|
US3536809A
(en)
|
1969-02-17 |
1970-10-27 |
Alza Corp |
Medication method
|
|
US3598123A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
|
US3845770A
(en)
|
1972-06-05 |
1974-11-05 |
Alza Corp |
Osmatic dispensing device for releasing beneficial agent
|
|
US3916899A
(en)
|
1973-04-25 |
1975-11-04 |
Alza Corp |
Osmotic dispensing device with maximum and minimum sizes for the passageway
|
|
US4008719A
(en)
|
1976-02-02 |
1977-02-22 |
Alza Corporation |
Osmotic system having laminar arrangement for programming delivery of active agent
|
|
DE3211934A1
(de)
*
|
1982-03-31 |
1983-10-13 |
Hoechst Ag, 6230 Frankfurt |
Salicylsaeurederivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
|
|
KR890002631B1
(ko)
|
1984-10-04 |
1989-07-21 |
몬산토 캄파니 |
생물학적으로 활성인 소마토트로핀을 지속적으로 유리하는 조성물
|
|
IE58110B1
(en)
|
1984-10-30 |
1993-07-14 |
Elan Corp Plc |
Controlled release powder and process for its preparation
|
|
US5073543A
(en)
|
1988-07-21 |
1991-12-17 |
G. D. Searle & Co. |
Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
|
|
IT1229203B
(it)
|
1989-03-22 |
1991-07-25 |
Bioresearch Spa |
Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
|
|
PH30995A
(en)
|
1989-07-07 |
1997-12-23 |
Novartis Inc |
Sustained release formulations of water soluble peptides.
|
|
US5120548A
(en)
|
1989-11-07 |
1992-06-09 |
Merck & Co., Inc. |
Swelling modulated polymeric drug delivery device
|
|
US5733566A
(en)
|
1990-05-15 |
1998-03-31 |
Alkermes Controlled Therapeutics Inc. Ii |
Controlled release of antiparasitic agents in animals
|
|
US5580578A
(en)
|
1992-01-27 |
1996-12-03 |
Euro-Celtique, S.A. |
Controlled release formulations coated with aqueous dispersions of acrylic polymers
|
|
TW333456B
(en)
|
1992-12-07 |
1998-06-11 |
Takeda Pharm Ind Co Ltd |
A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
|
|
US5591767A
(en)
|
1993-01-25 |
1997-01-07 |
Pharmetrix Corporation |
Liquid reservoir transdermal patch for the administration of ketorolac
|
|
US6087324A
(en)
|
1993-06-24 |
2000-07-11 |
Takeda Chemical Industries, Ltd. |
Sustained-release preparation
|
|
IT1270594B
(it)
|
1994-07-07 |
1997-05-07 |
Recordati Chem Pharm |
Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
|
|
WO1997001331A2
(en)
|
1995-06-27 |
1997-01-16 |
Takeda Chemical Industries, Ltd. |
Method of producing sustained-release preparation
|
|
TW448055B
(en)
|
1995-09-04 |
2001-08-01 |
Takeda Chemical Industries Ltd |
Method of production of sustained-release preparation
|
|
JP2909418B2
(ja)
|
1995-09-18 |
1999-06-23 |
株式会社資生堂 |
薬物の遅延放出型マイクロスフイア
|
|
US5980945A
(en)
|
1996-01-16 |
1999-11-09 |
Societe De Conseils De Recherches Et D'applications Scientifique S.A. |
Sustained release drug formulations
|
|
US6264970B1
(en)
|
1996-06-26 |
2001-07-24 |
Takeda Chemical Industries, Ltd. |
Sustained-release preparation
|
|
US6419961B1
(en)
|
1996-08-29 |
2002-07-16 |
Takeda Chemical Industries, Ltd. |
Sustained release microcapsules of a bioactive substance and a biodegradable polymer
|
|
CA2217134A1
(en)
|
1996-10-09 |
1998-04-09 |
Sumitomo Pharmaceuticals Co., Ltd. |
Sustained release formulation
|
|
ES2221019T3
(es)
|
1996-10-31 |
2004-12-16 |
Takeda Chemical Industries, Ltd. |
Preparacion de liberacion mantenida.
