JP2024127887A5 - - Google Patents

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JP2024127887A5
JP2024127887A5 JP2024090475A JP2024090475A JP2024127887A5 JP 2024127887 A5 JP2024127887 A5 JP 2024127887A5 JP 2024090475 A JP2024090475 A JP 2024090475A JP 2024090475 A JP2024090475 A JP 2024090475A JP 2024127887 A5 JP2024127887 A5 JP 2024127887A5
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Priority claimed from PCT/US2019/039582 external-priority patent/WO2020006285A1/en
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JP2024090475A 2018-06-27 2024-06-04 デオキシリボースを含むリンカー基を有するポリマー色素 Pending JP2024127887A (ja)

Applications Claiming Priority (4)

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US201862690656P 2018-06-27 2018-06-27
US62/690,656 2018-06-27
PCT/US2019/039582 WO2020006285A1 (en) 2018-06-27 2019-06-27 Polymeric dyes with linker groups comprising deoxyribose
JP2020572789A JP7580689B2 (ja) 2018-06-27 2019-06-27 デオキシリボースを含むリンカー基を有するポリマー色素

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JP2020572789A Division JP7580689B2 (ja) 2018-06-27 2019-06-27 デオキシリボースを含むリンカー基を有するポリマー色素

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JP2024127887A JP2024127887A (ja) 2024-09-20
JP2024127887A5 true JP2024127887A5 (enExample) 2025-03-18

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JP2020572789A Active JP7580689B2 (ja) 2018-06-27 2019-06-27 デオキシリボースを含むリンカー基を有するポリマー色素
JP2024090475A Pending JP2024127887A (ja) 2018-06-27 2024-06-04 デオキシリボースを含むリンカー基を有するポリマー色素

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US (3) US12006438B2 (enExample)
EP (1) EP3814366A1 (enExample)
JP (2) JP7580689B2 (enExample)
KR (2) KR102854332B1 (enExample)
CN (1) CN112313242A (enExample)
WO (1) WO2020006285A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105377994B (zh) 2013-08-22 2018-03-02 索尼公司 水溶性荧光染料或有色染料及其使用方法
WO2016138461A1 (en) 2015-02-26 2016-09-01 Sony Corporation Water soluble fluorescent or colored dyes comprising conjugating groups
EP3436529A1 (en) 2016-04-01 2019-02-06 Sony Corporation Ultra bright dimeric or polymeric dyes
KR102756931B1 (ko) 2016-04-06 2025-01-21 소니그룹주식회사 스페이싱 링커 그룹을 포함하는 초고명도 이량체성 또는 중합체성 염료
CN109071961B (zh) 2016-05-11 2021-04-27 索尼公司 超亮二聚或聚合染料
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
EP3639013A4 (en) 2017-06-16 2021-06-30 Duke University Resonator networks for improved label detection, computation, analyte sensing, and tunable random number generation
KR20200067132A (ko) 2017-10-05 2020-06-11 소니 주식회사 프로그램가능한 중합체성 약물
EP3691689A1 (en) 2017-10-05 2020-08-12 Sony Corporation Programmable dendritic drugs
CN111836645A (zh) 2017-11-16 2020-10-27 索尼公司 可编程的聚合药物
JP2021510696A (ja) 2018-01-12 2021-04-30 ソニー株式会社 生物学的に活性な化合物を含む剛性間隔基を有するポリマー
