|
US5681835A
(en)
|
1994-04-25 |
1997-10-28 |
Glaxo Wellcome Inc. |
Non-steroidal ligands for the estrogen receptor
|
|
US5414010A
(en)
*
|
1994-05-10 |
1995-05-09 |
Warner-Lambert Company |
Dimeric benzimidazoles as central nervous system agents
|
|
US6113918A
(en)
|
1997-05-08 |
2000-09-05 |
Ribi Immunochem Research, Inc. |
Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
|
|
GB9716557D0
(en)
|
1997-08-06 |
1997-10-08 |
Glaxo Group Ltd |
Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
|
|
US6312700B1
(en)
|
1998-02-24 |
2001-11-06 |
Andrew D. Weinberg |
Method for enhancing an antigen specific immune response with OX-40L
|
|
EP1065213A3
(en)
|
1999-07-02 |
2003-11-05 |
Japan Tobacco Inc. |
HCV polymerase suitable for crystal structure analysis and method for using the enzyme
|
|
EP1212422B1
(en)
|
1999-08-24 |
2007-02-21 |
Medarex, Inc. |
Human ctla-4 antibodies and their uses
|
|
US7605238B2
(en)
|
1999-08-24 |
2009-10-20 |
Medarex, Inc. |
Human CTLA-4 antibodies and their uses
|
|
JP3871503B2
(ja)
|
1999-08-30 |
2007-01-24 |
日本たばこ産業株式会社 |
免疫性疾患治療剤
|
|
JP4210454B2
(ja)
|
2001-03-27 |
2009-01-21 |
日本たばこ産業株式会社 |
炎症性腸疾患治療剤
|
|
NZ514403A
(en)
|
1999-12-27 |
2002-10-25 |
Japan Tobacco Inc |
Fused-ring compounds and use thereof as drugs
|
|
HU230847B1
(en)
|
2000-05-19 |
2018-08-28 |
Corixa Corp |
Prophylactic and therapeutic treatment of infectious and other diseases with mono and disaccharide-based compounds
|
|
US6448281B1
(en)
|
2000-07-06 |
2002-09-10 |
Boehringer Ingelheim (Canada) Ltd. |
Viral polymerase inhibitors
|
|
CA2417806C
(en)
|
2000-08-04 |
2011-05-10 |
Corixa Corporation |
New immunoeffector compounds
|
|
US6310224B1
(en)
|
2001-01-19 |
2001-10-30 |
Arco Chemical Technology, L.P. |
Epoxidation catalyst and process
|
|
SK286630B6
(sk)
|
2001-01-22 |
2009-02-05 |
Merck & Co., Inc. |
Nukleozidové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie
|
|
JP4212278B2
(ja)
|
2001-03-01 |
2009-01-21 |
日本たばこ産業株式会社 |
移植片拒絶反応抑制剤
|
|
EP1378509A4
(en)
|
2001-03-19 |
2009-03-25 |
Ono Pharmaceutical Co |
DRUGS WITH TRIAZASPIRO ç5.5] UNDECANDERIVATES AS ACTIVE SUBSTANCE
|
|
AR035543A1
(es)
|
2001-06-26 |
2004-06-16 |
Japan Tobacco Inc |
Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
|
|
CA2448737C
(en)
|
2001-07-20 |
2010-06-01 |
Boehringer Ingelheim (Canada) Ltd. |
Viral polymerase inhibitors
|
|
US6525028B1
(en)
|
2002-02-04 |
2003-02-25 |
Corixa Corporation |
Immunoeffector compounds
|
|
US6911434B2
(en)
|
2002-02-04 |
2005-06-28 |
Corixa Corporation |
Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds
|
|
IL164376A0
(en)
|
2002-04-03 |
2005-12-18 |
Applied Research Systems |
Ox4or binding agents, their preparation and pharmaceutical compositions containing them
|
|
WO2003085375A2
