ES2108059T3 - Procedimiento para la purificacion de anticuerpos monoclonales igg. - Google Patents

Procedimiento para la purificacion de anticuerpos monoclonales igg.

Info

Publication number
ES2108059T3
ES2108059T3 ES92108912T ES92108912T ES2108059T3 ES 2108059 T3 ES2108059 T3 ES 2108059T3 ES 92108912 T ES92108912 T ES 92108912T ES 92108912 T ES92108912 T ES 92108912T ES 2108059 T3 ES2108059 T3 ES 2108059T3
Authority
ES
Spain
Prior art keywords
monoclonal antibodies
purification
procedure
antibodies igg
igg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92108912T
Other languages
English (en)
Spanish (es)
Inventor
Norbert Dr Kothe
Dieter Dr Rudnick
Detlef Dr Rohm
Ulf Dr Bethke
Michael Dr Kloft
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotest Pharma GmbH
Original Assignee
Biotest Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotest Pharma GmbH filed Critical Biotest Pharma GmbH
Application granted granted Critical
Publication of ES2108059T3 publication Critical patent/ES2108059T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES92108912T 1991-06-08 1992-05-27 Procedimiento para la purificacion de anticuerpos monoclonales igg. Expired - Lifetime ES2108059T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4118912A DE4118912C1 (enExample) 1991-06-08 1991-06-08

Publications (1)

Publication Number Publication Date
ES2108059T3 true ES2108059T3 (es) 1997-12-16

Family

ID=6433511

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92108912T Expired - Lifetime ES2108059T3 (es) 1991-06-08 1992-05-27 Procedimiento para la purificacion de anticuerpos monoclonales igg.

Country Status (7)

Country Link
EP (1) EP0530447B1 (enExample)
JP (1) JP2644946B2 (enExample)
AT (1) ATE159532T1 (enExample)
DE (2) DE4118912C1 (enExample)
DK (1) DK0530447T3 (enExample)
ES (1) ES2108059T3 (enExample)
GR (1) GR3025603T3 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2706466B1 (fr) * 1993-06-14 1995-08-25 Aetsrn Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré.
IL121900A (en) * 1997-10-07 2001-12-23 Omrix Biopharmaceuticals Ltd A method for the purification of immunoglobulins
ID27417A (id) * 1998-06-09 2001-04-05 Statens Seruminstitut Proses untuk memproduksi immunoglobulin untuk pemberian melalui intravena dan produk-produk immunoglobulin lainnya
DK2270044T3 (en) 1998-06-09 2015-01-26 Csl Behring Ag Liquid immunoglobulin G (IgG) product
SE0001128D0 (sv) * 2000-03-30 2000-03-30 Amersham Pharm Biotech Ab A method of producing IgG
US20060257972A1 (en) * 2003-03-31 2006-11-16 Takashi Ishihara Purification of human monoclonal antibody and human polyclonal antibody
EP1532983A1 (en) 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulin preparations having increased stability
TWI391399B (zh) 2005-05-25 2013-04-01 赫孚孟拉羅股份公司 測定溶離多肽之鹽濃度之方法
RU2009148891A (ru) 2007-06-01 2011-07-20 Ф.Хоффманн-Ля Рош Аг (Ch) Очистка иммуноглобулина
CL2008002054A1 (es) 2007-07-17 2009-05-29 Hoffmann La Roche Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico.
AR067537A1 (es) 2007-07-17 2009-10-14 Hoffmann La Roche Purificacion de polipeptidos pegilados
WO2009058769A1 (en) * 2007-10-30 2009-05-07 Schering Corporation Purification of antibodies containing hydrophobic variants
KR20110086184A (ko) 2008-12-22 2011-07-27 에프. 호프만-라 로슈 아게 면역글로불린 정제
DK2531218T3 (en) 2010-02-04 2019-04-01 Csl Behring Ag immunoglobulin
JP2013519652A (ja) * 2010-02-12 2013-05-30 ディーエスエム アイピー アセッツ ビー．ブイ． 単一ユニット抗体精製
EP2361636A1 (en) 2010-02-26 2011-08-31 CSL Behring AG Immunoglobulin preparation and storage system for an immunoglobulin preparation
ES2500048T3 (es) 2010-09-14 2014-09-29 F. Hoffmann-La Roche Ag Procedimiento para purificar eritropoyetina pegilada
EA201300524A1 (ru) * 2010-11-01 2013-08-30 ДСМ АйПи АССЕТС Б.В. Очистка антител ионообменной хроматографией в едином блоке
KR20140062044A (ko) 2011-08-25 2014-05-22 에프. 호프만-라 로슈 아게 양이온 및 음이온 교환 크로마토그래피 방법
EP2596812B1 (de) * 2011-11-22 2015-06-10 Heraeus Medical GmbH Sterilisation von polymerisierbaren Monomeren
KR101917196B1 (ko) * 2014-03-11 2018-11-09 주식회사 녹십자홀딩스 면역글로불린의 정제방법
CN121371151A (zh) 2014-12-03 2026-01-23 瑞士杰特贝林生物制品有限公司 具有增加的稳定性的包含免疫球蛋白的药物产品
WO2018011381A1 (en) 2016-07-15 2018-01-18 F. Hoffmann-La Roche Ag Method for purifying pegylated erythropoietin
MX2021008983A (es) * 2019-01-30 2021-09-08 Amgen Inc Atributos de aflibercept y metodos de caracterizacion y modificacion de los mismos.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469630A (en) * 1983-11-25 1984-09-04 J. T. Baker Chemical Co. Purification of monoclonal antibodies
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
DE3640513A1 (de) * 1986-11-27 1988-06-09 Biotest Pharma Gmbh Verfahren zur herstellung eines virussicheren, lagerstabilen und intravenoes vertraeglichen immunglobulin-g-praeparates
DE3641115A1 (de) * 1986-12-02 1988-06-16 Lentia Gmbh Verfahren zur herstellung eines intravenoes anwendbaren und in fluessiger form stabilen immunglobulins
CA1323567C (en) * 1987-10-05 1993-10-26 Gene R. Nathans Method for purification of antibodies
US5118796A (en) * 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
CA2005600A1 (en) * 1988-12-20 1990-06-20 Cal-Henrik Heldin Endothelial cell growth factor

Also Published As

Publication number Publication date
DK0530447T3 (da) 1998-01-12
EP0530447A3 (en) 1993-08-18
EP0530447B1 (de) 1997-10-22
JP2644946B2 (ja) 1997-08-25
ATE159532T1 (de) 1997-11-15
JPH07267997A (ja) 1995-10-17
DE4118912C1 (enExample) 1992-07-02
GR3025603T3 (en) 1998-03-31
DE59208982D1 (de) 1997-11-27
EP0530447A2 (de) 1993-03-10

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