ES2751126T3 - Método de diseño para proteína de unión a ARN usando motivo de PPR, y uso del mismo - Google Patents

Método de diseño para proteína de unión a ARN usando motivo de PPR, y uso del mismo Download PDF

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ES2751126T3
ES2751126T3 ES12841435T ES12841435T ES2751126T3 ES 2751126 T3 ES2751126 T3 ES 2751126T3 ES 12841435 T ES12841435 T ES 12841435T ES 12841435 T ES12841435 T ES 12841435T ES 2751126 T3 ES2751126 T3 ES 2751126T3
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amino acids
ppr
rna
protein
motif
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Spanish (es)
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Takahiro Nakamura
Yusuke Yagi
Keiko Kobayashi
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Kyushu University NUC
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Kyushu University NUC
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8287—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for fertility modification, e.g. apomixis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8287—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for fertility modification, e.g. apomixis
    • C12N15/8289—Male sterility
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/30—Detection of binding sites or motifs
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/50—Mutagenesis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/85—Fusion polypeptide containing an RNA binding domain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2522/00—Reaction characterised by the use of non-enzymatic proteins
    • C12Q2522/10—Nucleic acid binding proteins
    • C12Q2522/101—Single or double stranded nucleic acid binding proteins
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Library & Information Science (AREA)
  • Computing Systems (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
ES12841435T 2011-10-21 2012-10-22 Método de diseño para proteína de unión a ARN usando motivo de PPR, y uso del mismo Active ES2751126T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011231346 2011-10-21
PCT/JP2012/077274 WO2013058404A1 (ja) 2011-10-21 2012-10-22 Pprモチーフを利用したrna結合性蛋白質の設計方法及びその利用

Publications (1)

Publication Number Publication Date
ES2751126T3 true ES2751126T3 (es) 2020-03-30

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ES12841435T Active ES2751126T3 (es) 2011-10-21 2012-10-22 Método de diseño para proteína de unión a ARN usando motivo de PPR, y uso del mismo

Country Status (8)

Country Link
US (7) US9513283B2 (enExample)
EP (2) EP2784157B1 (enExample)
JP (9) JP6164488B2 (enExample)
AU (5) AU2012326971C1 (enExample)
DK (1) DK2784157T3 (enExample)
ES (1) ES2751126T3 (enExample)
PT (1) PT2784157T (enExample)
WO (1) WO2013058404A1 (enExample)

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JP6164488B2 (ja) 2011-10-21 2017-07-19 国立大学法人九州大学 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
CA2873073A1 (en) * 2012-04-16 2013-10-24 The University Of Western Australia Peptides for the binding of nucleotide targets
NZ714264A (en) * 2013-04-22 2020-10-30 Univ Kyushu Nat Univ Corp Dna-binding protein using ppr motif, and use thereof
SG11201609211VA (en) 2014-03-05 2016-12-29 Nat Univ Corp Univ Kobe Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
JP6664693B2 (ja) 2015-09-09 2020-03-13 国立大学法人神戸大学 標的化したｄｎａ配列の核酸塩基を特異的に変換する、グラム陽性菌のゲノム配列の変換方法、及びそれに用いる分子複合体
ES2930643T3 (es) 2015-11-23 2022-12-20 Univ California Seguimiento y manipulación de ARN celular a través de la administración nuclear de CRISPR/CAS9
KR102061438B1 (ko) 2015-11-27 2019-12-31 고쿠리츠다이가쿠호진 고베다이가쿠 표적화 dna 서열 중의 핵산 염기가 특이적으로 전환되어 있는 단자엽식물 게놈 서열을 전환시키는 방법, 및 그것에 사용되는 분자 복합체
KR102407776B1 (ko) 2016-06-03 2022-06-10 고쿠리쓰다이가쿠호진 규슈다이가쿠 표적 mRNA로부터의 단백질 발현량을 향상시키기 위한 융합 단백질
US11136361B2 (en) 2016-06-03 2021-10-05 Kyushu University, National University Corporation Fusion protein for improving protein expression from target mRNA
CN109563137A (zh) * 2016-08-10 2019-04-02 富士胶片和光纯药株式会社 利用了ppr基序的dna结合性蛋白质及其应用
WO2018208998A1 (en) 2017-05-10 2018-11-15 The Regents Of The University Of California Directed editing of cellular rna via nuclear delivery of crispr/cas9
CN108932400B (zh) * 2017-05-24 2021-07-23 北京工业大学 一种考虑界面信息的有效的蛋白质-rna复合物结构预测方法
CN108959852B (zh) * 2017-05-24 2021-12-24 北京工业大学 基于氨基酸-核苷酸成对偏好性信息的蛋白质上与rna结合模块的预测方法
US20200071718A1 (en) 2018-06-08 2020-03-05 Locana, Inc. Rna-targeting fusion protein compositions and methods for use
KR102898966B1 (ko) 2019-05-29 2025-12-10 고쿠리쓰다이가쿠호진 규슈다이가쿠 응집이 적은 피피알 단백질 및 그의 이용
KR20220023985A (ko) 2019-05-29 2022-03-03 에딧포스 인코포레이티드 효율적인 피피알 단백질의 작제방법 및 그의 이용
CN114450031A (zh) 2019-07-10 2022-05-06 洛卡纳生物股份有限公司 靶向rna的敲低和替代组合物及使用方法
KR20220165747A (ko) * 2020-03-31 2022-12-15 에딧포스 인코포레이티드 표적 rna의 편집방법
JP2023551873A (ja) 2020-12-01 2023-12-13 ロックアネイビオ， インコーポレイテッド Ｃａｇリピート病を処置するためのｒｎａ標的化組成物および方法
JP2023551874A (ja) 2020-12-01 2023-12-13 ロックアネイビオ， インコーポレイテッド 筋強直性ジストロフィー１型を処置するためのｒｎａ標的化組成物および方法
WO2022221278A1 (en) 2021-04-12 2022-10-20 Locanabio, Inc. Compositions and methods comprising hybrid promoters
WO2022226375A1 (en) 2021-04-23 2022-10-27 Locanabio, Inc. Tissue-targeted modified aav capsids and methods of use thereof
JP2024514956A (ja) 2021-04-23 2024-04-03 ロックアネイビオ， インコーポレイテッド 組織標的化された改変ａａｖカプシドおよびその使用方法
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JP7125727B1 (ja) * 2021-09-07 2022-08-25 国立大学法人千葉大学 核酸配列改変用組成物および核酸配列の標的部位を改変する方法
CN116888671A (zh) * 2021-09-29 2023-10-13 京东方科技集团股份有限公司 Rna-蛋白质相互作用预测方法、装置、介质及电子设备
WO2023154807A2 (en) 2022-02-09 2023-08-17 Locanabio, Inc. Compositions and methods for modulating pre-mrna splicing