(en)
|
2002-04-04 |
2003-10-16 |
Achillion Pharmaceuticals, Inc. |
Hcv antiviral and cytotoxicity drug screening assay
|
|
DOP2003000641A
(es)
|
2002-05-10 |
2003-11-15 |
Pfizer |
Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan
|
|
DE60317677T2
(de)
|
2002-06-13 |
2008-10-30 |
Crucell Holland B.V. |
Ox40 (=cd134) rezeptor agonisten und therapeutische verwendung
|
|
AU2003281200A1
(en)
|
2002-07-03 |
2004-01-23 |
Tasuku Honjo |
Immunopotentiating compositions
|
|
DE60325498D1
(de)
|
2002-10-24 |
2009-02-05 |
Glaxo Group Ltd |
1-acyl-pyrrolidin-derivate für die behandlung von viralen infektionen
|
|
AU2003300911A1
(en)
|
2002-12-13 |
2004-07-09 |
Smithkline Beecham Corporation |
Heterocyclic compounds as ccr5 antagonists
|
|
AU2003300952A1
(en)
|
2002-12-13 |
2004-07-09 |
Smithkline Beecham Corporation |
Indane compounds as ccr5 antagonists
|
|
WO2004054581A2
(en)
|
2002-12-13 |
2004-07-01 |
Smithkline Beecham Corporation |
Cyclohexyl compounds as ccr5 antagonists
|
|
WO2004055016A1
(en)
|
2002-12-13 |
2004-07-01 |
Smithkline Beecham Corporation |
Pyrrolidine and azetidine compounds as ccr5 antagonists
|
|
DE60318891T2
(de)
|
2002-12-13 |
2009-01-22 |
Smithkline Beecham Corp. |
Cyclopropylverbindungen als ccr5 antagonisten
|
|
US7645771B2
(en)
|
2002-12-13 |
2010-01-12 |
Smithkline Beecham Corp. |
CCR5 antagonists as therapeutic agents
|
|
CN101899114A
(zh)
|
2002-12-23 |
2010-12-01 |
惠氏公司 |
抗pd-1抗体及其用途
|
|
US7960522B2
(en)
|
2003-01-06 |
2011-06-14 |
Corixa Corporation |
Certain aminoalkyl glucosaminide phosphate compounds and their use
|
|
US7223785B2
(en)
|
2003-01-22 |
2007-05-29 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
|
US7098231B2
(en)
|
2003-01-22 |
2006-08-29 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
|
US7563869B2
(en)
|
2003-01-23 |
2009-07-21 |
Ono Pharmaceutical Co., Ltd. |
Substance specific to human PD-1
|
|
US7148226B2
(en)
|
2003-02-21 |
2006-12-12 |
Agouron Pharmaceuticals, Inc. |
Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
|
|
WO2005014543A1
(ja)
|
2003-08-06 |
2005-02-17 |
Japan Tobacco Inc. |
縮合環化合物及びそのhcvポリメラーゼ阻害剤としての利用
|
|
CN102911161A
(zh)
|
2004-02-20 |
2013-02-06 |
贝林格尔.英格海姆国际有限公司 |
病毒聚合酶抑制剂
|
|
WO2005089777A1
(en)
|
2004-03-15 |
2005-09-29 |
Karaolis David K R |
A method for inhibiting cancer cell proliferation or increasing cancer cell apoptosis
|
|
JP2007534735A
(ja)
|
2004-04-28 |
2007-11-29 |
アロウ セラピューティクス リミテッド |
抗ウイルス剤として使用するためのモルホリニルアニリノキナゾリン誘導体
|
|
US7153848B2
(en)
|
2004-08-09 |
2006-12-26 |
Bristol-Myers Squibb Company |
Inhibitors of HCV replication
|
|
AU2005273619B2
(en)
|
2004-08-18 |
2009-05-28 |
Pfizer Inc. |
Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
|
|
GB0423673D0
(en)
|
2004-10-25 |
2004-11-24 |