US12194104B2 (en) 2018-01-12 2025-01-14 Sony Group Corporation Phosphoalkyl ribose polymers comprising biologically active compounds
EP4137818B1 (en) 2018-03-19 2025-12-10 Sony Group Corporation Use of divalent metals for enhancement of fluorescent signals
CN118480073A (zh) 2018-03-21 2024-08-13 索尼公司 具有连接体基团的聚合串联染料
JP2021519841A (ja) 2018-03-30 2021-08-12 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company ペンダントクロモフォアを有する水溶性ポリマー色素
CN112313242A (zh) 2018-06-27 2021-02-02 索尼公司 具有含脱氧核糖的连接体基团的聚合物染料
KR20210152523A (ko) * 2019-04-11 2021-12-15 소니그룹주식회사 프로그램 가능한 중합체성 약물
JP7239904B2 (ja) 2019-09-26 2023-03-15 ソニーグループ株式会社 リンカー基を有するポリマータンデム色素
JP2023552448A (ja) 2020-12-07 2023-12-15 ソニーグループ株式会社 二量体色素又はポリマー色素における輝度を増強するためのスペーシングリンカー基の設計
CN116917738A (zh) 2021-04-07 2023-10-20 贝克顿·迪金森公司 水溶性荧光聚合物染料
KR20240063130A (ko) * 2021-09-30 2024-05-09 소니그룹주식회사 중합체성 이중 약물의 자동 합성
JP2024536224A (ja) * 2021-09-30 2024-10-04 ソニーグループ株式会社 がん処置用のピロロベンゾジアゼピンコンジュゲート

Family Cites Families (180)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450305A (en) 1982-10-25 1984-05-22 American Cyanamid Company Poly(ethyleneoxy)-substituted-9,10-bis(phenylethynyl)anthracenes
US4476229A (en) 1982-11-08 1984-10-09 Abbott Laboratories Substituted carboxyfluoresceins
SU1121931A1 (ru) 1983-01-10 1988-04-15 Институт Биологической Химии Ан Бсср Конъюгаты тиреоидных гормонов с альбумином дл выработки антител к тиреоидным гормонам у животных
EP0355864A3 (en) 1984-03-15 1991-09-18 Wako Pure Chemical Industries, Ltd. Method of quantitatively measuring an oxidative substance by using triphenyl methane type leuco compounds as coloring matter
JPH0665677B2 (ja) 1985-03-09 1994-08-24 三菱化成株式会社 リン脂質類似構造を有するジオ−ルおよびその製造方法
US5268486A (en) 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US5053054A (en) 1988-09-12 1991-10-01 Ortho Pharmaceutical Corporation Methods and reagents for staining intracellular components
US5318894A (en) 1990-01-30 1994-06-07 Miles Inc. Composition, device and method of assaying for peroxidatively active substances
US6365730B1 (en) 1990-06-19 2002-04-02 Gene Shears Pty. Limited DNA-Armed ribozymes and minizymes
JPH04282391A (ja) 1991-03-08 1992-10-07 Fujisawa Pharmaceut Co Ltd エタノールアミン誘導体およびその製造法
US5698391A (en) 1991-08-23 1997-12-16 Isis Pharmaceuticals, Inc. Methods for synthetic unrandomization of oligomer fragments
DE69219610T2 (de) 1991-09-16 1997-10-02 Molecular Probes Inc Dimere unsymmetrische Cyaninfarbstoffe
ATE272068T1 (de) 1991-11-07 2004-08-15 Nanotronics Inc Hybridisierung von mit chromophoren und fluorophoren konjugierten polynukleotiden zur erzeugung eines donor-donor energietransfersystems
JPH08511002A (ja) 1993-04-13 1996-11-19 ナクスコー ポリヌクレオチド架橋剤としての非ヌクレオシドクマリン誘導体
ES2259791T3 (es) 1993-07-13 2006-10-16 Abbott Laboratories Conjugados sumamente fluorescentes de polimeros e intermedios.
