PE20231311A1 - Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos - Google Patents

Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos

Info

Publication number
PE20231311A1
PE20231311A1 PE2023001652A PE2023001652A PE20231311A1 PE 20231311 A1 PE20231311 A1 PE 20231311A1 PE 2023001652 A PE2023001652 A PE 2023001652A PE 2023001652 A PE2023001652 A PE 2023001652A PE 20231311 A1 PE20231311 A1 PE 20231311A1
Authority
PE
Peru
Prior art keywords
group
alkyl
gcn2
methods
halogen
Prior art date
Application number
PE2023001652A
Other languages
English (en)
Inventor
Daniel L Flynn
Patrick Kearney
Jeffery Zwicker
Gada Al-Ani
Salim Javed
Yu Mi Ahn
Kristen Stoltz
Bourdonnec Bertrand Le
Original Assignee
Deciphera Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deciphera Pharmaceuticals Llc filed Critical Deciphera Pharmaceuticals Llc
Publication of PE20231311A1 publication Critical patent/PE20231311A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Referido a un compuesto de formula I, o una sal farmaceuticamente aceptable, enantiomero, estereoisomero, o tautomero del mismo, donde: X1 se selecciona del grupo que consiste en CH y N; X2 y X3 se seleccionan en forma independiente entre si entre el grupo que consiste en N, CH, C-O-L2-E2, C-L2-E2, y C-N(R2)-L2-E2; X4 se selecciona del grupo que consiste en CR3 y N; X10 se selecciona del grupo que consiste en CR5 y N; X11 se selecciona del grupo que consiste en CR7 y N; R1 se selecciona del grupo que consiste en H, alquilo, (C=O)R13, cicloalquilo, entre otros; R2 se selecciona del grupo que consiste en H y alquilo; R3 se selecciona del grupo que consiste en H, alquilo, y halogeno; R4 y R5 se seleccionan en forma independiente entre si entre el grupo que consiste en halogeno, H, alcoxi, alquilamino, entre otros; R6 y R7 se seleccionan en forma independiente entre si entre el grupo que consiste en halogeno, H, y alquilo; R13 se selecciona del grupo que consiste en H, alquilo, cicloalquilo, entre otros; A se selecciona del grupo que consiste en un heteroarilo de 5 miembros sustituido, un heteroarilo de 6 miembros sustituido, una piridona, y un anillo arilo sustituido. Estos compuestos son inhibidores de GCN2 Y PERK quinasas. Tambien se refiere a metodos de preparacion de dichos compuestos, compuestos intermediarios, una composicion farmaceutica, y su uso en el tratamiento del cancer, tales como cancer colorrectal, cancer de pulmon, mesotelioma, entre otros.
PE2023001652A 2020-11-18 2021-11-17 Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos PE20231311A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063115496P 2020-11-18 2020-11-18
US202163185846P 2021-05-07 2021-05-07
PCT/US2021/059678 WO2022109001A1 (en) 2020-11-18 2021-11-17 Gcn2 and perk kinase inhibitors and methods of use thereof

Publications (1)

Publication Number Publication Date
PE20231311A1 true PE20231311A1 (es) 2023-08-24

Family

ID=78844846

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2023001652A PE20231311A1 (es) 2020-11-18 2021-11-17 Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos

Country Status (14)

