JP2025138846A5 - - Google Patents
Info
- Publication number
- JP2025138846A5 JP2025138846A5 JP2025113743A JP2025113743A JP2025138846A5 JP 2025138846 A5 JP2025138846 A5 JP 2025138846A5 JP 2025113743 A JP2025113743 A JP 2025113743A JP 2025113743 A JP2025113743 A JP 2025113743A JP 2025138846 A5 JP2025138846 A5 JP 2025138846A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- salt
- independently
- occurrence
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962845160P | 2019-05-08 | 2019-05-08 | |
| US62/845,160 | 2019-05-08 | ||
| JP2021565931A JP7824080B2 (ja) | 2019-05-08 | 2020-05-08 | オリゴヌクレオチドの収束液相合成 |
| PCT/US2020/032070 WO2020227618A2 (en) | 2019-05-08 | 2020-05-08 | Convergent liquid phase syntheses of oligonucleotides |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021565931A Division JP7824080B2 (ja) | 2019-05-08 | 2020-05-08 | オリゴヌクレオチドの収束液相合成 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025138846A JP2025138846A (ja) | 2025-09-25 |
| JP2025138846A5 true JP2025138846A5 (https=) | 2025-10-03 |
Family
ID=70919104
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021565931A Active JP7824080B2 (ja) | 2019-05-08 | 2020-05-08 | オリゴヌクレオチドの収束液相合成 |
| JP2025113743A Pending JP2025138846A (ja) | 2019-05-08 | 2025-07-04 | オリゴヌクレオチドの収束液相合成 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021565931A Active JP7824080B2 (ja) | 2019-05-08 | 2020-05-08 | オリゴヌクレオチドの収束液相合成 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12378276B2 (https=) |
| EP (1) | EP3966219A2 (https=) |
| JP (2) | JP7824080B2 (https=) |
| KR (1) | KR20220007104A (https=) |
| CN (3) | CN119143828A (https=) |
| AU (1) | AU2020268415B2 (https=) |
| BR (1) | BR112021022219A2 (https=) |
| CA (1) | CA3139545A1 (https=) |
| EA (1) | EA202193010A1 (https=) |
| IL (2) | IL287798B2 (https=) |
| MA (1) | MA55891A (https=) |
| MX (1) | MX2021013587A (https=) |
| WO (1) | WO2020227618A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2831232A4 (en) | 2012-03-30 | 2015-11-04 | Univ Washington | METHOD FOR MODULATING TAU EXPRESSION TO REDUCE PROBLEMS AND MODIFY A NEURODEGENERATIVE SYNDROME |
| TW202246503A (zh) | 2013-07-19 | 2022-12-01 | 美商百健Ｍａ公司 | 用於調節τ蛋白表現之組合物 |
| KR20230106665A (ko) | 2020-11-11 | 2023-07-13 | 바이오젠 엠에이 인코포레이티드 | 올리고뉴클레오티드, 시약, 및 그의 제조 방법 |
| TW202310854A (zh) * | 2021-07-23 | 2023-03-16 | 美商百健Ｍａ公司 | 用於減少ｔａｕ表現之方法 |
| WO2024083746A1 (en) | 2022-10-17 | 2024-04-25 | Bachem Holding Ag | Method and composition for oligonucleotide synthesis |
| WO2024089953A1 (ja) * | 2022-10-27 | 2024-05-02 | 住友化学株式会社 | オリゴヌクレオチドの製造方法 |
| JPWO2024185775A1 (https=) | 2023-03-06 | 2024-09-12 | ||
| GB202305283D0 (en) * | 2023-04-11 | 2023-05-24 | Exactmer Ltd | Liquid-phase process for preparing oligonucleotides |
| JP7433684B1 (ja) * | 2023-05-24 | 2024-02-20 | 塩野フィネス株式会社 | 疑似固相保護基、それを用いたヌクレオシド保護体又はオリゴヌクレオチド保護体、オリゴアミダイト前駆体の製造方法 |
| EP4695265A1 (en) | 2023-10-16 | 2026-02-18 | Bachem Holding AG | Method and composition for oligonucleotide synthesis |
| US20250206769A1 (en) * | 2023-12-22 | 2025-06-26 | Imec Vzw | Synthesizing a Nucleic Acid or Nucleic Acid Analogue |
| WO2025235761A1 (en) | 2024-05-09 | 2025-11-13 | Biogen Ma Inc. | Reagents and processes for preparing oligonucleotides |
| WO2026085433A2 (en) | 2024-10-17 | 2026-04-23 | Biogen Ma Inc. | Methods for preparing oligonucleotide conjugates |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2096658A1 (en) | 1990-11-20 | 1992-05-21 | Sankyo Company, Limited | Anti-sense nucleic acid derivative |