DE69431669T2 (de) 1993-09-02 2003-10-23 Ribozyme Pharmaceuticals, Inc. Enzymatische nukleiksaüre die nicht-nukleotide enthaltet
US5886177A (en) 1994-01-11 1999-03-23 Isis Pharmaceuticals, Inc. Phosphate linked oligomers
US6171859B1 (en) 1994-03-30 2001-01-09 Mitokor Method of targeting conjugate molecules to mitochondria
US5994143A (en) 1996-02-01 1999-11-30 Abbott Laboratories Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment
US6218108B1 (en) 1997-05-16 2001-04-17 Research Corporation Technologies, Inc. Nucleoside analogs with polycyclic aromatic groups attached, methods of synthesis and uses therefor
DE19633268A1 (de) 1996-08-19 1998-02-26 Hoechst Ag Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung
US5696157A (en) 1996-11-15 1997-12-09 Molecular Probes, Inc. Sulfonated derivatives of 7-aminocoumarin
JP2001511128A (ja) 1997-01-28 2001-08-07 ファルマシア・アンド・アップジョン・カンパニー 水不溶性ポルフィリンの脂質錯体の凍結乾燥物
US6893868B2 (en) 1997-02-20 2005-05-17 Onco Immunin, Inc. Homo-doubly labeled compositions for the detection of enzyme activity in biological samples
US5986030A (en) 1997-04-15 1999-11-16 Nalco Chemical Company Fluorescent water soluble polymers
DE19717904A1 (de) 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
JP3078793B2 (ja) 1998-04-30 2000-08-21 株式会社分子バイオホトニクス研究所 ロタキサン構造を有する色素、ラベル化剤、およびラベル化方法
US6716452B1 (en) 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US7060708B2 (en) 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6627400B1 (en) 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US6514700B1 (en) 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US20020142329A1 (en) * 1999-04-30 2002-10-03 Aclara Biosciences, Inc. Compositions and methods employing cleavable electrophoretic tag reagents
US7037654B2 (en) * 1999-04-30 2006-05-02 Aclara Biosciences, Inc. Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
WO2001007430A1 (en) 1999-07-22 2001-02-01 Nalco Chemical Compant Fluorescent water-soluble polymers
US6479650B1 (en) 1999-12-14 2002-11-12 Research Corporation Technologies, Inc. Fluorescent nucleoside analogs and combinatorial fluorophore arrays comprising same
AU2001245643A1 (en) 2000-03-14 2001-09-24 Genigma Corporation Biomarkers for the labeling, visual detection and quantification of biomolecules
ATE487136T1 (de) 2000-03-28 2010-11-15 Nanosphere Inc Nanopartikel mit gebundenen oligonukleotiden und verwendungen derselben
US20040067498A1 (en) * 2000-04-28 2004-04-08 Ahmed Chenna Detection of nucleic acid sequences by cleavage and separation of tag-containing structures
WO2001085997A1 (en) 2000-05-08 2001-11-15 Qtl Biosystems Llc Improvements to the fluorescent polymer-qtl approach to biosensing
AU2001265252A1 (en) 2000-05-31 2001-12-11 The Johns-Hopkins University Biologically useful polyphosphates
US20020099013A1 (en) 2000-11-14 2002-07-25 Thomas Piccariello Active agent delivery systems and methods for protecting and administering active agents
WO2002022883A1 (en) 2000-09-11 2002-03-21 The Trustees Of Columbia University In The City Of New York Combinatorial fluorescence energy transfer tags and uses thereof