Country Link
US (1) US11912668B2 (es)
EP (1) EP4247795A1 (es)
JP (1) JP2023549540A (es)
KR (1) KR20230121758A (es)
AU (1) AU2021381949A1 (es)
BR (1) BR112023009531A2 (es)
CA (1) CA3198943A1 (es)
CL (1) CL2023001399A1 (es)
CO (1) CO2023006705A2 (es)
IL (1) IL302807A (es)
MX (1) MX2023005747A (es)
PE (1) PE20231311A1 (es)
TW (1) TW202237568A (es)
WO (1) WO2022109001A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202008749D0 (en) 2020-06-09 2020-07-22 Ip2Ipo Innovations Ltd Novel compounds
US11912668B2 (en) 2020-11-18 2024-02-27 Deciphera Pharmaceuticals, Llc GCN2 and perk kinase inhibitors and methods of use thereof
MX2024003028A (es) * 2021-09-10 2024-03-26 Black Diamond Therapeutics Inc Derivados de 6 aza quinolina y usos relacionados.
TW202339730A (zh) * 2021-12-03 2023-10-16 美商迪賽孚爾製藥有限公司 Ｇｃｎ２及ｐｅｒｋ激酶抑制劑及其使用方法
WO2023159322A1 (en) * 2022-02-25 2023-08-31 Ontario Institute For Cancer Research (Oicr) Quinazoline derivatives as inhibitors of the gcn2 kinase, compositions and uses thereof
WO2023196659A1 (en) * 2022-04-08 2023-10-12 Alesta Therapeutics BV Gcn2 modulator compounds
WO2023218195A1 (en) * 2022-05-11 2023-11-16 Ip2Ipo Innovations Limited Gcn2 inhibitorr
WO2023239165A1 (ko) * 2022-06-08 2023-12-14 한국화학연구원 페닐설폰아마이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
WO2024081916A1 (en) * 2022-10-14 2024-04-18 Black Diamond Therapeutics, Inc. Methods of treating cancers using isoquinoline or 6-aza-quinoline derivatives

