|
US5674708A
(en)
|
1989-06-23 |
1997-10-07 |
Trustees Of The University Of Pennsylvania |
α-1-antichymotrypsin analogues having elastase inhibitory activity
|
|
DE69233760D1
(de)
|
1991-03-01 |
2009-06-25 |
Dyax Corp |
Inhibitoren der menschlichen Elastase von Neutrophilen
|
|
AU655301B2
(en)
|
1991-05-23 |
1994-12-15 |
Merrell Pharmaceuticals Inc. |
Inhibitors of cathepsin G and elastase for preventing connective tissue degradation
|
|
US5216022A
(en)
|
1991-12-19 |
1993-06-01 |
Cortech, Inc. |
Aromatic esters of phenylenedialkanoates as inhibitors of human neutrophil elastase
|
|
GB9307555D0
(en)
|
1992-04-16 |
1993-06-02 |
Zeneca Ltd |
Heterocyclic compounds
|
|
DE69314169T2
(de)
|
1992-04-16 |
1998-01-15 |
Zeneca Ltd |
Peptide mit eine alphaaminoboronaire gruppe and ihre verwendung als elastasehemmer
|
|
US5441960A
(en)
|
1992-04-16 |
1995-08-15 |
Zeneca Limited |
1-pyrimidinylacetamide human leukocyte elastate inhibitors
|
|
US5486529A
(en)
|
1992-04-16 |
1996-01-23 |
Zeneca Limited |
Certain pyridyl ketones for treating diseases involving leukocyte elastase
|
|
EP0636144A1
(en)
|
1992-04-16 |
1995-02-01 |
Zeneca Limited |
Alpha-aminoboronic acid peptides and their use as elastase inhibitors
|
|
GB9211783D0
(en)
|
1992-06-04 |
1992-07-15 |
Ici Plc |
Amide derivatives
|
|
GB9214053D0
(en)
|
1992-07-02 |
1992-08-12 |
Ici Plc |
Heterocyclic amides
|
|
GB9402680D0
(en)
|
1994-02-11 |
1994-04-06 |
Zeneca Ltd |
Pyrrolidine derivatives
|
|
AU690986B2
(en)
|
1994-06-02 |
1998-05-07 |
Merrell Pharmaceuticals Inc. |
Perfluoroalkyl ketone inhibitors of elastase and processes for making the same
|
|
KR100347285B1
(ko)
|
1994-06-02 |
2003-01-15 |
아벤티스 파마슈티칼스 인크. |
신규의엘라스타제저해제
|
|
US5618792A
(en)
|
1994-11-21 |
1997-04-08 |
Cortech, Inc. |
Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
|
|
GB9502152D0
(en)
|
1995-02-03 |
1995-03-29 |
Zeneca Ltd |
Proline derivatives
|
|
IL125859A0
(en)
|
1996-03-28 |
1999-04-11 |
Glaxo Group Ltd |
Pyrrolopyrrolone derivatives useful as inhibitors of neutrophil elastase
|
|
AU726406B2
(en)
|
1996-04-12 |
2000-11-09 |
Regents Of The University Of Michigan, The |
Mutant plasminogen activator-inhibitor type 1 (PAI-1) and uses thereof
|
|
PE107899A1
(es)
|
1997-09-09 |
1999-11-17 |
Glaxo Group Ltd |
Derivados de pirrolopirrolona como inhibidores de elastasa leucocitaria
|
|
GB9719187D0
(en)
|
1997-09-09 |
1997-11-12 |
Glaxo Group Ltd |
Compounds
|
|
KR20010078724A
(ko)
|
1998-06-03 |
2001-08-21 |
존 더블류. 갈루치 2세 |
세린 프로테아제 저해제로서의 인돌 및테트라히드로이소퀴놀린을 함유하는 α-케토 옥사디아졸
|
|
US6255453B1
(en)
|
1998-06-03 |
2001-07-03 |
Cortech, Inc. |
Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors
|
|
US20030069187A1
(en)
|
2001-10-05 |
2003-04-10 |
