JP2025024050A5 - - Google Patents
Info
- Publication number
- JP2025024050A5 JP2025024050A5 JP2024196277A JP2024196277A JP2025024050A5 JP 2025024050 A5 JP2025024050 A5 JP 2025024050A5 JP 2024196277 A JP2024196277 A JP 2024196277A JP 2024196277 A JP2024196277 A JP 2024196277A JP 2025024050 A5 JP2025024050 A5 JP 2025024050A5
- Authority
- JP
- Japan
- Prior art keywords
- host cell
- seq
- transcription factor
- amino acid
- set forth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18180164.8 | 2018-06-27 | ||
| EP18180164 | 2018-06-27 | ||
| JP2020573043A JP7645076B2 (ja) | 2018-06-27 | 2019-06-27 | 転写因子の使用によってタンパク質発現を増加させるための手段及び方法 |
| PCT/EP2019/067133 WO2020002494A1 (en) | 2018-06-27 | 2019-06-27 | Means and methods for increased protein expression by use of transcription factors |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020573043A Division JP7645076B2 (ja) | 2018-06-27 | 2019-06-27 | 転写因子の使用によってタンパク質発現を増加させるための手段及び方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025024050A JP2025024050A (ja) | 2025-02-19 |
| JP2025024050A5 true JP2025024050A5 (https=) | 2025-10-02 |
Family
ID=62916411
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020573043A Active JP7645076B2 (ja) | 2018-06-27 | 2019-06-27 | 転写因子の使用によってタンパク質発現を増加させるための手段及び方法 |
| JP2024196277A Pending JP2025024050A (ja) | 2018-06-27 | 2024-11-08 | 転写因子の使用によってタンパク質発現を増加させるための手段及び方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020573043A Active JP7645076B2 (ja) | 2018-06-27 | 2019-06-27 | 転写因子の使用によってタンパク質発現を増加させるための手段及び方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20210269811A1 (https=) |
| EP (1) | EP3814491A1 (https=) |
| JP (2) | JP7645076B2 (https=) |
| KR (1) | KR20210032972A (https=) |
| CN (1) | CN112955547B (https=) |
| AU (1) | AU2019294515B2 (https=) |
| CA (1) | CA3103988A1 (https=) |
| SG (1) | SG11202012529VA (https=) |
| WO (1) | WO2020002494A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018119142A1 (en) | 2016-12-21 | 2018-06-28 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| BR112022015325A2 (pt) * | 2020-02-04 | 2022-09-27 | Clara Foods Co | Sistemas e métodos para alta produção de microganismos recombinantes e uso dos mesmos |
| ES3034258T3 (en) | 2020-04-01 | 2025-08-14 | Lonza Ag | Helper factors for expressing proteins in yeast |
| CA3175683A1 (en) * | 2020-04-29 | 2021-11-04 | Xueyang FENG | Compositions and methods for enhancing recombinant biosynthesis of cannabinoids |
| CN114657190B (zh) * | 2022-04-06 | 2023-08-29 | 暨南大学 | Msn2p作为负调控因子在提高宿主细胞中蛋白表达中的应用 |
| CN114836461B (zh) * | 2022-05-31 | 2024-03-29 | 华南理工大学 | 表达胶原蛋白酶的重组质粒、酵母菌株及其发酵培养基和发酵培养方法 |
| CN115725632B (zh) * | 2022-07-26 | 2023-12-22 | 深圳技术大学 | 一种Aomsn2过表达米曲霉工程菌及其构建方法与应用 |
| EP4634389A1 (en) * | 2022-12-16 | 2025-10-22 | Boehringer Ingelheim RCV GmbH & Co KG | Means and methods for increased protein expression by use of a combination of transport proteins and either chaperones or transcription factors |
| WO2025129656A1 (zh) * | 2023-12-22 | 2025-06-26 | 中国科学院深圳先进技术研究院 | 一种模块化正交真核转录因子模型构建方法 |
| CN117777275B (zh) * | 2024-02-23 | 2024-05-31 | 北京国科星联科技有限公司 | 一种促进人乳铁蛋白在马克斯克鲁维酵母中分泌表达的方法 |
| CN119220426B (zh) * | 2024-12-05 | 2025-04-25 | 通化安睿特生物制药股份有限公司 | 一种重组毕赤酵母工程菌及其构建方法和应用 |
| CN119799530B (zh) * | 2024-12-31 | 2025-12-16 | 溧阳市优甜生物科技有限公司 | 重组酵母细胞及其在生产索马甜中的用途 |
| CN120249088B (zh) * | 2025-06-05 | 2025-09-09 | 上海欣瑞特生物医药技术有限公司 | 一种用于制备重组犬白蛋白的重组工程菌及其应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4601893A (en) | 1984-02-08 | 1986-07-22 | Pfizer Inc. | Laminate device for controlled and prolonged release of substances to an ambient environment and method of use |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| DE4027453A1 (de) | 1990-08-30 | 1992-03-05 | Degussa | Neue plasmide aus corynebacterium glutamicum und davon abgeleitete plasmidvektoren |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| DE4343591A1 (de) | 1993-12-21 | 1995-06-22 | Evotec Biosystems Gmbh | Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| DE4440118C1 (de) | 1994-11-11 | 1995-11-09 | Forschungszentrum Juelich Gmbh | Die Genexpression in coryneformen Bakterien regulierende DNA |
