JPWO2022018186A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2022018186A5 JPWO2022018186A5 JP2022577750A JP2022577750A JPWO2022018186A5 JP WO2022018186 A5 JPWO2022018186 A5 JP WO2022018186A5 JP 2022577750 A JP2022577750 A JP 2022577750A JP 2022577750 A JP2022577750 A JP 2022577750A JP WO2022018186 A5 JPWO2022018186 A5 JP WO2022018186A5
- Authority
- JP
- Japan
- Prior art keywords
- pharma
- seq
- compound
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024187587A JP2025020197A (ja) | 2020-07-22 | 2024-10-24 | 経口送達に好適なｇｌｐ－１受容体およびｇｉｐ受容体共作動薬 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063055026P | 2020-07-22 | 2020-07-22 | |
| US63/055,026 | 2020-07-22 | ||
| EP20192414.9 | 2020-08-24 | ||
| EP20192414 | 2020-08-24 | ||
| US202163156988P | 2021-03-05 | 2021-03-05 | |
| US63/156,988 | 2021-03-05 | ||
| PCT/EP2021/070485 WO2022018186A1 (en) | 2020-07-22 | 2021-07-22 | Co-agonists at glp-1 and gip receptors suitable for oral delivery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024187587A Division JP2025020197A (ja) | 2020-07-22 | 2024-10-24 | 経口送達に好適なｇｌｐ－１受容体およびｇｉｐ受容体共作動薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023534131A JP2023534131A (ja) | 2023-08-08 |
| JPWO2022018186A5 true JPWO2022018186A5 (enExample) | 2024-07-24 |
| JP7581385B2 JP7581385B2 (ja) | 2024-11-12 |
Family
ID=77179985
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022577750A Active JP7581385B2 (ja) | 2020-07-22 | 2021-07-22 | 経口送達に好適なｇｌｐ－１受容体およびｇｉｐ受容体共作動薬 |
| JP2024187587A Pending JP2025020197A (ja) | 2020-07-22 | 2024-10-24 | 経口送達に好適なｇｌｐ－１受容体およびｇｉｐ受容体共作動薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024187587A Pending JP2025020197A (ja) | 2020-07-22 | 2024-10-24 | 経口送達に好適なｇｌｐ－１受容体およびｇｉｐ受容体共作動薬 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US20230272029A1 (enExample) |
| EP (1) | EP4185607A1 (enExample) |
| JP (2) | JP7581385B2 (enExample) |
| KR (2) | KR102446310B1 (enExample) |
| CN (1) | CN116157143A (enExample) |
| AU (1) | AU2021312323A1 (enExample) |
| BR (1) | BR112023000270A2 (enExample) |
| CA (1) | CA3184717A1 (enExample) |
| CL (1) | CL2023000087A1 (enExample) |
| CO (1) | CO2023000097A2 (enExample) |
| IL (1) | IL299701A (enExample) |
| MX (1) | MX2023000303A (enExample) |
| PE (1) | PE20231841A1 (enExample) |
| TW (2) | TWI801942B (enExample) |
| WO (1) | WO2022018186A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230272029A1 (en) | 2020-07-22 | 2023-08-31 | Novo Nordisk A/S | Co-agonists at glp-1 and gip receptors suitable for oral delivery |
| WO2023012263A1 (en) | 2021-08-04 | 2023-02-09 | Novo Nordisk A/S | Solid oral peptide formulations |
| TW202330584A (zh) * | 2022-01-20 | 2023-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 前藥及其用途 |
| AR129903A1 (es) * | 2022-07-13 | 2024-10-09 | Hangzhou Zhongmeihuadong Pharmaceutical Co Ltd | Agonista dual de glp-1 / gip, método de preparación y uso del mismo |
