JP6164488B2 - Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 - Google Patents

Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 Download PDF

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JP6164488B2
JP6164488B2 JP2013539727A JP2013539727A JP6164488B2 JP 6164488 B2 JP6164488 B2 JP 6164488B2 JP 2013539727 A JP2013539727 A JP 2013539727A JP 2013539727 A JP2013539727 A JP 2013539727A JP 6164488 B2 JP6164488 B2 JP 6164488B2
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rna
amino acids
ppr
motif
protein
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JPWO2013058404A1 (ja
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崇裕 中村
崇裕 中村
祐介 八木
祐介 八木
啓子 小林
啓子 小林
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Kyushu University NUC
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    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G16B30/10—Sequence alignment; Homology search
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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    • C12Q2522/00—Reaction characterised by the use of non-enzymatic proteins
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JP2013539727A 2011-10-21 2012-10-22 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用 Active JP6164488B2 (ja)

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JP2011231346 2011-10-21
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JP2013539727A JP6164488B2 (ja) 2011-10-21 2012-10-22 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
PCT/JP2012/077274 WO2013058404A1 (ja) 2011-10-21 2012-10-22 Pprモチーフを利用したrna結合性蛋白質の設計方法及びその利用

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JP2017112764A Division JP6270192B2 (ja) 2011-10-21 2017-06-07 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用

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JP2017244766A Active JP6934644B2 (ja) 2011-10-21 2017-12-21 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
JP2021086108A Active JP7157483B2 (ja) 2011-10-21 2021-05-21 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
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JP2021086108A Active JP7157483B2 (ja) 2011-10-21 2021-05-21 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
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JP2023183886A Active JP7590019B2 (ja) 2011-10-21 2023-10-26 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
JP2024194918A Active JP7789426B2 (ja) 2011-10-21 2024-11-07 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用

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US (7) US9513283B2 (enExample)
EP (2) EP2784157B1 (enExample)
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AU (5) AU2012326971C1 (enExample)
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JP6164488B2 (ja) 2011-10-21 2017-07-19 国立大学法人九州大学 Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の設計方法及びその利用
CA2873073A1 (en) * 2012-04-16 2013-10-24 The University Of Western Australia Peptides for the binding of nucleotide targets
NZ714264A (en) * 2013-04-22 2020-10-30 Univ Kyushu Nat Univ Corp Dna-binding protein using ppr motif, and use thereof
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JP6664693B2 (ja) 2015-09-09 2020-03-13 国立大学法人神戸大学 標的化したｄｎａ配列の核酸塩基を特異的に変換する、グラム陽性菌のゲノム配列の変換方法、及びそれに用いる分子複合体
ES2930643T3 (es) 2015-11-23 2022-12-20 Univ California Seguimiento y manipulación de ARN celular a través de la administración nuclear de CRISPR/CAS9
KR102061438B1 (ko) 2015-11-27 2019-12-31 고쿠리츠다이가쿠호진 고베다이가쿠 표적화 dna 서열 중의 핵산 염기가 특이적으로 전환되어 있는 단자엽식물 게놈 서열을 전환시키는 방법, 및 그것에 사용되는 분자 복합체
KR102407776B1 (ko) 2016-06-03 2022-06-10 고쿠리쓰다이가쿠호진 규슈다이가쿠 표적 mRNA로부터의 단백질 발현량을 향상시키기 위한 융합 단백질
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CN109563137A (zh) * 2016-08-10 2019-04-02 富士胶片和光纯药株式会社 利用了ppr基序的dna结合性蛋白质及其应用
WO2018208998A1 (en) 2017-05-10 2018-11-15 The Regents Of The University Of California Directed editing of cellular rna via nuclear delivery of crispr/cas9
CN108932400B (zh) * 2017-05-24 2021-07-23 北京工业大学 一种考虑界面信息的有效的蛋白质-rna复合物结构预测方法
CN108959852B (zh) * 2017-05-24 2021-12-24 北京工业大学 基于氨基酸-核苷酸成对偏好性信息的蛋白质上与rna结合模块的预测方法
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KR20220023985A (ko) 2019-05-29 2022-03-03 에딧포스 인코포레이티드 효율적인 피피알 단백질의 작제방법 및 그의 이용
CN114450031A (zh) 2019-07-10 2022-05-06 洛卡纳生物股份有限公司 靶向rna的敲低和替代组合物及使用方法
KR20220165747A (ko) * 2020-03-31 2022-12-15 에딧포스 인코포레이티드 표적 rna의 편집방법
JP2023551873A (ja) 2020-12-01 2023-12-13 ロックアネイビオ， インコーポレイテッド Ｃａｇリピート病を処置するためのｒｎａ標的化組成物および方法
JP2023551874A (ja) 2020-12-01 2023-12-13 ロックアネイビオ， インコーポレイテッド 筋強直性ジストロフィー１型を処置するためのｒｎａ標的化組成物および方法
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JP2024514956A (ja) 2021-04-23 2024-04-03 ロックアネイビオ， インコーポレイテッド 組織標的化された改変ａａｖカプシドおよびその使用方法
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JP7125727B1 (ja) * 2021-09-07 2022-08-25 国立大学法人千葉大学 核酸配列改変用組成物および核酸配列の標的部位を改変する方法
CN116888671A (zh) * 2021-09-29 2023-10-13 京东方科技集团股份有限公司 Rna-蛋白质相互作用预测方法、装置、介质及电子设备
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