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JP2002355041A (ja) * 2001-04-25 2002-12-10 Mitsubishi Chemicals Corp 細胞質雄性不稔から可稔への回復に関与する遺伝子
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US8344122B2 (en) 2008-03-12 2013-01-01 Tohoku University Fertility restorer gene and fertility restoration method for CW-type male sterile cytoplasm of rice
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JP2013128413A (ja) 2010-03-11 2013-07-04 Kyushu Univ Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の改変方法
JP6164488B2 (ja) * 2011-10-21 2017-07-19 国立大学法人九州大学 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
CA2873073A1 (en) * 2012-04-16 2013-10-24 The University Of Western Australia Peptides for the binding of nucleotide targets

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JP2017192391A (ja) 2017-10-26
US10943671B2 (en) 2021-03-09
AU2017254874B2 (en) 2019-09-12
JP7590019B2 (ja) 2024-11-26
JP2018042569A (ja) 2018-03-22
JP6454398B2 (ja) 2019-01-16
AU2019280013A1 (en) 2020-01-16
AU2019280013B2 (en) 2022-03-31
DK2784157T3 (da) 2019-10-21
JP2024010112A (ja) 2024-01-23
JP2025020327A (ja) 2025-02-12
JP2018078896A (ja) 2018-05-24
AU2025204996A1 (en) 2025-07-24
US20140335521A1 (en) 2014-11-13
US20210249103A1 (en) 2021-08-12
US20200294626A1 (en) 2020-09-17
US20180247018A1 (en) 2018-08-30
EP2784157A1 (en) 2014-10-01
EP2784157B1 (en) 2019-09-18
JP7381133B2 (ja) 2023-11-15
AU2012326971A1 (en) 2014-06-12
US20240047005A1 (en) 2024-02-08
AU2012326971C1 (en) 2018-02-08
JP6934644B2 (ja) 2021-09-15
JP7157483B2 (ja) 2022-10-20
US20170124252A1 (en) 2017-05-04
US20190311783A1 (en) 2019-10-10
AU2022204654B2 (en) 2025-04-03
US10679731B2 (en) 2020-06-09
JP2021130678A (ja) 2021-09-09
AU2012326971B2 (en) 2017-10-19
US10340028B2 (en) 2019-07-02
EP3611261A1 (en) 2020-02-19
PT2784157T (pt) 2019-10-29
JP2022177289A (ja) 2022-11-30
JP6164488B2 (ja) 2017-07-19
EP2784157A4 (en) 2015-07-01
JP2017148078A (ja) 2017-08-31
JP6270192B2 (ja) 2018-01-31
WO2013058404A1 (ja) 2013-04-25
JPWO2013058404A1 (ja) 2015-04-02
US11742056B2 (en) 2023-08-29
JP7789426B2 (ja) 2025-12-22
JP6267388B2 (ja) 2018-01-24
AU2022204654A1 (en) 2022-07-21
US9513283B2 (en) 2016-12-06
AU2017254874A1 (en) 2017-11-16

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