ATE159532T1 - Verfahren zur reinigung von igg-monoklonalen antikörpern - Google Patents

Verfahren zur reinigung von igg-monoklonalen antikörpern

Info

Publication number
ATE159532T1
ATE159532T1 AT92108912T AT92108912T ATE159532T1 AT E159532 T1 ATE159532 T1 AT E159532T1 AT 92108912 T AT92108912 T AT 92108912T AT 92108912 T AT92108912 T AT 92108912T AT E159532 T1 ATE159532 T1 AT E159532T1
Authority
AT
Austria
Prior art keywords
monoclonal antibodies
igg monoclonal
purifying igg
purifying
immunotherapy
Prior art date
Application number
AT92108912T
Other languages
German (de)
English (en)
Inventor
Norbert Dr Kothe
Dieter Dr Rudnick
Detlef Dr Rohm
Ulf Dr Bethke
Michael Dr Kloft
Original Assignee
Biotest Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotest Pharma Gmbh filed Critical Biotest Pharma Gmbh
Application granted granted Critical
Publication of ATE159532T1 publication Critical patent/ATE159532T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT92108912T 1991-06-08 1992-05-27 Verfahren zur reinigung von igg-monoklonalen antikörpern ATE159532T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4118912A DE4118912C1 (enExample) 1991-06-08 1991-06-08

Publications (1)

Publication Number Publication Date
ATE159532T1 true ATE159532T1 (de) 1997-11-15

Family

ID=6433511

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92108912T ATE159532T1 (de) 1991-06-08 1992-05-27 Verfahren zur reinigung von igg-monoklonalen antikörpern

Country Status (7)

Country Link
EP (1) EP0530447B1 (enExample)
JP (1) JP2644946B2 (enExample)
AT (1) ATE159532T1 (enExample)
DE (2) DE4118912C1 (enExample)
DK (1) DK0530447T3 (enExample)
ES (1) ES2108059T3 (enExample)
GR (1) GR3025603T3 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2706466B1 (fr) * 1993-06-14 1995-08-25 Aetsrn Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré.
IL121900A (en) * 1997-10-07 2001-12-23 Omrix Biopharmaceuticals Ltd A method for the purification of immunoglobulins
DK2270044T3 (en) 1998-06-09 2015-01-26 Csl Behring Ag Liquid immunoglobulin G (IgG) product
SK288128B6 (sk) * 1998-06-09 2013-10-02 Csl Behring Ag Process for purifying immunoglobulin G (IgG), liquid immunoglobulin product and use thereof for the preparation of a medicament
SE0001128D0 (sv) * 2000-03-30 2000-03-30 Amersham Pharm Biotech Ab A method of producing IgG
WO2004087761A1 (ja) * 2003-03-31 2004-10-14 Kirin Beer Kabushiki Kaisha ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製
EP1532983A1 (en) 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulin preparations having increased stability
TWI391399B (zh) 2005-05-25 2013-04-01 Hoffmann La Roche 測定溶離多肽之鹽濃度之方法
AU2008256411B2 (en) 2007-06-01 2013-08-22 F. Hoffmann-La Roche Ag Immunoglobulin purification
CL2008002054A1 (es) 2007-07-17 2009-05-29 Hoffmann La Roche Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico.
AR067537A1 (es) 2007-07-17 2009-10-14 Hoffmann La Roche Purificacion de polipeptidos pegilados
WO2009058769A1 (en) * 2007-10-30 2009-05-07 Schering Corporation Purification of antibodies containing hydrophobic variants
CN102264392A (zh) 2008-12-22 2011-11-30 弗·哈夫曼-拉罗切有限公司 免疫球蛋白纯化
PL2531218T3 (pl) 2010-02-04 2019-05-31 Csl Behring Ag Preparat immunoglobuliny
JP2013519652A (ja) * 2010-02-12 2013-05-30 ディーエスエム アイピー アセッツ ビー．ブイ． 単一ユニット抗体精製
EP2361636A1 (en) 2010-02-26 2011-08-31 CSL Behring AG Immunoglobulin preparation and storage system for an immunoglobulin preparation
EP2616101B1 (en) 2010-09-14 2014-07-09 F.Hoffmann-La Roche Ag Method for purifying pegylated erythropoietin
WO2012059308A1 (en) * 2010-11-01 2012-05-10 Dsm Ip Assets B.V. Single unit ion exchange chromatography antibody purification
EP2748178B1 (en) 2011-08-25 2018-10-31 F. Hoffmann-La Roche AG Cation and anion exchange chromatography method
ES2546064T3 (es) * 2011-11-22 2015-09-18 Heraeus Medical Gmbh Esterilización de monómeros polimerizables
CN106459140B (zh) * 2014-03-11 2019-12-10 株式会社绿十字控股 用于纯化免疫球蛋白的方法
HUE052280T2 (hu) 2014-12-03 2021-04-28 Csl Behring Ag Immunoglobulinokat tartalmazó megnövelt stabilitású gyógyszerészeti termék
MX391087B (es) 2016-07-15 2025-03-21 Hoffmann La Roche Método para purificar eritropoyetina pegilada.
AU2020216368B2 (en) * 2019-01-30 2025-04-24 Amgen Inc. Aflibercept attributes and methods of characterizing and modifying thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469630A (en) * 1983-11-25 1984-09-04 J. T. Baker Chemical Co. Purification of monoclonal antibodies
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
DE3640513A1 (de) * 1986-11-27 1988-06-09 Biotest Pharma Gmbh Verfahren zur herstellung eines virussicheren, lagerstabilen und intravenoes vertraeglichen immunglobulin-g-praeparates
DE3641115A1 (de) * 1986-12-02 1988-06-16 Lentia Gmbh Verfahren zur herstellung eines intravenoes anwendbaren und in fluessiger form stabilen immunglobulins
CA1323567C (en) * 1987-10-05 1993-10-26 Gene R. Nathans Method for purification of antibodies
US5118796A (en) * 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
CA2005600A1 (en) * 1988-12-20 1990-06-20 Cal-Henrik Heldin Endothelial cell growth factor

Also Published As

Publication number Publication date
JP2644946B2 (ja) 1997-08-25
JPH07267997A (ja) 1995-10-17
GR3025603T3 (en) 1998-03-31
EP0530447B1 (de) 1997-10-22
ES2108059T3 (es) 1997-12-16
EP0530447A2 (de) 1993-03-10
DK0530447T3 (da) 1998-01-12
DE4118912C1 (enExample) 1992-07-02
EP0530447A3 (en) 1993-08-18
DE59208982D1 (de) 1997-11-27

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