Family Cites Families (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4038932A1 (de) 1990-12-06 1992-06-11 Roehm Gmbh Diuretische und antikaliuretisch wirksame pteridinderivate
US6060477A (en) 1995-06-07 2000-05-09 Cell Pathways, Inc. Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives
ID24653A (id) 1997-03-19 2000-07-27 Basf Ag Zat-zat terapi
SK3852001A3 (en) 1998-09-18 2003-03-04 Basf Ag 4-Aminopyrrolopyrimidines as kinase inhibitors
US6713474B2 (en) 1998-09-18 2004-03-30 Abbott Gmbh & Co. Kg Pyrrolopyrimidines as therapeutic agents
US7276506B2 (en) 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
US7071199B1 (en) 1999-09-17 2006-07-04 Abbott Gmbh & Cco. Kg Kinase inhibitors as therapeutic agents
CZ2002936A3 (cs) 1999-09-17 2002-10-16 Abbott Gmbh & Co. Kg Pyrazolopyrimidiny jako terapeutické prostředky
US6921763B2 (en) 1999-09-17 2005-07-26 Abbott Laboratories Pyrazolopyrimidines as therapeutic agents
WO2001072751A1 (en) 2000-03-29 2001-10-04 Knoll Gesellschaft Mit Beschraenkter Haftung Pyrrolopyrimidines as tyrosine kinase inhibitors
US20030199525A1 (en) 2002-03-21 2003-10-23 Hirst Gavin C. Kinase inhibitors
US20030225098A1 (en) 2002-03-21 2003-12-04 Hirst Gavin C. Kinase inhibitors
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
US7279576B2 (en) 2002-12-31 2007-10-09 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
WO2004100868A2 (en) 2003-04-23 2004-11-25 Abbott Laboratories Method of treating transplant rejection
JP2006528685A (ja) 2003-05-06 2006-12-21 スミスクライン ビーチャム コーポレーション 新規化合物
US20050026944A1 (en) 2003-07-24 2005-02-03 Patrick Betschmann Thienopyridine and furopyridine kinase inhibitors
US7202363B2 (en) 2003-07-24 2007-04-10 Abbott Laboratories Thienopyridine and furopyridine kinase inhibitors
WO2005025574A2 (en) 2003-09-12 2005-03-24 4 Aza Bioscience Nv PTERIDINE DERIVATIVES FOR THE TREATMENT OF SEPTIC SHOCK AND TNF-α-RELATED DISEASES.
EP1673343A4 (en) 2003-10-08 2008-09-10 Irm Llc COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
WO2005056552A1 (en) 2003-12-09 2005-06-23 Vertex Pharmaceuticals Incorporated Naphthyridine derivatives and their use as modulators of muscarinic receptors
EP1696927A4 (en) 2003-12-19 2007-10-31 Merck & Co Inc MITOTIC INHIBITORS OF KINESIN
EP1730148A4 (en) 2004-02-03 2009-08-19 Abbott Lab USE OF AMINOBENZOXAZOLES AS THERAPEUTIC AGENTS
RU2007102226A (ru) 2004-06-23 2008-07-27 Айрм Ллк (Bm) Соединения и композиции в качестве ингибиторов протеинкиназы
US20070054916A1 (en) 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
CA2592118C (en) 2004-12-23 2015-11-17 Deciphera Pharmaceuticals, Llc Urea derivatives as enzyme modulators
WO2006102079A1 (en) 2005-03-17 2006-09-28 Novartis Ag N- [3- (1-amin0-5, 6, 7, 8-tetrahydro-2 , 4, 4b-triazafluoren-9-yl)-phenyl] benzamides as tyrosine/threonine kinase inhibitors, in particular b-raf kinase
US20090318456A1 (en) 2006-07-06 2009-12-24 Gilead Sciences, Inc. Substituted pteridines for the treatment and prevention of viral infections
US8188113B2 (en) 2006-09-14 2012-05-29 Deciphera Pharmaceuticals, Inc. Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
US7897762B2 (en) 2006-09-14 2011-03-01 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of proliferative diseases
PT2074122E (pt) 2006-09-15 2011-08-24 Pfizer Prod Inc Compostos de pirido(2,3-d)-pirimidinona e sua utilização como inibidores de pi3
