JP2023520924A5 - - Google Patents
Info
- Publication number
- JP2023520924A5 JP2023520924A5 JP2022561468A JP2022561468A JP2023520924A5 JP 2023520924 A5 JP2023520924 A5 JP 2023520924A5 JP 2022561468 A JP2022561468 A JP 2022561468A JP 2022561468 A JP2022561468 A JP 2022561468A JP 2023520924 A5 JP2023520924 A5 JP 2023520924A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- heteroaryl
- alkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063007327P | 2020-04-08 | 2020-04-08 | |
| US63/007,327 | 2020-04-08 | ||
| US202063043920P | 2020-06-25 | 2020-06-25 | |
| US63/043,920 | 2020-06-25 | ||
| US202063072873P | 2020-08-31 | 2020-08-31 | |
| US63/072,873 | 2020-08-31 | ||
| US202063126493P | 2020-12-16 | 2020-12-16 | |
| US63/126,493 | 2020-12-16 | ||
| PCT/US2021/026477 WO2021207550A1 (en) | 2020-04-08 | 2021-04-08 | Compounds and methods for modulating splicing |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023520924A JP2023520924A (ja) | 2023-05-22 |
| JP2023520924A5 true JP2023520924A5 (enExample) | 2024-04-18 |
| JP7797407B2 JP7797407B2 (ja) | 2026-01-13 |
Family
ID=75747105
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022561468A Active JP7797407B2 (ja) | 2020-04-08 | 2021-04-08 | スプライシングを調節するための化合物及び方法 |
| JP2022561469A Active JP7882782B2 (ja) | 2020-04-08 | 2021-04-08 | スプライシングを調節するための化合物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022561469A Active JP7882782B2 (ja) | 2020-04-08 | 2021-04-08 | スプライシングを調節するための化合物及び方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20240287097A1 (enExample) |
| EP (2) | EP4132936A1 (enExample) |
| JP (2) | JP7797407B2 (enExample) |
| KR (2) | KR20230004575A (enExample) |
| CN (2) | CN116096725A (enExample) |
| AU (2) | AU2021251220A1 (enExample) |
| BR (2) | BR112022020418A2 (enExample) |
| CA (2) | CA3175205A1 (enExample) |
| CL (1) | CL2022002779A1 (enExample) |
| CO (1) | CO2022015926A2 (enExample) |
| CR (1) | CR20220567A (enExample) |
| IL (1) | IL297149A (enExample) |
| MX (2) | MX2022012677A (enExample) |
| WO (2) | WO2021207550A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2020001425A (es) | 2017-08-04 | 2020-08-06 | Skyhawk Therapeutics Inc | Metodos y composiciones para modular el empalme. |
| WO2020163248A1 (en) | 2019-02-04 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| WO2020163541A1 (en) | 2019-02-05 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| JP7603594B2 (ja) | 2019-02-06 | 2024-12-20 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
| IL297963A (en) | 2020-05-07 | 2023-01-01 | Adorx Therapeutics Ltd | Antagonists of the adenosine a2a receptor |
| WO2021231571A1 (en) | 2020-05-13 | 2021-11-18 | Chdi Foundation, Inc. | Htt modulators for treating huntington's disease |
| EP4308577B1 (en) * | 2021-03-17 | 2024-12-25 | F. Hoffmann-La Roche AG | New thiadiazolopyrimidone derivatives |
| CR20230437A (es) * | 2021-03-17 | 2023-10-16 | Hoffmann La Roche | Nuevos derivados de tiazolopirimidinona |
| EP4308572B1 (en) * | 2021-03-17 | 2025-04-23 | F. Hoffmann-La Roche AG | New thienopyrimidinone derivatives |
| TW202330552A (zh) * | 2021-10-13 | 2023-08-01 | 美商雷密克斯醫療公司 | 調節剪接之化合物及方法 |
| AU2022394333A1 (en) | 2021-11-17 | 2024-06-27 | Chdi Foundation, Inc. | HTT modulators for treating Huntington’s disease |
| JP2024541481A (ja) * | 2021-11-24 | 2024-11-08 | リミックス セラピューティクス インコーポレイテッド | スプライシングを調整するための化合物及び方法 |
| CN115112899B (zh) * | 2022-06-15 | 2024-08-16 | 四川大学华西医院 | 检测羧肽酶a4的试剂和/或系统在制备恶性胸腔积液筛查产品中的用途 |
| CN121653249B (zh) * | 2026-02-09 | 2026-05-26 | 中国医学科学院医学生物学研究所 | Dnal1基因作为靶点在筛选防治寨卡病毒或2型登革病毒感染药物中的应用 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB242502A (en) * | 1925-03-10 | 1925-11-12 | Hoe & Co R | Improvements in stapling and folding mechanism |
