JP2024010112A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2024010112A5 JP2024010112A5 JP2023183886A JP2023183886A JP2024010112A5 JP 2024010112 A5 JP2024010112 A5 JP 2024010112A5 JP 2023183886 A JP2023183886 A JP 2023183886A JP 2023183886 A JP2023183886 A JP 2023183886A JP 2024010112 A5 JP2024010112 A5 JP 2024010112A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acids
- ppr
- combination
- constituting
- asparagine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940024606 amino acid Drugs 0.000 claims 42
- 235000001014 amino acid Nutrition 0.000 claims 42
- 150000001413 amino acids Chemical class 0.000 claims 42
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Chemical compound OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 20
- 229960001230 asparagine Drugs 0.000 claims 18
- 235000009582 asparagine Nutrition 0.000 claims 18
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 15
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 15
- 235000003704 aspartic acid Nutrition 0.000 claims 15
- 229960005261 aspartic acid Drugs 0.000 claims 15
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 15
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 10
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 10
- 239000004473 Threonine Substances 0.000 claims 10
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 6
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 6
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 6
- 239000004474 valine Substances 0.000 claims 6
- 229960004295 valine Drugs 0.000 claims 6
- 235000014393 valine Nutrition 0.000 claims 6
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 238000012986 modification Methods 0.000 claims 4
- 230000004048 modification Effects 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 239000004471 Glycine Substances 0.000 claims 3
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 3
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Chemical group OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 3
- 229960000310 isoleucine Drugs 0.000 claims 3
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 3
- 235000014705 isoleucine Nutrition 0.000 claims 3
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 3
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical group OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 2
- 229930182817 methionine Natural products 0.000 claims 2
- 229930024421 Adenine Natural products 0.000 claims 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 229960000643 adenine Drugs 0.000 claims 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 229940035893 uracil Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024194918A JP7789426B2 (ja) | 2011-10-21 | 2024-11-07 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011231346 | 2011-10-21 | ||
| JP2011231346 | 2011-10-21 | ||
| JP2021086108A JP7157483B2 (ja) | 2011-10-21 | 2021-05-21 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
| JP2022158241A JP7381133B2 (ja) | 2011-10-21 | 2022-09-30 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022158241A Division JP7381133B2 (ja) | 2011-10-21 | 2022-09-30 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024194918A Division JP7789426B2 (ja) | 2011-10-21 | 2024-11-07 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024010112A JP2024010112A (ja) | 2024-01-23 |
| JP2024010112A5 true JP2024010112A5 (enExample) | 2024-07-23 |
| JP7590019B2 JP7590019B2 (ja) | 2024-11-26 |
Family
ID=48141047