US7893066B2 (en) 2006-10-05 2011-02-22 Gilead Palo Alto, Inc. Pyridol[2,3-B]pyrazinones for use as stearoyl CoA desaturase inhibitors
JP2010505881A (ja) 2006-10-05 2010-02-25 ギリアード・パロ・アルト・インコーポレイテッド ステアロイルＣｏＡデサチュラーゼインヒビターとして使用するための二環式窒素含有複素環式化合物
US7790756B2 (en) 2006-10-11 2010-09-07 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
JP2010506948A (ja) 2006-10-20 2010-03-04 アイアールエム・リミテッド・ライアビリティ・カンパニー Ｃ−ｋｉｔおよびｐｄｇｆｒ受容体を調節するための組成物および方法
WO2008077649A1 (en) 2006-12-26 2008-07-03 Gilead Sciences, Inc. Pyrido(3,2-d)pyrimidines useful for treating viral infectons
WO2008123891A1 (en) 2007-04-09 2008-10-16 Cv Therapeutics, Inc. PTERIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
BRPI0807717A2 (pt) 2007-04-20 2014-05-20 Deciphera Pharmaceuticals Llc Inibidores de quinase úteis para o tratamento de doenças mieloproliferativas e outras doenças proliferativas.
JP2011511005A (ja) 2008-02-04 2011-04-07 オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド ２−アミノピリジン系キナーゼ阻害薬
US20110136766A1 (en) 2008-03-04 2011-06-09 Vitae Pharmaceuticals, Inc. Aurora kinase inhibitors
JP2011516546A (ja) 2008-04-10 2011-05-26 ギリアード サイエンシーズ， インコーポレイテッド ステアロイル−ＣｏＡデサチュラーゼのインヒビターとして使用するための二環式窒素含有複素環化合物
US8536187B2 (en) 2008-07-03 2013-09-17 Gilead Sciences, Inc. 2,4,6-trisubstituted pyrido(3,2-d)pyrimidines useful for treating viral infections
UY31982A (es) 2008-07-16 2010-02-26 Boehringer Ingelheim Int Derivados de 1,2-dihidropiridin-3-carboxamidas n-sustituidas
UY31984A (es) 2008-07-16 2010-02-26 Boehringer Ingelheim Int DERIVADOS DE 1-(3,4-difluorobencil)-6-oxo-1,6-dihidropirimidin-5-carboxamidas N-sustituidas y de 2-(3,4-difluorobencil)-3-oxo-2,3-dihidro-1H-pirazol-4-carboxamidas N-sustituidas.
ES2570429T3 (es) 2008-10-16 2016-05-18 Univ California Inhibidores de heteroaril quinasa de anillo condensado
JP5444365B2 (ja) 2008-10-29 2014-03-19 デシフェラ ファーマシューティカルズ，エルエルシー 抗癌活性および抗増殖活性を示すシクロプロパンアミドおよび類似物質
WO2011047384A2 (en) 2009-10-16 2011-04-21 The Regents Of The University Of California Methods of inhibiting ire1
US9765037B2 (en) 2010-01-28 2017-09-19 University Of Washington Through Its Center For Commercialization Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases
CN103068384B (zh) 2010-04-29 2015-03-11 德西费拉制药有限责任公司 表现出抗癌和抗增生活性的环丙基二甲酰胺以及类似物
AU2011248441A1 (en) 2010-04-29 2012-12-20 Deciphera Pharmaceuticals, Llc Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activites
JP2014501261A (ja) 2010-12-23 2014-01-20 アムジエン・インコーポレーテツド 複素環化合物およびそれらの使用
AR085958A1 (es) 2011-04-08 2013-11-06 Afraxis Inc 8-etil-6-(aril)pirido[2,3-d]pirimidin-7(8h)-onas para el tratamiento de trastornos del cns y cancer
WO2012158795A1 (en) 2011-05-17 2012-11-22 Principia Biopharma Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
AU2012100477A4 (en) 2011-08-26 2012-06-14 Paul Alan Alessi Improvements relating to brush harvesters
MX2014005292A (es) 2011-11-04 2014-09-11 Afraxis Holdings Inc Inhibidores de pak para el tratamiento de síndrome del x frágil.
US8921565B2 (en) 2011-11-22 2014-12-30 Deciphera Pharmaceuticals, Llc Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activities
AR090151A1 (es) 2012-03-07 2014-10-22 Lilly Co Eli Compuestos inhibidores de raf
WO2013134298A1 (en) 2012-03-07 2013-09-12 Deciphera Pharmaceuticals, Llc Raf inhibitor compounds
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