| JPS57142989A (en) * | 1981-02-27 | 1982-09-03 | Dai Ichi Seiyaku Co Ltd | Thiazolopyrimidine derivative |
| JPS58177997A (ja) * | 1982-04-12 | 1983-10-18 | Dai Ichi Seiyaku Co Ltd | チアジアゾロピリミジノン誘導体 |
| ES2016293B3 (es) * | 1986-03-19 | 1990-11-01 | Kumiai Chemical Industry Co | Fungicida agricola-horticola. |
| TW449600B (en) * | 1994-04-19 | 2001-08-11 | Takeda Chemical Industries Ltd | Condensed-ring thiophene derivatives, their production and use |
| US6153614A (en) | 1998-07-16 | 2000-11-28 | Abbott Laboratories | Piperazinyl pyrimidine dione compounds selective for adrenoceptors |
| AR038118A1 (es) | 2002-01-14 | 2004-12-29 | Upjohn Co | Compuestos derivados de la bencinamida del acido 7-oxo-4,7-dihidrotien[2,3-b[piridin-6-carboxilico 3-sustituido que son utiles como antivirales |
| US20060194871A1 (en) | 2003-04-11 | 2006-08-31 | Barvian Kevin K | Heterocyclic mchr1 antagoists |
| WO2005047293A1 (en) * | 2003-11-07 | 2005-05-26 | Neurocrine Biosciences, Inc. | Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto |
| US7745447B2 (en) * | 2005-10-26 | 2010-06-29 | Bristol-Myers Squibb Company | Substituted thieno[3,2-D]pyrimidines as non-basic melanin concentrating hormone receptor-1 antagonists |
| US8618115B2 (en) | 2005-10-26 | 2013-12-31 | Bristol-Myers Squibb Company | Substituted thieno[3,2-d]pyrimidinones as MCHR1 antagonists and methods for using them |
| KR100846988B1 (ko) | 2006-03-06 | 2008-07-16 | 제일약품주식회사 | 신규한 티에노피리미딘 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 함유하는 약학조성물 |
| WO2008057601A2 (en) * | 2006-11-08 | 2008-05-15 | The Rockefeller University | Organic compounds |
| EP2593106A4 (en) | 2010-07-16 | 2014-01-01 | Univ Rockefeller | ORGANIC CONNECTIONS |
| JP2014519519A (ja) | 2011-06-15 | 2014-08-14 | タケダ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規３，４，４ａ，１０ｂ−テトラヒドロ−１Ｈ−チオピラノ［４，３−ｃ］イソキノリン化合物 |
| US20130102601A1 (en) | 2011-10-21 | 2013-04-25 | F. Hoffmann-La Roche Ltd | Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| WO2013109632A2 (en) | 2012-01-16 | 2013-07-25 | The Rockefeller University | Organic compounds |
| EP3406252B1 (en) | 2012-02-10 | 2020-05-13 | PTC Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
| US8729263B2 (en) | 2012-08-13 | 2014-05-20 | Novartis Ag | 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions |
| TWI693227B (zh) * | 2014-04-23 | 2020-05-11 | 日商田邊三菱製藥股份有限公司 | 新穎二環性或三環性雜環化合物 |
| AU2015261046C1 (en) | 2014-05-15 | 2019-07-25 | F. Hoffmann-La Roche Ag | Compounds for treating spinal muscular atrophy |
| WO2015185531A1 (de) | 2014-06-05 | 2015-12-10 | Bayer Cropscience Aktiengesellschaft | Bicyclische verbindungen als schädlingsbekämpfungsmittel |
| EP3256126B1 (en) | 2015-02-09 | 2024-03-27 | F. Hoffmann-La Roche AG | Compounds for the treatment of cancer |
| EP3310169B1 (en) | 2015-05-30 | 2023-05-17 | PTC Therapeutics, Inc. | Methods for modulating rna splicing |
| CN106279211B (zh) | 2015-06-03 | 2020-09-15 | 北京大学 | 一种噻唑并嘧啶酮化合物及其制备方法和应用 |
| JP6791717B2 (ja) * | 2015-10-22 | 2020-11-25 | 田辺三菱製薬株式会社 | 医薬組成物 |
| AR106472A1 (es) * | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
| CA3119019C (en) | 2015-12-10 | 2024-06-11 | Ptc Therapeutics, Inc. | Compounds and methods for treating huntington's disease |
| SG11201902588PA (en) * | 2016-09-23 | 2019-05-30 | Bayer Ag | N3-Cyclically Substituted Thienouracils And Use Thereof |
| JP2019535789A (ja) | 2016-11-28 | 2019-12-12 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｒｎａスプライシングを調節する方法 |
| CN111372611A (zh) | 2017-06-14 | 2020-07-03 | Ptc医疗公司 | 修饰rna剪接的方法 |
| KR102736865B1 (ko) * | 2017-06-21 | 2024-12-03 | 샤이 테라퓨틱스 엘엘씨 | 암, 염증성 질환, 신경발달질환 및 섬유증 질환의 치료를 위하여 Ras 수퍼패밀리와 상호작용하는 화합물 |
