|
US7018809B1
(en)
|
1991-09-19 |
2006-03-28 |
Genentech, Inc. |
Expression of functional antibody fragments
|
|
DK1399484T3
(da)
*
|
2001-06-28 |
2010-11-08 |
Domantis Ltd |
Dobbelt-specifik ligand og anvendelse af denne
|
|
US20100047171A1
(en)
*
|
2006-01-24 |
2010-02-25 |
Roland Beckmann |
Fusion Proteins That Contain Natural Junctions
|
|
JP2009537145A
(ja)
*
|
2006-05-15 |
2009-10-29 |
バイラル ロジック システムズ テクノロジー コーポレーション |
免疫学的疾患および障害を治療するためのｃｄ４７と関連した組成物および方法
|
|
EP2111869A1
(en)
|
2008-04-23 |
2009-10-28 |
Stichting Sanquin Bloedvoorziening |
Compositions and methods to enhance the immune system
|
|
BR112012017164A2
(pt)
|
2009-12-22 |
2019-09-24 |
Novartis Ag |
proteína de fusão de região constante de anticorpo-cd47 tetravalente
|
|
BR112013031762A2
(pt)
|
2011-06-16 |
2016-09-13 |
Novartis Ag |
proteínas solúveis para utilização como terapêuticos
|
|
ES2816647T3
(es)
|
2012-01-17 |
2021-04-05 |
Univ Leland Stanford Junior |
Reactivos SIRP-alfa de alta afinidad
|
|
US20140140989A1
(en)
|
2012-02-06 |
2014-05-22 |
Inhibrx Llc |
Non-Platelet Depleting and Non-Red Blood Cell Depleting CD47 Antibodies and Methods of Use Thereof
|
|
KR102100388B1
(ko)
|
2012-02-06 |
2020-04-13 |
인히브릭스, 인크. |
Cd47 항체 및 그 사용 방법
|
|
MX360352B
(es)
*
|
2012-02-15 |
2018-10-30 |
Hoffmann La Roche |
Cromatografia de afinidad basada en receptores fc.
|
|
DK3725807T3
(da)
|
2012-12-03 |
2026-01-12 |
Novimmune Sa |
Anti-cd47 antistoffer og fremgangsmåder til anvendelse deraf
|
|
BR112015013431A2
(pt)
|
2012-12-12 |
2017-11-14 |
Vasculox Inc |
anticorpos monoclonais ou respectivos fragmentos ligantes de antígenos, composição farmacêutica, e usos de anticorpo monoclonal ou respectivo fragmento ligante de antígenos
|
|
US9221908B2
(en)
|
2012-12-12 |
2015-12-29 |
Vasculox, Inc. |
Therapeutic CD47 antibodies
|
|
PL3575326T3
(pl)
|
2012-12-17 |
2022-07-11 |
Pf Argentum Ip Holdings Llc |
Leczenie komórek chorobowych cd47+ z użyciem fuzji sirp alfa-fc
|
|
NZ710695A
(en)
|
2013-02-06 |
2020-05-29 |
Inhibrx Inc |
Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof
|
|
CA2919076C
(en)
*
|
2013-07-31 |
2024-01-30 |
Amgen Inc. |
Stabilization of fc-containing polypeptides
|
|
WO2016023040A1
(en)
|
2014-08-08 |
2016-02-11 |
Alexo Therapeutics International |
Sirp-alpha variant constructs and uses thereof
|
|
PL3180363T3
(pl)
*
|
2014-08-15 |
2020-02-28 |
Merck Patent Gmbh |
Białka fuzyjne immunoglobulin sirp-alfa
|
|
EP3012271A1
(en)
|
2014-10-24 |
2016-04-27 |
Effimune |
Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and infectious diseases
|
|
EP3221358B1
(en)
|
2014-11-18 |
2021-07-21 |
Janssen Pharmaceutica, N.V. |
Cd47 antibodies, methods, and uses
|
|
MX391051B
(es)
|
2014-12-30 |
2025-03-21 |
Celgene Corp |
Anticuerpos anti-cd47 y usos de los mismos.
|
|
PT3277821T
(pt)
|
2015-03-31 |
2019-10-31 |
Novimmune Sa |
Método para otimizar a montagem e produção de complexos proteicos hetero-multiméricos
|
|
CN106146670B
(zh)
|
2015-04-24 |
2019-01-15 |
宜明昂科生物医药技术（上海）有限公司 |
一种新的重组双功能融合蛋白及其制备和应用
|
|
US10358472B2
(en)
|
2015-05-06 |
2019-07-23 |
The Board Of Trustees Of The Leland Stanford Junior University |
High affinity CD47 analogs
|
|
CN114425077A
(zh)
|
2015-05-18 |
2022-05-03 |
起源生物医药公司 |
Sirp多肽组合物和使用方法
|
|
AU2016304794B2
(en)
|
2015-08-07 |
2021-07-15 |
ALX Oncology Inc. |
Constructs having a SIRP-alpha domain or variant thereof
|
|
RU2748401C2
(ru)
|
2015-09-18 |
2021-05-25 |
Арч Онколоджи, Инк. |
Терапевтические антитела к CD47
|
|
WO2017053423A1
(en)
|
2015-09-21 |
2017-03-30 |
Erasmus University Medical Center |
Anti-cd47 antibodies and methods of use
|
|
WO2017068164A1
(en)
|
2015-10-21 |
2017-04-27 |
Ose Immunotherapeutics |
Methods and compositions for modifying macrophage polarization into pro-inflammatory cells to treat cancer
|
|
PT3402820T
(pt)
|
2016-01-11 |
2020-08-20 |
Forty Seven Inc |
Anticorpos monoclonais anti-cd47 quiméricos, de ratinho ou humanizados
|
|
BR112018070823A2
(pt)
|
2016-04-14 |
2019-02-05 |
Ose Immunotherapeutics |
anticorpo sirpa anti-humano ou fragmento de ligação a antígeno do mesmo ou mimético de anticorpo de ligação a antígeno, composição farmacêutica, produto de combinação, molécula de ácido nucleico isolada, vetor, célula hospedeira isolada, polipeptídeo, métodos para fabricar um anticorpo, in vitro ou ex vivo para determinar células positivas para sirpa, de diagnóstico e para prever a resposta de um sujeito, e, uso de um anticorpo anti-sirpa ou um fragmento de ligação a antígeno do mesmo ou um mimético de ligação a anticorpo e in vitro ou ex vivo de pelo menos um anticorpo sirpa anti-humano ou fragmento de ligação a antígeno do mesmo ou mimético de anticorpo de ligação a antígeno.