| WO2024110614A1 (en) | 2022-11-25 | 2024-05-30 | Novo Nordisk A/S | Oral administration of peptide therapeutics, such as glp-1 |
| CN117646017A (zh) * | 2023-11-02 | 2024-03-05 | 中国人民解放军海军军医大学 | Gip/glp-1双激动剂多肽编码基因、及其重组乳酸菌和应用 |
| TW202529796A (zh) * | 2023-11-22 | 2025-08-01 | 大陸商杭州中美華東製藥有限公司 | Glp-1r/gipr雙標靶激動劑在製備動物藥的用途 |
| KR20250083391A (ko) | 2023-11-30 | 2025-06-10 | 노보 노르디스크 에이/에스 | Glp-1, gip, 및 아밀린 수용체의 삼중작용제 |
| WO2025133045A1 (en) | 2023-12-22 | 2025-06-26 | Novo Nordisk A/S | Fermentation process |
| WO2025149039A1 (zh) * | 2024-01-12 | 2025-07-17 | 杭州中美华东制药有限公司 | 长效glp-1/gip双激动剂的药物组合物 |
| WO2025176999A2 (en) * | 2024-02-23 | 2025-08-28 | Ip2Ipo Innovations Limited | Novel compounds |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG192405A1 (en) | 2008-06-17 | 2013-08-30 | Univ Indiana Res & Tech Corp | Gip-based mixed agonists for treatment of metabolic disorders and obesity |
| EP2376097A4 (en) | 2008-12-19 | 2012-10-03 | Univ Indiana Res & Tech Corp | PEPTIDE PRODRUGS OF AMIDE-BASED GLUCAGON SUPERFAMILY |
| MX2011006527A (es) | 2008-12-19 | 2011-08-17 | Univ Indiana Res & Tech Corp | Agentes medicinales unidos a dipeptido. |
| RU2012101274A (ru) | 2009-06-16 | 2013-07-27 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Соединения глюкагона, активные в отношении рецептора gip |
| WO2011080103A1 (en) | 2009-12-16 | 2011-07-07 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| KR20130083843A (ko) | 2010-06-24 | 2013-07-23 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 디펩티드 연결된 약제 |
| MX2012014576A (es) | 2010-06-24 | 2013-02-21 | Univ Indiana Res & Tech Corp | Profarmacos de peptido de la superfamilia de glucagon basado en amida. |
| RS60321B1 (sr) | 2010-12-16 | 2020-07-31 | Novo Nordisk As | Čvrste kompozicije koje sadrže glp-1 agonist i so n-(8-(2- hidroksibenzoil)amino)kaprilne kiseline |
| AU2011348202A1 (en) * | 2010-12-22 | 2013-07-04 | Marcadia Biotech, Inc. | Methods for treating metabolic disorders and obesity with GIP and GLP-1 receptor-active glucagon-based peptides |
| NZ612297A (en) | 2010-12-22 | 2015-10-30 | Univ Indiana Res & Tech Corp | Glucagon analogs exhibiting gip receptor activity |
| CN103764673A (zh) | 2011-06-10 | 2014-04-30 | 北京韩美药品有限公司 | 葡萄糖依赖性促胰岛素多肽类似物、其药物组合物及应用 |
| RS58636B1 (sr) * | 2012-03-22 | 2019-05-31 | Novo Nordisk As | Kompozicije koje sadrže sredstvo za isporuku i njihova priprema |
| AU2013255751B2 (en) | 2012-05-03 | 2017-10-05 | Zealand Pharma A/S | GIP-GLP-1 dual agonist compounds and methods |
| WO2013189988A1 (en) | 2012-06-20 | 2013-12-27 | Novo Nordisk A/S | Tablet formulation comprising a peptide and a delivery agent |
| RS57347B1 (sr) | 2012-06-21 | 2018-08-31 | Univ Indiana Res & Tech Corp | Analozi glukagona koji ispoljavaju aktivnost gip receptora |