DE60116510T2 (de) 2000-09-19 2006-07-13 Li-Cor, Inc., Lincoln Cyaninfarbstoffe
US6448407B1 (en) 2000-11-01 2002-09-10 Pe Corporation (Ny) Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
GB2372256A (en) 2001-02-14 2002-08-21 Kalibrant Ltd Detectable entity comprising a plurality of detectable units releasably connected together by stimulus-cleavable linkers for use in fluorescence detection
US6743905B2 (en) 2001-04-16 2004-06-01 Applera Corporation Mobility-modified nucleobase polymers and methods of using same
US8323903B2 (en) 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
JP3813890B2 (ja) 2002-03-22 2006-08-23 富士写真フイルム株式会社 3層レジストプロセス用中間層材料組成物及びそれを用いたパターン形成方法
US20040086914A1 (en) 2002-07-12 2004-05-06 Affymetrix, Inc. Nucleic acid labeling methods
AU2003262833A1 (en) 2002-08-23 2004-03-11 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent glycosides and methods for their use
EA007653B1 (ru) 2002-08-26 2006-12-29 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Способы и композиции обнаружения и анализа полинуклеотидов с помощью светособирающих полихромофоров
US20040138467A1 (en) 2002-11-26 2004-07-15 French Roger Harquail Aromatic and aromatic/heteroaromatic molecular structures with controllable electron conducting properties
WO2004062475A2 (en) 2003-01-10 2004-07-29 Albert Einstein College Of Medicine Of Yeshiva University Fluorescent assays for protein kinases
US7238792B2 (en) 2003-03-18 2007-07-03 Washington State University Research Foundation Foldable polymers as probes
US7172907B2 (en) 2003-03-21 2007-02-06 Ge Healthcare Bio-Sciences Corp. Cyanine dye labelling reagents with meso-substitution
WO2005016960A2 (en) 2003-08-14 2005-02-24 Diatos Amino acid sequences facilitating penetration of a substance of interest into cells and/or cell nuclei
JP2007534308A (ja) 2003-11-19 2007-11-29 アレロジック・バイオサイエンシズ・コーポレーション 複数のフルオロフォアで標識したオリゴヌクレオチド
AU2003296419A1 (en) 2003-12-09 2005-07-21 Molecular Probes, Inc. Pyrenyloxysulfonic acid fluorescent agents
US7626014B2 (en) 2004-04-27 2009-12-01 Alnylam Pharmaceuticals Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
WO2006002167A2 (en) 2004-06-17 2006-01-05 University Of Florida Research Foudation, Inc. Multi-acceptor molecular probes and applications thereof
US20060035302A1 (en) 2004-06-21 2006-02-16 Applera Corporation Kinase substrates with multiple phosphorylation sites
ES2461858T3 (es) 2004-08-13 2014-05-21 Epoch Biosciences, Inc. Colorantes fluorescentes de fosfonato y conjugados
US8586718B2 (en) 2004-09-14 2013-11-19 Applied Biosystems, Llc Multi-chromophoric quencher constructs for use in high sensitivity energy transfer probes
US8153706B2 (en) 2004-10-25 2012-04-10 Hewlett-Packard Development Company, L.P. Polymeric colorants having pigment and dye components and corresponding ink compositions
EP1655317B1 (en) 2004-11-09 2007-06-13 Ipagsa Industrial, SL. Thermally reactive infrared absorption polymers and their use in a heat sensitive lithographic printing plate