|
|
AU2017250029C1
(en)
|
2016-04-15 |
2022-03-24 |
Pfizer Inc. |
Macrophage stimulation in CD47 blockade therapy
|
|
EP3454900A4
(en)
|
2016-05-09 |
2020-01-29 |
Celgene Corporation |
CD47 ANTIBODIES AND METHODS OF USE
|
|
CN109689684B
(zh)
|
2016-07-06 |
2022-09-23 |
细胞基因公司 |
具有低免疫原性的抗体及其用途
|
|
CN109862910A
(zh)
|
2016-08-03 |
2019-06-07 |
小利兰·斯坦福大学托管委员会 |
破坏巨噬细胞上的Fc受体接合增强抗SIRPα抗体疗法的功效
|
|
JOP20190009A1
(ar)
*
|
2016-09-21 |
2019-01-27 |
Alx Oncology Inc |
أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها
|
|
AU2017332960B2
(en)
|
2016-10-20 |
2019-09-12 |
I-Mab Biopharma Us Limited |
Novel CD47 monoclonal antibodies and uses thereof
|
|
EP3529276A4
(en)
|
2016-10-21 |
2020-06-17 |
Arch Oncology, Inc. |
CD47 THERAPEUTIC ANTIBODIES
|
|
CA3042581A1
(en)
|
2016-11-03 |
2018-05-11 |
Trillium Therapeutics Inc. |
Enhancement of cd47 blockade therapy by proteasome inhibitors
|
|
CA3042583A1
(en)
|
2016-11-03 |
2018-05-11 |
Trillium Therapeutics Inc. |
Improvements in cd47 blockade therapy by hdac inhibitors
|
|
CN108779179B
(zh)
|
2016-11-28 |
2022-02-08 |
江苏恒瑞医药股份有限公司 |
Cd47抗体、其抗原结合片段及其医药用途
|
|
AU2017371070B2
(en)
|
2016-12-09 |
2025-01-02 |
Alector Llc |
Anti-SIRP-alpha antibodies and methods of use thereof
|
|
KR102642385B1
(ko)
*
|
2017-02-06 |
2024-03-04 |
오리오니스 바이오사이언시스 엔브이 |
표적화된 키메라 단백질 및 이의 용도
|
|
JP7179743B2
(ja)
|
2017-02-17 |
2022-11-29 |
オーエスイー・イミュノセラピューティクス |
抗ＳＩＲＰｇ抗体の新規の使用
|
|
JP7170331B2
(ja)
|
2017-03-22 |
2022-11-14 |
アーチ オンコロジー，インコーポレイテッド |
固形及び血液癌の治療のための併用療法
|
|
WO2018183182A1
(en)
|
2017-03-27 |
2018-10-04 |
Celgene Corporation |
Methods and compositions for reduction of immunogenicity
|
|
CN110958888A
(zh)
|
2017-03-28 |
2020-04-03 |
延龄草治疗公司 |
Cd47阻断疗法
|
|
KR102702926B1
(ko)
|
2017-04-13 |
2024-09-06 |
사이로파 비.브이. |
항-sirp 알파 항체
|
|
CN118271443A
(zh)
|
2017-05-16 |
2024-07-02 |
拜奥迪斯私人有限公司 |
抗SIRPα抗体
|
|
US20190062428A1
(en)
|
2017-06-19 |
2019-02-28 |
Surface Oncology, Inc. |
Combination of anti-cd47 antibodies and cell death-inducing agents, and uses thereof
|
|
WO2018237168A1
(en)
|
2017-06-21 |
2018-12-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
Dosing parameters for cd47 targeting therapies to hematologic malignancies
|
|
BR112020001653A2
(pt)
|
2017-07-26 |
2020-07-21 |
Forty Seven, Inc. |
anticorpos anti-sirp-alfa e métodos relacionados
|
|
CN109422811A
(zh)
|
2017-08-29 |
2019-03-05 |
信达生物制药(苏州)有限公司 |
抗cd47抗体及其用途
|
|
US20210347848A1
(en)
*
|
2018-08-31 |
2021-11-11 |
ALX Oncology Inc. |
Decoy polypeptides
|