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013539727A Active JP6164488B2 (ja) | 2011-10-21 | 2012-10-22 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
| JP2017112764A Active JP6270192B2 (ja) | 2011-10-21 | 2017-06-07 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
| JP2017112765A Active JP6267388B2 (ja) | 2011-10-21 | 2017-06-07 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
| JP2017244766A Active JP6934644B2 (ja) | 2011-10-21 | 2017-12-21 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
| JP2017244765A Active JP6454398B2 (ja) | 2011-10-21 | 2017-12-21 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
| JP2021086108A Active JP7157483B2 (ja) | 2011-10-21 | 2021-05-21 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
| JP2022158241A Active JP7381133B2 (ja) | 2011-10-21 | 2022-09-30 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
| JP2023183886A Active JP7590019B2 (ja) | 2011-10-21 | 2023-10-26 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
Family Applications Before (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013539727A Active JP6164488B2 (ja) | 2011-10-21 | 2012-10-22 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
| JP2017112764A Active JP6270192B2 (ja) | 2011-10-21 | 2017-06-07 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
| JP2017112765A Active JP6267388B2 (ja) | 2011-10-21 | 2017-06-07 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
| JP2017244766A Active JP6934644B2 (ja) | 2011-10-21 | 2017-12-21 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
| JP2017244765A Active JP6454398B2 (ja) | 2011-10-21 | 2017-12-21 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
| JP2021086108A Active JP7157483B2 (ja) | 2011-10-21 | 2021-05-21 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
| JP2022158241A Active JP7381133B2 (ja) | 2011-10-21 | 2022-09-30 | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 |
Country Status (8)
| Country | Link |
|---|---|
| US (7) | US9513283B2 (enExample) |
| EP (2) | EP3611261A1 (enExample) |
| JP (8) | JP6164488B2 (enExample) |
| AU (5) | AU2012326971C1 (enExample) |
| DK (1) | DK2784157T3 (enExample) |
| ES (1) | ES2751126T3 (enExample) |
| PT (1) | PT2784157T (enExample) |
| WO (1) | WO2013058404A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9513283B2 (en) | 2011-10-21 | 2016-12-06 | Kyushu University, National University Corporation | Method for designing RNA binding protein utilizing PPR motif, and use thereof |
| AU2013248928A1 (en) * | 2012-04-16 | 2014-12-04 | The State Board Of Higher Education On Behalf Of The University Of Oregon | Peptides for the binding of nucleotide targets |
| SG11201508730TA (en) * | 2013-04-22 | 2015-11-27 | Univ Kyushu Nat Univ Corp | Dna-binding protein using ppr motif, and use thereof |
| SG11201609211VA (en) * | 2014-03-05 | 2016-12-29 | Nat Univ Corp Univ Kobe | Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same |
| US10767173B2 (en) | 2015-09-09 | 2020-09-08 | National University Corporation Kobe University | Method for converting genome sequence of gram-positive bacterium by specifically converting nucleic acid base of targeted DNA sequence, and molecular complex used in same |
| EP4163374A1 (en) | 2015-11-23 | 2023-04-12 | The Regents of the University of California | Tracking and manipulating cellular rna via nuclear delivery of crispr/cas9 |
| US11220693B2 (en) | 2015-11-27 | 2022-01-11 | National University Corporation Kobe University | Method for converting monocot plant genome sequence in which nucleic acid base in targeted DNA sequence is specifically converted, and molecular complex used therein |
