JP2023539584A5 - - Google Patents
Info
- Publication number
- JP2023539584A5 JP2023539584A5 JP2023512797A JP2023512797A JP2023539584A5 JP 2023539584 A5 JP2023539584 A5 JP 2023539584A5 JP 2023512797 A JP2023512797 A JP 2023512797A JP 2023512797 A JP2023512797 A JP 2023512797A JP 2023539584 A5 JP2023539584 A5 JP 2023539584A5
- Authority
- JP
- Japan
- Prior art keywords
- groups
- group
- general formula
- pharmaceutically acceptable
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025280769A JP2026053592A (ja) | 2020-09-01 | 2025-12-24 | 縮合イミダゾール誘導体、その調製方法及びその医薬的応用 |
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010905693 | 2020-09-01 | ||
| CN202010905693.4 | 2020-09-01 | ||
| CN202010984336 | 2020-09-18 | ||
| CN202010984336.1 | 2020-09-18 | ||
| CN202011124085 | 2020-10-20 | ||
| CN202011124085.6 | 2020-10-20 | ||
| CN202011253077.1 | 2020-11-11 | ||
| CN202011253077 | 2020-11-11 | ||
| CN202011407911 | 2020-12-04 | ||
| CN202011407911.8 | 2020-12-04 | ||
| CN202011627733.X | 2020-12-31 | ||
| CN202011627733 | 2020-12-31 | ||
| PCT/CN2021/115915 WO2022007979A1 (zh) | 2020-09-01 | 2021-09-01 | 稠合咪唑类衍生物、其制备方法及其在医药上的应用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025280769A Division JP2026053592A (ja) | 2020-09-01 | 2025-12-24 | 縮合イミダゾール誘導体、その調製方法及びその医薬的応用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023539584A JP2023539584A (ja) | 2023-09-15 |
| JP2023539584A5 true JP2023539584A5 (https=) | 2024-06-11 |
| JP7812052B2 JP7812052B2 (ja) | 2026-02-09 |
Family
ID=79552285
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023512797A Active JP7812052B2 (ja) | 2020-09-01 | 2021-09-01 | 縮合イミダゾール誘導体、その調製方法及びその医薬的応用 |
| JP2025280769A Pending JP2026053592A (ja) | 2020-09-01 | 2025-12-24 | 縮合イミダゾール誘導体、その調製方法及びその医薬的応用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025280769A Pending JP2026053592A (ja) | 2020-09-01 | 2025-12-24 | 縮合イミダゾール誘導体、その調製方法及びその医薬的応用 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US12227499B2 (https=) |
| EP (2) | EP4706757A3 (https=) |
| JP (2) | JP7812052B2 (https=) |
| KR (1) | KR20230058660A (https=) |
| CN (5) | CN119930603A (https=) |
| AU (1) | AU2021306414B2 (https=) |
| CA (1) | CA3188891A1 (https=) |
| DK (1) | DK4209490T3 (https=) |
| FI (1) | FI4209490T3 (https=) |
| MX (1) | MX2023001980A (https=) |
| PT (1) | PT4209490T (https=) |
| TW (1) | TW202220985A (https=) |
| WO (1) | WO2022007979A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202144340A (zh) | 2020-04-03 | 2021-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用 |
| TW202206429A (zh) * | 2020-04-29 | 2022-02-16 | 美商迦舒布魯姆生物有限公司 | 雜環ｇｌｐ—１促效劑 |
| MX2022015026A (es) * | 2020-06-04 | 2023-01-04 | Hangzhou Sciwind Biosciences Co Ltd | Compuesto heteroaromatico de imidazol de cinco miembros y uso del mismo. |
| JP2023537501A (ja) | 2020-08-06 | 2023-09-01 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環ｇｌｐ－１アゴニスト |
| EP4204415A4 (en) | 2020-08-28 | 2025-03-26 | Gasherbrum Bio, Inc. | HETEROCYCLIC GLP-1 AGONISTS |
| CA3188891A1 (en) | 2020-09-01 | 2022-01-13 | Fanglong Yang | Fused imidazole derivative, preparation method therefor, and medical use thereof |
| CR20230330A (es) * | 2021-01-28 | 2023-11-15 | Carmot Therapeutics Inc | Agonistas del receptor gpcr, composiciones farmaceuticas que los comprenden y métodos para su uso |
| TWI843104B (zh) | 2021-05-20 | 2024-05-21 | 美商美國禮來大藥廠 | 類升糖素肽1受體促效劑 |
