IL99912A - Cyclosporins their preparation and pharmaceutical compositions containing them - Google Patents

Cyclosporins their preparation and pharmaceutical compositions containing them

Info

Publication number
IL99912A
IL99912A IL9991291A IL9991291A IL99912A IL 99912 A IL99912 A IL 99912A IL 9991291 A IL9991291 A IL 9991291A IL 9991291 A IL9991291 A IL 9991291A IL 99912 A IL99912 A IL 99912A
Authority
IL
Israel
Prior art keywords
meleu
ciclosporin
hydroxy
meval
mebmt
Prior art date
Application number
IL9991291A
Other languages
English (en)
Other versions
IL99912A0 (en
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27517009&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL99912(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB909023859A external-priority patent/GB9023859D0/en
Priority claimed from GB909023971A external-priority patent/GB9023971D0/en
Priority claimed from GB909023970A external-priority patent/GB9023970D0/en
Priority claimed from GB909023972A external-priority patent/GB9023972D0/en
Priority claimed from GB919116836A external-priority patent/GB9116836D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IL99912A0 publication Critical patent/IL99912A0/xx
Publication of IL99912A publication Critical patent/IL99912A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
IL9991291A 1990-11-02 1991-10-31 Cyclosporins their preparation and pharmaceutical compositions containing them IL99912A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB909023859A GB9023859D0 (en) 1990-11-02 1990-11-02 Chemical products
GB909023971A GB9023971D0 (en) 1990-11-05 1990-11-05 New use of a cyclosporin derivative
GB909023970A GB9023970D0 (en) 1990-11-05 1990-11-05 New use of a cyclosporin derivative
GB909023972A GB9023972D0 (en) 1990-11-05 1990-11-05 New use of a cyclosporin derivative
GB919116836A GB9116836D0 (en) 1991-08-05 1991-08-05 Organic compounds

Publications (2)

Publication Number Publication Date
IL99912A0 IL99912A0 (en) 1992-08-18
IL99912A true IL99912A (en) 1996-09-12

Family

ID=27517009

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9991291A IL99912A (en) 1990-11-02 1991-10-31 Cyclosporins their preparation and pharmaceutical compositions containing them

Country Status (24)

Country Link
US (3) US5767069A (en:Method)
EP (1) EP0484281B2 (en:Method)
JP (1) JP2740775B2 (en:Method)
KR (1) KR100203556B1 (en:Method)
AT (1) ATE148469T1 (en:Method)
AU (1) AU649277B2 (en:Method)
CA (1) CA2054590C (en:Method)
CY (1) CY2159B1 (en:Method)
CZ (1) CZ280909B6 (en:Method)
DE (1) DE69124459T3 (en:Method)
DK (1) DK0484281T4 (en:Method)
ES (1) ES2095926T5 (en:Method)
FI (1) FI111730B (en:Method)
GR (2) GR3022592T3 (en:Method)
HU (1) HU212674B (en:Method)
IE (1) IE913824A1 (en:Method)
IL (1) IL99912A (en:Method)
MX (1) MX9101869A (en:Method)
MY (1) MY134806A (en:Method)
NZ (1) NZ240421A (en:Method)
PL (1) PL168609B1 (en:Method)
PT (1) PT99410B (en:Method)
SA (1) SA92120344B1 (en:Method)
SK (1) SK278808B6 (en:Method)

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* Cited by examiner, † Cited by third party
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ES2065273B1 (es) * 1993-05-25 1995-09-16 Biogal Gyogyszergyar Procedimiento para la purificacion de ciclosporina a.
US5639852A (en) * 1994-09-01 1997-06-17 Wisconsin Alumni Research Foundation Immunostimulatory agents
US5948693A (en) * 1994-09-01 1999-09-07 Wisconsin Alumni Research Foundation Solid phase synthesis of immunosuppressive agents
US6696413B2 (en) 1995-06-16 2004-02-24 Hexal Ag Pharmaceutical preparation with cyclosporin A
CN1141317C (zh) * 1995-07-17 2004-03-10 碳化学公司 有抗人体免疫缺损病毒作用的环孢菌素衍生物
JP3089350B2 (ja) * 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド シクロフィリンロタマーゼ活性の阻害剤
EP0944394A4 (en) * 1996-03-12 2003-05-14 Picower Inst Med Res TREATING HIV INFECTION BY INFLUENCING CYCLOPHILIN RECEPTOR ACTIVITY IN THE HOST CELL
CN1130373C (zh) * 1996-09-13 2003-12-10 诺瓦蒂斯有限公司 [3'－脱氧－3'－氧代－MeBmt]'环孢菌素制备方法
FR2757522B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757521B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757520B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent
FR2762843B1 (fr) * 1997-04-30 1999-12-10 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
DE69840586D1 (de) 1997-10-08 2009-04-02 Isotechnika Inc Deuterierte Cyclosporin-analoga und ihre Verwendung als immunmodulierende Agenzien
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
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Also Published As

Publication number Publication date
DE69124459T2 (de) 1997-07-10
EP0484281A2 (en) 1992-05-06
ES2095926T3 (es) 1997-03-01
US6255100B1 (en) 2001-07-03
CA2054590A1 (en) 1992-05-03
CA2054590C (en) 2003-09-16
FI915135L (fi) 1992-05-03
CZ280909B6 (cs) 1996-05-15
HU212674B (en) 1996-09-30
PL292248A1 (en) 1992-07-27
MX9101869A (es) 1993-04-01
MY134806A (en) 2007-12-31
PT99410B (pt) 1999-04-30
SA92120344B1 (ar) 2004-01-24
AU649277B2 (en) 1994-05-19
HUT62337A (en) 1993-04-28
KR100203556B1 (ko) 1999-06-15
KR920009390A (ko) 1992-06-25
JP2740775B2 (ja) 1998-04-15
DE69124459T3 (de) 2001-05-31
DK0484281T3 (en:Method) 1997-02-17
FI915135A0 (fi) 1991-10-30
JPH05208996A (ja) 1993-08-20
HK1005741A1 (en) 1999-01-22
EP0484281B1 (en) 1997-01-29
PT99410A (pt) 1992-09-30
EP0484281A3 (en) 1993-02-24
SK278808B6 (sk) 1998-03-04
PL168609B1 (pl) 1996-03-29
GR3035323T3 (en) 2001-04-30
FI111730B (fi) 2003-09-15
US5981479A (en) 1999-11-09
CY2159B1 (en) 2002-08-23
HU913446D0 (en) 1992-01-28
DK0484281T4 (da) 2001-02-05
EP0484281B2 (en) 2000-11-22
GR3022592T3 (en) 1997-05-31
IL99912A0 (en) 1992-08-18
AU8692391A (en) 1992-05-07
NZ240421A (en) 1993-04-28
ES2095926T5 (es) 2001-02-16
IE913824A1 (en) 1992-05-22
CS329791A3 (en) 1992-05-13
US5767069A (en) 1998-06-16
DE69124459D1 (de) 1997-03-13
ATE148469T1 (de) 1997-02-15

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