. Azole compounds, their production and use
TW318841B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1995-02-17 1997-11-01 Takeda Pharm Industry Co Ltd
US6060604A (en) 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US5700825A (en) * 1995-03-31 1997-12-23 Florida State University Radiosensitizing diamines and their pharmaceutical preparations
DE19520597A1 (de) * 1995-06-06 1996-12-12 Bayer Ag Mercapto-bis-triazole
BR9606547A (pt) * 1995-08-02 1997-10-14 Uriach & Cia Sa J Novos derivados de pirimidona com atividade fungicida
ES2120885B1 (es) * 1996-03-15 1999-06-16 Uriach & Cia Sa J Nuevas tienopirimidonas con actividad antifungica.
CA2201478A1 (en) * 1995-08-02 1997-02-13 J. Uriach & Cia S.A. New carboxamides with antifungal activity
ES2107376B1 (es) * 1995-08-02 1998-07-01 Uriach & Cia Sa J Nuevos derivados de pirimidona con actividad antifungica.
GB9602080D0 (en) 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
AU715603B2 (en) * 1996-04-03 2000-02-03 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6001835A (en) * 1996-04-03 1999-12-14 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1998039305A1 (en) * 1997-03-05 1998-09-11 Takeda Chemical Industries, Ltd. Crystalline form of a bis 1,2,4-triazole compound
DE69816284T2 (de) 1997-03-31 2004-05-27 Takeda Chemical Industries, Ltd. Azol-verbindungen, ihre herstellung und ihre verwendung
EP0884311A3 (en) * 1997-06-06 1999-01-27 Takeda Chemical Industries, Ltd. Triazole Derivatives and their production
US6133485A (en) * 1998-04-15 2000-10-17 Synphar Laboratories, Inc. Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols
CA2345612A1 (en) 1998-09-29 2000-04-06 Masao Nagao Anti-fungal composition
ES2159488B1 (es) * 2000-03-07 2002-04-16 Uriach & Cia Sa J Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica.
PL365072A1 (en) * 2000-03-07 2004-12-27 Ranbaxy Laboratories Limited Azole compounds as therapeutic agents for fungal infections
IN191188B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2000-03-07 2003-10-04 Ranbaxy Lab Ltd
EA200300725A1 (ru) * 2000-12-26 2004-04-29 Ранбакси Лабораторис Лимитед Соединение азола в качестве противогрибковых средств
ES2252209T3 (es) * 2001-03-23 2006-05-16 Richter Gedeon Vegyeszeti Gyar R.T. Proceso para preparar fluconazol y sus modificaciones cristalinas.
IN191819B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 2001-07-19 2004-01-03 Ranbaxy Lab Ltd
IN192526B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 2001-09-25 2004-04-24 Ranbaxy Lab
US7028055B2 (en) * 2002-03-22 2006-04-11 Sun Microsystems, Inc. Method and apparatus for improving transaction specification by marking application states
EA200401336A1 (ru) * 2002-04-12 2006-02-24 Ранбакси Лабораторис Лимитед Производные 2,2,4-тризамещенного тетрагидрофурана в качестве противогрибковых средств
EP1537868B1 (en) * 2002-06-18 2011-08-24 Pola Pharma Inc. Antifungal medicinal compositions
AU2002328176A1 (en) * 2002-08-26 2004-03-11 Ranbaxy Laboratories Limited Azole derivatives as antifungal agents
KR100572996B1 (ko) * 2003-08-12 2006-04-25 한국화학연구원 불소화 비닐 에테르 측쇄기를 갖는 아졸계 살균제 화합물및 그의 제조방법
CN103554042B (zh) * 2004-11-18 2016-08-10 Synta医药公司 调节hsp90活性的三唑化合物
CN1304376C (zh) * 2005-03-04 2007-03-14 清华大学 一种卤化烷基咪唑型离子液体的制备方法
AU2006279794B2 (en) * 2005-08-12 2011-04-07 Synta Pharmaceuticals Corp. Pyrazole compounds that modulate HSP90 activity
WO2007094819A2 (en) * 2005-08-18 2007-08-23 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
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AU2007267860B2 (en) * 2006-05-25 2012-08-09 Synta Pharmaceuticals Corp. Triazole compounds that modulate Hsp90 activity
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CN102824342B (zh) * 2011-06-17 2016-03-30 全哲山 一类用作抗癫痫药的化合物及其可药用盐
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Citations (3)

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US4625036A (en) * 1983-03-08 1986-11-25 Imperial Chemical Industries Plc Antifungal azole compounds
US4925863A (en) * 1984-09-05 1990-05-15 Imperial Chemical Industries Plc Antifugal azole compounds
US5126359A (en) * 1988-11-04 1992-06-30 Bayer Aktiengesellschaft Substituted bisazoles and their use as medicaments

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DK159205C (da) * 1983-03-16 1991-03-04 Pfizer Bis(triazol)alkanol-forbindelser, anvendelse af disse, farmaceutiske praeparater og landbrugsfungicider indeholdende disse og fremgangsmaade til behandling af planter eller froe, som har en svampeinfektion
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
HUT53889A (en) * 1988-03-04 1990-12-28 Sankyo Co. Ltd.,Jp Fungicides comprising triazole derivatives as active ingredient and process for producing the active ingredient

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US4625036A (en) * 1983-03-08 1986-11-25 Imperial Chemical Industries Plc Antifungal azole compounds
US4925863A (en) * 1984-09-05 1990-05-15 Imperial Chemical Industries Plc Antifugal azole compounds
US5126359A (en) * 1988-11-04 1992-06-30 Bayer Aktiengesellschaft Substituted bisazoles and their use as medicaments

Also Published As

Publication number Publication date
NO931533L (no) 1993-10-29
KR940005616A (ko) 1994-03-21
HU9301226D0 (en) 1993-07-28
PH31082A (en) 1998-02-05
KR100257619B1 (en) 2000-07-01
DE69319380T2 (de) 1998-10-29
AU3822193A (en) 1993-11-04
FI931901A7 (fi) 1993-10-29
AU655544B2 (en) 1994-12-22
JP2818097B2 (ja) 1998-10-30
US5466820A (en) 1995-11-14
NO303284B1 (no) 1998-06-22
HUT64327A (en) 1993-12-28
TW218017B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-12-21
DK0567982T3 (da) 1999-04-12
JPH06293740A (ja) 1994-10-21
EP0567982B1 (en) 1998-07-01
FI931901A0 (fi) 1993-04-27
US5371101A (en) 1994-12-06
SG48939A1 (en) 1998-05-18
FI931901L (fi) 1993-10-29
DE69319380D1 (de) 1998-08-06
NO931533D0 (no) 1993-04-27
CN1079467A (zh) 1993-12-15
ATE167857T1 (de) 1998-07-15
NZ247488A (en) 1995-02-24
CA2094962A1 (en) 1993-10-29
EP0567982A1 (en) 1993-11-03
HU211474A9 (en) 1995-11-28
ES2118160T3 (es) 1998-09-16

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