|
|
ZA9711385B
(en)
|
1996-12-20 |
1999-06-18 |
Takeda Chemical Industries Ltd |
Method of producing a sustained-release preparation
|
|
US5891474A
(en)
|
1997-01-29 |
1999-04-06 |
Poli Industria Chimica, S.P.A. |
Time-specific controlled release dosage formulations and method of preparing same
|
|
US6613358B2
(en)
|
1998-03-18 |
2003-09-02 |
Theodore W. Randolph |
Sustained-release composition including amorphous polymer
|
|
KR19990085365A
(ko)
|
1998-05-16 |
1999-12-06 |
허영섭 |
지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법
|
|
US6248363B1
(en)
|
1999-11-23 |
2001-06-19 |
Lipocine, Inc. |
Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
|
|
JP2006503094A
(ja)
*
|
2002-10-16 |
2006-01-26 |
スミスクライン ビーチャム コーポレーション |
化合物
|
|
ATE540033T1
(de)
*
|
2005-11-14 |
2012-01-15 |
Vertex Pharma |
Als modulatoren von spannungsgesteuerten ionenkanälen geeignete chinazoline
|
|
WO2008135830A1
(en)
|
2007-05-03 |
2008-11-13 |
Pfizer Limited |
N- [6-amino-s- (phenyl) pyrazin-2-yl] -isoxazole-4-carboxamide derivatives and related compounds as nav1.8 channel modulators for the treatment of pain
|
|
MD20140037A2
(ro)
|
2011-10-26 |
2014-08-31 |
Pfizer Limited |
Derivaţi de (4-fenilimidazol-2-il)etilamină utili ca modulatori ai canalului de sodiu
|
|
CA2861439C
(en)
|
2012-02-03 |
2016-07-12 |
Pfizer Inc. |
Benzimidazole and imidazopyridine derivatives as sodium channel modulators
|
|
AR094668A1
(es)
|
2013-01-31 |
2015-08-19 |
Vertex Pharma |
Amidas como moduladores de canales de sodio
|
|
ES2857687T3
(es)
|
2013-01-31 |
2021-09-29 |
Vertex Pharma |
Piridona amidas como moduladores de los canales de sodio
|
|
CN105073738B
(zh)
|
2013-01-31 |
2018-01-05 |
沃泰克斯药物股份有限公司 |
作为钠通道调节剂的喹啉及喹喔啉酰胺类
|
|
PE20160548A1
(es)
|
2013-07-19 |
2016-05-21 |
Vertex Pharma |
Sulfonamidas como moduladores de canales de sodio
|
|
CA2931550C
(en)
|
2013-12-13 |
2023-09-26 |
Vertex Pharmaceuticals Incorporated |
Prodrugs of pyridone amides useful as modulators of sodium channels
|
|
RS60906B1
(sr)
*
|
2014-10-06 |
2020-11-30 |
Vertex Pharma |
Modulatori regulatora transmembranske provodljivosti za cističnu fibrozu
|
|
EP3625214B1
(en)
|
2017-05-16 |
2022-07-06 |
Vertex Pharmaceuticals Incorporated |
Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels
|
|
CA3069720A1
(en)
|
2017-07-11 |
2019-01-17 |
Vertex Pharmaceuticals Incorporated |
Carboxamides as modulators of sodium channels
|
|
WO2019157505A1
(en)
|
2018-02-12 |
2019-08-15 |
Vertex Pharmaceuticals Incorporated |
A method of treating pain
|
|
AU2019301628C1
(en)
|
2018-07-09 |
2025-02-06 |
Lieber Institute, Inc. |
Pyridine carboxamide compounds for inhibiting NaV1.8
|
|
SG11202100137TA
(en)
|
2018-07-09 |
2021-02-25 |
Lieber Institute Inc |
PYRIDAZINE COMPOUNDS FOR INHIBITING Nav1.8
|
|
KR102860523B1
(ko)
|
2018-11-02 |
2025-09-16 |
머크 샤프 앤드 돔 엘엘씨 |
Nav1.8 억제제로서의 2-아미노-n-헤테로아릴-니코틴아미드
|
|
US12344595B2
(en)
|
2018-11-02 |
2025-07-01 |
Merck Sharp & Dohme Llc |
2-amino-n-phenyl-nicotinamides as NAV1.8 inhibitors
|
|
WO2020146682A1
(en)
|
2019-01-10 |
2020-07-16 |
Vertex Pharmaceuticals Incorporated |
Carboxamides as modulators of sodium channels
|
|
WO2020219867A1
(en)
|
2019-04-25 |
2020-10-29 |
Vertex Pharmaceuticals Incorporated |
Pyridone amide co-crystal compositions for the treatment of pain
|
|
US20230103791A1
(en)
|
2019-06-27 |
2023-04-06 |
Glaxosmithkline Intellectual Property Development Limited |
2,3-dihydroquinazolin compounds as nav1.8 inhibitors
|
|
WO2021032074A1
(zh)
|
2019-08-19 |
2021-02-25 |
江苏恒瑞医药股份有限公司 |
苯甲酰胺稠芳环类衍生物、其制备方法及其在医药上的应用
|
|
MX2022006865A
(es)
|
2019-12-06 |
2022-07-11 |
Vertex Pharma |
Tetrahidrofuranos sustituidos como moduladores de canales de sodio.
|
|
BR112022024476A2
(pt)
|
2020-06-17 |
2022-12-27 |
Merck Sharp & Dohme Llc |
5-oxopirrolidino-3-carboxamidas como inibidores de nav1.8
|
|
EP4167994A4
(en)
|
2020-06-17 |
2024-07-24 |
Merck Sharp & Dohme LLC |
2-OXO-OXAZOLIDINE-5-CARBOXAMIDE AS NAV1.8 INHIBITORS
|
|
JP7323723B2
(ja)
|
2020-06-17 |
2023-08-08 |
メルク・シャープ・アンド・ドーム・エルエルシー |
Ｎａｖ１．８阻害剤としての２－オキソイミダゾリジン－４－カルボキサミド
|
|
WO2022121805A1
(zh)
*
|
2020-12-07 |
2022-06-16 |
成都康弘药业集团股份有限公司 |
作为Nav1.8抑制剂的并环化合物及其用途
|