| WO2017209122A1 (ja) | 2016-06-03 | 2017-12-07 | 国立大学法人九州大学 | 標的ｍＲＮＡからのタンパク質発現量を向上させるための融合タンパク質 |
| ES2874230T3 (es) * | 2016-06-03 | 2021-11-04 | Univ Kyushu Nat Univ Corp | Proteína de fusión para mejorar la expresión de proteínas a partir de ARNm diana |
| US20190177378A1 (en) * | 2016-08-10 | 2019-06-13 | Fujifilm Wako Pure Chemical Corporation | Dna-binding protein using ppr motif, and use thereof |
| AU2018265022A1 (en) | 2017-05-10 | 2019-11-21 | The Regents Of The University Of California | Directed editing of cellular RNA via nuclear delivery of CRISPR/Cas9 |
| CN108959852B (zh) * | 2017-05-24 | 2021-12-24 | 北京工业大学 | 基于氨基酸-核苷酸成对偏好性信息的蛋白质上与rna结合模块的预测方法 |
| CN108932400B (zh) * | 2017-05-24 | 2021-07-23 | 北京工业大学 | 一种考虑界面信息的有效的蛋白质-rna复合物结构预测方法 |
| US20200071718A1 (en) | 2018-06-08 | 2020-03-05 | Locana, Inc. | Rna-targeting fusion protein compositions and methods for use |
| IL288417B2 (en) | 2019-05-29 | 2024-10-01 | Editforce Inc | PPR protein causing less aggregation and use of the same |
| JP7491515B2 (ja) | 2019-05-29 | 2024-05-28 | エディットフォース株式会社 | 効率的なｐｐｒタンパク質の作製方法及びその利用 |
| JP2022540446A (ja) | 2019-07-10 | 2022-09-15 | ロックアネイビオ， インコーポレイテッド | Ｒｎａ標的ノックダウン及び置換の組成物及び使用方法 |
| US20230125942A1 (en) | 2020-03-31 | 2023-04-27 | Editforce, Inc. | Method for editing target rna |
| JP2023551874A (ja) | 2020-12-01 | 2023-12-13 | ロックアネイビオ， インコーポレイテッド | 筋強直性ジストロフィー１型を処置するためのｒｎａ標的化組成物および方法 |
| JP2023551873A (ja) | 2020-12-01 | 2023-12-13 | ロックアネイビオ， インコーポレイテッド | Ｃａｇリピート病を処置するためのｒｎａ標的化組成物および方法 |
| WO2022221278A1 (en) | 2021-04-12 | 2022-10-20 | Locanabio, Inc. | Compositions and methods comprising hybrid promoters |
| WO2022226375A1 (en) | 2021-04-23 | 2022-10-27 | Locanabio, Inc. | Tissue-targeted modified aav capsids and methods of use thereof |
| JP2024514956A (ja) | 2021-04-23 | 2024-04-03 | ロックアネイビオ， インコーポレイテッド | 組織標的化された改変ａａｖカプシドおよびその使用方法 |
| WO2022230924A1 (ja) * | 2021-04-30 | 2022-11-03 | 国立大学法人大阪大学 | 筋強直性ジストロフィー１型治療薬 |
| JP7125727B1 (ja) | 2021-09-07 | 2022-08-25 | 国立大学法人千葉大学 | 核酸配列改変用組成物および核酸配列の標的部位を改変する方法 |
| WO2023050204A1 (zh) * | 2021-09-29 | 2023-04-06 | 京东方科技集团股份有限公司 | Rna-蛋白质相互作用预测方法、装置、介质及电子设备 |
| WO2023154807A2 (en) | 2022-02-09 | 2023-08-17 | Locanabio, Inc. | Compositions and methods for modulating pre-mrna splicing |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4102099B2 (ja) | 2001-04-25 | 2008-06-18 | アンスティテュ ナシオナル ドゥ ラ ルシェルシュ アグロノミック | 細胞質雄性不稔から可稔への回復に関与するタンパク質及びそれをコードする遺伝子 |
| US20040117868A1 (en) | 2002-01-29 | 2004-06-17 | Jun Imamura | Protein participating in restoration from cytoplasmic male sterility to fertility and gene encoding the same |
| ATE517912T1 (de) | 2001-04-25 | 2011-08-15 | Agronomique Inst Nat Rech | Protein, das an der wiederherstellung der fruchtbarkeit nach cytoplasmischer männlicher sterilität beteiligt ist, und ein dieses codierendes gen |
| JP2002355041A (ja) * | 2001-04-25 | 2002-12-10 | Mitsubishi Chemicals Corp | 細胞質雄性不稔から可稔への回復に関与する遺伝子 |
| US20060041961A1 (en) * | 2004-03-25 | 2006-02-23 | Abad Mark S | Genes and uses for pant improvement |
| US8344122B2 (en) | 2008-03-12 | 2013-01-01 | Tohoku University | Fertility restorer gene and fertility restoration method for CW-type male sterile cytoplasm of rice |
| NO2510096T3 (enExample) | 2009-12-10 | 2015-03-21 | ||
| JP2013128413A (ja) | 2010-03-11 | 2013-07-04 | Kyushu Univ | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の改変方法 |
| US9513283B2 (en) * | 2011-10-21 | 2016-12-06 | Kyushu University, National University Corporation | Method for designing RNA binding protein utilizing PPR motif, and use thereof |
