|
US5208036A
(en)
|
1985-01-07 |
1993-05-04 |
Syntex (U.S.A.) Inc. |
N-(ω, (ω-1)-dialkyloxy)- and N-(ω, (ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US5057540A
(en)
|
1987-05-29 |
1991-10-15 |
Cambridge Biotech Corporation |
Saponin adjuvant
|
|
US4912094B1
(en)
|
1988-06-29 |
1994-02-15 |
Ribi Immunochem Research Inc. |
Modified lipopolysaccharides and process of preparation
|
|
US5279833A
(en)
|
1990-04-04 |
1994-01-18 |
Yale University |
Liposomal transfection of nucleic acids into animal cells
|
|
US5264618A
(en)
|
1990-04-19 |
1993-11-23 |
Vical, Inc. |
Cationic lipids for intracellular delivery of biologically active molecules
|
|
US5283185A
(en)
|
1991-08-28 |
1994-02-01 |
University Of Tennessee Research Corporation |
Method for delivering nucleic acids into cells
|
|
AU6014094A
(en)
|
1992-12-02 |
1994-06-22 |
Baylor College Of Medicine |
Episomal vectors for gene therapy
|
|
CN1135181A
(zh)
|
1993-09-14 |
1996-11-06 |
Cytel有限公司 |
使用泛dr结合肽改变免疫应答
|
|
US5505947A
(en)
|
1994-05-27 |
1996-04-09 |
The University Of North Carolina At Chapel Hill |
Attenuating mutations in Venezuelan Equine Encephalitis virus
|
|
US7153510B1
(en)
|
1995-05-04 |
2006-12-26 |
Yale University |
Recombinant vesiculoviruses and their uses
|
|
US5840838A
(en)
|
1996-02-29 |
1998-11-24 |
University Of Kentucky Research Foundation |
Process for enhancing the activity of amyloid β peptides
|
|
AU753688B2
(en)
|
1997-03-10 |
2002-10-24 |
Ottawa Civic Loeb Research Institute |
Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
|
|
TWI239847B
(en)
|
1997-12-02 |
2005-09-21 |
Elan Pharm Inc |
N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
|
|
US7264810B2
(en)
|
2001-01-19 |
2007-09-04 |
Cytos Biotechnology Ag |
Molecular antigen array
|
|
WO2004044195A2
(en)
|
2002-11-12 |
2004-05-27 |
Risø National Laboratory |
Polynucleotides encoding agmatine coumaroyltransferase (act) and uses thereof
|
|
KR20050101537A
(ko)
|
2002-12-24 |
2005-10-24 |
뉴로켐 (인터내셔널) 리미티드 |
베타-아밀로이드 관련 질환의 치료를 위한 치료 제제
|
|
WO2004087733A2
(en)
|
2003-03-28 |
2004-10-14 |
New York University |
Prevention and treatment of alzheimer amyloid deposition
|
|
WO2006121656A2
(en)
|
2005-05-05 |
2006-11-16 |
Merck & Co., Inc. |
Peptide conjugate compositions and methods for the prevention and treatment of alzheimer's disease
|
|
CA2657953A1
(en)
|
2005-07-19 |
2007-01-25 |
University Of Rochester |
Alpha-synuclein antibodies and methods related thereto
|
|
HUE033325T2
(en)
|
2007-01-05 |
2017-11-28 |
Univ Zuerich |
Anti-beta-amyloid binder antibodies and their use
|
|
WO2008084483A1
(en)
|
2007-01-11 |
2008-07-17 |
Ramot At Tel Aviv University Ltd. |
Novel therapeutics based on tau/microtubule dynamics
|
|
ES2610474T3
(es)
|
2007-01-11 |
2017-04-27 |
Michael Bacher |
Diagnóstico y tratamiento de la enfermedad de Alzheimer y otras enfermedades neurodegenerativas causantes de demencia
|
|
PL2583978T3
(pl)
|
2007-02-23 |
2016-07-29 |
Prothena Biosciences Ltd Co |
Profilaktyka i leczenie chorób synukleinopatycznych i amyloidogennych
|
|
LT3067066T
(lt)
|
2007-02-23 |
2019-06-25 |
Prothena Biosciences Limited |
Sinukleopatinių ir amiloidogeninių ligų prevencija ir gydymas
|
|
AT506819B1
(de)
|
2008-06-12 |
2011-06-15 |
Affiris Forschungs Und Entwicklungs Gmbh |
Vakzin zur behandlung von alzheimer-krankheit
|
|
EP4218794A3
(en)
*
|
2009-06-10 |
2023-09-13 |
New York University |
Immunological targeting of pathological tau proteins
|
|
CN102596236B
(zh)
|
2009-07-30 |
2015-06-24 |
辉瑞疫苗有限责任公司 |
抗原性Tau肽及其用途
|
|
GB201113570D0
(en)
|
2011-08-05 |
2011-09-21 |
Glaxosmithkline Biolog Sa |