CA2874461C (en) 2012-06-18 2021-10-12 Principia Biopharma Inc. Formulations containing reversible covalent compounds
CN102746241B (zh) 2012-07-02 2014-11-05 西安交通大学 2,3,5-三取代苯甲酰胺类化合物及其制备方法和用途
US20140038991A1 (en) 2012-08-06 2014-02-06 Astar Biotech Llc Protein Kinase Inhibitors
GB201216017D0 (en) 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Inhibitor compounds
AU2013315528A1 (en) 2012-09-14 2015-03-12 Eternity Bioscience Inc. Aminoisoquinoline derivatives as protein kinase inhibitors
WO2014145004A1 (en) 2013-03-15 2014-09-18 Deciphera Pharmaceuticals, Llc Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activities
US9309224B2 (en) 2013-03-15 2016-04-12 Deciphera Pharmaceuticals, Llc. N-acyl-N′-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities
US9133183B2 (en) 2013-03-15 2015-09-15 Deciphera Pharmaceuticals, Llc Imidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities
MX365574B (es) 2013-03-15 2019-06-06 Deciphera Pharmaceuticals Llc 2-aminopirimidin-6-onas y analogos que exhiben actividades anticancerosas y antiproliferativas.
US9193719B2 (en) 2013-03-15 2015-11-24 Deciphera Pharmaceuticals, Llc 1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities
JP6495886B2 (ja) 2013-03-15 2019-04-03 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂｔｋ阻害剤としての複素環式芳香族化合物
CN110563700A (zh) 2013-03-15 2019-12-13 德西费拉制药有限责任公司 展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物
US9457019B2 (en) 2013-11-07 2016-10-04 Deciphera Pharmaceuticals, Llc Methods for inhibiting tie-2 kinase useful in the treatment of cancer
CN105330699B (zh) 2014-08-13 2018-12-04 山东汇睿迪生物技术有限公司 一种含磷吡啶并[2,3-d]嘧啶-7-酮类化合物或其药学上可接受的盐、药物组合物及其应用
CN105481858B (zh) 2014-10-11 2019-05-17 上海医药集团股份有限公司 一种含氮稠杂环化合物、其制备方法、组合物及应用
CN105968108B (zh) 2016-05-12 2017-07-04 淮海工学院 一种合成帕布昔利布中间体的方法
DK3472165T3 (da) * 2016-06-21 2023-12-11 Nerviano Medical Sciences Srl N-(substituererede-phenyl)-sulfonamidderivater som kinasehæmmere
CN109153680B (zh) 2016-07-07 2021-04-23 株式会社大熊制药 4-氨基吡唑并[3,4-d]嘧啶基氮杂双环衍生物及含其的药物组合物
US10926459B2 (en) 2016-09-12 2021-02-23 Covestro Deutschland Ag Powder-based additive manufacturing process at low temperatures
DK3524603T3 (da) 2016-12-19 2022-07-04 Abbisko Therapeutics Co Ltd Fgfr4-hæmmer, fremgangsmåde til fremstilling deraf og farmaceutisk anvendelse deraf
CN110382490A (zh) 2016-12-26 2019-10-25 中国医学科学院药物研究所 喹唑啉类化合物及其制备方法、用途和药物组合物
SG11201907909TA (en) 2017-02-27 2019-09-27 Betta Pharmaceuticals Co Ltd Fgfr inhibitor and application thereof
WO2018222173A1 (en) 2017-05-30 2018-12-06 Deciphera Pharmaceuticals, Inc. Use of 1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl]-3-phenylurea and analogs for the treatment of cancers associated with genetic abnormalities in platelet derived growth factor receptor alpha
AU2018278311B2 (en) 2017-06-01 2021-10-07 Cornell University IRE1 small molecule inhibitors
TW201908311A (zh) 2017-06-13 2019-03-01 英商葛蘭素史克智慧財產發展有限公司 化合物
CN109721531B (zh) 2017-10-27 2022-07-29 中国科学院合肥物质科学研究院 一种新型的脂质体激酶抑制剂
CN111566089B (zh) 2017-11-10 2023-11-17 康奈尔大学 Ire1小分子抑制剂
EP3746059A1 (en) 2018-01-31 2020-12-09 Deciphera Pharmaceuticals, LLC Combination therapy for the treatment of gastrointestinal stromal tumors
CN112119064B (zh) 2018-09-14 2023-06-23 上海和誉生物医药科技有限公司 Fgfr抑制剂、其制备方法和应用
US11612606B2 (en) 2018-10-03 2023-03-28 Genentech, Inc. 8-aminoisoquinoline compounds and uses thereof