| HRP20181300T1 (hr) | 2012-12-21 | 2018-10-05 | Sanofi | Derivati eksendina-4 kao dvostruki glp1/gip- ili trostruki glp1/gip/glukagon agonisti |
| US20160058881A1 (en) | 2013-03-15 | 2016-03-03 | Indiana University Research And Technology Corporation | Prodrugs with prolonged action |
| KR20210086717A (ko) * | 2013-05-02 | 2021-07-08 | 노보 노르디스크 에이/에스 | Glp-1 화합물의 경구 투여 |
| UA118558C2 (uk) | 2013-05-28 | 2019-02-11 | Такеда Фармасьютікал Компані Лімітед | Пептидна сполука |
| HK1226084A1 (zh) | 2013-08-16 | 2017-09-22 | Medimmune Limited | 用於治疗糖尿病的gip和glp-1受体双重激动剂 |
| WO2015035419A1 (en) | 2013-09-09 | 2015-03-12 | Hoffmann-La Roche Inc. | Dosages of gip/glp-1 co-agonist peptides for human administration |
| CA2929459C (en) * | 2013-11-06 | 2022-05-03 | Zealand Pharma A/S | Gip-glp-1 dual agonist compounds and methods |
| EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
| WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| TW201625670A (zh) * | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| GB2528436A (en) | 2014-07-15 | 2016-01-27 | Lancaster Univ Business Entpr Ltd | Treatment of neurological diseases |
| WO2016049174A1 (en) | 2014-09-24 | 2016-03-31 | Indiana University Research And Technology Corporation | Lipidated amide-based insulin prodrugs |
| WO2016077220A1 (en) | 2014-11-10 | 2016-05-19 | Mb2 Llc | Gip/glp-1 co-agonist peptides for human administration |
| JP2018012644A (ja) | 2014-11-26 | 2018-01-25 | 武田薬品工業株式会社 | ペプチド化合物 |
| JOP20200119A1 (ar) * | 2015-01-09 | 2017-06-16 | Lilly Co Eli | مركبات مساعد مشترك من gip وglp-1 |
| WO2016131893A1 (en) | 2015-02-18 | 2016-08-25 | Medimmune Limited | Incretin fusion polypeptides |
| US20170112897A1 (en) | 2015-10-23 | 2017-04-27 | Cedars-Sinai Medical Center | Methods for treating brain insulin resistance |
| JP6995042B2 (ja) | 2016-05-24 | 2022-02-04 | 武田薬品工業株式会社 | ペプチド化合物 |
| GB201620611D0 (en) | 2016-12-05 | 2017-01-18 | Univ Of Lancaster | Treatment of neurological diseases |
| JOP20180028A1 (ar) | 2017-03-31 | 2019-01-30 | Takeda Pharmaceuticals Co | مركب ببتيد |
| CN111683676B (zh) | 2018-02-02 | 2024-06-18 | 诺和诺德股份有限公司 | 包含glp-1激动剂、n-(8-(2-羟基苯甲酰基)氨基)辛酸的盐和润滑剂的固体组合物 |
| SG11202010297UA (en) | 2018-05-04 | 2020-11-27 | Novo Nordisk As | Gip derivatives and uses thereof |
| CA3178366A1 (en) | 2018-07-23 | 2020-01-30 | Eli Lilly And Company | Gip/glp1 co-agonist compounds |
| WO2020023388A1 (en) | 2018-07-23 | 2020-01-30 | Eli Lilly And Company | Method of using a gip/glp1 co-agonist for diabetes |
| KR20250044806A (ko) | 2018-07-23 | 2025-04-01 | 일라이 릴리 앤드 캄파니 | 요법을 위한 gip/glp1 공효능제 사용 방법 |
| BR112021020071A2 (pt) * | 2019-04-11 | 2021-12-14 | Jiangsu Hansoh Pharmaceutical Group Co Ltd | Compostos agonistas duplos do receptor de glp-1 e gip e uso dos mesmos |
