DK0530447T3 - Fremgangsmåde til rensning af IgG-monoklonale antistoffer - Google Patents

Fremgangsmåde til rensning af IgG-monoklonale antistoffer

Info

Publication number
DK0530447T3
DK0530447T3 DK92108912.4T DK92108912T DK0530447T3 DK 0530447 T3 DK0530447 T3 DK 0530447T3 DK 92108912 T DK92108912 T DK 92108912T DK 0530447 T3 DK0530447 T3 DK 0530447T3
Authority
DK
Denmark
Prior art keywords
monoclonal antibodies
igg monoclonal
purifying igg
purifying
immunotherapy
Prior art date
Application number
DK92108912.4T
Other languages
Danish (da)
English (en)
Inventor
Norbert Dr Kothe
Dieter Dr Rudnick
Ulf Dr Bethke
Michael Dr Kloft
Detlef Dr Rohm
Original Assignee
Biotest Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotest Pharma Gmbh filed Critical Biotest Pharma Gmbh
Application granted granted Critical
Publication of DK0530447T3 publication Critical patent/DK0530447T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK92108912.4T 1991-06-08 1992-05-27 Fremgangsmåde til rensning af IgG-monoklonale antistoffer DK0530447T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4118912A DE4118912C1 (enExample) 1991-06-08 1991-06-08

Publications (1)

Publication Number Publication Date
DK0530447T3 true DK0530447T3 (da) 1998-01-12

Family

ID=6433511

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92108912.4T DK0530447T3 (da) 1991-06-08 1992-05-27 Fremgangsmåde til rensning af IgG-monoklonale antistoffer

Country Status (7)

Country Link
EP (1) EP0530447B1 (enExample)
JP (1) JP2644946B2 (enExample)
AT (1) ATE159532T1 (enExample)
DE (2) DE4118912C1 (enExample)
DK (1) DK0530447T3 (enExample)
ES (1) ES2108059T3 (enExample)
GR (1) GR3025603T3 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2706466B1 (fr) * 1993-06-14 1995-08-25 Aetsrn Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré.
IL121900A (en) * 1997-10-07 2001-12-23 Omrix Biopharmaceuticals Ltd A method for the purification of immunoglobulins
JP4685238B2 (ja) * 1998-06-09 2011-05-18 ツエー・エス・エル・ベーリング・アクチエンゲゼルシヤフト 静脈投与用免疫グロブリン及び他の免疫グロブリン生成物の製造法
IL140155A (en) * 1998-06-09 2005-12-18 Statens Seruminstitut Process for producing immunoglobulins for intravenous administration and other immunoglobulin products
SE0001128D0 (sv) * 2000-03-30 2000-03-30 Amersham Pharm Biotech Ab A method of producing IgG
JPWO2004087761A1 (ja) * 2003-03-31 2006-07-27 麒麟麦酒株式会社 ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製
EP1532983A1 (en) 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulin preparations having increased stability
TWI391399B (zh) 2005-05-25 2013-04-01 Hoffmann La Roche 測定溶離多肽之鹽濃度之方法
MX2009012786A (es) 2007-06-01 2009-12-10 Hoffmann La Roche Purificacion de inmunoglobulina.
CL2008002053A1 (es) 2007-07-17 2009-05-22 Hoffmann La Roche Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion.
CL2008002054A1 (es) 2007-07-17 2009-05-29 Hoffmann La Roche Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico.
WO2009058769A1 (en) * 2007-10-30 2009-05-07 Schering Corporation Purification of antibodies containing hydrophobic variants
EP2379108B1 (en) 2008-12-22 2014-06-25 F. Hoffmann-La Roche AG Immunoglobulin purification
JP6078344B2 (ja) 2010-02-04 2017-02-08 ツェー・エス・エル・ベーリング・アクチエンゲゼルシャフト 免疫グロブリン製剤
AU2011214361C1 (en) * 2010-02-12 2016-01-14 Dpx Holdings B.V. Single unit antibody purification
EP2361636A1 (en) 2010-02-26 2011-08-31 CSL Behring AG Immunoglobulin preparation and storage system for an immunoglobulin preparation
RU2566267C2 (ru) 2010-09-14 2015-10-20 Ф. Хоффманн-Ля Рош Аг Способ очистки пегилированного эритропоэтина
WO2012059308A1 (en) * 2010-11-01 2012-05-10 Dsm Ip Assets B.V. Single unit ion exchange chromatography antibody purification
RU2014108241A (ru) 2011-08-25 2015-09-27 Ф.Хоффманн-Ля Рош Аг Способ катион- и анионобменной хроматографии
EP2596812B1 (de) * 2011-11-22 2015-06-10 Heraeus Medical GmbH Sterilisation von polymerisierbaren Monomeren
WO2015137530A1 (ko) * 2014-03-11 2015-09-17 주식회사 녹십자홀딩스 면역글로불린의 정제방법
HUE052280T2 (hu) 2014-12-03 2021-04-28 Csl Behring Ag Immunoglobulinokat tartalmazó megnövelt stabilitású gyógyszerészeti termék
AU2017295037B2 (en) 2016-07-15 2021-07-22 F. Hoffmann-La Roche Ag Method for purifying PEGylated erythropoietin
US20220098279A1 (en) * 2019-01-30 2022-03-31 Amgen Inc. Aflibercept attributes and methods of characterizing and modifying thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469630A (en) * 1983-11-25 1984-09-04 J. T. Baker Chemical Co. Purification of monoclonal antibodies
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
DE3640513A1 (de) * 1986-11-27 1988-06-09 Biotest Pharma Gmbh Verfahren zur herstellung eines virussicheren, lagerstabilen und intravenoes vertraeglichen immunglobulin-g-praeparates
DE3641115A1 (de) * 1986-12-02 1988-06-16 Lentia Gmbh Verfahren zur herstellung eines intravenoes anwendbaren und in fluessiger form stabilen immunglobulins
CA1323567C (en) * 1987-10-05 1993-10-26 Gene R. Nathans Method for purification of antibodies
US5118796A (en) * 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
CA2005600A1 (en) * 1988-12-20 1990-06-20 Cal-Henrik Heldin Endothelial cell growth factor

Also Published As

Publication number Publication date
JPH07267997A (ja) 1995-10-17
JP2644946B2 (ja) 1997-08-25
EP0530447A3 (en) 1993-08-18
ATE159532T1 (de) 1997-11-15
ES2108059T3 (es) 1997-12-16
GR3025603T3 (en) 1998-03-31
DE59208982D1 (de) 1997-11-27
DE4118912C1 (enExample) 1992-07-02
EP0530447B1 (de) 1997-10-22
EP0530447A2 (de) 1993-03-10

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