EP2502946B1 (en) 2005-01-10 2017-10-04 The Regents of The University of California Cationic conjugated polymers suitable for strand-specific polynucleiotide detection in homogeneous and solid state assays
EP1866387B1 (en) 2005-03-09 2013-05-08 Cepheid Polar dyes
US8227621B2 (en) 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
JP2009510198A (ja) 2005-09-26 2009-03-12 インヴィトロジェン コーポレーション 紫色レーザー励起性色素及びその使用方法
EP1949108B1 (en) 2005-11-18 2013-09-25 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Modified cardiolipin and uses therefor
WO2007068618A1 (en) 2005-12-12 2007-06-21 Ciba Holding Inc. Organic semiconductors and their manufacture
US20070148094A1 (en) 2005-12-22 2007-06-28 Uzgiris Egidijus E Polymeric imaging agents and medical imaging methods
WO2007094135A1 (ja) 2006-02-15 2007-08-23 Gifu University オリゴヌクレオチド誘導体及びその利用
WO2007122388A2 (en) 2006-04-13 2007-11-01 Midatech Limited Nanoparticles containing three various ligands for providing immune responses against infectious agents
EP2054770A2 (en) 2006-08-12 2009-05-06 STX Aprilis, Inc. Sensitizer dyes for photoacid generating systems using short visible wavelengths
US8217389B2 (en) 2006-10-12 2012-07-10 Idemitsu Kosan, Co., Ltd. Organic thin film transistor device and organic thin film light-emitting transistor
EP2064290B1 (en) 2006-10-27 2013-10-09 Life Technologies Corporation Fluorogenic ph sensitive dyes and their method of use
US8053588B2 (en) 2007-03-07 2011-11-08 Kabushiki Kaisha Toyota Chuo Kenkyusho Organosilane compound and organosilica obtained therefrom
US9556210B2 (en) 2007-04-23 2017-01-31 Sabag-Rfa Ltd. System for delivering therapeutic agents into living cells and cells nuclei
WO2008129548A2 (en) 2007-04-23 2008-10-30 Segev Laboratories Limited A system for delivering therapeutic agents into living cells and cells nuclei
US9156865B2 (en) 2007-04-23 2015-10-13 Deliversir Ltd System for delivering therapeutic agents into living cells and cells nuclei
US7976585B2 (en) 2007-05-11 2011-07-12 BASF SE Ludwigshafen Polymeric dyes
EP2014698A1 (en) 2007-07-12 2009-01-14 Crystax Pharmaceuticals S.L. Polymers and their use as fluorescent labels
TWI409280B (zh) 2007-07-31 2013-09-21 American Dye Source Inc 聚合物染料、塗覆層組合物及熱微影印刷板
GB2456298A (en) 2008-01-07 2009-07-15 Anthony Ian Newman Electroluminescent materials comprising oxidation resistant fluorenes
KR101564796B1 (ko) 2008-03-10 2015-10-30 고쿠리츠다이가쿠호우진 도쿄다이가쿠 비하전성 친수성 블록 및 측사슬의 일부에 소수성 기가 도입된 카티온성 폴리아미노산 블록을 포함하여 이루어지는 공중합체, 그 사용
CA2721980C (en) 2008-04-21 2017-01-03 The Regents Of The University Of California Selective high-affinity poly dentate ligands and methods of making such
KR101041446B1 (ko) 2008-07-21 2011-06-14 부산대학교 산학협력단 공액고분자 2단계 fret 시스템 및 바이오센서
JPWO2010026957A1 (ja) 2008-09-03 2012-02-02 国立大学法人富山大学 水溶性ロタキサン型蛍光色素および蛍光性有機分子
WO2010055789A1 (ja) 2008-11-14 2010-05-20 独立行政法人科学技術振興機構 オリゴヌクレオチド誘導体、ラベル化剤及びその利用
WO2010059051A2 (en) 2008-11-20 2010-05-27 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Rapid fret based pathogen diagnosis