EP3891137A1 (en) 2018-12-03 2021-10-13 Cornell University Ire1 small molecule inhibitors
MX2021007927A (es) 2018-12-28 2021-10-26 Deciphera Pharmaceuticals Llc Metodos para tratar trastornos usando inhibidores de csf1r.
EP3941919A1 (en) 2019-01-03 2022-01-26 Genentech, Inc. Pyrido-pyrimidinone and pteridinone compounds as inhibitors of endoribonuclease inositol requiring enzyme i (ire i alpha) for the treatment of cancer diseases
WO2020147097A1 (zh) 2019-01-18 2020-07-23 中国科学院合肥物质科学研究院 一种新型的脂质体激酶抑制剂
KR20200100429A (ko) 2019-02-18 2020-08-26 한국과학기술연구원 단백질 키나아제 저해 활성을 갖는 신규한 피리도[3,4-d]피리미딘-8-온 유도체 및 이를 포함하는 암의 예방, 개선 또는 치료용 약학 조성물
TWI756636B (zh) 2019-02-18 2022-03-01 美商建南德克公司 嘧啶并嘧啶化合物及使用方法
WO2020177729A1 (zh) 2019-03-06 2020-09-10 江苏恒瑞医药股份有限公司 稠合芳香环类衍生物、其制备方法及其在医药上的应用
US20220388964A1 (en) 2019-04-12 2022-12-08 Hibercell, Inc. (aza)indazolyl-aryl sulfonamide and related compounds and their use in treating medical conditions
HRP20231310T1 (hr) 2019-05-10 2024-02-02 Deciphera Pharmaceuticals, Llc Heteroarilaminopirimidin amidni inhibitori autofagije i postupci njihove primjene
EP3966207B1 (en) 2019-05-10 2023-11-01 Deciphera Pharmaceuticals, LLC Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof
WO2020232401A1 (en) 2019-05-15 2020-11-19 Cornell University Combination therapies with ire1 small molecule inhibitors
WO2020232403A1 (en) 2019-05-15 2020-11-19 Cornell University Treatment of fibrosis with ire1 small molecule inhibitors
WO2020243376A1 (en) 2019-05-31 2020-12-03 Agios Pharmaceuticals, Inc. Heterobicyclic inhibitors of mat2a and methods of use for treating cancer
WO2020252165A1 (en) 2019-06-11 2020-12-17 Genentech, Inc. Quinazolinyl compounds and methods of use
PE20221083A1 (es) 2019-06-17 2022-07-05 Deciphera Pharmaceuticals Llc Inhibidores de la autofagia de la amida aminopirimidina y sus metodos de uso
US20230277522A9 (en) 2019-08-12 2023-09-07 Deciphera Pharmaceuticals, Llc Methods for treating vascular malformations
TW202122082A (zh) 2019-08-12 2021-06-16 美商迪賽孚爾製藥有限公司 治療胃腸道基質瘤方法
KR20220045189A (ko) 2019-08-12 2022-04-12 데시페라 파마슈티칼스, 엘엘씨. 위장관 기질 종양을 치료하는 방법
EP4327827A3 (en) 2019-12-30 2024-05-29 Deciphera Pharmaceuticals, LLC Amorphous kinase inhibitor formulations and methods of use thereof
KR20220123058A (ko) 2019-12-30 2022-09-05 데시페라 파마슈티칼스, 엘엘씨. 1-(4-브로모-5-(1-에틸-7-(메틸아미노)-2-옥소-1,2-디히드로-1,6-나프티리딘-3-일)-2-플루오로페닐)-3-페닐우레아의 조성물
KR102396930B1 (ko) 2020-01-15 2022-05-12 한국과학기술연구원 피리도[3,4-d]피리미딘 유도체 및 이를 포함하는 치료용 약학 조성물
KR20220143717A (ko) * 2020-02-17 2022-10-25 알레스타 테라퓨틱스 비브이 Gcn2 조정제 화합물
US11912668B2 (en) 2020-11-18 2024-02-27 Deciphera Pharmaceuticals, Llc GCN2 and perk kinase inhibitors and methods of use thereof
CA3200031A1 (en) 2020-11-25 2022-06-02 Deciphera Pharmaceuticals, Llc Anti-viral activity of vps34 inhibitors
CN117136062A (zh) 2020-11-25 2023-11-28 德西费拉制药有限责任公司 Vps34抑制剂的抗病毒活性
EP4251156A1 (en) 2020-11-25 2023-10-04 Deciphera Pharmaceuticals, LLC Anti-viral activity of vps34 inhibitors
WO2022115562A1 (en) 2020-11-25 2022-06-02 Deciphera Pharmaceuticals, Llc Morpholino derivatives as vsp34 inhibitors for use in the treatment of a viral infection
JP2023550641A (ja) 2020-11-25 2023-12-04 デシフェラ・ファーマシューティカルズ，エルエルシー ウイルス感染症の治療に使用するためのｖｓｐ３４阻害剤としてのモルホリノ誘導体
CA3199988A1 (en) 2020-11-25 2022-06-02 Daniel L. Flynn Pyridylpyridone derivatives as vsp34 inhibitors for use in the treatment of a viral infection

