JP2644946B2 - ＩｇＧ− モノクロナール抗体の精製方法及びその使用方法 - Google Patents

ＩｇＧ− モノクロナール抗体の精製方法及びその使用方法

Info

Publication number
JP2644946B2
JP2644946B2 JP4145807A JP14580792A JP2644946B2 JP 2644946 B2 JP2644946 B2 JP 2644946B2 JP 4145807 A JP4145807 A JP 4145807A JP 14580792 A JP14580792 A JP 14580792A JP 2644946 B2 JP2644946 B2 JP 2644946B2
Authority
JP
Japan
Prior art keywords
igg
monoclonal antibody
antibody
solution
chromatographed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP4145807A
Other languages
English (en)
Japanese (ja)
Other versions
JPH07267997A (ja
Inventor
ノルベルト・コーテ
デイーター・ルートニック
デトレーフ・ローム
ウルフ・ベートケ
ミッヒヤエル・クロフト
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIOTESUTO AG
Original Assignee
BIOTESUTO AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIOTESUTO AG filed Critical BIOTESUTO AG
Publication of JPH07267997A publication Critical patent/JPH07267997A/ja
Application granted granted Critical
Publication of JP2644946B2 publication Critical patent/JP2644946B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP4145807A 1991-06-08 1992-06-05 ＩｇＧ− モノクロナール抗体の精製方法及びその使用方法 Expired - Fee Related JP2644946B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4118912A DE4118912C1 (enExample) 1991-06-08 1991-06-08
DE4118912:4 1991-06-08

Publications (2)

Publication Number Publication Date
JPH07267997A JPH07267997A (ja) 1995-10-17
JP2644946B2 true JP2644946B2 (ja) 1997-08-25

Family

ID=6433511

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4145807A Expired - Fee Related JP2644946B2 (ja) 1991-06-08 1992-06-05 ＩｇＧ− モノクロナール抗体の精製方法及びその使用方法

Country Status (7)

Country Link
EP (1) EP0530447B1 (enExample)
JP (1) JP2644946B2 (enExample)
AT (1) ATE159532T1 (enExample)
DE (2) DE4118912C1 (enExample)
DK (1) DK0530447T3 (enExample)
ES (1) ES2108059T3 (enExample)
GR (1) GR3025603T3 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2706466B1 (fr) * 1993-06-14 1995-08-25 Aetsrn Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré.
IL121900A (en) * 1997-10-07 2001-12-23 Omrix Biopharmaceuticals Ltd A method for the purification of immunoglobulins
ID27417A (id) * 1998-06-09 2001-04-05 Statens Seruminstitut Proses untuk memproduksi immunoglobulin untuk pemberian melalui intravena dan produk-produk immunoglobulin lainnya
DK2270044T3 (en) 1998-06-09 2015-01-26 Csl Behring Ag Liquid immunoglobulin G (IgG) product
SE0001128D0 (sv) * 2000-03-30 2000-03-30 Amersham Pharm Biotech Ab A method of producing IgG
US20060257972A1 (en) * 2003-03-31 2006-11-16 Takashi Ishihara Purification of human monoclonal antibody and human polyclonal antibody
EP1532983A1 (en) 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulin preparations having increased stability
TWI391399B (zh) 2005-05-25 2013-04-01 赫孚孟拉羅股份公司 測定溶離多肽之鹽濃度之方法
RU2009148891A (ru) 2007-06-01 2011-07-20 Ф.Хоффманн-Ля Рош Аг (Ch) Очистка иммуноглобулина
CL2008002054A1 (es) 2007-07-17 2009-05-29 Hoffmann La Roche Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico.
AR067537A1 (es) 2007-07-17 2009-10-14 Hoffmann La Roche Purificacion de polipeptidos pegilados
WO2009058769A1 (en) * 2007-10-30 2009-05-07 Schering Corporation Purification of antibodies containing hydrophobic variants
KR20110086184A (ko) 2008-12-22 2011-07-27 에프. 호프만-라 로슈 아게 면역글로불린 정제
DK2531218T3 (en) 2010-02-04 2019-04-01 Csl Behring Ag immunoglobulin
JP2013519652A (ja) * 2010-02-12 2013-05-30 ディーエスエム アイピー アセッツ ビー．ブイ． 単一ユニット抗体精製
EP2361636A1 (en) 2010-02-26 2011-08-31 CSL Behring AG Immunoglobulin preparation and storage system for an immunoglobulin preparation
ES2500048T3 (es) 2010-09-14 2014-09-29 F. Hoffmann-La Roche Ag Procedimiento para purificar eritropoyetina pegilada
EA201300524A1 (ru) * 2010-11-01 2013-08-30 ДСМ АйПи АССЕТС Б.В. Очистка антител ионообменной хроматографией в едином блоке
KR20140062044A (ko) 2011-08-25 2014-05-22 에프. 호프만-라 로슈 아게 양이온 및 음이온 교환 크로마토그래피 방법
EP2596812B1 (de) * 2011-11-22 2015-06-10 Heraeus Medical GmbH Sterilisation von polymerisierbaren Monomeren
KR101917196B1 (ko) * 2014-03-11 2018-11-09 주식회사 녹십자홀딩스 면역글로불린의 정제방법
CN121371151A (zh) 2014-12-03 2026-01-23 瑞士杰特贝林生物制品有限公司 具有增加的稳定性的包含免疫球蛋白的药物产品
WO2018011381A1 (en) 2016-07-15 2018-01-18 F. Hoffmann-La Roche Ag Method for purifying pegylated erythropoietin
MX2021008983A (es) * 2019-01-30 2021-09-08 Amgen Inc Atributos de aflibercept y metodos de caracterizacion y modificacion de los mismos.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469630A (en) * 1983-11-25 1984-09-04 J. T. Baker Chemical Co. Purification of monoclonal antibodies
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
DE3640513A1 (de) * 1986-11-27 1988-06-09 Biotest Pharma Gmbh Verfahren zur herstellung eines virussicheren, lagerstabilen und intravenoes vertraeglichen immunglobulin-g-praeparates
DE3641115A1 (de) * 1986-12-02 1988-06-16 Lentia Gmbh Verfahren zur herstellung eines intravenoes anwendbaren und in fluessiger form stabilen immunglobulins
CA1323567C (en) * 1987-10-05 1993-10-26 Gene R. Nathans Method for purification of antibodies
US5118796A (en) * 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
CA2005600A1 (en) * 1988-12-20 1990-06-20 Cal-Henrik Heldin Endothelial cell growth factor

Also Published As

Publication number Publication date
DK0530447T3 (da) 1998-01-12
EP0530447A3 (en) 1993-08-18
ES2108059T3 (es) 1997-12-16
EP0530447B1 (de) 1997-10-22
ATE159532T1 (de) 1997-11-15
JPH07267997A (ja) 1995-10-17
DE4118912C1 (enExample) 1992-07-02
GR3025603T3 (en) 1998-03-31
DE59208982D1 (de) 1997-11-27
EP0530447A2 (de) 1993-03-10

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