US9416210B2 (en) 2008-12-12 2016-08-16 The University Of Massachusetts Zwitterionic polymers with therapeutic moieties
SG177676A1 (en) 2009-07-16 2012-02-28 Beckman Coulter Inc Novel fluorescent dyes and uses thereof
WO2011057295A2 (en) 2009-11-09 2011-05-12 University of Washington Center for Commercialization Functionalized chromophoric polymer dots and bioconjugates thereof
US9400273B1 (en) 2009-12-09 2016-07-26 Life Technologies Corporation 7-hydroxycoumarin-based cell-tracking reagents
WO2011088193A2 (en) 2010-01-13 2011-07-21 University Of Medicine And Dentistry Of New Jersey Fluorophore chelated lanthanide luminiscent probes with improved quantum efficiency
WO2011113020A1 (en) 2010-03-11 2011-09-15 Glumetrics, Inc. Measurement devices and methods for measuring analyte concentration incorporating temperature and ph correction
CA2794307A1 (en) 2010-03-26 2011-09-29 Mersana Therapeutics, Inc. Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof
WO2011150079A1 (en) 2010-05-25 2011-12-01 Carnegie Mellon University Targeted probes of cellular physiology
WO2012005310A1 (ja) 2010-07-08 2012-01-12 旭硝子株式会社 含フッ素芳香族化合物、有機半導体材料および有機薄膜デバイス
ES2626437T3 (es) 2010-09-22 2017-07-25 The Board Of Regents Of The University Of Texas System Copolímero en bloque novedoso y composiciones micelares y procedimientos de uso de las mismas
CA2821411C (en) 2010-12-13 2020-02-25 Marek Kwiatkowski Functionalized polymers
WO2012086857A1 (ko) 2010-12-21 2012-06-28 (주)파낙스이엠 광역학 진단 또는 치료를 위한 결합체 및 이의 제조방법
CN102174078A (zh) 2011-01-10 2011-09-07 中国药科大学 肿瘤细胞选择性穿膜肽的应用
CA2857493C (en) 2011-07-15 2019-06-11 Glumetrics, Inc. Combinations of fluorphores and pyridinium boronic acid quenchers for use in analyte sensors
JP2014527071A (ja) 2011-08-31 2014-10-09 マリンクロッド エルエルシー H−ホスホネートによるナノ粒子pegの改変
US20130059343A1 (en) 2011-09-06 2013-03-07 Li-Cor, Inc. Nucleotide derivatives
US9085761B1 (en) * 2012-06-14 2015-07-21 Affymetrix, Inc. Methods and compositions for amplification of nucleic acids
DK2895607T3 (da) 2012-09-12 2021-05-25 Quark Pharmaceuticals Inc Dobbeltstrengede oligonukleotidmolekyler til ddit4 og fremgangsmåder til anvendelse deraf
WO2014055253A1 (en) 2012-10-04 2014-04-10 The General Hospital Corporation Methods of synthesizing and using peg-like fluorochromes
CN104918639B (zh) 2012-10-22 2018-01-26 萨拜格Rfa公司 用于将治疗剂递送到活细胞和细胞核中的系统
WO2014102803A1 (en) 2012-12-31 2014-07-03 Yeda Research And Development Co. Ltd. Molecular sensor and methods of use thereof
US9545447B2 (en) 2013-01-04 2017-01-17 The Texas A&M University System Polymer-drug systems
WO2014175974A2 (en) 2013-03-13 2014-10-30 Elitech Holding B.V. Artificial nucleic acids
WO2014159392A1 (en) 2013-03-14 2014-10-02 Dana-Farber Cancer Institute, Inc. Bromodomain binding reagents and uses thereof
WO2014144793A1 (en) 2013-03-15 2014-09-18 Visen Medical, Inc. Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection
WO2014147642A1 (en) 2013-03-19 2014-09-25 Council Of Scientific & Industrial Research Substituted fluoranthene-7-carbonitriles as fluorescent dyes for cell imaging applications