Rao Srinivasa K. |
Elastase inhibitors
|
|
US20030119073A1
(en)
|
2001-12-21 |
2003-06-26 |
Stephen Quirk |
Sensors and methods of detection for proteinase enzymes
|
|
GB0219896D0
(en)
|
2002-08-27 |
2002-10-02 |
Bayer Ag |
Dihydropyridine derivatives
|
|
TW200500341A
(en)
|
2002-11-12 |
2005-01-01 |
Astrazeneca Ab |
Novel compounds
|
|
SE0302324D0
(sv)
|
2003-08-28 |
2003-08-28 |
Astrazeneca Ab |
Novel compounds
|
|
SE0302323D0
(sv)
|
2003-08-28 |
2003-08-28 |
Astrazeneca Ab |
Novel compounds
|
|
SE0302487D0
(sv)
|
2003-09-18 |
2003-09-18 |
Astrazeneca Ab |
Novel compounds
|
|
SE0302486D0
(sv)
|
2003-09-18 |
2003-09-18 |
Astrazeneca Ab |
Novel compounds
|
|
JP4825195B2
(ja)
|
2004-02-26 |
2011-11-30 |
バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト |
１，４−ジアリール−ジヒドロピリミジン−２オン化合物およびヒト好中球エラスターゼ阻害剤としてのそれらの使用
|
|
ES2394177T3
(es)
|
2004-02-26 |
2013-01-23 |
Bayer Intellectual Property Gmbh |
1,4-diaril-dihidropirimidin-2-onas y su uso como inhibidores de elastasa de neutrófilos humanos
|
|
WO2006070012A1
(en)
|
2004-12-30 |
2006-07-06 |
Ingenium Pharmaceuticals Ag |
Agents useful in treating inflammatory bowel disease
|
|
GB0502258D0
(en)
|
2005-02-03 |
2005-03-09 |
Argenta Discovery Ltd |
Compounds and their use
|
|
TW200700392A
(en)
|
2005-03-16 |
2007-01-01 |
Astrazeneca Ab |
Novel compounds
|
|
GB0512940D0
(en)
|
2005-06-24 |
2005-08-03 |
Argenta Discovery Ltd |
Compounds and their use
|
|
GB0605469D0
(en)
|
2006-03-17 |
2006-04-26 |
Argenta Discovery Ltd |
Multimers of heterocyclic compounds and their use
|
|
DK2024367T3
(da)
|
2006-05-04 |
2011-01-03 |
Pulmagen Therapeutics Inflammation Ltd |
Tetrahydropyrrolopyrimidindioner og deres anvendelse som inhibitorer af human neutrofil elastase
|
|
WO2009013444A1
(en)
|
2007-07-25 |
2009-01-29 |
Argenta Discovery Limited |
Tetrahydropyrrolopyrimidinediones and their use as human neutrophil elastase inhibitors
|
|
TW200808763A
(en)
|
2006-05-08 |
2008-02-16 |
Astrazeneca Ab |
Novel compounds I
|
|
TW200808771A
(en)
|
2006-05-08 |
2008-02-16 |
Astrazeneca Ab |
Novel compounds II
|
|
EP2019837B1
(en)
|
2006-05-23 |
2011-03-23 |
Irm Llc |
Compounds and compositions as channel activating protease inhibitors
|
|
EP2027143A2
(en)
|
2006-05-23 |
2009-02-25 |
Irm Llc |
Compounds and compositions as channel activating protease inhibitors
|
|
ES2293832B1
(es)
|
2006-07-17 |
2009-05-04 |
Cargoflet S.A. |
Sistema de transporte masivo de gas natural a alta presion por via maritima.
|
|
US20110003858A1
(en)
|
2006-09-04 |
2011-01-06 |
Bergstroem Lena |
Multimeric heterocyclic compounds useful as neutrophil elastase inhibitors
|
|
MX2009002960A
(es)
|
2006-09-21 |
2009-06-26 |
Activx Biosciences Inc |
Inhibidores de serina hidrolasa.