Glaxo Group Ltd |
Compounds
|
|
EP1676834A1
(en)
|
2004-12-30 |
2006-07-05 |
Sanofi-Aventis Deutschland GmbH |
Fused bicyclic carboxamide derivates for use as CXCR2 inhibitors in the treatment of inflammation
|
|
DK2439273T3
(da)
|
2005-05-09 |
2019-06-03 |
Ono Pharmaceutical Co |
Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika
|
|
UA92746C2
(en)
|
2005-05-09 |
2010-12-10 |
Акилайон Фармасьютикалз, Инк. |
Thiazole compounds and methods of use
|
|
PL1879573T3
(pl)
|
2005-05-10 |
2013-05-31 |
Incyte Holdings Corp |
Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania
|
|
PT1907424E
(pt)
|
2005-07-01 |
2015-10-09 |
Squibb & Sons Llc |
Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1)
|
|
EP1782826A1
(en)
|
2005-11-08 |
2007-05-09 |
GBF Gesellschaft für Biotechnologische Forschung mbH |
PQS and c-diGMP and its conjugates as adjuvants and their uses in pharmaceutical compositions
|
|
AU2008247382B2
(en)
|
2007-05-07 |
2014-06-05 |
Medimmune, Llc |
Anti-ICOS antibodies and their use in treatment of oncology, transplantation and autoimmune disease
|
|
BR122017025062B8
(pt)
|
2007-06-18 |
2021-07-27 |
Merck Sharp & Dohme |
anticorpo monoclonal ou fragmento de anticorpo para o receptor de morte programada humano pd-1, polinucleotídeo e composição compreendendo o referido anticorpo ou fragmento
|
|
PT2594590E
(pt)
|
2007-12-14 |
2015-01-14 |
Bristol Myers Squibb Co |
Moléculas de ligação ao recetor humano ox40
|
|
EP2262837A4
(en)
|
2008-03-12 |
2011-04-06 |
Merck Sharp & Dohme |
PD-1 BINDING PROTEINS
|
|
JP2012500855A
(ja)
|
2008-08-25 |
2012-01-12 |
アンプリミューン、インコーポレーテッド |
Pd−1アンタゴニストおよび感染性疾患を処置するための方法
|
|
US8552154B2
(en)
|
2008-09-26 |
2013-10-08 |
Emory University |
Anti-PD-L1 antibodies and uses therefor
|
|
JP5933975B2
(ja)
|
2008-11-12 |
2016-06-15 |
メディミューン,エルエルシー |
抗体製剤
|
|
EP3255060A1
(en)
|
2008-12-09 |
2017-12-13 |
F. Hoffmann-La Roche AG |
Anti-pd-l1 antibodies and their use to enhance t-cell function
|
|
PL2504364T3
(pl)
|
2009-11-24 |
2017-12-29 |
Medimmune Limited |
Ukierunkowane środki wiążące przeciwko B7-H1
|
|
WO2011066342A2
(en)
|
2009-11-24 |
2011-06-03 |
Amplimmune, Inc. |
Simultaneous inhibition of pd-l1/pd-l2
|
|
US20110280877A1
(en)
|
2010-05-11 |
2011-11-17 |
Koji Tamada |
Inhibition of B7-H1/CD80 interaction and uses thereof
|
|
CA2809089C
(en)
|
2010-08-23 |
2018-12-18 |
Board Of Regents, The University Of Texas System |
Anti-ox40 antibodies and methods of using the same
|
|
EP3147297B1
(en)
|
2011-03-31 |
2018-12-12 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Antibodies directed against icos and uses thereof
|
|
MX368257B
(es)
|
2011-08-01 |
2019-09-26 |
Genentech Inc |
Antagonistas de unión al eje pd-1e inhibidores de mek y sus usos en el tratamiento de cáncer.
