CA3175205A1 - Compounds and methods for modulating splicing - Google Patents

Compounds and methods for modulating splicing

Info

Publication number
CA3175205A1
CA3175205A1 CA3175205A CA3175205A CA3175205A1 CA 3175205 A1 CA3175205 A1 CA 3175205A1 CA 3175205 A CA3175205 A CA 3175205A CA 3175205 A CA3175205 A CA 3175205A CA 3175205 A1 CA3175205 A1 CA 3175205A1
Authority
CA
Canada
Prior art keywords
compound
heterocyclyl
heteroaryl
alkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3175205A
Other languages
English (en)
French (fr)
Inventor
Dominic Reynolds
Michael W. Seiler
Anant A. AGRAWAL
Frederic VAILLANCOURT
Peter Smith
Serge Leger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Remix Therapeutics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA3175205A1 publication Critical patent/CA3175205A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Replacement Of Web Rolls (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
CA3175205A 2020-04-08 2021-04-08 Compounds and methods for modulating splicing Pending CA3175205A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202063007327P 2020-04-08 2020-04-08
US63/007,327 2020-04-08
US202063043920P 2020-06-25 2020-06-25
US63/043,920 2020-06-25
US202063072873P 2020-08-31 2020-08-31
US63/072,873 2020-08-31
US202063126493P 2020-12-16 2020-12-16
US63/126,493 2020-12-16
PCT/US2021/026435 WO2021207530A1 (en) 2020-04-08 2021-04-08 Compounds and methods for modulating splicing

Publications (1)

Publication Number Publication Date
CA3175205A1 true CA3175205A1 (en) 2021-10-14

Family

ID=75747105

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3175205A Pending CA3175205A1 (en) 2020-04-08 2021-04-08 Compounds and methods for modulating splicing
CA3175193A Pending CA3175193A1 (en) 2020-04-08 2021-04-08 Compounds and methods for modulating splicing

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3175193A Pending CA3175193A1 (en) 2020-04-08 2021-04-08 Compounds and methods for modulating splicing

Country Status (14)

Country Link
US (2) US20240287097A1 (enExample)
EP (2) EP4132936A1 (enExample)
JP (2) JP7797407B2 (enExample)
KR (2) KR20230004575A (enExample)
CN (2) CN116096725A (enExample)
AU (2) AU2021251220A1 (enExample)
BR (2) BR112022020418A2 (enExample)
CA (2) CA3175205A1 (enExample)
CL (1) CL2022002779A1 (enExample)
CO (1) CO2022015926A2 (enExample)
CR (1) CR20220567A (enExample)
IL (1) IL297149A (enExample)
MX (2) MX2022012677A (enExample)
WO (2) WO2021207550A1 (enExample)

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WO2020163541A1 (en) 2019-02-05 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
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CR20230437A (es) * 2021-03-17 2023-10-16 Hoffmann La Roche Nuevos derivados de tiazolopirimidinona
EP4308572B1 (en) * 2021-03-17 2025-04-23 F. Hoffmann-La Roche AG New thienopyrimidinone derivatives
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AU2022394333A1 (en) 2021-11-17 2024-06-27 Chdi Foundation, Inc. HTT modulators for treating Huntington’s disease
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CN115112899B (zh) * 2022-06-15 2024-08-16 四川大学华西医院 检测羧肽酶a4的试剂和/或系统在制备恶性胸腔积液筛查产品中的用途
CN121653249B (zh) * 2026-02-09 2026-05-26 中国医学科学院医学生物学研究所 Dnal1基因作为靶点在筛选防治寨卡病毒或2型登革病毒感染药物中的应用

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Also Published As

Publication number Publication date
IL297149A (en) 2022-12-01
EP4132936A1 (en) 2023-02-15
BR112022020337A2 (pt) 2022-12-13
US20240279239A1 (en) 2024-08-22
WO2021207530A8 (en) 2021-12-02
KR20230005210A (ko) 2023-01-09
EP4132935A1 (en) 2023-02-15
BR112022020418A2 (pt) 2023-05-02
MX2022012676A (es) 2023-01-11
CL2022002779A1 (es) 2023-04-28
US20240287097A1 (en) 2024-08-29
CA3175193A1 (en) 2021-10-14
CN116096725A (zh) 2023-05-09
AU2021251220A1 (en) 2022-11-03
WO2021207550A1 (en) 2021-10-14
JP7882782B2 (ja) 2026-06-30
AU2021253571A1 (en) 2022-11-10
WO2021207530A1 (en) 2021-10-14
JP2023520924A (ja) 2023-05-22
MX2022012677A (es) 2023-01-11
CO2022015926A2 (es) 2022-11-29
CR20220567A (es) 2023-01-13
JP2023520925A (ja) 2023-05-22
CN116134036A (zh) 2023-05-16
JP7797407B2 (ja) 2026-01-13
KR20230004575A (ko) 2023-01-06

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