| JPH10229891A (ja) | 1997-02-20 | 1998-09-02 | Mitsubishi Rayon Co Ltd | マロン酸誘導体の製造法 |
| GB9704162D0 (en) | 1997-02-28 | 1997-04-16 | Medical Res Council | Assay methods and means |
| US6949356B1 (en) | 1999-10-20 | 2005-09-27 | Microbia, Inc. | Methods for improving secondary metabolite production in fungi |
| EP1373470B1 (en) * | 2001-02-20 | 2013-04-24 | Intrexon Corporation | Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
| JP2003000240A (ja) | 2001-06-22 | 2003-01-07 | National Research Inst Of Brewing | 麹菌の固体培養発現遺伝子を制御する転写因子をコードするdna |
| WO2003012036A2 (en) | 2001-07-27 | 2003-02-13 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Systems for in vivo site-directed mutagenesis using oligonucleotides |
| EP1680447A2 (en) * | 2003-10-24 | 2006-07-19 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Orthogonal gene switches |
| US20050130306A1 (en) * | 2003-12-10 | 2005-06-16 | Richard Voellmy | Viral vectors whose replication and, optionally, passenger gene are controlled by a gene switch activated by heat in the presence or absence of a small molecule regulator |
| SI22056A (sl) * | 2005-05-05 | 2006-12-31 | Kemijski Institut | Visoko-produkcijski rekombinantni sevi kvasovk s spremenjeno galaktozno regulacijo transkripcije |
| CA2644273A1 (en) * | 2006-04-05 | 2008-03-27 | Metanomics Gmbh | Process for the production of a fine chemical |
| CN101679992A (zh) * | 2007-04-20 | 2010-03-24 | 波利门科学生物免疫研究有限公司 | 酵母菌表达系统 |
| WO2009058956A1 (en) * | 2007-11-01 | 2009-05-07 | Danisco Us, Inc. | Signal sequences and co-expressed chaperones for improving protein production in a host cell |
| KR20100117465A (ko) * | 2009-04-24 | 2010-11-03 | 삼성전자주식회사 | 호스트셀의 알코올 내성을 증대시키는 단리된 폴리뉴클레오티드, 이를 포함하는 벡터, 호스트셀 및 이를 이용한 알코올의 생산방법 |
| EP2258854A1 (en) | 2009-05-20 | 2010-12-08 | FH Campus Wien | Eukaryotic host cell comprising an expression enhancer |
| JP5585952B2 (ja) | 2009-12-08 | 2014-09-10 | 独立行政法人酒類総合研究所 | エタノールの製造方法 |
| WO2011159153A2 (en) * | 2010-06-15 | 2011-12-22 | Universiteit Utrecht Holding B.V. | Inducible promoter and its use |
| CN102643852B (zh) * | 2011-02-28 | 2015-04-08 | 华东理工大学 | 光可控的基因表达系统 |
| JP6295512B2 (ja) | 2012-03-15 | 2018-03-20 | 株式会社豊田中央研究所 | 酵母における外来遺伝子の発現産物の生産方法、酵母における発現調節剤及びその利用 |
| CN106661541B (zh) * | 2014-04-17 | 2021-09-03 | 贝林格尔·英格海姆Rcv两合公司 | 被工程化为过表达辅助蛋白的重组宿主细胞 |
| AU2015248807B2 (en) | 2014-04-17 | 2021-07-22 | Boehringer Ingelheim Rcv Gmbh & Co Kg | Recombinant host cell for expressing proteins of interest |
| CN104031854B (zh) * | 2014-06-20 | 2017-02-22 | 广西科学院 | 一株提高对乙醇耐受性的酿酒酵母基因工程菌株及其构建方法 |
| KR102287810B1 (ko) * | 2014-07-28 | 2021-08-09 | 삼성전자주식회사 | Msn2의 활성이 증가되도록 유전적으로 조작된, 스트레스 내성을 갖는 효모 세포 및 그를 이용하여 락테이트를 생산하는 방법 |
| EP3180440A4 (en) * | 2014-08-11 | 2018-01-10 | Butamax Advanced Biofuels LLC | Yeast preparations and methods of making the same |
| EP3334751A1 (en) * | 2015-08-13 | 2018-06-20 | Glykos Finland Oy | Regulatory protein deficient trichoderma cells and methods of use thereof |
| US12060394B2 (en) * | 2016-04-28 | 2024-08-13 | The Trustees Of Dartmouth College | Nucleic acid constructs for co-expression of chimeric antigen receptor and transcription factor, cells containing and therapeutic use thereof |
| CN107267529B (zh) * | 2017-07-20 | 2019-09-27 | 昆明理工大学 | 一种锌指蛋白转录因子基因RkMSN4及其应用 |
-
2019
- 2019-06-27 JP JP2020573043A patent/JP7645076B2/ja active Active
- 2019-06-27 CN CN201980056449.0A patent/CN112955547B/zh active Active
- 2019-06-27 EP EP19741973.2A patent/EP3814491A1/en active Pending
- 2019-06-27 WO PCT/EP2019/067133 patent/WO2020002494A1/en not_active Ceased
- 2019-06-27 SG SG11202012529VA patent/SG11202012529VA/en unknown
- 2019-06-27 US US17/254,238 patent/US20210269811A1/en active Pending
- 2019-06-27 KR KR1020217002744A patent/KR20210032972A/ko active Pending
- 2019-06-27 AU AU2019294515A patent/AU2019294515B2/en active Active
- 2019-06-27 CA CA3103988A patent/CA3103988A1/en active Pending
-
2024
- 2024-11-08 JP JP2024196277A patent/JP2025024050A/ja active Pending
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