|
|
AU2007342223B2
(en)
|
2007-01-10 |
2011-02-24 |
Irm Llc |
Compounds and compositions as channel activating protease inhibitors
|
|
CA2677487A1
(en)
|
2007-02-09 |
2008-08-14 |
Irm Llc |
Compounds and compositions as channel activating protease inhibitors
|
|
WO2008104752A1
(en)
|
2007-02-26 |
2008-09-04 |
Astrazeneca Ab |
Dihydropyridones as elastase inhibitors
|
|
WO2009037413A1
(en)
|
2007-09-19 |
2009-03-26 |
Argenta Discovery Limited |
Dimers of 5- [ (4-cyanophenyl) sulfinyl] -6-methyl-2-oxo-1- [3- (trifluoromethyl)phenyl] -1,2-dihydropyridine-3-carboxamide as inhibitors of human neutrophil elastase for treating respiratory diseases
|
|
WO2009058076A1
(en)
|
2007-11-02 |
2009-05-07 |
Astrazeneca Ab |
2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
|
|
WO2009061271A1
(en)
|
2007-11-06 |
2009-05-14 |
Astrazeneca Ab |
Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
|
|
WO2009060206A1
(en)
|
2007-11-07 |
2009-05-14 |
Argenta Discovery Limited |
3,4,6,7-tetrahydro-1h-pyrrolo[3,4-d]pyrimidine-2,5-diones and their therapeutic use
|
|
WO2009060158A1
(en)
|
2007-11-07 |
2009-05-14 |
Argenta Discovery Limited |
4- (4-cyanophenyl) -1- (3-trifluoromethylphenyl) -3,4, 6, 7-tetrahydro-1h-pyrrolo [3, 4- d] pyrimidine-2, 5-dione derivatives and their use as human neutrophil elastase inhibitors
|
|
GB0817429D0
(en)
|
2008-09-23 |
2008-10-29 |
Argenta Discovery Ltd |
Enzyme inhibitors
|
|
TW201036957A
(en)
*
|
2009-02-20 |
2010-10-16 |
Astrazeneca Ab |
Novel salt 628
|
|
AU2010302420B2
(en)
|
2009-10-02 |
2013-07-04 |
Astrazeneca Ab |
2-pyridone compounds used as inhibitors of neutrophil elastase
|
|
US20110212181A1
(en)
|
2010-02-26 |
2011-09-01 |
The University Of Hong Kong |
Compositions and methods for treating chronic respiratory inflammation
|
|
WO2011110852A1
(en)
|
2010-03-10 |
2011-09-15 |
Astrazeneca Ab |
Polymorphic forms of 6- [2- (4 -cyanophenyl) - 2h - pyrazol - 3 - yl] - 5 -methyl - 3 - oxo - 4 - (trifluoromethyl - phenyl) 3,4-dihydropyrazine-2-carboxylic acid ethylamide
|
|
GB201004179D0
(en)
|
2010-03-12 |
2010-04-28 |
Pulmagen Therapeutics Inflamma |
Enzyme inhibitors
|
|
GB201004178D0
(en)
|
2010-03-12 |
2010-04-28 |
Pulmagen Therapeutics Inflamma |
Enzyme inhibitors
|
|
EP2766366B1
(en)
|
2011-09-14 |
2016-11-09 |
Chiesi Farmaceutici S.p.A. |
Tetrahydrotriazolopyrimidine derivatives as human neutrophil elastase inhbitors
|
|
WO2013084199A1
(en)
|
2011-12-07 |
2013-06-13 |
Universidade De Lisboa |
Boron heterocycles as new inhibitors of human neutrophil elastase
|
|
RU2638537C2
(ru)
|
2012-07-12 |
2017-12-14 |
КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. |
Ингибирование ферментов
|
|
US9102624B2
(en)
|
2012-08-23 |
2015-08-11 |
Boehringer Ingelheim International Gmbh |
Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
|
|
US20140057926A1
(en)
|
2012-08-23 |
2014-02-27 |
Boehringer Ingelheim International Gmbh |
Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
|
|
US20140057920A1
(en)
|
2012-08-23 |
2014-02-27 |
