JP2023549540A - Ｇｃｎ２およびｐｅｒｋキナーゼ阻害剤およびその使用方法 - Google Patents

Ｇｃｎ２およびｐｅｒｋキナーゼ阻害剤およびその使用方法 Download PDF

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JP2023549540A
JP2023549540A JP2023528988A JP2023528988A JP2023549540A JP 2023549540 A JP2023549540 A JP 2023549540A JP 2023528988 A JP2023528988 A JP 2023528988A JP 2023528988 A JP2023528988 A JP 2023528988A JP 2023549540 A JP2023549540 A JP 2023549540A
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alkyl
halogen
haloalkyl
alkoxy
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JP2023549540A5 (https=
Inventor
フリン，ダニエル・エル
カーニー，パトリック
ツヴィッカー，ジェフリー
アル－アニ，ガダ
ジェーブド，サリム
アン，ユ・ミ
ストルツ，クリステン
ル・ブルドネック，ベルトラン
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デシフェラ・ファーマシューティカルズ，エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2023528988A 2020-11-18 2021-11-17 Ｇｃｎ２およびｐｅｒｋキナーゼ阻害剤およびその使用方法 Pending JP2023549540A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063115496P 2020-11-18 2020-11-18
US63/115,496 2020-11-18
US202163185846P 2021-05-07 2021-05-07
US63/185,846 2021-05-07
PCT/US2021/059678 WO2022109001A1 (en) 2020-11-18 2021-11-17 Gcn2 and perk kinase inhibitors and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2023549540A true JP2023549540A (ja) 2023-11-27
JP2023549540A5 JP2023549540A5 (https=) 2024-11-25

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Country Status (14)

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US (2) US11912668B2 (https=)
EP (1) EP4247795A1 (https=)
JP (1) JP2023549540A (https=)
KR (1) KR20230121758A (https=)
AU (1) AU2021381949A1 (https=)
BR (1) BR112023009531A2 (https=)
CA (1) CA3198943A1 (https=)
CL (1) CL2023001399A1 (https=)
CO (1) CO2023006705A2 (https=)
IL (1) IL302807A (https=)
MX (1) MX2023005747A (https=)
PE (1) PE20231311A1 (https=)
TW (1) TW202237568A (https=)
WO (1) WO2022109001A1 (https=)

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GB202008749D0 (en) 2020-06-09 2020-07-22 Ip2Ipo Innovations Ltd Novel compounds
IL302807A (en) 2020-11-18 2023-07-01 Deciphera Pharmaceuticals Llc Gcn2 and perk kinase inhibitors and methods of use thereof
CA3229293A1 (en) * 2021-09-10 2023-03-16 Pui Yee Ng 6-aza-quinoline derivatives and related uses
PE20250609A1 (es) * 2021-12-03 2025-02-26 Deciphera Pharmaceuticals Llc Inhibidores de gcn2 y perk quinasa y metodos de uso de los mismos
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US20250263400A1 (en) * 2022-04-08 2025-08-21 Alesta Therapeutics BV Gcn2 modulator compounds
AU2023269328A1 (en) * 2022-05-11 2024-12-12 Ip2Ipo Innovations Limited Gcn2 inhibitorr
CN119343346A (zh) * 2022-06-08 2025-01-21 韩国化学研究院 苯磺酰胺衍生物、其制备方法及含有其作为活性成分的预防或治疗癌症的药物组合物
AU2023358792A1 (en) * 2022-10-14 2025-04-17 Black Diamond Therapeutics, Inc. Methods of treating cancers using isoquinoline or 6-aza-quinoline derivatives
WO2025043350A1 (en) * 2023-08-30 2025-03-06 Ontario Institute For Cancer Research (Oicr) Triazolopyridopyrimidine and dihydroimidazopyridopyrimidine derivatives as inhibitors of the gcn2 kinase, compositions and uses thereof
WO2025043349A1 (en) * 2023-08-30 2025-03-06 Ontario Institute For Cancer Research (Oicr) Pyrimidopyridone and pteridone derivatives as inhibitors of the gcn2 kinase, compositions and uses thereof
WO2025076441A1 (en) * 2023-10-06 2025-04-10 Alesta Therapeutics BV Compounds of gcn2 modulators

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