|
|
CA2845810C
(en)
|
2011-08-23 |
2017-03-28 |
Board Of Regents, The University Of Texas System |
Anti-ox40 antibodies and methods of using the same
|
|
KR20150004416A
(ko)
|
2012-04-30 |
2015-01-12 |
글렌 엔. 바버 |
면역 반응의 조절
|
|
HK1203971A1
(en)
|
2012-05-15 |
2015-11-06 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
|
|
EP2858722B8
(en)
|
2012-06-08 |
2018-02-21 |
Aduro BioTech, Inc. |
Compostions and methods for cancer immunotherapy
|
|
US9695247B2
(en)
|
2012-09-03 |
2017-07-04 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Antibodies directed against ICOS for treating graft-versus-host disease
|
|
BR112015007672A2
(pt)
|
2012-10-04 |
2017-08-08 |
Dana Farber Cancer Inst Inc |
anticorpos anti-pd-l1 monoclonais humanos e métodos de uso
|
|
US9695212B2
(en)
|
2012-12-13 |
2017-07-04 |
Aduro Biotech, Inc. |
Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
|
|
PE20160080A1
(es)
|
2013-05-18 |
2016-02-21 |
Aduro Biotech Inc |
Composiciones y metodos para activar la senalizacion que depende del estimulador del gen de interferon
|
|
JP2016538344A
(ja)
|
2013-11-19 |
2016-12-08 |
ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago |
癌処置としてのstingアゴニストの使用
|
|
CR20160564A
(es)
|
2014-06-04 |
2017-01-20 |
Glaxosmithkline Ip Dev Ltd |
Dinucleótidos cíclicos como moduladores de sting
|
|
RU2715038C2
(ru)
|
2014-07-11 |
2020-02-21 |
Дженентек, Инк. |
Антитела анти-pd-l1 и способы их диагностического применения
|
|
MA41414A
(fr)
|
2015-01-28 |
2017-12-05 |
Centre Nat Rech Scient |
Protéines de liaison agonistes d' icos
|
|
RS60614B1
(sr)
|
2015-03-23 |
2020-08-31 |
Jounce Therapeutics Inc |
Antitela za icos
|
|
PT3440076T
(pt)
*
|
2016-04-07 |
2022-07-29 |
Glaxosmithkline Ip Dev Ltd |
Amidas heterocíclicas úteis como modeladores de proteína
|
|
JP2019510802A
(ja)
|
2016-04-07 |
2019-04-18 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited |
タンパク質調節物質として有用な複素環アミド
|
|
PT3523287T
(pt)
|
2016-10-04 |
2021-10-06 |
Merck Sharp & Dohme |
Compostos de benzo[b]tiofeno como agonistas de sting
|
|
WO2018234807A1
(en)
|
2017-06-22 |
2018-12-27 |
Curadev Pharma Limited |
Heterocyclic small molecule modulators of human sting
|
|
GB2563642A
(en)
|
2017-06-22 |
2018-12-26 |
Curadev Pharma Ltd |
Small molecule modulators of human STING
|
|
US20200138827A1
(en)
|
2017-06-22 |
2020-05-07 |
Curadev Pharma Limited |
Small molecule modulators of human sting
|
|
UA125730C2
(uk)
|
2017-06-22 |
2022-05-25 |
Курадев Фарма Лімітед |
Низькомолекулярні модулятори sting людини
|
|
JP2020530838A
(ja)
|
2017-08-04 |
2020-10-29 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
がん治療のためのベンゾ[b]チオフェンSTINGアゴニスト
|
|
CA3077337A1
(en)
|
2017-10-05 |
2019-04-11 |
Glaxosmithkline Intellectual Property Development Limited |
Modulators of stimulator of interferon genes (sting)
|
|
AU2018344902B2
(en)
|
2017-10-05 |
2021-06-03 |
Glaxosmithkline Intellectual Property Development Limited |
Modulators of stimulator of interferon genes (STING) useful in treating HIV
|
|
CN110016025B
(zh)
|
2018-01-08 |
2021-08-06 |
成都先导药物开发股份有限公司 |
一种免疫调节剂
|
|
WO2019165032A1
(en)
|
2018-02-21 |
2019-08-29 |
The Scripps Research Institute |
Agonists of stimulator of interferon genes sting
|
|
JP7326319B2
(ja)
|
2018-04-03 |
2023-08-15 |
メルク・シャープ・アンド・ドーム・エルエルシー |
Stingアゴニストとしてのベンゾチオフェン類及び関連する化合物
|
|
EP3774765A4
(en)
|
2018-04-03 |
2021-12-29 |
Merck Sharp & Dohme Corp. |
Aza-benzothiophene compounds as sting agonists
|
|
GB201807924D0
(en)
|
2018-05-16 |
2018-06-27 |
Ctxt Pty Ltd |
Compounds
|
|
JP7570235B2
(ja)
*
|
2018-05-25 |
2024-10-21 |
インサイト・コーポレイション |
Sting活性化剤としての三環式複素環式化合物
|