JP2740775B2 - 新規シクロスポリン類 - Google Patents

新規シクロスポリン類

Info

Publication number
JP2740775B2
JP2740775B2 JP3287501A JP28750191A JP2740775B2 JP 2740775 B2 JP2740775 B2 JP 2740775B2 JP 3287501 A JP3287501 A JP 3287501A JP 28750191 A JP28750191 A JP 28750191A JP 2740775 B2 JP2740775 B2 JP 2740775B2
Authority
JP
Japan
Prior art keywords
cyclosporin
meleu
hydroxy
mebmt
meval
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP3287501A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05208996A (ja
Inventor
スー・ヨン・コー
ハンス・コーベル
ブリギッテ・ローゼンヴィルス
ディーター・ゼーバッハ
ルネ・ペー・トラベール
ローラン・ヴェンガー
ピエトロ・ボーリンガー
Original Assignee
ノバルティス アクチエンゲゼルシャフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27517009&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2740775(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB909023859A external-priority patent/GB9023859D0/en
Priority claimed from GB909023971A external-priority patent/GB9023971D0/en
Priority claimed from GB909023970A external-priority patent/GB9023970D0/en
Priority claimed from GB909023972A external-priority patent/GB9023972D0/en
Priority claimed from GB919116836A external-priority patent/GB9116836D0/en
Application filed by ノバルティス アクチエンゲゼルシャフト filed Critical ノバルティス アクチエンゲゼルシャフト
Publication of JPH05208996A publication Critical patent/JPH05208996A/ja
Application granted granted Critical
Publication of JP2740775B2 publication Critical patent/JP2740775B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
JP3287501A 1990-11-02 1991-11-01 新規シクロスポリン類 Expired - Lifetime JP2740775B2 (ja)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
GB909023859A GB9023859D0 (en) 1990-11-02 1990-11-02 Chemical products
GB909023971A GB9023971D0 (en) 1990-11-05 1990-11-05 New use of a cyclosporin derivative
GB909023970A GB9023970D0 (en) 1990-11-05 1990-11-05 New use of a cyclosporin derivative
GB909023972A GB9023972D0 (en) 1990-11-05 1990-11-05 New use of a cyclosporin derivative
GB9023971.6 1991-08-05
GB9023970.8 1991-08-05
GB919116836A GB9116836D0 (en) 1991-08-05 1991-08-05 Organic compounds
GB9023859.3 1991-08-05
GB9116836.9 1991-08-05
GB9023972.4 1991-08-05

Publications (2)

Publication Number Publication Date
JPH05208996A JPH05208996A (ja) 1993-08-20
JP2740775B2 true JP2740775B2 (ja) 1998-04-15

Family

ID=27517009

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3287501A Expired - Lifetime JP2740775B2 (ja) 1990-11-02 1991-11-01 新規シクロスポリン類

Country Status (24)