CN103319378B (zh) 2013-06-27 2015-06-10 中国科学院宁波材料技术与工程研究所 两性离子有机小分子太阳能电池阴极界面材料及其制法和用途
KR101572901B1 (ko) 2013-07-12 2015-12-15 부산대학교 산학협력단 2-단계 fret를 이용한 공액고분자 전해질 및 압타머 프로브 기반 표적 물질의 검출 방법 및 형광 센서
CN105377994B (zh) 2013-08-22 2018-03-02 索尼公司 水溶性荧光染料或有色染料及其使用方法
US10406246B2 (en) 2013-10-17 2019-09-10 Deutsches Kresbsforschungszentrum Double-labeled probe for molecular imaging and use thereof
JP5802865B1 (ja) 2013-11-11 2015-11-04 オリンパス株式会社 処置システム
EP3077454A1 (en) 2013-12-06 2016-10-12 Monosol, LLC Fluorescent tracer for water-soluble films, related methods, and related articles
WO2015091953A1 (en) 2013-12-20 2015-06-25 Roche Diagnostics Gmbh Use of compounds comprising two or more hydrophobic domains and a hydrophilic domain comprising peg moieties for stabilization of a cell
EP3094687B1 (en) 2014-01-16 2020-02-12 Sony Corporation Water soluble fluorescent or colored dyes
JP6374172B2 (ja) 2014-01-31 2018-08-15 富士フイルム株式会社 着色組成物、およびこれを用いた硬化膜、カラーフィルタ、パターン形成方法、カラーフィルタの製造方法、固体撮像素子、画像表示装置ならびに染料多量体
CN104072727A (zh) 2014-06-23 2014-10-01 华南理工大学 一种含磷脂酰胆碱基的2,7-芴的共轭聚合物及其制备方法与应用
US10617670B2 (en) 2014-10-10 2020-04-14 Pfizer Inc. Synergistic auristatin combinations
WO2016077625A1 (en) 2014-11-12 2016-05-19 Stayton Patrick S Stabilized polymeric carriers for therapeutic agent delivery
WO2016074093A1 (en) 2014-11-14 2016-05-19 Angiochem Inc. Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin
CN107406353A (zh) 2015-02-26 2017-11-28 索尼公司 苯基乙炔基萘染料和用于它们用途的方法
WO2016138461A1 (en) 2015-02-26 2016-09-01 Sony Corporation Water soluble fluorescent or colored dyes comprising conjugating groups
CN107207874A (zh) 2015-03-12 2017-09-26 贝克顿·迪金森公司 聚合物bodipy染料及其使用方法
AU2016248347A1 (en) 2015-04-15 2017-11-30 Biosearch Technologies, Inc. Dual quencher probes
EP3294811B1 (en) 2015-05-11 2024-02-28 Sony Group Corporation Ultra bright dimeric or polymeric dyes
US9670318B2 (en) 2015-05-28 2017-06-06 Miltenyi Biotec Gmbh Bright fluorochromes based on multimerization of fluorescent dyes
JP6997455B2 (ja) 2015-06-02 2022-01-17 ユニバーシティ・オブ・ワシントン 自立非汚染性ポリマー、それらの組成物、および関連モノマー
CN108289964B (zh) 2015-08-10 2022-08-12 杭州多禧生物科技有限公司 新型连接体及其用于药物和生物分子的特异性偶联
WO2017062271A2 (en) 2015-10-06 2017-04-13 Merck Sharp & Dohme Corp. Antibody drug conjugate for anti-inflammatory applications
SI3380124T1 (sl) 2015-11-25 2024-10-30 Legochem Biosciences, Inc. Konjugati, ki obsegajo samožrtvujoče skupine in z njimi povezani postopki
AU2016364431B2 (en) 2015-12-04 2020-08-27 Zenyaku Kogyo Co., Ltd. Anti-IL-17 aptamer having improved retention in blood
US9913992B2 (en) 2015-12-22 2018-03-13 Colgate-Palmolive Company Oral treatment device
JP2017124994A (ja) 2016-01-15 2017-07-20 靖彦 中村 癌治療及び癌再発防止のための装置並びにポルフィリン類含有製剤
US11434377B2 (en) 2016-04-01 2022-09-06 Sony Corporation Ultra bright dimeric or polymeric dyes with rigid spacing groups
EP3436529A1 (en) 2016-04-01 2019-02-06 Sony Corporation Ultra bright dimeric or polymeric dyes