Vaccine
|
|
EP3275461A1
(en)
*
|
2011-09-19 |
2018-01-31 |
Axon Neuroscience SE |
Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease field
|
|
WO2013059786A1
(en)
|
2011-10-21 |
2013-04-25 |
The Ohio State University |
Methylated peptides derived from tau protein and their antibodies for diagnosis and therapy of alzheimer's disease
|
|
EP2887955B1
(en)
|
2012-08-21 |
2020-08-19 |
Institute for Molecular Medicine, Inc. |
Compositions and methods related to diseases associated with deposits of amyloid, tau, and alpha-synuclein
|
|
US20170368167A9
(en)
|
2012-08-21 |
2017-12-28 |
The Institute For Molecular Medicine |
Compositions and methods related to neurological disorders
|
|
UA118441C2
(uk)
|
2012-10-08 |
2019-01-25 |
Протена Біосаєнсиз Лімітед |
Антитіло, що розпізнає альфа-синуклеїн
|
|
JP2015536347A
(ja)
|
2012-11-16 |
2015-12-21 |
ザ ヘンリー エム. ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド |
淋菌性MtrEペプチドおよびワクチン
|
|
WO2014165271A2
(en)
|
2013-03-13 |
2014-10-09 |
Neotope Biosciences Limited |
Tau immunotherapy
|
|
WO2015098963A1
(ja)
|
2013-12-26 |
2015-07-02 |
東亞合成株式会社 |
カルレティキュリンの発現促進方法および該方法に用いられる合成ペプチド
|
|
US10562973B2
(en)
|
2014-04-08 |
2020-02-18 |
Prothena Bioscience Limited |
Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein
|
|
WO2015165961A1
(en)
|
2014-04-29 |
2015-11-05 |
Affiris Ag |
Treatment and prevention of alzheimer's disease (ad)
|
|
IL286493B
(en)
|
2015-11-06 |
2022-07-01 |
Memorial Sloan Kettering Cancer Center |
Triterpene saponin analogues, methods of producing same, compositions comprising same and uses thereof
|
|
EP3452507B1
(en)
|
2016-05-02 |
2022-10-19 |
Prothena Biosciences Limited |
Tau immunotherapy
|
|
US10906964B2
(en)
|
2016-05-02 |
2021-02-02 |
Prothena Biosciences Limited |
Antibodies recognizing tau
|
|
MX2018013384A
(es)
|
2016-05-02 |
2019-02-28 |
Prothena Biosciences Ltd |
Anticuerpos que reconocen tau.
|
|
JP7136790B2
(ja)
|
2017-02-17 |
2022-09-13 |
ブリストル-マイヤーズ スクイブ カンパニー |
アルファ-シヌクレインに対する抗体およびその使用
|
|
IL269963B2
(en)
|
2017-04-13 |
2024-09-01 |
Adjuvance Tech Inc |
Triterpene saponin synthesis, intermediates and adjuvant combinations
|
|
US20200164065A1
(en)
|
2017-04-25 |
2020-05-28 |
Adjuvance Technologies, Inc. |
Triterpene saponin analogues
|
|
SG11201910066QA
(en)
|
2017-05-02 |
2019-11-28 |
Prothena Biosciences Ltd |
Antibodies recognizing tau
|
|
JP2021508672A
(ja)
|
2017-06-16 |
2021-03-11 |
ユナイテッド ニューロサイエンスUnited Neuroscience |
シヌクレイノパチーの治療のためのアルファ−シヌクレインタンパク質のc末端からのペプチド免疫原及びその製剤
|
|
EP3692373A1
(en)
|
2017-10-02 |
2020-08-12 |
The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Assay for the detection of alpha-synuclein seeding activity associated with synucleinopathies
|
|
WO2019070813A2
(en)
|
2017-10-03 |
2019-04-11 |
The Trustees Of Columbia University In The City Of New York |
USE OF PEPTIDES AS BIOMARKERS IN THE DIAGNOSIS, CONFIRMATION AND TREATMENT OF A NEUROLOGICAL DISORDER
|
|
JP2020536946A
(ja)
|
2017-10-16 |
2020-12-17 |
アジュバンス・テクノロジーズ・インコーポレーテッド |
トリテルペンサポニン類似物
|
|
TW202333768A
(zh)
|
2017-10-25 |
2023-09-01 |
美商健生醫藥公司 |
Tau胜肽之組成物及其用途
|
|
GB201803387D0
(en)
|
2018-03-02 |
2018-04-18 |
One Health Ventures Ltd |
Disease detection
|
|
TW202000907A
(zh)
|
2018-05-23 |
2020-01-01 |
美商葛利史東腫瘤科技公司 |
共有抗原
|
|
CN109022460B
(zh)
|
2018-08-31 |
2021-05-28 |
西藏自治区农牧科学院农业研究所 |
一种bahd酰基转移酶基因及其用途
|
|
WO2020120644A1
(en)
|
2018-12-13 |
2020-06-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
New anti tau svqivykpv epitope single domain antibody
|
|
CN110684122B
(zh)
|
2019-10-29 |
2021-03-02 |
中国人民解放军军事科学院军事医学研究院 |
重组Tau表位嵌合多聚体抗原、其制备方法和应用
|