| WO2023011539A1 (zh) * | 2021-08-04 | 2023-02-09 | 上海翰森生物医药科技有限公司 | 环烯类衍生物调节剂、其制备方法和应用 |
| CA3229524A1 (en) * | 2021-08-24 | 2023-02-03 | Qinghua MAO | Imidazocyclic compound and application thereof |
| WO2023029380A1 (zh) | 2021-08-30 | 2023-03-09 | 杭州德睿智药科技有限公司 | 作为glp1r激动剂的新型芳醚取代杂环类化合物 |
| PT4408840T (pt) | 2021-09-27 | 2025-10-07 | Terns Pharmaceuticals Inc | Ácidos benzimidazolocarboxílicos como agonistas de glp-1r |
| WO2023057414A1 (en) | 2021-10-05 | 2023-04-13 | Astrazeneca Ab | Certain octahydrofuro[3,4- b]pyrazines as glp-1 receptor modulators |
| MX2024004131A (es) | 2021-10-05 | 2024-04-22 | Astrazeneca Ab | Ciertos 2,5-diazabiciclo[4.2.0]octanos como moduladores del receptor de glp-1. |
| US20250115612A1 (en) | 2021-10-05 | 2025-04-10 | Astrazeneca Ab | Certain 2,5-diazabicyclo[4.2.0]octanes and octahydrofuro[3,4-b]pyrazines as glp-1 receptor modulators |
| CN118401519A (zh) | 2021-10-25 | 2024-07-26 | 拓臻制药公司 | 作为glp-1r激动剂的化合物 |
| US20250042882A1 (en) | 2021-12-16 | 2025-02-06 | Astrazeneca Ab | Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators |
| WO2023111144A1 (en) | 2021-12-16 | 2023-06-22 | Astrazeneca Ab | Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators |
| US20250049778A1 (en) * | 2021-12-23 | 2025-02-13 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Crystalline form of glp-1 receptor agonist and preparation method therefor |
| EP4455141B1 (en) * | 2021-12-23 | 2026-03-25 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutically acceptable salt and crystalline form of a glp-1 receptor agonist for the treatment of diabetes |
| CN119095843A (zh) | 2022-02-23 | 2024-12-06 | 拓臻制药公司 | 作为glp-1r激动剂的化合物 |
| WO2023246833A1 (zh) * | 2022-06-23 | 2023-12-28 | 西藏海思科制药有限公司 | 一种五并五元环衍生物的药物组合物及其在医药上的应用 |
| WO2024102625A1 (en) | 2022-11-11 | 2024-05-16 | Eli Lilly And Company | Glucagon-like peptide 1 receptor agonists |
| KR20250085816A (ko) | 2022-11-16 | 2025-06-12 | 일라이 릴리 앤드 캄파니 | 글루카곤-유사 펩티드 1 수용체 효능제 |
| WO2024131869A1 (en) * | 2022-12-22 | 2024-06-27 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| CN116102555A (zh) * | 2022-12-23 | 2023-05-12 | 华中药业股份有限公司 | 咪唑并芳杂基类衍生物及其应用 |
| TW202434574A (zh) * | 2023-02-02 | 2024-09-01 | 大陸商江蘇豪森藥業集團有限公司 | 一種環烯類化合物的鹽、晶型及其製備方法和應用 |
| EP4568664B1 (en) | 2023-04-07 | 2026-04-01 | Terns Pharmaceuticals, Inc. | Combination comprising a thr-beta agonist and a glp-1r agonist for use in treating obesity |
| WO2025007843A1 (zh) * | 2023-07-03 | 2025-01-09 | 德睿智药(苏州)新药研发有限公司 | 作为glp1r激动剂的新型前药化合物或稠环化合物 |
| CN120981457A (zh) | 2023-09-14 | 2025-11-18 | 歌礼制药(中国)有限公司 | Glp-1r激动剂及其治疗方法 |
| TW202521534A (zh) | 2023-11-24 | 2025-06-01 | 香港商歌禮製藥(中國)有限公司 | Glp-1r 激動劑及其治療方法 |
| WO2025148954A1 (zh) * | 2024-01-09 | 2025-07-17 | 山东盛迪医药有限公司 | 一种glp-1r激动剂药物组合物及其应用 |
| WO2025162257A1 (zh) * | 2024-02-01 | 2025-08-07 | 上海森辉医药有限公司 | 制备苯并二氧杂环或其盐方法 |
| TW202600132A (zh) | 2024-03-08 | 2026-01-01 | 美商安尼波那生物公司 | 用於治療肥胖症及提高減重之方法 |
| WO2025252201A1 (zh) * | 2024-06-07 | 2025-12-11 | 江苏豪森药业集团有限公司 | 一种环烯类衍生物的制备方法 |
| WO2026017039A1 (zh) * | 2024-07-15 | 2026-01-22 | 成都地奥九泓制药厂 | Glp-1受体激动剂化合物的盐、晶型、制备方法及其药物组合物和用途 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7138530B2 (en) | 2002-05-28 | 2006-11-21 | 3-Dimensional Pharmaceuticals, Inc. | Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions |
| EA018225B1 (ru) | 2008-03-07 | 2013-06-28 | Транстек Фарма, Инк. | Соединения оксадиазоантрацена для лечения диабета |