KR102756931B1 (ko) 2016-04-06 2025-01-21 소니그룹주식회사 스페이싱 링커 그룹을 포함하는 초고명도 이량체성 또는 중합체성 염료
WO2017197014A2 (en) 2016-05-10 2017-11-16 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
US11370922B2 (en) 2016-05-10 2022-06-28 Sony Corporation Ultra bright polymeric dyes with peptide backbones
CN109071961B (zh) 2016-05-11 2021-04-27 索尼公司 超亮二聚或聚合染料
WO2017214165A1 (en) 2016-06-06 2017-12-14 Sony Corporation Ionic polymers comprising fluorescent or colored reporter groups
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
CN109844538A (zh) 2016-09-01 2019-06-04 生命科技股份有限公司 用于增强荧光的组合物和方法
GB2554666B (en) 2016-09-30 2019-12-18 Sumitomo Chemical Co Composite Particle
CN106589005B (zh) 2016-11-01 2019-08-06 北京擎科生物科技有限公司 一种荧光信号放大探针中间体、荧光探针及其制备方法
JP7030133B2 (ja) 2017-02-27 2022-03-04 イヴァンティ,インコーポレイテッド ロールベースコンピュータセキュリティ構成のシステム及び方法
US12398104B2 (en) 2017-04-27 2025-08-26 The Procter & Gamble Company Odorless thiols for permanent waving, straightening and depilatory applications
CA3064132C (en) 2017-07-07 2024-06-04 Gregory Keyes Fatty acid derivatives and their use
EP3691689A1 (en) 2017-10-05 2020-08-12 Sony Corporation Programmable dendritic drugs
KR20200067132A (ko) 2017-10-05 2020-06-11 소니 주식회사 프로그램가능한 중합체성 약물
CN111836645A (zh) 2017-11-16 2020-10-27 索尼公司 可编程的聚合药物
CN111465608A (zh) 2017-12-13 2020-07-28 索尼公司 包含生物学活性化合物的离子型聚合物
JP2021506883A (ja) 2017-12-21 2021-02-22 メルサナ セラピューティクス インコーポレイテッド ピロロベンゾジアゼピン抗体結合体
CN111565757A (zh) 2018-01-12 2020-08-21 索尼公司 包含生物活性化合物的磷酸烷基聚合物
US12194104B2 (en) 2018-01-12 2025-01-14 Sony Group Corporation Phosphoalkyl ribose polymers comprising biologically active compounds
JP2021510696A (ja) 2018-01-12 2021-04-30 ソニー株式会社 生物学的に活性な化合物を含む剛性間隔基を有するポリマー
EP4137818B1 (en) 2018-03-19 2025-12-10 Sony Group Corporation Use of divalent metals for enhancement of fluorescent signals
CN118480073A (zh) 2018-03-21 2024-08-13 索尼公司 具有连接体基团的聚合串联染料
GB201807815D0 (en) 2018-05-14 2018-06-27 Hypha Discovery Ltd Hydroxylation techniques
CN112313242A (zh) 2018-06-27 2021-02-02 索尼公司 具有含脱氧核糖的连接体基团的聚合物染料
EP3820944A1 (en) 2018-07-13 2021-05-19 Sony Corporation Polymeric dyes having a backbone comprising organophosphate units
KR20210152523A (ko) 2019-04-11 2021-12-15 소니그룹주식회사 프로그램 가능한 중합체성 약물
KR20210152524A (ko) 2019-04-11 2021-12-15 소니그룹주식회사 프로그램 가능한 중합체성 약물
EP3952918A1 (en) 2019-04-11 2022-02-16 Sony Group Corporation Programmable polymeric drugs
WO2020219959A1 (en) 2019-04-24 2020-10-29 Magenta Therapeutics, Inc. Anti-cd45 antibody drug conjugates and uses thereof
JP7239904B2 (ja) 2019-09-26 2023-03-15 ソニーグループ株式会社 リンカー基を有するポリマータンデム色素
WO2021067483A1 (en) 2019-09-30 2021-04-08 Sony Corporation Nucleotide probes
EP4251764A1 (en) 2020-11-25 2023-10-04 Sony Group Corporation Polymer dyes
JP2023552448A (ja) 2020-12-07 2023-12-15 ソニーグループ株式会社 二量体色素又はポリマー色素における輝度を増強するためのスペーシングリンカー基の設計
EP4355754A1 (en) 2021-06-16 2024-04-24 Sony Group Corporation Method for preparing fluorophore- and chromophore-containing conjugates for visual detection of analyte molecules

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