|
ES2325440T3
(es)
|
2003-02-20 |
2009-09-04 |
Smithkline Beecham Corporation |
Compuestos de pirimidina.
|
|
WO2005099363A2
(en)
|
2004-03-26 |
2005-10-27 |
Whitehead Institute For Biomedical Research |
Methods of diagnosing, preventing and treating cancer metastasis
|
|
GB0512324D0
(en)
|
2005-06-16 |
2005-07-27 |
Novartis Ag |
Organic compounds
|
|
PE20060664A1
(es)
|
2004-09-15 |
2006-08-04 |
Novartis Ag |
Amidas biciclicas como inhibidores de cinasa
|
|
UA95244C2
(ru)
|
2005-06-22 |
2011-07-25 |
Плексикон, Инк. |
Соединения и способ модулирования активности киназ, и показания для их применения
|
|
BRPI0709680B8
(pt)
|
2006-03-27 |
2021-05-25 |
Nerviano Medical Sciences Srl |
derivados de pirrol, tiofeno e furano substituídos por piridil e piridimil como inibidores de quinase
|
|
PE20121126A1
(es)
|
2006-12-21 |
2012-08-24 |
Plexxikon Inc |
Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
|
|
WO2008079909A1
(en)
|
2006-12-21 |
2008-07-03 |
Plexxikon, Inc. |
Pyrrolo [2,3-b] pyridines as kinase modulators
|
|
JP2010514695A
(ja)
|
2006-12-21 |
2010-05-06 |
プレキシコン,インコーポレーテッド |
キナーゼ調節のための化合物および方法およびそのための適応症
|
|
AU2008273889B2
(en)
|
2007-07-09 |
2012-03-08 |
Astrazeneca Ab |
Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
|
|
WO2009012283A1
(en)
|
2007-07-17 |
2009-01-22 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
MY150032A
(en)
|
2007-07-19 |
2013-11-29 |
Merck Sharp & Dohme |
Heterocyclic amide compounds as protein kinase inhibitors
|
|
WO2009071480A2
(en)
|
2007-12-04 |
2009-06-11 |
Nerviano Medical Sciences S.R.L. |
Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors
|
|
WO2009108827A1
(en)
*
|
2008-02-29 |
2009-09-03 |
Wyeth |
Fused tricyclic pyrazolo[1, 5-a]pyrimidines, methods for preparation and uses thereof
|
|
EP2254886B1
(en)
|
2008-03-28 |
2016-05-25 |
Nerviano Medical Sciences S.r.l. |
3,4-dihydro-2h-pyrazino[1,2-a]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
|
|
PE20091846A1
(es)
|
2008-05-19 |
2009-12-16 |
Plexxikon Inc |
DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS
|
|
WO2009143018A2
(en)
|
2008-05-19 |
2009-11-26 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
ES2554513T3
(es)
|
2008-05-23 |
2015-12-21 |
Novartis Ag |
Derivados de quinolinas y quinoxalinas como inhibidores de la proteína tirosina quinasa
|
|
JP5767965B2
(ja)
|
2008-06-10 |
2015-08-26 |
プレキシコン インコーポレーテッドPlexxikon Inc. |
キナーゼを調節する5h−ピロロ[2,3−b]ピラジン誘導体、およびその適応症
|
|
JP5746032B2
(ja)
|
2008-09-19 |
2015-07-08 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
3,4−ジヒドロ−2H−ピロロ[1,2−a]ピラジン−1−オン誘導体
|
|
JO3265B1
(ar)
|
2008-12-09 |
2018-09-16 |
Novartis Ag |
مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض
|
|
WO2010111527A1
(en)
|
2009-03-26 |
2010-09-30 |
Plexxikon, Inc. |
Pyrazolo [ 3, 4 -b] pyridines as kinase inhibitors and their medical use
|
|
US8546413B2
(en)
|
2009-06-15 |
2013-10-01 |
Nerviano Medical Sciences S.R.L. |
Substituted pyrimidinylpyrrolopyridinone derivatives, process for their preparation and their use as kinase inhibitors
|
|
WO2011092120A1
(en)
|
2010-01-29 |
2011-08-04 |
Nerviano Medical Sciences S.R.L. |
6,7- dihydroimidazo [1,5-a] pyrazin-8 (5h) - one derivatives as protein kinase modulators
|
|
ES2594927T3
(es)
|
2010-02-18 |
2016-12-23 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Métodos para prevenir las metástasis cancerosas
|
|
EP2668190B1
(en)
|
2011-01-26 |
2016-08-17 |
Nerviano Medical Sciences S.r.l. |
Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors
|
|
WO2012101029A1
(en)
|
2011-01-26 |
2012-08-02 |
Nerviano Medical Sciences S.R.L. |
Tricyclic derivatives, process for their preparation and their use as kinase inhibitors
|
|
US9624213B2
(en)
|
2011-02-07 |
2017-04-18 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
CN103403002B
(zh)
|
2011-02-24 |
2016-06-22 |
内尔维阿诺医学科学有限公司 |
作为激酶抑制剂的噻唑基苯基-苯磺酰氨基衍生物
|
|
EP2702055A1
(en)
|
2011-04-11 |
2014-03-05 |
Nerviano Medical Sciences S.r.l. |
Pyrazolyl-pyrimidine derivatives as kinase inhibitors
|
|
JP5970537B2
(ja)
|
2011-04-19 |
2016-08-17 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
キナーゼ阻害薬として活性な置換ピリミジニル−ピロール
|
|
PT2707359T
