ES2108059T3 - Procedimiento para la purificacion de anticuerpos monoclonales igg. - Google Patents
Procedimiento para la purificacion de anticuerpos monoclonales igg.Info
- Publication number
- ES2108059T3 ES2108059T3 ES92108912T ES92108912T ES2108059T3 ES 2108059 T3 ES2108059 T3 ES 2108059T3 ES 92108912 T ES92108912 T ES 92108912T ES 92108912 T ES92108912 T ES 92108912T ES 2108059 T3 ES2108059 T3 ES 2108059T3
- Authority
- ES
- Spain
- Prior art keywords
- monoclonal antibodies
- purification
- procedure
- antibodies igg
- igg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
LA INVENCION SE REFIERE A UN PROCESO PARA LA LIMPIEZA DE ANTICUERPOS MONOCLONALES IGG POR COMBINACION DE TRES PASOS DE CROMATOGRAFIA, A SABER, EN UN CAMBIADOR DE ANIONES, EN UN CAMBIADOR DE CATIONES Y EN UNA FASE HIDROFOBA CON UN PASO DE ESTERILIZACION ESPECIFICO. POR ELLO SE OBTIENE UNA SOLUCION DE ANTICUERPOS CON UNA PUREZA DE POR LO MENOS EL 99,5 % QUE, POR CONSIGUIENTE, SE PUEDE EMPLEAR EN INMUNOTERAPIA POR VIA INTRAVENOSA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4118912A DE4118912C1 (es) | 1991-06-08 | 1991-06-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2108059T3 true ES2108059T3 (es) | 1997-12-16 |
Family
ID=6433511
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92108912T Expired - Lifetime ES2108059T3 (es) | 1991-06-08 | 1992-05-27 | Procedimiento para la purificacion de anticuerpos monoclonales igg. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0530447B1 (es) |
JP (1) | JP2644946B2 (es) |
AT (1) | ATE159532T1 (es) |
DE (2) | DE4118912C1 (es) |
DK (1) | DK0530447T3 (es) |
ES (1) | ES2108059T3 (es) |
GR (1) | GR3025603T3 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2706466B1 (fr) * | 1993-06-14 | 1995-08-25 | Aetsrn | Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré. |
IL121900A (en) * | 1997-10-07 | 2001-12-23 | Omrix Biopharmaceuticals Ltd | A method for the purification of immunoglobulins |
KR100501263B1 (ko) | 1998-06-09 | 2005-07-18 | 스태튼스 세룸 인스티튜트 | 정맥 주사용 면역글로불린의 제조 방법 및 그 외의 면역글로불린 제품 |
ES2421736T3 (es) | 1998-06-09 | 2013-09-05 | Csl Behring Ag | Procedimiento para la preparación de inmunoglobulinas para administración intravenosa y otros productos inmunoglobulínicos |
SE0001128D0 (sv) * | 2000-03-30 | 2000-03-30 | Amersham Pharm Biotech Ab | A method of producing IgG |
JPWO2004087761A1 (ja) * | 2003-03-31 | 2006-07-27 | 麒麟麦酒株式会社 | ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製 |
EP1532983A1 (en) | 2003-11-18 | 2005-05-25 | ZLB Bioplasma AG | Immunoglobulin preparations having increased stability |
TWI391399B (zh) | 2005-05-25 | 2013-04-01 | Hoffmann La Roche | 測定溶離多肽之鹽濃度之方法 |
KR101226353B1 (ko) | 2007-06-01 | 2013-01-24 | 에프. 호프만-라 로슈 아게 | 면역글로불린 정제 |
CL2008002054A1 (es) | 2007-07-17 | 2009-05-29 | Hoffmann La Roche | Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico. |
CL2008002053A1 (es) | 2007-07-17 | 2009-05-22 | Hoffmann La Roche | Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion. |
WO2009058769A1 (en) * | 2007-10-30 | 2009-05-07 | Schering Corporation | Purification of antibodies containing hydrophobic variants |