Country Link
US (3) US5767069A (en:Method)
EP (1) EP0484281B2 (en:Method)
JP (1) JP2740775B2 (en:Method)
KR (1) KR100203556B1 (en:Method)
AT (1) ATE148469T1 (en:Method)
AU (1) AU649277B2 (en:Method)
CA (1) CA2054590C (en:Method)
CY (1) CY2159B1 (en:Method)
CZ (1) CZ280909B6 (en:Method)
DE (1) DE69124459T3 (en:Method)
DK (1) DK0484281T4 (en:Method)
ES (1) ES2095926T5 (en:Method)
FI (1) FI111730B (en:Method)
GR (2) GR3022592T3 (en:Method)
HU (1) HU212674B (en:Method)
IE (1) IE913824A1 (en:Method)
IL (1) IL99912A (en:Method)
MX (1) MX9101869A (en:Method)
MY (1) MY134806A (en:Method)
NZ (1) NZ240421A (en:Method)
PL (1) PL168609B1 (en:Method)
PT (1) PT99410B (en:Method)
SA (1) SA92120344B1 (en:Method)
SK (1) SK278808B6 (en:Method)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993014780A1 (en) * 1992-01-28 1993-08-05 Abraham Karpas The use of a compound for the manufacture of a medicament for the treatment of hiv infection
GB9204466D0 (en) * 1992-03-02 1992-04-15 Sandoz Ltd Improvements in or relating to organic compounds
ES2065273B1 (es) * 1993-05-25 1995-09-16 Biogal Gyogyszergyar Procedimiento para la purificacion de ciclosporina a.
US5639852A (en) * 1994-09-01 1997-06-17 Wisconsin Alumni Research Foundation Immunostimulatory agents
US5948693A (en) * 1994-09-01 1999-09-07 Wisconsin Alumni Research Foundation Solid phase synthesis of immunosuppressive agents
US6696413B2 (en) 1995-06-16 2004-02-24 Hexal Ag Pharmaceutical preparation with cyclosporin A
CN1141317C (zh) * 1995-07-17 2004-03-10 碳化学公司 有抗人体免疫缺损病毒作用的环孢菌素衍生物
JP3089350B2 (ja) * 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド シクロフィリンロタマーゼ活性の阻害剤
EP0944394A4 (en) * 1996-03-12 2003-05-14 Picower Inst Med Res TREATING HIV INFECTION BY INFLUENCING CYCLOPHILIN RECEPTOR ACTIVITY IN THE HOST CELL
CN1130373C (zh) * 1996-09-13 2003-12-10 诺瓦蒂斯有限公司 [3'－脱氧－3'－氧代－MeBmt]'环孢菌素制备方法
FR2757522B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757521B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757520B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent
FR2762843B1 (fr) * 1997-04-30 1999-12-10 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
DE69840586D1 (de) 1997-10-08 2009-04-02 Isotechnika Inc Deuterierte Cyclosporin-analoga und ihre Verwendung als immunmodulierende Agenzien
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
ZA99981B (en) * 1998-02-17 2000-08-08 Du Pont Pharm Co Oral liquid formulations of benzoxazinones HIV reverse transcriptase inhibitors.
GB9811854D0 (en) * 1998-06-02 1998-07-29 Ciba Geigy Ag Organic compounds
FR2780061B1 (fr) 1998-06-22 2001-09-07 Rhone Poulenc Rorer Sa Nouveau procede de preparation de derives de cyclosporine
AU759480B2 (en) * 1998-07-01 2003-04-17 Debiopharm S.A. Novel cyclosporin with improved activity profile
CA2358448C (en) 1998-12-30 2009-02-10 Dexcel Ltd. Dispersible concentrate for the delivery of cyclosporin
US6521595B1 (en) * 1999-11-19 2003-02-18 Lg Chemical, Ltd. Nonimmunosuppressive [γ-hydroxy-methylleucine4] cyclosporin A, hair growth stimulator and external composition for skin using the same
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US6995139B2 (en) * 2001-04-20 2006-02-07 Debiopharm S.A. Cyclic undecapeptide pro-drugs and uses thereof
KR100695611B1 (ko) * 2001-05-17 2007-03-14 주식회사 엘지생활건강 [감마 히드록시 엔-메틸 엘-루신4] 사이클로스포린유도체를 유효성분으로 하는 모발 성장 촉진제
RU2321593C9 (ru) 2001-10-19 2008-06-20 Изотехника Инк. Синтез аналогов циклоспорина
PL206018B1 (pl) * 2001-10-19 2010-06-30 Isotechnika Inc Preparat farmaceutyczny, sposób jego wytwarzania, mikroemulsja i zastosowanie tego preparatu farmaceutycznego
WO2003038032A2 (de) * 2001-10-25 2003-05-08 Viromics Gmbh Mittel zur hemmung der synthese von virusproteinen
US7108988B2 (en) * 2001-11-02 2006-09-19 The J. David Gladstone Institutes Methods of identifying agents for inhibiting lentivirus replication
JP2006524232A (ja) 2003-03-17 2006-10-26 アルバニー モレキュラー リサーチ インコーポレーティッド 新規サイクロスポリン
GB0320638D0 (en) * 2003-09-03 2003-10-01 Novartis Ag Organic compounds
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
EP1742652A2 (en) * 2004-04-08 2007-01-17 Novartis AG Use of cyclosporins for treatment of cerebral ischemia and brain and spinal cord injury
EP1893226A1 (en) * 2004-07-13 2008-03-05 Novartis AG Cyclosporins to treat alzheimer's disease
