JP2644946B2 - ＩｇＧ− モノクロナール抗体の精製方法及びその使用方法 - Google Patents

ＩｇＧ− モノクロナール抗体の精製方法及びその使用方法

Info

Publication number
JP2644946B2
JP2644946B2 JP4145807A JP14580792A JP2644946B2 JP 2644946 B2 JP2644946 B2 JP 2644946B2 JP 4145807 A JP4145807 A JP 4145807A JP 14580792 A JP14580792 A JP 14580792A JP 2644946 B2 JP2644946 B2 JP 2644946B2
Authority
JP
Japan
Prior art keywords
igg
monoclonal antibody
antibody
solution
chromatographed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP4145807A
Other languages
English (en)
Japanese (ja)
Other versions
JPH07267997A (ja
Inventor
ノルベルト・コーテ
デイーター・ルートニック
デトレーフ・ローム
ウルフ・ベートケ
ミッヒヤエル・クロフト
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIOTESUTO AG
Original Assignee
BIOTESUTO AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIOTESUTO AG filed Critical BIOTESUTO AG
Publication of JPH07267997A publication Critical patent/JPH07267997A/ja
Application granted granted Critical
Publication of JP2644946B2 publication Critical patent/JP2644946B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP4145807A 1991-06-08 1992-06-05 ＩｇＧ− モノクロナール抗体の精製方法及びその使用方法 Expired - Fee Related JP2644946B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4118912:4 1991-06-08
DE4118912A DE4118912C1 (enExample) 1991-06-08 1991-06-08

Publications (2)

Publication Number Publication Date
JPH07267997A JPH07267997A (ja) 1995-10-17
JP2644946B2 true JP2644946B2 (ja) 1997-08-25

Family

ID=6433511

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4145807A Expired - Fee Related JP2644946B2 (ja) 1991-06-08 1992-06-05 ＩｇＧ− モノクロナール抗体の精製方法及びその使用方法

Country Status (7)

Country Link
EP (1) EP0530447B1 (enExample)
JP (1) JP2644946B2 (enExample)
AT (1) ATE159532T1 (enExample)
DE (2) DE4118912C1 (enExample)
DK (1) DK0530447T3 (enExample)
ES (1) ES2108059T3 (enExample)
GR (1) GR3025603T3 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2706466B1 (fr) * 1993-06-14 1995-08-25 Aetsrn Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré.
IL121900A (en) * 1997-10-07 2001-12-23 Omrix Biopharmaceuticals Ltd A method for the purification of immunoglobulins
ES2229784T3 (es) * 1998-06-09 2005-04-16 Statens Serum Institut Proceso de produccion de inmunoglobulinas para administracion intravenosa y otros productos de inmunoglobulina.
DK2272870T3 (da) 1998-06-09 2013-08-05 Csl Behring Ag Fremgangsmåde til fremstilling af immunoglobuliner med henblik på intravenøs indgivelse og andre immunoglobulin-lignende produkter.
SE0001128D0 (sv) * 2000-03-30 2000-03-30 Amersham Pharm Biotech Ab A method of producing IgG
EP1614693A4 (en) * 2003-03-31 2006-07-19 Kirin Brewery Purification of a human monoclonal antibody and human polyclonal antibody
EP1532983A1 (en) 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulin preparations having increased stability
TWI320788B (en) 2005-05-25 2010-02-21 Hoffmann La Roche Method for the purification of antibodies
RU2009148891A (ru) 2007-06-01 2011-07-20 Ф.Хоффманн-Ля Рош Аг (Ch) Очистка иммуноглобулина
AR067537A1 (es) 2007-07-17 2009-10-14 Hoffmann La Roche Purificacion de polipeptidos pegilados
AR067536A1 (es) 2007-07-17 2009-10-14 Hoffmann La Roche Metodo para obtener una eritropoyetina mono-pegilada en una forma sustancialmente homogenea
WO2009058769A1 (en) * 2007-10-30 2009-05-07 Schering Corporation Purification of antibodies containing hydrophobic variants
JP2012513425A (ja) 2008-12-22 2012-06-14 エフ．ホフマン−ラ ロシュ アーゲー 免疫グロブリンの精製
CA2788863C (en) 2010-02-04 2020-07-07 Csl Behring Ag Immunoglobulin preparation
MX2012009283A (es) 2010-02-12 2012-09-07 Dsm Ip Assets Bv Purificacion de anticuerpo de una unidad.
EP2361636A1 (en) 2010-02-26 2011-08-31 CSL Behring AG Immunoglobulin preparation and storage system for an immunoglobulin preparation
JP5735650B2 (ja) 2010-09-14 2015-06-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｐｅｇ化エリスロポエチンを精製するための方法
MX2013004720A (es) * 2010-11-01 2013-05-28 Dsm Ip Assets Bv Purificacion de anticuerpos mediante cromatografia de intercambio ionico de una uncia unidad.
RU2014108241A (ru) 2011-08-25 2015-09-27 Ф.Хоффманн-Ля Рош Аг Способ катион- и анионобменной хроматографии
ES2546064T3 (es) 2011-11-22 2015-09-18 Heraeus Medical Gmbh Esterilización de monómeros polimerizables
US10287315B2 (en) 2014-03-11 2019-05-14 Green Cross Holdings Corporation Method for purifying immunoglobulin
MX388043B (es) 2014-12-03 2025-03-19 Csl Behring Ag Producto farmacéutico con estabilidad incrementada que comprende inmunoglobulinas.
WO2018011381A1 (en) 2016-07-15 2018-01-18 F. Hoffmann-La Roche Ag Method for purifying pegylated erythropoietin
CA3127228A1 (en) * 2019-01-30 2020-08-06 Amgen Inc. Aflibercept attributes and methods of characterizing and modifying thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469630A (en) * 1983-11-25 1984-09-04 J. T. Baker Chemical Co. Purification of monoclonal antibodies
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
DE3640513A1 (de) * 1986-11-27 1988-06-09 Biotest Pharma Gmbh Verfahren zur herstellung eines virussicheren, lagerstabilen und intravenoes vertraeglichen immunglobulin-g-praeparates
DE3641115A1 (de) * 1986-12-02 1988-06-16 Lentia Gmbh Verfahren zur herstellung eines intravenoes anwendbaren und in fluessiger form stabilen immunglobulins
CA1323567C (en) * 1987-10-05 1993-10-26 Gene R. Nathans Method for purification of antibodies
US5118796A (en) * 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
CA2005600A1 (en) * 1988-12-20 1990-06-20 Cal-Henrik Heldin Endothelial cell growth factor