| AU2013248928A1 (en) * | 2012-04-16 | 2014-12-04 | The State Board Of Higher Education On Behalf Of The University Of Oregon | Peptides for the binding of nucleotide targets |
-
2012
- 2012-10-22 US US14/352,697 patent/US9513283B2/en active Active
- 2012-10-22 ES ES12841435T patent/ES2751126T3/es active Active
- 2012-10-22 EP EP19191694.9A patent/EP3611261A1/en active Pending
- 2012-10-22 JP JP2013539727A patent/JP6164488B2/ja active Active
- 2012-10-22 DK DK12841435.6T patent/DK2784157T3/da active
- 2012-10-22 EP EP12841435.6A patent/EP2784157B1/en active Active
- 2012-10-22 WO PCT/JP2012/077274 patent/WO2013058404A1/ja not_active Ceased
- 2012-10-22 AU AU2012326971A patent/AU2012326971C1/en active Active
- 2012-10-22 PT PT128414356T patent/PT2784157T/pt unknown
-
2016
- 2016-10-26 US US15/335,243 patent/US9984202B2/en active Active
-
2017
- 2017-06-07 JP JP2017112764A patent/JP6270192B2/ja active Active
- 2017-06-07 JP JP2017112765A patent/JP6267388B2/ja active Active
- 2017-10-31 AU AU2017254874A patent/AU2017254874B2/en active Active
- 2017-12-21 JP JP2017244766A patent/JP6934644B2/ja active Active
- 2017-12-21 JP JP2017244765A patent/JP6454398B2/ja active Active
-
2018
- 2018-04-25 US US15/962,127 patent/US10340028B2/en active Active
-
2019
- 2019-06-04 US US16/431,429 patent/US10679731B2/en active Active
- 2019-12-11 AU AU2019280013A patent/AU2019280013B2/en active Active
-
2020
- 2020-06-05 US US16/894,295 patent/US10943671B2/en active Active
-
2021
- 2021-03-08 US US17/195,449 patent/US11742056B2/en active Active
- 2021-05-21 JP JP2021086108A patent/JP7157483B2/ja active Active
-
2022
- 2022-06-29 AU AU2022204654A patent/AU2022204654B2/en active Active
- 2022-09-30 JP JP2022158241A patent/JP7381133B2/ja active Active
-
2023
- 2023-07-13 US US18/221,440 patent/US20240047005A1/en active Pending
- 2023-10-26 JP JP2023183886A patent/JP7590019B2/ja active Active
-
2025
- 2025-06-30 AU AU2025204996A patent/AU2025204996A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024010112A5 (enExample) | ||
| Sorger et al. | Trimerization of a yeast transcriptional activator via a coiled-coil motif | |
| Plater et al. | Effects of site-directed mutations on the chaperone-like activity of αB-crystallin | |
| JP2023113843A5 (enExample) | ||
| DK1200583T3 (da) | Fremstilling af beta-foldeblad-proteiner med specifikke bindingsegenskaber | |
| JPS638396A (ja) | ポリ標識化オリゴヌクレオチド誘導体 | |
| JP2008505985A5 (enExample) | ||
| JP2024100936A5 (enExample) | ||
| JP2024099834A5 (enExample) | ||
| JP2024099833A5 (enExample) | ||
| JP2023171909A5 (enExample) | ||
| JP3595345B2 (ja) | ペプチド核酸のモノマー及びオリゴマー | |
| Crowe et al. | One-step purification of recombinant proteins with the 6xHis tag and Ni-NTA resin | |
| JP2024102242A5 (enExample) | ||
| Banks et al. | The HMG-I (Y) A· T-hook peptide motif confers DNA-binding specificity to a structured chimeric protein | |
| JPWO2021116462A5 (enExample) | ||
| JP2024009801A5 (enExample) | ||
| JP2018507905A (ja) | ＢＥＴ阻害剤及びαアミノ酸エステルの共有結合コンジュゲート | |
| EP1704160A4 (en) | METHOD AND COMPOSITIONS FOR IDENTIFYING RNA-BINDING PROTEINS | |
| Takahashi et al. | Construction of peptides with nucleobase amino acids: design and synthesis of the nucleobase-conjugated peptides derived from HIV-1 Rev and their binding properties to HIV-1 RRE RNA | |
| EP1336616B1 (en) | Activated peptides and conjugates | |
| JPS63304987A (ja) | アンギオゲニン類の遺伝子工学産生方法 | |
| JPWO2022018186A5 (enExample) | ||
| JPWO2021256530A5 (enExample) | ||
| JPWO2020241876A5 (enExample) |