US7671017B2 (en) 2004-07-14 2010-03-02 Novartis Ag Use of a combination of cyclosporine and pegylated interferon for treating hepatitis C (HCV)
KR100597309B1 (ko) 2004-09-17 2006-07-05 주식회사 핸슨바이오텍 세베키아 베니하나를 이용한 [감마 히드록실메틸루신4] 사이클로스포린 a의 제조방법
EP1809656A4 (en) * 2004-09-29 2009-03-25 Amr Technology Inc CYCLOSPORINAL KINANALOGA AND ITS PHARMACEUTICAL APPLICATIONS
WO2006039164A2 (en) 2004-09-29 2006-04-13 Amr Technology, Inc. Novel cyclosporin analogues and their pharmaceutical uses
CA2583494C (en) * 2004-10-01 2014-01-21 Scynexis, Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis c infection
US7196161B2 (en) * 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
US7361636B2 (en) * 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
US7135455B2 (en) * 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
US7151085B2 (en) * 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
KR100777488B1 (ko) 2004-12-15 2007-11-28 주식회사 핸슨바이오텍 세베키아 베니하나 (Sebekia benihana)배양물로부터 감마-히드록실메틸루신4 사이클로스포린 A를 효과적이고 선택적으로 회수하는 방법
KR20070089954A (ko) * 2004-12-23 2007-09-04 노파르티스 아게 플라비비리대 치료용 화합물
RU2007128099A (ru) 2004-12-23 2009-01-27 Новартис АГ (CH) Композиции для лечения гепатита с
JP5322647B2 (ja) * 2005-09-30 2013-10-23 スシネキス インク ウイルス感染の治療及び予防のためのシクロスポリンａのアリールアルキル及びヘテロアリールアルキル誘導体
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
EP2007789B1 (en) 2006-04-11 2015-05-20 Novartis AG Spirocyclic HCV/HIV inhibitors and their uses
ATE502633T1 (de) 2006-05-19 2011-04-15 Scynexis Inc Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
CN101502196A (zh) * 2006-06-02 2009-08-05 克洛德·安妮·佩里西恩 激活电子的管理
US7576057B2 (en) * 2006-11-20 2009-08-18 Scynexis, Inc. Cyclic peptides
WO2008127613A1 (en) * 2007-04-11 2008-10-23 Scynexis, Inc. New pharmaceutical compositions
NZ584356A (en) * 2007-09-26 2011-10-28 Univ Oregon Health & Science Cyclic undecapeptides and derivatives as multiple sclerosis therapies
US20090306033A1 (en) * 2008-06-06 2009-12-10 Keqiang Li Novel cyclic peptides
CN102083852A (zh) * 2008-06-06 2011-06-01 西尼克斯公司 环孢菌素类似物及其在治疗hcv感染中的应用
JP5726733B2 (ja) * 2008-07-30 2015-06-03 シクロフィリン ファーマシューティカルズ コープ． 非免疫抑制性シクロスポリン類似体分子
JP5780969B2 (ja) 2008-12-31 2015-09-16 サイネクシス，インコーポレーテッド シクロスポリンａの誘導体
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
US8481483B2 (en) * 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US20110182850A1 (en) 2009-04-10 2011-07-28 Trixi Brandl Organic compounds and their uses
US8512690B2 (en) 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
GB0909754D0 (en) * 2009-06-05 2009-07-22 Magnani Mauro Drug delivery systems
EP2516387B1 (en) * 2009-12-21 2018-02-21 Institut National de la Sante et de la Recherche Medicale (INSERM) Inhibitors of cyclophilins for use in the prevention and/or the treatment of viral pathologies or infections
KR20120125610A (ko) 2009-12-30 2012-11-16 싸이넥시스, 인크. 시클로스포린 유사체
WO2012009715A2 (en) 2010-07-16 2012-01-19 S&T Global Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection
CN103153330B (zh) 2010-08-12 2017-08-18 美国科技环球有限公司 新的环孢霉素衍生物在病毒感染的治疗和预防中的应用
CN103179966B (zh) 2010-10-08 2017-03-15 诺瓦提斯公司 磺酰胺ns3抑制剂的维生素e制剂
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
HRP20190096T1 (hr) 2010-12-15 2019-02-22 Contravir Pharmaceuticals, Inc. Molekule analoga ciklosporina modificirani na amino kiselini 1 i 3
US20120253007A1 (en) * 2011-03-28 2012-10-04 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Synthesis of Cyclosporin H
US20140205566A1 (en) 2012-11-30 2014-07-24 Novartis Ag Cyclic nucleuoside derivatives and uses thereof
US20170246187A1 (en) 2014-08-28 2017-08-31 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
US20160361322A1 (en) 2015-06-15 2016-12-15 Lipocine Inc. Composition and method for oral delivery of androgen prodrugs
JP2020503269A (ja) 2016-11-28 2020-01-30 リポカイン インコーポレーテッド 経口ウンデカン酸テストステロン療法
EP3824296A4 (en) 2018-07-20 2022-04-27 Lipocine Inc. LIVER DISEASE
CN111449050A (zh) 2019-01-20 2020-07-28 睿诺医疗科技（上海）有限公司 环孢菌素类似物及其用途
TWI887279B (zh) 2019-10-12 2025-06-21 大陸商睿諾醫療科技（上海）有限公司 腎毒素引起的腎損傷的治療和預防
CA3172601A1 (en) 2020-03-26 2021-09-30 Ching-Pong Mak Preparation of cyclosporin derivatives
JP2023521161A (ja) 2020-04-15 2023-05-23 ファーサイト メディカル テクノロジー （シャンハイ） カンパニー リミテッド 臓器傷害の予防及び処置