| CN110642935A (zh) | 2019-09-25 | 2020-01-03 | 成都奥达生物科技有限公司 | 一种替瑞帕肽类似物 |
| CN110684082B (zh) | 2019-10-08 | 2021-12-10 | 江苏诺泰澳赛诺生物制药股份有限公司 | Gip和glp-1双激动多肽化合物及药学上可接受的盐与用途 |
| US20230272029A1 (en) | 2020-07-22 | 2023-08-31 | Novo Nordisk A/S | Co-agonists at glp-1 and gip receptors suitable for oral delivery |
-
2021
- 2021-07-22 US US18/017,041 patent/US20230272029A1/en active Pending
- 2021-07-22 PE PE2023000026A patent/PE20231841A1/es unknown
- 2021-07-22 IL IL299701A patent/IL299701A/en unknown
- 2021-07-22 TW TW110126883A patent/TWI801942B/zh active
- 2021-07-22 KR KR1020217034294A patent/KR102446310B1/ko active Active
- 2021-07-22 JP JP2022577750A patent/JP7581385B2/ja active Active
- 2021-07-22 TW TW111150185A patent/TW202315883A/zh unknown
- 2021-07-22 WO PCT/EP2021/070485 patent/WO2022018186A1/en not_active Ceased
- 2021-07-22 KR KR1020217034342A patent/KR20230029480A/ko not_active Ceased
- 2021-07-22 BR BR112023000270A patent/BR112023000270A2/pt unknown
- 2021-07-22 MX MX2023000303A patent/MX2023000303A/es unknown
- 2021-07-22 US US17/383,192 patent/US20220177538A1/en not_active Abandoned
- 2021-07-22 AU AU2021312323A patent/AU2021312323A1/en active Pending
- 2021-07-22 CN CN202180059832.9A patent/CN116157143A/zh active Pending
- 2021-07-22 EP EP21749558.9A patent/EP4185607A1/en active Pending
- 2021-07-22 CA CA3184717A patent/CA3184717A1/en active Pending
-
2022
- 2022-01-12 US US17/574,079 patent/US11779648B2/en active Active
- 2022-11-04 US US17/980,990 patent/US20230120597A1/en not_active Abandoned
-
2023
- 2023-01-05 CO CONC2023/0000097A patent/CO2023000097A2/es unknown
- 2023-01-09 CL CL2023000087A patent/CL2023000087A1/es unknown
-
2024
- 2024-10-24 JP JP2024187587A patent/JP2025020197A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024100936A5 (enExample) | ||
| JPWO2022018186A5 (enExample) | ||
| JP2024099834A5 (enExample) | ||
| JP2024102242A5 (enExample) | ||
| JP2024010112A5 (enExample) | ||
| SU850005A3 (ru) | Способ получени амино-производныхпРОпАНдиОлА или иХ фАРМАцЕВТичЕСКипРиЕМлЕМыХ СОлЕй C КиСлОТАМи | |
| JP2022115976A5 (enExample) | ||
| TW200843728A (en) | Antiparasitic agents | |
| JP2005524605A5 (enExample) | ||
| JP2023106355A5 (enExample) | ||
| JP4823899B2 (ja) | ３−（アミノ）−３−シクロブチルメチル−２−ヒドロキシ−プロピオンアミドまたはその塩の調製のためのプロセスおよび中間体 | |
| JP2004528385A5 (enExample) | ||
| JP2004532624A5 (enExample) | ||
| JP2004523545A5 (enExample) | ||
| JPH10509967A (ja) | 第三級アミン塩又は第四級アンモニウム塩の存在下対応する酸の塩素化による５−アミノ−２，４，６−トリヨードイソフタル酸ジクロライドの製造法 | |
| JPH1129545A5 (enExample) | ||
| JP2004502767A5 (enExample) | ||
| JPWO2020014588A5 (enExample) | ||
| JP2008505852A5 (enExample) | ||
| JP2005508382A5 (enExample) | ||
| JPWO2023044423A5 (enExample) | ||
| JPWO2022168971A5 (enExample) | ||
| CN1914169A (zh) | 作为环氧合酶－2抑制剂的二芳基－2－(5h)－呋喃酮的氧化氮释放前药 | |
| JPWO2021074198A5 (enExample) | ||
| JP2005502324A5 (enExample) |