Boehringer Ingelheim International Gmbh |
Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
|
|
US20140221335A1
(en)
|
2013-02-06 |
2014-08-07 |
Boehringer Ingelheim International Gmbh |
Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
|
|
US9115093B2
(en)
|
2013-03-04 |
2015-08-25 |
Boehringer Ingelheim International Gmbh |
Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
|
|
RU2016123379A
(ru)
|
2013-12-16 |
2017-12-19 |
КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. |
Тетрагидротриазолопиримидиновые соединения в качестве ингибиторов нейтрофильной эластазы человека
|
|
LT3087094T
(lt)
|
2013-12-27 |
2022-09-26 |
Spexis Ag |
Beta plaukų segtuko struktūros peptidų mimetikai, kaip selektyvūs elastazės slopikliai
|
|
JP6499182B2
(ja)
|
2013-12-27 |
2019-04-10 |
ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ |
選択的エラスターゼ阻害剤としてのβ−ヘアピンペプチド模倣体
|
|
US9221807B2
(en)
|
2014-02-21 |
2015-12-29 |
Boehringer Ingelheim International Gmbh |
Substituted pyridones and pyrazinones and their use as inhibitors of neutrophil elastase activity
|
|
WO2015200349A2
(en)
*
|
2014-06-24 |
2015-12-30 |
The California Institute For Biomedical Research |
Elastase inhibitors
|
|
US9458113B2
(en)
|
2014-07-31 |
2016-10-04 |
Boehringer Ingelheim International Gmbh |
Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
|
|
US9475779B2
(en)
|
2014-07-31 |
2016-10-25 |
Boehringer Ingelheim International Gmbh |
Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
|
|
US9657015B2
(en)
*
|
2014-07-31 |
2017-05-23 |
Boehringer Ingelheim International Gmbh |
Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
|
|
US9440930B2
(en)
|
2014-07-31 |
2016-09-13 |
Boehringer Ingelheim International Gmbh |
Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
|
|
US9290457B2
(en)
|
2014-07-31 |
2016-03-22 |
Boehringer Ingelheim International Gmbh |
Substituted dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
|
|
WO2016020070A1
(en)
|
2014-08-05 |
2016-02-11 |
Gerard Voerman |
Mutants of leech derived neutrophil elastase inhibitors and uses thereof
|
|
WO2016050835A2
(en)
|
2014-10-02 |
2016-04-07 |
Ruprecht-Karls-Universität Heidelberg |
Selective inhibitors of neutrophil elastase for treating neuropathic pain and chronic pain states harbouring a neuropathic component
|
|
US9890169B2
(en)
|
2015-12-14 |
2018-02-13 |
Chiesi Farmaceutici S.P.A. |
Triazolinone compounds as HNE inhibitors
|
|
JP6990663B2
(ja)
|
2016-05-31 |
2022-01-13 |
シエッシ ファーマスーティシ エス．ピー．エー． |
ヒト好中球エラスターゼ阻害剤としてのイミダゾロン化合物
|
|
CA3054267A1
(en)
*
|
2017-02-21 |
2018-08-30 |
Kamada Ltd. |
Methods and uses of alpha 1-antitrypsin for early intervention in pulmonary diseases
|
|
AU2020349353A1
(en)
*
|
2019-09-17 |
2022-04-14 |
Duke University |
Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
|
|
WO2021178448A1
(en)
*
|
2020-03-02 |
2021-09-10 |
Motor Life Sciences, Llc |
Compositions and methods for diagnosing, preventing, and treating amyotrophic lateral sclerosis in patients with hypofunctional anti-trypsin activity
|