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2455859C2 (de) 1973-12-06 1983-12-15 Sandoz-Patent-GmbH, 7850 Lörrach Das Antibiotikum Cyclosporin A (S 7481/F-1), seine Herstellung und Verwendung
US4304855A (en) * 1977-05-05 1981-12-08 The Upjohn Company Allylic methyl-hydroxylated novobiocins
CH667274A5 (de) * 1984-03-23 1988-09-30 Sandoz Ag Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
EP0194972B1 (en) * 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
US4814323A (en) * 1986-03-25 1989-03-21 Andrieu J M Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
EP0283801A3 (en) * 1987-03-27 1990-05-30 Abbott Laboratories Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
EP0373260B1 (en) * 1987-06-22 1994-03-09 Merck & Co. Inc. Cyclosporin derivatives with modified "8-amino acid"
GB8717300D0 (en) * 1987-07-22 1987-08-26 Nat Res Dev Cyclosporins
US4981799A (en) * 1987-08-21 1991-01-01 Takeda Chemical Industries, Ltd. Acylamino acid racemase, production and use thereof
US4914188A (en) † 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
US5081024A (en) * 1988-09-05 1992-01-14 Nissan Chemical Industries, Ltd. Process for producing optically active amino acids
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8

Also Published As

Publication number Publication date
DE69124459T2 (de) 1997-07-10
EP0484281A2 (en) 1992-05-06
ES2095926T3 (es) 1997-03-01
US6255100B1 (en) 2001-07-03
CA2054590A1 (en) 1992-05-03
CA2054590C (en) 2003-09-16
FI915135L (fi) 1992-05-03
CZ280909B6 (cs) 1996-05-15
HU212674B (en) 1996-09-30
PL292248A1 (en) 1992-07-27
MX9101869A (es) 1993-04-01
MY134806A (en) 2007-12-31
PT99410B (pt) 1999-04-30
SA92120344B1 (ar) 2004-01-24
AU649277B2 (en) 1994-05-19
HUT62337A (en) 1993-04-28
KR100203556B1 (ko) 1999-06-15
KR920009390A (ko) 1992-06-25
DE69124459T3 (de) 2001-05-31
DK0484281T3 (en:Method) 1997-02-17
FI915135A0 (fi) 1991-10-30
JPH05208996A (ja) 1993-08-20
HK1005741A1 (en) 1999-01-22
EP0484281B1 (en) 1997-01-29
PT99410A (pt) 1992-09-30
EP0484281A3 (en) 1993-02-24
SK278808B6 (sk) 1998-03-04
PL168609B1 (pl) 1996-03-29
GR3035323T3 (en) 2001-04-30
FI111730B (fi) 2003-09-15
US5981479A (en) 1999-11-09
IL99912A (en) 1996-09-12
CY2159B1 (en) 2002-08-23
HU913446D0 (en) 1992-01-28
DK0484281T4 (da) 2001-02-05
EP0484281B2 (en) 2000-11-22
GR3022592T3 (en) 1997-05-31
IL99912A0 (en) 1992-08-18
AU8692391A (en) 1992-05-07
NZ240421A (en) 1993-04-28
ES2095926T5 (es) 2001-02-16
IE913824A1 (en) 1992-05-22
CS329791A3 (en) 1992-05-13
US5767069A (en) 1998-06-16
DE69124459D1 (de) 1997-03-13
ATE148469T1 (de) 1997-02-15

Similar Documents

Publication Publication Date Title
JP2740775B2 (ja) 新規シクロスポリン類
EP0056782B1 (en) Novel cyclosporins
US4639434A (en) Novel cyclosporins
US4764503A (en) Novel cyclosporins
JP4350898B2 (ja) 活性の特徴が改善された新規のシクロスポリン
US4914188A (en) Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
CA2036963A1 (en) Immunosuppressive cyclosporin analogs with modified amino acids at position-8
HU204101B (en) Process for producing cyclic peptolids and pharmaceutical compositions comprising such compounds
GB2207678A (en) Novel immunosuppressive fluorinated cyclosporin analogs
RU2085589C1 (ru) Циклоспорины
HK1005741B (en) Cyclosporins
AU596071B2 (en) Novel cyclosporins
RO110144B1 (ro) Noi ciclosporine, procedeu de sinteză a acestora și metodă de tratament și prevenire a SIDA
NO310028B1 (no) Cyklosporiner, deres anvendelse og fremstilling samt en biologisk ren kilde

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20080130

Year of fee payment: 10

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20090130

Year of fee payment: 11

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20090130

Year of fee payment: 11

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20100130

Year of fee payment: 12

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110130

Year of fee payment: 13

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110130

Year of fee payment: 13

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120130

Year of fee payment: 14

EXPY Cancellation because of completion of term
FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120130

Year of fee payment: 14