Also Published As

Publication number Publication date
AU2021381949A1 (en) 2023-06-15
EP4247795A1 (en) 2023-09-27
IL302807A (en) 2023-07-01
CA3198943A1 (en) 2022-05-27
US11912668B2 (en) 2024-02-27
MX2023005747A (es) 2023-07-28
JP2023549540A (ja) 2023-11-27
CL2023001399A1 (es) 2023-12-15
WO2022109001A1 (en) 2022-05-27
CO2023006705A2 (es) 2023-09-29
US20220274934A1 (en) 2022-09-01
BR112023009531A2 (pt) 2023-10-03
KR20230121758A (ko) 2023-08-21
TW202237568A (zh) 2022-10-01

Similar Documents

Publication Publication Date Title
PE20231311A1 (es) Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos
PE20230249A1 (es) Compuestos de heteroarilo biciclicos y usos de estos
CY1122949T1 (el) ΠΥΡΑΖΟΛΟ[1,5-a]ΠΥΡΑΖΙΝ-4-ΥΛΟ ΠΑΡΑΓΩΓΑ ΩΣ JAK-ΑΝΑΣΤΟΛΕΙΣ
PE20220567A1 (es) Nuevos derivados piperidinilo, un proceso para su preparacion y composiciones farmaceuticas que los contienen
EA202190137A1 (ru) Нафтиридиноновые соединения для применения в качестве активаторов t-клеток
PE20220931A1 (es) Inhibidores de shp2 fosfatasa de tipo pirazolo[3,4-b]pirazina
PE20241068A1 (es) Moduladores de profarmacos de la via de estres integrada
PH12020552004A1 (en) Heterocyclic compounds as kinase inhibitors, compositions comprising the heterocyclic compound, and methods of use thereof
AR103064A1 (es) Compuestos moduladores de fxr (nr1h4)
PE20212303A1 (es) Inhibidores aza-heterobiciclicos de mat2a y metodos de uso en el tratamiento de cancer
AR102722A2 (es) Un derivado de pirazolo-quinazolina, su uso, un procedimiento para prepararlos, composiciones farmacéuticas que los comprenden, compuestos utilizables en su preparación, una biblioteca de dos o más compuestos, y un producto o kit
AR111808A1 (es) Derivados de pirimidina como moduladores del receptor de pge2
AR110789A1 (es) Compuestos moduladores del receptor de hidrocarburos de arilo (ahr)
PE20211703A1 (es) Compuesto derivado heterotriciclico novedoso y uso del mismo
AR110790A1 (es) Compuestos moduladores del receptor de hidrocarburos de arilo (ahr)
PE20240687A1 (es) Compuestos de indazol como inhibidores de cinasas
EA201791816A1 (ru) Ингибиторы kv1.3 и их применение в медицине
EA201990902A1 (ru) Ингибиторы тирозинкиназы брутона
AR111494A1 (es) Compuestos de anilinoquinazolina c₅ y su uso en el tratamiento del cáncer
AR097755A1 (es) Derivados sustituidos de fenilalanina como moduladores del factor xia
PE20181017A1 (es) Compuestos heteroarilo y su uso como farmacos terapeuticos
AR116022A1 (es) Compuestos heteroaromáticos como inhibidores de vanina
CL2020002550A1 (es) Compuestos de pirazol sustituidos con heteroarilo y uso farmacéutico de los mismos.
AR098723A1 (es) Derivados de pirazolopirimidin-2-ilo como inhibidores de jak
PE20220277A1 (es) Compuestos de imidazopiridazina e imidazopiridina como inhibidores de quinasa-2 de tipo receptor de activina