JP2024519029A - Ｐｄ－１遺伝子編集された腫瘍浸潤リンパ球及び免疫療法におけるその使用 - Google Patents

Ｐｄ－１遺伝子編集された腫瘍浸潤リンパ球及び免疫療法におけるその使用 Download PDF

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JP2024519029A
JP2024519029A JP2023571261A JP2023571261A JP2024519029A JP 2024519029 A JP2024519029 A JP 2024519029A JP 2023571261 A JP2023571261 A JP 2023571261A JP 2023571261 A JP2023571261 A JP 2023571261A JP 2024519029 A JP2024519029 A JP 2024519029A
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til population
population
expansion
tils
til
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JP2024519029A5 (enExample
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ジー． フォーグト，フレデリック
リッチピチャイ，クリット
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アイオバンス バイオセラピューティクス，インコーポレイテッド
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    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C12N2501/20—Cytokines; Chemokines
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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JP2023571261A 2021-05-17 2022-05-16 Ｐｄ－１遺伝子編集された腫瘍浸潤リンパ球及び免疫療法におけるその使用 Pending JP2024519029A (ja)

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US202163189650P 2021-05-17 2021-05-17
US63/189,650 2021-05-17
PCT/US2022/029496 WO2022245754A1 (en) 2021-05-17 2022-05-16 Pd-1 gene-edited tumor infiltrating lymphocytes and uses of same in immunotherapy

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JP2024519029A true JP2024519029A (ja) 2024-05-08
JP2024519029A5 JP2024519029A5 (enExample) 2025-05-22

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US (1) US20240269180A1 (enExample)
EP (1) EP4340850A1 (enExample)
JP (1) JP2024519029A (enExample)
CA (1) CA3219148A1 (enExample)
WO (1) WO2022245754A1 (enExample)

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CN106061488B (zh) * 2013-12-02 2021-04-09 菲奥医药公司 癌症的免疫治疗
WO2023039488A1 (en) * 2021-09-09 2023-03-16 Iovance Biotherapeutics, Inc. Processes for generating til products using pd-1 talen knockdown
CN115944650B (zh) * 2023-01-03 2023-11-28 青岛大学 肿瘤浸润细胞在制备抗肿瘤药物中的应用及模型构建方法
WO2025054540A1 (en) * 2023-09-08 2025-03-13 Iovance Biotherapeutics, Inc. Methods of gene-editing using programmable nucleases

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