WO2010072381A1 (en) | 2008-12-22 | 2010-07-01 | F. Hoffmann-La Roche Ag | Immunoglobulin purification |
TR201903403T4 (tr) | 2010-02-04 | 2019-04-22 | Csl Behring Ag | İmmünoglobulin preparatı. |
US20130131318A1 (en) | 2010-02-12 | 2013-05-23 | Diderik Reinder Kremer | Single unit antibody purification |
EP2361636A1 (en) | 2010-02-26 | 2011-08-31 | CSL Behring AG | Immunoglobulin preparation and storage system for an immunoglobulin preparation |
BR112013005890B1 (pt) | 2010-09-14 | 2022-02-08 | F Hoffmann-La Roche Ag | Método para purificar eritropoietina peguilada |
CN103189390A (zh) * | 2010-11-01 | 2013-07-03 | 帝斯曼知识产权资产管理有限公司 | 单一单元离子交换色谱抗体纯化 |
WO2013026803A1 (en) | 2011-08-25 | 2013-02-28 | F. Hoffmann-La Roche Ag | Cation and anion exchange chromatography method |
ES2546064T3 (es) | 2011-11-22 | 2015-09-18 | Heraeus Medical Gmbh | Esterilización de monómeros polimerizables |
WO2015137530A1 (ko) * | 2014-03-11 | 2015-09-17 | 주식회사 녹십자홀딩스 | 면역글로불린의 정제방법 |
SG11201811553UA (en) | 2016-07-15 | 2019-01-30 | Hoffmann La Roche | Method for purifying pegylated erythropoietin |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4469630A (en) * | 1983-11-25 | 1984-09-04 | J. T. Baker Chemical Co. | Purification of monoclonal antibodies |
US4743680A (en) * | 1985-02-01 | 1988-05-10 | New York University | Method for purifying antihemophilic factor |
DE3640513A1 (de) * | 1986-11-27 | 1988-06-09 | Biotest Pharma Gmbh | Verfahren zur herstellung eines virussicheren, lagerstabilen und intravenoes vertraeglichen immunglobulin-g-praeparates |
DE3641115A1 (de) * | 1986-12-02 | 1988-06-16 | Lentia Gmbh | Verfahren zur herstellung eines intravenoes anwendbaren und in fluessiger form stabilen immunglobulins |
CA1323567C (en) * | 1987-10-05 | 1993-10-26 | Gene R. Nathans | Method for purification of antibodies |
US5118796A (en) * | 1987-12-09 | 1992-06-02 | Centocor, Incorporated | Efficient large-scale purification of immunoglobulins and derivatives |
CA2005600A1 (en) * | 1988-12-20 | 1990-06-20 | Cal-Henrik Heldin | Endothelial cell growth factor |
-
1991
- 1991-06-08 DE DE4118912A patent/DE4118912C1/de not_active Expired - Fee Related
-
1992
- 1992-05-27 DE DE59208982T patent/DE59208982D1/de not_active Expired - Lifetime
- 1992-05-27 AT AT92108912T patent/ATE159532T1/de active
- 1992-05-27 DK DK92108912.4T patent/DK0530447T3/da active
- 1992-05-27 ES ES92108912T patent/ES2108059T3/es not_active Expired - Lifetime
- 1992-05-27 EP EP92108912A patent/EP0530447B1/de not_active Expired - Lifetime
- 1992-06-05 JP JP4145807A patent/JP2644946B2/ja not_active Expired - Fee Related
-
1997
- 1997-12-05 GR GR970403248T patent/GR3025603T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0530447B1 (de) | 1997-10-22 |
DE59208982D1 (de) | 1997-11-27 |
ATE159532T1 (de) | 1997-11-15 |
DE4118912C1 (es) | 1992-07-02 |
JP2644946B2 (ja) | 1997-08-25 |
GR3025603T3 (en) | 1998-03-31 |
EP0530447A2 (de) | 1993-03-10 |
JPH07267997A (ja) | 1995-10-17 |
EP0530447A3 (en) | 1993-08-18 |
DK0530447T3 (da) | 1998-01-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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