| MX2020001425A (es) | 2017-08-04 | 2020-08-06 | Skyhawk Therapeutics Inc | Metodos y composiciones para modular el empalme. |
| US20230152257A1 (en) | 2017-09-25 | 2023-05-18 | Skyhawk Therapeutics, Inc. | Methods and compositions for screening and identification of splicing |
| US10584133B2 (en) | 2018-03-30 | 2020-03-10 | Biotheryx, Inc. | Thienopyrimidinone compounds |
| JP2021521200A (ja) | 2018-04-10 | 2021-08-26 | スカイホーク・セラピューティクス・インコーポレーテッド | 癌の処置のための化合物 |
| WO2020004594A1 (ja) * | 2018-06-27 | 2020-01-02 | 株式会社リボルナバイオサイエンス | 脊髄性筋萎縮症の予防または治療剤 |
| CR20230437A (es) * | 2021-03-17 | 2023-10-16 | Hoffmann La Roche | Nuevos derivados de tiazolopirimidinona |
| EP4308577B1 (en) * | 2021-03-17 | 2024-12-25 | F. Hoffmann-La Roche AG | New thiadiazolopyrimidone derivatives |
-
2021
- 2021-04-08 MX MX2022012677A patent/MX2022012677A/es unknown
- 2021-04-08 CN CN202180040958.1A patent/CN116096725A/zh active Pending
- 2021-04-08 IL IL297149A patent/IL297149A/en unknown
- 2021-04-08 MX MX2022012676A patent/MX2022012676A/es unknown
- 2021-04-08 EP EP21722693.5A patent/EP4132936A1/en active Pending
- 2021-04-08 JP JP2022561468A patent/JP7797407B2/ja active Active
- 2021-04-08 CA CA3175205A patent/CA3175205A1/en active Pending
- 2021-04-08 EP EP21722687.7A patent/EP4132935A1/en active Pending
- 2021-04-08 US US17/917,868 patent/US20240287097A1/en active Pending
- 2021-04-08 KR KR1020227039049A patent/KR20230004575A/ko active Pending
- 2021-04-08 AU AU2021251220A patent/AU2021251220A1/en active Pending
- 2021-04-08 AU AU2021253571A patent/AU2021253571A1/en active Pending
- 2021-04-08 KR KR1020227039044A patent/KR20230005210A/ko active Pending
- 2021-04-08 BR BR112022020418A patent/BR112022020418A2/pt active Search and Examination
- 2021-04-08 JP JP2022561469A patent/JP7882782B2/ja active Active
- 2021-04-08 CR CR20220567A patent/CR20220567A/es unknown
- 2021-04-08 WO PCT/US2021/026477 patent/WO2021207550A1/en not_active Ceased
- 2021-04-08 WO PCT/US2021/026435 patent/WO2021207530A1/en not_active Ceased
- 2021-04-08 BR BR112022020337A patent/BR112022020337A2/pt unknown
- 2021-04-08 US US17/917,842 patent/US20240279239A1/en active Pending
- 2021-04-08 CN CN202180040768.XA patent/CN116134036A/zh active Pending
- 2021-04-08 CA CA3175193A patent/CA3175193A1/en active Pending
-
2022
- 2022-10-07 CL CL2022002779A patent/CL2022002779A1/es unknown
- 2022-11-04 CO CONC2022/0015926A patent/CO2022015926A2/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2023520925A5 (enExample) | ||
| JP2023515618A5 (enExample) | ||
| JP2023515617A5 (enExample) | ||
| JP2023515620A5 (enExample) | ||
| JP2023515621A5 (enExample) | ||
| JP2023520916A5 (enExample) | ||
| JP6466348B2 (ja) | スルファモイル−アリールアミドおよびｂ型肝炎を処置するための医薬品としてのその使用 | |
| JP2024520481A5 (enExample) | ||
| IL295956A (en) | Heterocyclic amides and their use for modulating splicing | |
| JP6106605B2 (ja) | オレフィン含有核輸送調節剤およびその使用 | |
| RU2655914C2 (ru) | Соединения дигидропиримидина и их применение в фармацевтических препаратах | |
| IL295953A (en) | Pyridazine derivatives regulate nucleic acid splicing | |
| JP2023513680A5 (enExample) | ||
| JP2023553835A5 (enExample) | ||
| TW202045164A (zh) | 化合物、組合物及方法 | |
| JP2022529700A5 (enExample) | ||
| IL295955A (en) | Compounds and methods for modulating splicing | |
| JP2022544714A5 (enExample) | ||
| JP2015531773A (ja) | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 | |
| JP2017504650A5 (enExample) | ||
| JP2014510774A5 (enExample) | ||
| JP2024505571A5 (enExample) | ||
| TW201006804A (en) | Triazole derivative or salt thereof | |
| FR2943669A1 (fr) | Derives de nicotinamide,leur preparation et leur application en therapeutique | |
| HK1256417A1 (zh) | 氰基噻吩并三唑并二氮杂环庚三烯及其用途 |