| US5510476A (en) | 1994-07-07 | 1996-04-23 | Isis Pharmaceuticals, Inc. | Carbocation scavenging during oligonucleotide synthesis |
| AU738032B2 (en) | 1995-10-19 | 2001-09-06 | Proligo Llc | Method for solution phase synthesis of oligonucleotides |
| EP1386925A1 (en) * | 2002-07-31 | 2004-02-04 | Girindus AG | Method for preparing oligonucleotides |
| EP3470072A1 (en) | 2005-06-23 | 2019-04-17 | Biogen MA Inc. | Compositions and methods for modulation of smn2 splicing |
| CN102282155B (zh) | 2008-12-02 | 2017-06-09 | 日本波涛生命科学公司 | 磷原子修饰的核酸的合成方法 |
| JP5548852B2 (ja) | 2009-05-29 | 2014-07-16 | 国立大学法人東京農工大学 | 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法 |
| ES2699827T3 (es) | 2009-06-17 | 2019-02-13 | Biogen Ma Inc | Composiciones y métodos para la modulación de corte y empalme de SMN2 en un sujeto |
| US20120184724A1 (en) * | 2009-09-22 | 2012-07-19 | Agilent Technologies, Inc. | Protected monomers and methods of deprotection for rna synthesis |
| JP5705512B2 (ja) | 2010-11-26 | 2015-04-22 | 農工大ティー・エル・オー株式会社 | 高分散性液相支持体を用いたオリゴヌクレオチド合成法 |
| DK2711370T3 (en) * | 2011-05-17 | 2018-02-26 | Ajinomoto Kk | PROCEDURE FOR THE PREPARATION OF OLIGONUCLEOTIDES |
| US8846885B2 (en) | 2012-02-17 | 2014-09-30 | Ajinomoto Co., Inc. | Oligonucleotide with protected base |
| EP2816053B1 (en) | 2012-02-17 | 2021-03-24 | Ajinomoto Co., Inc. | Base-protected oligonucleotide |
| US9284344B2 (en) * | 2012-05-30 | 2016-03-15 | Hokkaido System Science Co., Ltd. | Oligonucleotide synthesis method using highly dispersible liquid-phase support |
| US10214555B2 (en) * | 2012-11-14 | 2019-02-26 | Takeda Pharmaceutical Company Limitjed | Method for liquid-phase synthesis of nucleic acid |
| HUE050704T2 (hu) | 2014-04-01 | 2020-12-28 | Biogen Ma Inc | Összetételek a SOD-1 expressziójának modulálására |
| CN113717239B (zh) | 2015-01-21 | 2024-12-24 | 味之素株式会社 | 沉淀促进剂以及使用其的沉淀方法 |
| CN116063365A (zh) | 2015-12-16 | 2023-05-05 | 味之素株式会社 | 寡核苷酸的制备方法以及核苷、核苷酸或寡核苷酸 |
| WO2017111137A1 (ja) * | 2015-12-22 | 2017-06-29 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| AU2016381992B2 (en) | 2015-12-28 | 2024-01-04 | Chugai Seiyaku Kabushiki Kaisha | Method for promoting efficiency of purification of Fc region-containing polypeptide |
| TW201906855A (zh) | 2017-05-02 | 2019-02-16 | 日商日產化學工業股份有限公司 | 寡核苷酸之製造方法 |
-
2020
- 2020-05-08 CN CN202411234221.5A patent/CN119143828A/zh active Pending
- 2020-05-08 EP EP20729413.3A patent/EP3966219A2/en active Pending
- 2020-05-08 BR BR112021022219A patent/BR112021022219A2/pt unknown
- 2020-05-08 WO PCT/US2020/032070 patent/WO2020227618A2/en not_active Ceased
- 2020-05-08 EA EA202193010A patent/EA202193010A1/ru unknown
- 2020-05-08 JP JP2021565931A patent/JP7824080B2/ja active Active
- 2020-05-08 AU AU2020268415A patent/AU2020268415B2/en active Active
- 2020-05-08 CN CN202080044020.2A patent/CN114206897B/zh active Active
- 2020-05-08 CN CN202411234328.XA patent/CN119462804A/zh active Pending
- 2020-05-08 MA MA055891A patent/MA55891A/fr unknown
- 2020-05-08 MX MX2021013587A patent/MX2021013587A/es unknown
- 2020-05-08 CA CA3139545A patent/CA3139545A1/en active Pending
- 2020-05-08 IL IL287798A patent/IL287798B2/en unknown
- 2020-05-08 US US17/608,802 patent/US12378276B2/en active Active
- 2020-05-08 KR KR1020217039894A patent/KR20220007104A/ko active Pending
- 2020-05-08 IL IL319933A patent/IL319933A/en unknown
-
2025
- 2025-07-04 JP JP2025113743A patent/JP2025138846A/ja active Pending
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