Also Published As

Publication number Publication date
EP0530447B1 (de) 1997-10-22
GR3025603T3 (en) 1998-03-31
ES2108059T3 (es) 1997-12-16
JPH07267997A (ja) 1995-10-17
DK0530447T3 (da) 1998-01-12
EP0530447A2 (de) 1993-03-10
EP0530447A3 (en) 1993-08-18
ATE159532T1 (de) 1997-11-15
DE59208982D1 (de) 1997-11-27
DE4118912C1 (enExample) 1992-07-02

Similar Documents

Publication Publication Date Title
JP2644946B2 (ja) ＩｇＧ− モノクロナール抗体の精製方法及びその使用方法
US6835379B2 (en) Method of producing IgG
JP4359347B2 (ja) 抗体の高収率精製およびウイルス不活性化のためのクロマトグラフイー法
US5164487A (en) Manufacturing intravenous tolerable immunoglobulin-g preparation
AU656552B2 (en) Process for isolating human albumin from supernatant IV, in particular IV-4, or from COHN's fraction V or from an analogous supernatant or fraction
JPH07103044B2 (ja) Ｃ１不活性化剤を含有する医薬の調製方法
JP3148222B2 (ja) 非変性静脈内投与可能なＩｇＭ―及び／又は／ＩｇＡ―含有免疫グロブリン製剤及びその製造方法
US4359389A (en) Method for the purification of interferon
AU2001273907A1 (en) A method of producing IgG
JPH01207239A (ja) 高純度のヒト因子ｉｘ濃縮物および他の血漿蛋白質およびそれらの治療学的使用
HU182554B (en) Process for producing preparation of serum protein for intravenous application
JPS6136228A (ja) 肝炎表面抗原の精製方法
JPS63503352A (ja) タンパク質の精製
CA2018511C (en) Process for the preparation of purified albumin solutions
CA2252986A1 (en) Process for preparing functional recombinant tissue factor
US7041798B1 (en) Method for the chromatographic fractionation of plasma or serum, preparations, so obtained, and their use
JPH0646873A (ja) ヒト血清アルブミンの高度精製方法
EP1928915B1 (en) An ultra-high yield intravenous immune globulin preparation
JPH04502914A (ja) 免疫グロブリンを可溶化するための塩基性アミノ酸の使用
EP0200966B1 (en) Method of stabilizing urokinase precursor and dry preparation containing said precursor
JPS62259596A (ja) ハイブリツドタンパク質の精製方法
WO2021262041A1 (ru) Способ получения высокоочищенного рекомбинантного ингибитора с1-эстеразы человека
JP2519561B2 (ja) 酸性糖タンパク質
JPH09176195A (ja) 遺伝子操作由来のヒト血清アルブミンより得られる高純度ヒト血清アルブミン含有組成物
CN112409476A (zh) 四种血液来源蛋白的纯化方法

Legal Events

Date Code Title Description
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 19970318

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20090502

Year of fee payment: 12

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20100502

Year of fee payment: 13

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110502

Year of fee payment: 14

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110502

Year of fee payment: 14

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120502

Year of fee payment: 15

LAPS Cancellation because of no payment of annual fees