(pt)
|
2011-05-12 |
2017-01-09 |
Nerviano Medical Sciences Srl |
Derivados de indazol substituídos ativos como inibidores de quinase
|
|
JP6016915B2
(ja)
|
2011-07-28 |
2016-10-26 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
キナーゼ阻害剤として活性なアルキニル置換ピリミジニルピロール
|
|
JP6063945B2
(ja)
|
2011-10-07 |
2017-01-18 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
キナーゼ阻害剤としての4−アルキル置換3,4−ジヒドロピロロ[1,2−a]ピラジン−1(2H)−オン誘導体
|
|
US9145418B2
(en)
|
2011-10-07 |
2015-09-29 |
Nerviano Medical Sciences S.R.L. |
Substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ones as protein kinase inhibitors
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
SG11201500125QA
(en)
|
2012-07-11 |
2015-02-27 |
Blueprint Medicines Corp |
Inhibitors of the fibroblast growth factor receptor
|
|
BR112015002152B1
(pt)
|
2012-08-02 |
2021-04-27 |
Nerviano Medical Sciences S.R.L. |
Compostos de pirróis substituídos ativos como inibidores de quinases, processo para a preparação de tais compostos, composição farmacêutica, método in vitro para a inibição da atividade de proteínas quinases da família jak e produto compreendendo os referidos compostos
|
|
ES2755772T3
(es)
|
2012-11-07 |
2020-04-23 |
Nerviano Medical Sciences Srl |
Pirimidinil y piridinilpirrolopiridinonas sustituidas, proceso para su preparación y su uso como inhibidores de cinasas
|
|
CA2877847A1
(en)
|
2012-11-29 |
2014-06-05 |
Yeda Research And Development Co. Ltd. |
Methods of preventing tumor metastasis, treating and prognosing cancer and identifying agents which are putative metastasis inhibitors
|
|
WO2014160521A1
(en)
|
2013-03-15 |
2014-10-02 |
Blueprint Medicines Corporation |
Piperazine derivatives and their use as kit modulators
|
|
EP2997030B1
(en)
|
2013-05-14 |
2017-08-09 |
Nerviano Medical Sciences S.R.L. |
Pyrrolo[2,3-d]pyrimidine derivatives, process for their preparation and their use as kinase inhibitors
|
|
CN105228983A
(zh)
|
2013-05-30 |
2016-01-06 |
普莱希科公司 |
用于激酶调节的化合物及其适应症
|
|
EP3027654B1
(en)
|
2013-07-30 |
2019-09-25 |
Blueprint Medicines Corporation |
Pik3c2g fusions
|
|
EP3628749A1
(en)
|
2013-07-30 |
2020-04-01 |
Blueprint Medicines Corporation |
Ntrk2 fusions
|
|
WO2015058129A1
(en)
|
2013-10-17 |
2015-04-23 |
Blueprint Medicines Corporation |
Compositions useful for treating disorders related to kit
|
|
SI3057969T1
(sl)
|
2013-10-17 |
2018-10-30 |
Blueprint Medicines Corporation |
Sestavki, uporabni za zdravljenje motenj, povezanih s KIT
|
|
RS63405B1
(sr)
|
2013-10-25 |
2022-08-31 |
Blueprint Medicines Corp |
Inhibitori receptora faktora rasta fibroblasta
|
|
US9695165B2
(en)
|
2014-01-15 |
2017-07-04 |
Blueprint Medicines Corporation |
Inhibitors of the fibroblast growth factor receptor
|
|
ES2933350T3
(es)
|
2014-01-24 |
2023-02-06 |
Turning Point Therapeutics Inc |
Macrociclos de diarilo como moduladores de proteína quinasas
|
|
WO2015161274A1
(en)
|
2014-04-18 |
2015-10-22 |
Blueprint Medicines Corporation |
Pik3ca fusions
|
|
US20170044621A1
(en)
|
2014-04-18 |
2017-02-16 |
Blueprint Medicines Corporation |
Met fusions
|
|
EP3155118A1
(en)
|
2014-06-10 |
2017-04-19 |
Blueprint Medicines Corporation |
Pkn1 fusions
|
|
WO2015191666A2
(en)
|
2014-06-10 |
2015-12-17 |
Blueprint Medicines Corporation |
Raf1 fusions
|
|
US10370724B2
(en)
|
2014-07-17 |
2019-08-06 |
Blueprint Medicines Corporation |
PRKC fusions
|
|
WO2016011144A1
(en)
|
2014-07-17 |
2016-01-21 |
Blueprint Medicines Corporation |
Tert fusions
|
|
US10370725B2
(en)
|
2014-07-17 |
2019-08-06 |
Blueprint Medicines Corporation |
FGR fusions
|
|
US9688680B2
(en)
|
2014-08-04 |
2017-06-27 |
Blueprint Medicines Corporation |
Compositions useful for treating disorders related to kit
|
|
KR102562866B1
(ko)
|
2014-11-14 |
2023-08-04 |
네르비아노 메디칼 사이언시스 에스.알.엘. |
단백질 키나아제 억제제로서의 6-아미노-7-바이사이클로-7-데아자-퓨린 유도체
|
|
EP3221700B1
(en)
|
2014-11-18 |
2022-06-22 |
Blueprint Medicines Corporation |
Prkacb fusions
|
|
BR112017023764A2
(pt)
*
|
2015-05-05 |
2018-07-31 |
Bayer Pharma AG |
derivados de ciclohexano substituído por amido
|
|
WO2018226150A1
(en)
*
|
2017-06-05 |
2018-12-13 |
Medivir Aktiebolag |
Pyrazolopyrimidine as malt-1 inhibitors
|