| CN102378574B (zh) | 2009-03-30 | 2013-11-20 | 转化技术制药公司 | 取代的偶氮蒽衍生物、药物组合物及其使用方法 |
| US8420655B2 (en) * | 2009-12-04 | 2013-04-16 | Boehringer Ingelheim International Gmbh | Benzimidazole inhibitors of leukotriene production |
| CN105980379B (zh) | 2014-12-08 | 2018-09-07 | 江苏恒瑞医药股份有限公司 | 吡啶甲酰胺类衍生物、其制备方法及其在医药上的应用 |
| JOP20190060A1 (ar) | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
| KR102314286B1 (ko) | 2016-12-16 | 2021-10-21 | 화이자 인코포레이티드 | Glp-1 수용체 작용제 및 이의 용도 |
| US10934279B2 (en) * | 2018-06-13 | 2021-03-02 | Pfizer Inc. | GLP-1 receptor agonists and uses thereof |
| MA54555A (fr) * | 2018-11-22 | 2021-09-29 | Qilu Regor Therapeutics Inc | Agonistes de glp-1r et leurs utilisations |
| CN112955444B (zh) * | 2019-01-22 | 2023-12-12 | 江苏恒瑞医药股份有限公司 | 一种新型的小分子cd73抑制剂、其制备方法及其在医药上的应用 |
| TW202144340A (zh) | 2020-04-03 | 2021-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用 |
| TW202206429A (zh) * | 2020-04-29 | 2022-02-16 | 美商迦舒布魯姆生物有限公司 | 雜環ｇｌｐ—１促效劑 |
| CA3192601A1 (en) | 2020-08-21 | 2022-02-24 | Terns Pharmaceuticals, Inc. | Compounds as glp-1r agonists |
| CA3188891A1 (en) | 2020-09-01 | 2022-01-13 | Fanglong Yang | Fused imidazole derivative, preparation method therefor, and medical use thereof |
| US20240083886A1 (en) | 2020-10-13 | 2024-03-14 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| EP4229050A4 (en) | 2020-10-13 | 2024-12-11 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| CN117222631A (zh) | 2021-03-24 | 2023-12-12 | 诚益生物(美国)公司 | 苯基-[1,3]二氧杂环戊烯并[4,5-c]吡啶基-苯基-、苯基-[1,3]二氧杂环戊烯并[4,5-c]吡啶基-杂芳基-或苯基-[1,3]二氧杂环戊烯并[4,5-c]吡啶基-哌啶基-甲基-氧杂环丁烷基甲基-1h-苯并[d]咪唑-甲酸衍生物及其使用方法 |
| CN117177970A (zh) * | 2021-04-30 | 2023-12-05 | 上海翰森生物医药科技有限公司 | 多环类衍生物调节剂、其制备方法和应用 |
| WO2023011539A1 (zh) | 2021-08-04 | 2023-02-09 | 上海翰森生物医药科技有限公司 | 环烯类衍生物调节剂、其制备方法和应用 |
-
2021
- 2021-09-01 CA CA3188891A patent/CA3188891A1/en active Pending
- 2021-09-01 CN CN202510138614.4A patent/CN119930603A/zh active Pending
- 2021-09-01 CN CN202510139459.8A patent/CN119930604A/zh active Pending
- 2021-09-01 AU AU2021306414A patent/AU2021306414B2/en active Active
- 2021-09-01 CN CN202180050847.9A patent/CN115884969B/zh active Active
- 2021-09-01 KR KR1020237009937A patent/KR20230058660A/ko active Pending
- 2021-09-01 EP EP26153808.6A patent/EP4706757A3/en active Pending
- 2021-09-01 US US18/043,508 patent/US12227499B2/en active Active
- 2021-09-01 CN CN202510139492.0A patent/CN119930605A/zh active Pending
- 2021-09-01 FI FIEP21837580.6T patent/FI4209490T3/fi active
- 2021-09-01 MX MX2023001980A patent/MX2023001980A/es unknown
- 2021-09-01 DK DK21837580.6T patent/DK4209490T3/da active
- 2021-09-01 CN CN202510138725.5A patent/CN119954797A/zh active Pending
- 2021-09-01 WO PCT/CN2021/115915 patent/WO2022007979A1/zh not_active Ceased
- 2021-09-01 JP JP2023512797A patent/JP7812052B2/ja active Active
- 2021-09-01 TW TW110132457A patent/TW202220985A/zh unknown
- 2021-09-01 EP EP21837580.6A patent/EP4209490B1/en active Active
- 2021-09-01 PT PT218375806T patent/PT4209490T/pt unknown
-
2024
- 2024-03-21 US US18/612,631 patent/US12473279B2/en active Active
-
2025
- 2025-01-07 US US19/012,024 patent/US20250282773A1/en active Pending
- 2025-03-26 US US19/091,638 patent/US12459937B2/en active Active
- 2025-12-24 JP JP2025280769A patent/JP2026053592A/ja active Pending
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